DRSC/TRiP Functional Genomics Resources

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Protein Alignment HERC2 and hyd

DIOPT Version :9

Sequence 1:NP_608388.2 Gene:HERC2 / 33035 FlyBaseID:FBgn0031107 Length:4912 Species:Drosophila melanogaster
Sequence 2:NP_001287262.1 Gene:hyd / 41181 FlyBaseID:FBgn0002431 Length:2887 Species:Drosophila melanogaster


Alignment Length:1198 Identity:245/1198 - (20%)
Similarity:404/1198 - (33%) Gaps:372/1198 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly  3859 EPQVRGGIHLM------HSDYFKTLAALACDMQLDAALPATSSSSSSSAAPGAISSTGDVHKWAW 3917
            |.|::.|.:|.      |..:...|:|.|...|..|  ||||||.:.....|: :|..|      
  Fly  1871 EAQLKFGAYLTNYTDPNHPLHPLNLSAQASSSQTPA--PATSSSVNGVNIMGS-NSRRD------ 1926

  Fly  3918 FKRYCIAVRVAQSLIRRTELP--------------RAFCLEVRKK--FAEMLPSSSSN-SNANPG 3965
            |..||:::..:.:...|..||              .||...:|..  |.:...:.|.. :|.:|.
  Fly  1927 FFTYCLSLMRSHTSEHRDALPVLDITALRHIAYVLDAFVYYMRNDSGFYDKQDTISGRINNLSPM 1991

  Fly  3966 CQS-------PGASMLNSTTSLSSSTVSNVSPPPGITGEQPDLHCHAHQLESTSTLLHEDHTL-F 4022
            .:|       ......|:...:|:|     |.|.|..|.:.    ||....|.|||     :| .
  Fly  1992 TESYDTDDELANLEEFNADVQMSAS-----SMPSGSQGTRR----HAFFARSESTL-----SLGC 2042

  Fly  4023 QAPHDAQLLQWLNRRPDDWALSWGGASTIYGWGHNHRGQLGGLEGSRIKTPTPCEALSLLRPVQL 4087
            .||...:|       |.|.|:..                              .:...||:|   
  Fly  2043 SAPEGFEL-------PLDMAMPL------------------------------ADKPHLLQP--- 2067

  Fly  4088 AGGEQSLFAVTPDGKLFATGYGSGGRL--GVGGSDSWAIPTLLG---SL---QHVFVKKVAVNSG 4144
            ....|.|||..|  .|..|...:.|..  |.|||.....||.||   ||   :.|: :.|.::| 
  Fly  2068 NSKRQELFANLP--LLVTTNANNSGATNDGDGGSIFDYTPTRLGFSNSLKRNERVY-ETVPIDS- 2128

  Fly  4145 GKHCLALTTEGEVYAWGEG-------------------EDGKLGHGNRMSYDRPKLVEHLNGMSV 4190
                 :.|.:|.|....||                   :..|...||:..|::..|:|     :.
  Fly  2129 -----SKTGDGNVTNKAEGSTDSNIYVQLKKKQGSDDFKSHKEADGNQSKYEKVVLME-----TD 2183

  Fly  4191 ADIACGSAHSAAITASGHVLTWGKGRYGRLGHGDSEDQLRPKLVEA--------LLGYRAIDIAC 4247
            ..:...|..:.|:.|:                       ||:::.|        ....|::.:..
  Fly  2184 DSLPSTSKSTEALMAT-----------------------RPEVIIAPNKASVSPATAARSVIVLA 2225

  Fly  4248 GSGDAQTLCITDDDNVWSWGDGDYGKLGRGGSDGCKLPYKIESLAGLGVVKVECGSQF------- 4305
            |....:|  |..|.|.:|     ...|.......|...|:..:...|.:.... ||||       
  Fly  2226 GGSCLKT--IDSDINNYS-----ASNLSTAEQAKCDTQYQKSTSDHLLLFPAR-GSQFYQSNFSE 2282

  Fly  4306 -----------SVALTKSGAVYTWGKGDFHRLGHGSVDHVRRPKKVAALQGKK-IISIATGSLH- 4357
                       .:.|...|.|:....|    :.||||....|...|..::.:: :..:..|... 
  Fly  2283 LPSWNFLLSRWKLTLDLFGRVFMDDVG----MEHGSVLPELRGFPVKEMRFRRHMEKLRNGQQRD 2343

  Fly  4358 CVACS-----DSGEVYTWGD-------------------------NDEGQLGDGTV----TAIQR 4388
            .|.|.     :|..|.|:.:                         .||...|.|..    |:|..
  Fly  2344 LVLCKLERNRESLIVQTFKELNTQFGNQSRRIQPPITFNRVKVTFKDEPGEGSGVARSFYTSIAE 2408

  Fly  4389 PRLVAAL------------QGKHIV--------KVTCGSAHTLAL-----STSQL---SERLRPL 4425
            ..|.:|.            ..|::|        :...||:...:.     |.|::   |.|.|..
  Fly  2409 ALLASAKIPNLESVQVGTNHSKYVVPFSSILRSRTVSGSSRDQSTLQRRGSNSKILWRSARERKA 2473

