DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HERC2 and kibra

DIOPT Version :9

Sequence 1:	NP_608388.2	Gene:	HERC2 / 33035	FlyBaseID:	FBgn0031107	Length:	4912	Species:	Drosophila melanogaster
Sequence 2:	NP_001034055.1	Gene:	kibra / 41783	FlyBaseID:	FBgn0262127	Length:	1288	Species:	Drosophila melanogaster

Alignment Length:	962	Identity:	167/962 - (17%)
Similarity:	278/962 - (28%)	Gaps:	387/962 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly  2125 RLLQLILAQWG-AEEEPRMPALVHQLFATLGRIALHCPGDASLLPTAEGKARVLL---------- 2178
            |..::...:|. ||....:..|..||...:.||.   ||...     ..|.|:||
  Fly   333 RFAEMAKTKWQYAEWRKHIKKLQQQLADHVERIE---PGQLE-----SDKDRILLIQEKEKLLND 389

  Fly  2179 --TASHSGSVAEELVALLRRLHTLPSWNPVINSFLAQKLCVAAEL------------LAEQSHST 2229
              :.|......||...:.:..|.|.  ..:..::.|...|||..|            |.|...||
  Fly   390 LNSISLKSRSEEEKRVIHQTRHKLE--EDLKEAYEANNTCVANRLRFHEEKQLLLDKLQEALKST 452

  Fly  2230 ALDSEQVFVLGVLGAMGGHDLRPRVGLHCFHEGSHMVIASFTPKGRCLLAPGGVGSGVGFVKVQL 2294
            .|..|:                    |..|...|...|:|              ||.:|.:.
  Fly   453 KLLEER--------------------LKSFSSESTFSISS--------------GSSLGSLS--- 480

  Fly  2295 PAVMPHLDHTVFSLSRLPMNEMLLNAWTVLLYGPAPELRELPSSADGRLDLALLRA------QQL 2353
                     |..|.|.|...::.::                |.:.|..:|:..||.      ||.
  Fly   481 ---------TASSKSALSFTDIYID----------------PFAVDSPIDVVDLRRRSQRLFQQH 520

  Fly  2354 QMAVLHTNGVLYRHQVALRRILKQRAPGSIYASPDEPDRSDAESQQPGEQDQQLSSGSGQEPQLL 2418
            |...||          .:..:|:|:....:..||    ||....:.|.....:.::|:.|.||.|
  Fly   521 QQQRLH----------PVHPVLQQQQSAEVTLSP----RSSLSMETPPASPMKYNAGADQTPQAL 571

  Fly  2419 --------------------------------------IQCILLRA-----TQASPVKACYSYMD 2440
                                                  :.|::|.|     ...:|       ::
  Fly   572 KEEPTYANALPAPPAYTAPPPVPISGVRARPYDLDSTVLDCMMLEAKLQKLNMGTP-------LN 629

  Fly  2441 LATAALNCIQ---SLATQAHQELSEGGGVPPNGRALSSPPQPTMVHGVPVYNVARKEQKPSEQVE 2502
            ||.|.|:.|.   ||.....:.||..... .|.|::|:......|.|......|.:...|.:::.
  Fly   630 LAVAPLSPISEKPSLLDLPQEMLSRSSST-SNTRSVSAAVSNESVAGDSGVFEASRAHLPRKELA 693

  Fly  2503 Q------------------------KSKWPAAATDAQL------------------IGQIMEMGF 2525
            |                        .:.|.|:|.::|:                  :|...:..|
  Fly   694 QVQIGLKYLKQEGVLVVSLERANNLLALWTASADNSQVYLRAALLPNSLTSIRTKALGDFQKPVF 758

  Fly  2526 TRR-TVELALKQL---SLQA----------EIMPT---------PE-QIVQWILEHPDVCANTIE 2566
            ... .|.:.|.:|   |||.          ||:.|         || ..::|.        |.:.
  Fly   759 NDTFAVPITLDKLLTKSLQVTVVTMTGQKEEIIGTVQISMAEFNPEDSTLKWY--------NVLS 815

