DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment HERC2 and Als2

DIOPT Version :9

Sequence 1:NP_608388.2 Gene:HERC2 / 33035 FlyBaseID:FBgn0031107 Length:4912 Species:Drosophila melanogaster
Sequence 2:NP_649347.1 Gene:Als2 / 40410 FlyBaseID:FBgn0037116 Length:1486 Species:Drosophila melanogaster


Alignment Length:953 Identity:193/953 - (20%)
Similarity:328/953 - (34%) Gaps:277/953 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly  4039 DDWALSWGG-----ASTIYGWGHNHRGQLGGLEGSRIKTPTPCEALSLLRPVQLAGGEQSLFAVT 4098
            ||.||  ||     :.|||..|...:....||        .|.:.....|....||||  |..:|
  Fly     6 DDSAL--GGQEERESFTIYHEGRELQLHWRGL--------PPLQRFPASRICSNAGGE--LLLLT 58

  Fly  4099 PDGKLFATGYGSGGRLGVGGSDSWAIPTLLGSLQHVFVKKVAVN-------SGGKHCLALTTEGE 4156
            .|..|::.                   .|..:.:|:.::.:..:       ||.:....:.|.|.
  Fly    59 TDHALYSA-------------------KLQANREHMDLQLLRTDVVDMDFCSGSQELFVVLTNGS 104

  Fly  4157 V--YAWGEGEDGKLGHGN---RMSYDRPKLVEHLNGMSVADIACGSAHSAAITASGHVLTWGKGR 4216
            |  .|.|.|.|  :||.:   .:.:|..:|  |..|:.:..:.|.:.....:.|||.  |:..|.
  Fly   105 VQRQATGSGRD--VGHPHAWQTLGFDPLEL--HAEGVRIRRVCCSAQGVVFVGASGE--TYVMGS 163

  Fly  4217 YGRLGHGDSEDQLRPKLVEALLGYRAIDIACG-------------SGDAQTLCIT------DDDN 4262
            .|.:...:.:.: ..:|.|.  |...:|:|.|             :.||..|.:.      :|:.
  Fly   164 CGEVFKAEQQPR-HMRLYEE--GKELLDLAAGNEHFVMLVAPYNLADDALQLSVASAKEEPEDER 225

  Fly  4263 VWSWGDGDYGKLGRGGSDGCKLPYKIESLAGLGVVKVECG-SQFSVA-----LTKSG------AV 4315
            .                               .|..:..| |:.|||     |...|      .:
  Fly   226 A-------------------------------SVKSISSGHSERSVAANTRHLLHQGYALLHTQL 259

  Fly  4316 YTWGKGDFHRLGHGSVDHVRRPK--KVAALQGKKIISIATGSLHCVACSDSGEVYTWGDNDEGQL 4378
            :|:|..:...||.|  ||:||..  ::..|....:.|||.|..|.||.:..|.:|.||.|:..||
  Fly   260 FTFGASNNGLLGSG--DHIRRANVMRLQKLDSMGVCSIAAGLEHTVARTLDGRLYHWGLNNHSQL 322

  Fly  4379 GDGTVT----AIQRPRLVAALQGKHIVKVTCGSAHTLALSTSQLSERLRPLPNPPLEYDLVRDLA 4439
            |:...:    .|........::....::.|||..|||.|:.|.....|:|.  ||:     |.|.
  Fly   323 GEDVSSPMEITITENTAALPIEQNSALEATCGDYHTLLLNASGQIHSLQPA--PPM-----RHLQ 380

  Fly  4440 PEALHARLILLHHFSELVCPCLAMLPISGDLS--------------LGALKDVLVYNIKEAAFRK 4490
            ..:.:|:.:|...........|.:|..||..:              |..|:..|...:|.   |:
  Fly   381 QSSTYAQTLLQLQLGAAWPRQLRLLMCSGGYTLQNQRQFQRQYHYYLSHLQSQLQLLLKH---RQ 442

  Fly  4491 VIQTTMVRDKQHG--PVIELNRIQVKRSRNRCNGLAGIDGMKSVF-GQMVQKLPLLTQEALALPH 4552
            .:||..:..:|..  |:..|..:.:...|..|..:|.:..::..: ...||...||         
  Fly   443 AVQTLEIWQRQSALEPLSALGPLLINWERILCLLVATLHSLEGFYRADFVQPADLL--------- 498

