DRSC/TRiP Functional Genomics Resources

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Protein Alignment HERC2 and Nedd4

DIOPT Version :9

Sequence 1:NP_608388.2 Gene:HERC2 / 33035 FlyBaseID:FBgn0031107 Length:4912 Species:Drosophila melanogaster
Sequence 2:NP_648993.1 Gene:Nedd4 / 39958 FlyBaseID:FBgn0259174 Length:1007 Species:Drosophila melanogaster


Alignment Length:494 Identity:120/494 - (24%)
Similarity:207/494 - (41%) Gaps:101/494 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly  4421 RLRPLPNPPLEYDLVRDLAP------EALH--ARLILLHHFS--------ELVCPCLA--MLPIS 4467
            |..|:||.....:  .||.|      |.:|  .|:..:.|.:        .|..|.:|  .:|.|
  Fly   564 RASPMPNQTRRVE--DDLGPLPEGWEERVHTDGRVFYIDHNTRTTQWEDPRLSNPNIAGQAVPYS 626

  Fly  4468 GDLSLGALKDVLVYNIKEAAFRKVIQTTMVRDKQHGPVIELNRIQVKRSRNRCNGLAGIDGMKSV 4532
            .|           |..|...|:..|:.         |....|:.:::..|.            |:
  Fly   627 RD-----------YKQKYEYFKSHIRK---------PTNVPNKFEIRIRRT------------SI 659

  Fly  4533 FGQMVQKLPLLTQEALALPHRVWKVKFVGESVDDCGGGYSESIAEMCDELQN-----------GS 4586
            .....:.:..:|:..| |..::| |:|.||:..|.||...|....:..|:.|           .:
  Fly   660 LEDSYRIISSVTKTDL-LKTKLW-VEFEGETGLDYGGLAREWFYLLSKEMFNPYYGLFEYSAMDN 722

  Fly  4587 VPLLINTPNGRGEAGANRDCFLLDPTLSSVLQMNMFRFLGVLMGIAVRTGSPLSINLAEPVWRQL 4651
            ..|.||  ||.|              |.:...::.|:|:|.:.|:||..|..|......|.::.:
  Fly   723 YTLQIN--NGSG--------------LCNEEHLSYFKFIGRIAGMAVYHGKLLDAFFIRPFYKMM 771

  Fly  4652 TGEVLRPTDLTEVDRDYVAGLLCIRNMDDDPKLFTALELPFST-----SSARGHEVPLSTRYTHI 4711
            ..:.:...|:..||.:|...|:.|:  ::||::   |||.|..     .....||:........:
  Fly   772 LQKPIDLKDMESVDTEYYNSLMWIK--ENDPRI---LELTFCLDEDVFGQKSQHELKPGGANIDV 831

  Fly  4712 SPRNRAEYVRLALGFR-LHEFDEQVKAVRDGMSKVIPVPLLSLFSAAELQAMVCGSPDIPLGLLK 4775
            :..|:.||::|.:.:| :....||:.:..||...:||:.|:.:|...||:.::||..:|.:...:
  Fly   832 TNENKDEYIKLVIEWRFVARVKEQMSSFLDGFGSIIPLNLIKIFDEHELELLMCGIQNIDVKDWR 896

  Fly  4776 SVATYKG-FDPSSALVTWFWEVMEEFTNQERSLFLRFVWGRTRLP----RTIADFRGRDFVLQVL 4835
            ....||| :..:..::.|||..:..|:|:.||..|:||.|.:|:|    :.:....|..  :..:
  Fly   897 ENTLYKGDYHMNHIIIQWFWRAVLSFSNEMRSRLLQFVTGTSRVPMNGFKELYGSNGPQ--MFTI 959

  Fly  4836 EK-NPPDHFLPESYTCFFLLKMPRYSCKAVLLEKLKYAI 4873
            || ..|::| |.::|||..|.:|.|.....|.:||..||
  Fly   960 EKWGTPNNF-PRAHTCFNRLDLPPYEGYLQLKDKLIKAI 997

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HERC2NP_608388.2 RCC1 638..683 CDD:278826
RCC1 687..737 CDD:278826
RCC1 740..787 CDD:278826
RCC1 790..841 CDD:278826
RCC1_2 828..857 CDD:290274
Cyt-b5 1290..1363 CDD:278597
MIB_HERC2 1928..1987 CDD:284184
UBA_HERC2 2515..2559 CDD:270585
Cul7 2624..2699 CDD:288381
APC10-HERC2 2762..2932 CDD:176485
RCC1 3037..3088 CDD:278826
RCC1 3091..3140 CDD:278826
RCC1 3144..3194 CDD:278826
RCC1 3197..3246 CDD:278826
RCC1 3250..3298 CDD:278826
RCC1 3302..3350 CDD:278826
RCC1_2 4136..4166 CDD:290274
RCC1 4154..4203 CDD:278826
RCC1 4206..4257 CDD:278826
RCC1 4260..4309 CDD:278826
RCC1 4312..4360 CDD:278826
RCC1 4364..4413 CDD:278826
HECTc 4509..4880 CDD:238033 98/388 (25%)
HECTc 4553..4878 CDD:214523 92/344 (27%)
Nedd4NP_648993.1 C2_NEDD4_NEDD4L 71..204 CDD:175999
WW 248..277 CDD:278809
WW 531..560 CDD:278809
WW 581..613 CDD:197736 5/31 (16%)
HECTc 650..1003 CDD:238033 97/386 (25%)
HECTc 674..1003 CDD:214523 94/350 (27%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45446989
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
32.740

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