  Fly  4426 PN-------PPLEYDLVRDLAPEALHARL-ILLHHFSELVCPCLAMLPISGDLSLGALKDVLVYN 4482
            .|       ||...|   :..||:|:..| :.|....|.:.|                   .:::
  Fly  2474 LNLDARPYTPPNSSD---NATPESLNDHLSVHLQQIGERLYP-------------------KIHS 2516

  Fly  4483 IKEAAFRKVIQTTMVRDKQHGPVIELNRIQVKRSRNRCNGLAGIDGMKSVFGQMVQKLPLLTQEA 4547
            |.:....|:.          |.::|:...|:         |:.|...:::..::.:.:.::|   
  Fly  2517 INQTHAPKIT----------GMLLEIPTPQL---------LSVISSDETLRQKVNEAIEIIT--- 2559

  Fly  4548 LALPHRVWKVKFVGESVDDCGGGYSESIAE-----------MCDELQNGSVPLLINTPNGRGEAG 4601
                   :|.|             ||:.|:           :.|.:.:.:.||.. :|..||   
  Fly  2560 -------FKQK-------------SETSAQSSQPKKSPSVVVVDPVDDDNEPLFY-SPGKRG--- 2600

  Fly  4602 ANRDCFLLDPT--LSSVLQMNMFRFLGVLMGIAVRTGSPLSINLAEPVWRQLTGEVLRPTDLTEV 4664
                  ...|.  .:|..::|.||.:|.|:|:.:.....|.:.|...|.:.:.|..::..||...
  Fly  2601 ------FYTPRQGFASFERINAFRNIGRLIGLCLLQNELLPLFLQRHVLKYILGRKIKFHDLAFF 2659

  Fly  4665 DRD-YVAGLLCIRNMD--DDPKLFTALELPF-----STSSARGHEVPLSTRYTHISPRNRAEYVR 4721
            |.. |.:....|:|..  :..:....:||.|     ........|:....|...::..|..||||
  Fly  2660 DPALYESFRQIIQNAQTKEGEETINRMELCFVIDLMKEEGCGNRELIPGGRDVAVTSSNIFEYVR 2724

  Fly  4722 LALGFRLHEFDEQ-VKAVRDGMSKVIPVPLLSLFSAAELQAMVCGSPDIPLGLLKSVATY----- 4780
            ....:||.:..|: ::|::||:..|:|...:...:|.:|:.::.|..||.:..|.|..|:     
  Fly  2725 RYTEYRLIKSQEKALEALKDGVFDVLPDNSMINLTAEDLRLLLNGVGDINVSTLISYTTFNDESS 2789

  Fly  4781 KGFDPSSALVTWFWEVMEEFTNQERSLFLRFVWGRTRLPRTIADFRGRDFVLQVLEKNPPDHFLP 4845
            :|.|.......|||.::|:....||...:.|..|...||   |...|...:..|..:...|..||
  Fly  2790 EGPDKLLKFKKWFWSIVEKMNIMERQDLVYFWTGSPALP---ASEEGFQPLPSVTIRPADDSHLP 2851

  Fly  4846 ESYTCFFLLKMPRYSCKAVLLEKLKYAI 4873
            .:.||...|.:|.||.|::|..|:..||
  Fly  2852 TANTCISRLYIPLYSSKSILRSKMLMAI 2879

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HERC2NP_608388.2 RCC1 638..683 CDD:278826
RCC1 687..737 CDD:278826
RCC1 740..787 CDD:278826
RCC1 790..841 CDD:278826
RCC1_2 828..857 CDD:290274
Cyt-b5 1290..1363 CDD:278597
MIB_HERC2 1928..1987 CDD:284184
UBA_HERC2 2515..2559 CDD:270585
Cul7 2624..2699 CDD:288381
APC10-HERC2 2762..2932 CDD:176485
RCC1 3037..3088 CDD:278826
RCC1 3091..3140 CDD:278826
RCC1 3144..3194 CDD:278826
RCC1 3197..3246 CDD:278826
RCC1 3250..3298 CDD:278826
RCC1 3302..3350 CDD:278826
RCC1_2 4136..4166 CDD:290274 7/48 (15%)
RCC1 4154..4203 CDD:278826 11/67 (16%)
RCC1 4206..4257 CDD:278826 6/58 (10%)
RCC1 4260..4309 CDD:278826 11/66 (17%)
RCC1 4312..4360 CDD:278826 10/49 (20%)
RCC1 4364..4413 CDD:278826 15/97 (15%)
HECTc 4509..4880 CDD:238033 88/392 (22%)
HECTc 4553..4878 CDD:214523 84/348 (24%)
hydNP_001287262.1 E3_UbLigase_EDD 150..196 CDD:288409
ZnF_UBR1 1217..1284 CDD:197698
ASF1_hist_chap 1535..1733 CDD:304562
PolyA 2498..2561 CDD:197769 12/110 (11%)
HECTc 2589..2885 CDD:238033 78/304 (26%)
HECTc 2589..2884 CDD:214523 78/304 (26%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45446994
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
21.830

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