  Fly  4553 RVWKVKFVGESVD--DCGGGYSESIAEMCDELQNGSVPLLINTPNGRGEAGANRDCFLLDPTLSS 4615
                  |:....:  |...||:::   .||          :.:.||.|||      .:....|||
  Fly   499 ------FICHYKEYIDLFDGYTKA---YCD----------VFSVNGFGEA------VVAITGLSS 538

  Fly  4616 VL-QMN--------------MFRFLGVLMGIAVRTGSPLSINLAEPVWRQLTGEVLRPTDLTEVD 4665
            .| ::|              :::.....|.:.|||.|....:  ...|.:.........:|....
  Fly   539 PLAELNEESYVTRLFQQPFSIYQLFVQFMELLVRTQSEYGEH--RVAWSEFARHSCISQELAVNT 601

  Fly  4666 RDYVAGLLCIRNMDDDPKL--FTALELPFSTSSARGHEVPLSTRYTHISPRNR-----AEYVRLA 4723
            :|:.:      :.|.:|::  |.........:||.   |||....:.||..:.     ::::...
  Fly   602 KDFWS------SNDRNPRIVQFRGRHRRVILTSAL---VPLKLVTSGISRSSNSFILFSDFLCQV 657

  Fly  4724 LGFRLHEFDEQVKAV-RDGMSKVIPVPLLSLFSAA-----------ELQAMVCGSPDIPLGLLKS 4776
            .|..|:.:......| .:|.|..:..|..|...:.           :||:.:..|...|||  ..
  Fly   658 SGNSLYSYPLTTLWVWTEGDSLRLTTPEKSFLVSTRSQEMRKVWLDQLQSSIIASLGKPLG--SP 720

  Fly  4777 VATYKG-----------FDPSSALVTWFWEVMEEFTNQERSLFLRFV----------------WG 4814
            |.:|:.           |....|..||...|:      ..:.:|.:.                :|
  Fly   721 VPSYRSTGYEFSREHPKFSRVKACGTWRKGVL------HGNCYLEYPDGSVYCGELQHGIIEGFG 779

  Fly  4815 RTRLPRT---IADFRGRDF----VLQVLEKNPPDHFLPESYTC 4850
            :..:|.|   :.:|:|..|    |.::..|:.|:..:.|...|
  Fly   780 KMVIPTTGLYVGNFKGGRFHGHGVYEMHCKDSPESEVYEGNFC 822

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HERC2NP_608388.2 RCC1 638..683 CDD:278826
RCC1 687..737 CDD:278826
RCC1 740..787 CDD:278826
RCC1 790..841 CDD:278826
RCC1_2 828..857 CDD:290274
Cyt-b5 1290..1363 CDD:278597
MIB_HERC2 1928..1987 CDD:284184
UBA_HERC2 2515..2559 CDD:270585
Cul7 2624..2699 CDD:288381
APC10-HERC2 2762..2932 CDD:176485
RCC1 3037..3088 CDD:278826
RCC1 3091..3140 CDD:278826
RCC1 3144..3194 CDD:278826
RCC1 3197..3246 CDD:278826
RCC1 3250..3298 CDD:278826
RCC1 3302..3350 CDD:278826
RCC1_2 4136..4166 CDD:290274 8/38 (21%)
RCC1 4154..4203 CDD:278826 13/53 (25%)
RCC1 4206..4257 CDD:278826 14/63 (22%)
RCC1 4260..4309 CDD:278826 7/54 (13%)
RCC1 4312..4360 CDD:278826 16/55 (29%)
RCC1 4364..4413 CDD:278826 15/52 (29%)
HECTc 4509..4880 CDD:238033 73/413 (18%)
HECTc 4553..4878 CDD:214523 66/368 (18%)
Als2NP_649347.1 RCC1 258..304 CDD:278826 15/47 (32%)
RCC1_2 292..321 CDD:290274 12/28 (43%)
RCC1 308..361 CDD:278826 15/52 (29%)
PH-like 616..715 CDD:302622 18/101 (18%)
VPS9 1373..1479 CDD:280383
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5184
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
10.900

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