  Fly  2567 EDTLP---------------LASSASSHDPEADSDNECPSSNSTTSSSTSSDTVEGQPMAVSGPA 2616
            ...:|               .|:.|:|:.|...::.|..|..||.:||.:|.....|       |
  Fly   816 SKFIPSFESLDIPSTSAAAAAAAVAASNAPNPGNNREESSDESTITSSQTSTLTRNQ-------A 873

  Fly  2617 PPVKFESRKDFQTADLYALYVRGLVRPGMTVRCCRDFEEIKQGDMGTVLIVDTEGLHDLNVQVDW 2681
            |.::.:.:   ..|:|..|      .|.....|..|.::.::.::....:|...||
  Fly   874 PCMELQEQ---MAAELLGL------GPLNEPECSDDDDDDEEEELDDKQLVSDVGL--------- 920

  Fly  2682 RNHGSTYWVCFVHIELVEAAQTHHQPRPPPIAVGARVRLRTSSLRYGMLCPLRLGRSQGSSAIGV 2746
                                                  :.:||:.:..|
  Fly   921 --------------------------------------MNSSSMLHAYL---------------- 931

  Fly  2747 VSSVRSKQLTVDFPDQPAWQGHINEVELVASQPTSATLPSLGDSCSQMPPSDLIEDWSRCIRSLT 2811
                  :.:..:|.|:             .:....|.||......||:.....::      ||.|
  Fly   932 ------QNMKQEFADK-------------ETNTDRAYLPEKSRGQSQLMDDRPVK------RSQT 971

  Fly  2812 VSSNEAAAKHLLN-----GSNQPWQSCSSGPCRHWIRLELHDR--ILVHSLTLK-VSPEDHSHMP 2868
            .:.:||.:|:..|     ..:.....|...|  |..:....:|  :..||...| |:...|:|:|
  Fly   972 FTPSEAFSKNRYNCRLNRSDSDSAMHCGVAP--HTFQRGAAERRSLRFHSKAPKSVTKLHHTHIP 1034

  Fly  2869 -SLLEIRVGDCVDSLKEYTWIPVPAGASRVLLMQQVPTYYPWVEVVVKQCQN 2919
             :.|::.:.......|.|            .|..|:.......||:.|.|:|
  Fly  1035 RTSLDLELDLQAQHSKLY------------FLNDQIAKLQNLKEVLQKACEN 1074

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HERC2	NP_608388.2	RCC1	638..683	CDD:278826
		RCC1	687..737	CDD:278826
		RCC1	740..787	CDD:278826
		RCC1	790..841	CDD:278826
		RCC1_2	828..857	CDD:290274
		Cyt-b5	1290..1363	CDD:278597
		MIB_HERC2	1928..1987	CDD:284184
		UBA_HERC2	2515..2559	CDD:270585	15/85 (18%)
		Cul7	2624..2699	CDD:288381	9/74 (12%)
		APC10-HERC2	2762..2932	CDD:176485	33/167 (20%)
		RCC1	3037..3088	CDD:278826
		RCC1	3091..3140	CDD:278826
		RCC1	3144..3194	CDD:278826
		RCC1	3197..3246	CDD:278826
		RCC1	3250..3298	CDD:278826
		RCC1	3302..3350	CDD:278826
		RCC1_2	4136..4166	CDD:290274
		RCC1	4154..4203	CDD:278826
		RCC1	4206..4257	CDD:278826
		RCC1	4260..4309	CDD:278826
		RCC1	4312..4360	CDD:278826
		RCC1	4364..4413	CDD:278826
		HECTc	4509..4880	CDD:238033
		HECTc	4553..4878	CDD:214523
kibra	NP_001034055.1	WW	57..87	CDD:238122
		WW	103..132	CDD:278809
		C2_Kibra	693..813	CDD:176062	19/127 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900