DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HERC2 and rcc2

DIOPT Version :9

Sequence 1:	NP_608388.2	Gene:	HERC2 / 33035	FlyBaseID:	FBgn0031107	Length:	4912	Species:	Drosophila melanogaster
Sequence 2:	NP_998341.1	Gene:	rcc2 / 406455	ZFINID:	ZDB-GENE-040426-2213	Length:	495	Species:	Danio rerio

Alignment Length:	413	Identity:	121/413 - (29%)
Similarity:	188/413 - (45%)	Gaps:	68/413 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly  4054 WGHNHRGQLGGLEGSRIKTPTPCEALSLLRPVQLAGGEQSLFAVTPDGKLFATGYGSGGRLGVGG 4118
            ||.:..|.|..::.|.: ...||.|.||:              :|.:|||::.|....|:||.|.
Zfish   110 WGPHRYGCLSDVQVSCV-VSGPCAAHSLI--------------ITTEGKLWSWGRNDKGQLGHGD 159

  Fly  4119 SDSWAIPTLLGSLQHVFVKKVAVNSGGKHCLALTTEGEVYAWGEGEDGKLGHGNRM-SYDRPKLV 4182
            :.....|.|:..|....:  ||...|..|.||||..|.||.:||.:.|:||.||:. :...|..:
Zfish   160 TKRLEAPKLIEGLGEEVI--VAAACGRNHTLALTENGTVYTFGENKLGQLGQGNQTDAVLSPATI 222

  Fly  4183 EHLNGMSVADIACGSAHSAAITASGHVLTWGKGRYGRLGHG------------DSEDQLRPKLVE 4235
            :: ||..:..:|||:..|..:...|::.::|...||:|||.            :.:.:|.|:.|.
Zfish   223 QY-NGQPIVKVACGAEFSMIVDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEFDCELIPRRVA 286

  Fly  4236 ALL------------GYRAIDIACGSGDAQTLCITDDDNVWSWGDGDYGKLGRGGSDGCKLP--Y 4286
            ..:            ...|.|:|||:.  .||.:.....|:|||.|.||:||........:|  .
Zfish   287 IFIEKTKDGQVLPVPNVVARDVACGAN--HTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLV 349

  Fly  4287 KIESLAGLGVVKVECGSQFSVALTKSGAVYTWGKGDFHRLGHGSVDHVRRPKKVAALQGKKIISI 4351
            |:....|.|..::.||.|.|.||::.|.::.||      :.:.|.:....||.|..|.|.||.|:
Zfish   350 KLFDFPGRGATQIYCGYQCSFALSEMGGLFFWG------VTNTSRESTMYPKAVQDLCGWKIRSL 408

  Fly  4352 ATGSLHCVACSDSGEVYTWGDNDE-GQLGDG-----TVTAIQRPRLVAALQGKHIVKVTCGSAHT 4410
            |.|....:..:|...: :||.:.. |:||.|     :.|..|.   |..|.|.:..:|..|.:|:
Zfish   409 ACGKSSIIVAADDSTI-SWGPSPTFGELGYGDNKPKSSTTAQE---VKTLDGVYSEQVVMGYSHS 469

  Fly  4411 LALS---TSQLSERLRPLP--NP 4428
            |.::   |.|..|:|:.||  ||
Zfish   470 LVIARQDTEQEKEKLKKLPEYNP 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HERC2	NP_608388.2	RCC1	638..683	CDD:278826
		RCC1	687..737	CDD:278826
		RCC1	740..787	CDD:278826
		RCC1	790..841	CDD:278826
		RCC1_2	828..857	CDD:290274
		Cyt-b5	1290..1363	CDD:278597
		MIB_HERC2	1928..1987	CDD:284184
		UBA_HERC2	2515..2559	CDD:270585
		Cul7	2624..2699	CDD:288381
		APC10-HERC2	2762..2932	CDD:176485
		RCC1	3037..3088	CDD:278826
		RCC1	3091..3140	CDD:278826
		RCC1	3144..3194	CDD:278826
		RCC1	3197..3246	CDD:278826
		RCC1	3250..3298	CDD:278826
		RCC1	3302..3350	CDD:278826
		RCC1_2	4136..4166	CDD:290274	13/29 (45%)
		RCC1	4154..4203	CDD:278826	17/49 (35%)
		RCC1	4206..4257	CDD:278826	17/74 (23%)
		RCC1	4260..4309	CDD:278826	17/50 (34%)
		RCC1	4312..4360	CDD:278826	14/47 (30%)
		RCC1	4364..4413	CDD:278826	15/54 (28%)
		HECTc	4509..4880	CDD:238033
		HECTc	4553..4878	CDD:214523
rcc2	NP_998341.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..56
		RCC1 1	76..138		10/42 (24%)
		RCC1_2	121..154	CDD:290274	11/47 (23%)
		RCC1 2	141..192		18/52 (35%)
		RCC1	141..190	CDD:278826	16/50 (32%)
		RCC1	193..242	CDD:278826	17/49 (35%)
		RCC1 3	194..244		17/50 (34%)
		RCC1	245..318	CDD:278826	17/74 (23%)
		RCC1 4	246..320		17/75 (23%)
		Required for interaction with RAC1. /evidence=ECO:0000250\|UniProtKB:Q9P258	291..298		0/6 (0%)
		RCC1 5	321..374		19/52 (37%)
		RCC1	323..372	CDD:278826	17/48 (35%)
		RCC1 6	376..420		14/49 (29%)
		RCC1 7	421..474		15/56 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820