DRSC/TRiP Functional Genomics Resources

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Protein Alignment HERC2 and Ube3a

DIOPT Version :9

Sequence 1:NP_608388.2 Gene:HERC2 / 33035 FlyBaseID:FBgn0031107 Length:4912 Species:Drosophila melanogaster
Sequence 2:NP_648452.1 Gene:Ube3a / 39266 FlyBaseID:FBgn0061469 Length:973 Species:Drosophila melanogaster


Alignment Length:1162 Identity:241/1162 - (20%)
Similarity:383/1162 - (32%) Gaps:374/1162 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly  3887 DAALPATSSSSSSSAAPGAISSTGDVHKWAWFKRYCIAVRVAQSLIRRT-ELPRAFCLEVRKKFA 3950
            |..||..||:|.|:|  ||:..                        |.| |:.|:....:.|::.
  Fly    10 DQHLPGVSSASGSAA--GAVGG------------------------RATPEMKRSAVRSLIKRYF 48

  Fly  3951 EMLPSSSSNSN-ANPGCQSPGASMLNSTTSLSSSTVSNVSPPPGITGEQPDLHCHAHQLESTSTL 4014
            ..|.|...|:| :|..|.|.|             .|:.::|        .::...|.||.|....
  Fly    49 HQLQSGCGNANCSNANCASSG-------------KVAPMTP--------NEVAARALQLFSQDAQ 92

  Fly  4015 LHEDHTL-FQAPHDAQLLQWLNRRPDDWALSWGGAST---------------------------- 4050
            |.|..|. ..:|.|..:|.     |:|.:.|..|:||                            
  Fly    93 LCEAFTSEANSPQDVDMLS-----PNDSSSSSSGSSTSTITSASTTTTTSRQSQSTPAAVVVPVS 152

  Fly  4051 ------------IYGWGHNHRGQLGGLEGSRIKTPTPCEALSLLRPVQLAGGEQSLFAVTPDGKL 4103
                        |.|..|:.    |..|..   |||.....||.....:|..||...|.:.|...
  Fly   153 SPYLTQSVPQLDIAGAEHSS----GDSEPC---TPTLAPVHSLDANSLIALYEQCRAADSYDRIC 210

  Fly  4104 FATG--YGSGGRLGVGGSDSWAIPTLLGSLQHVFVKKVAVNSGGKHCLAL------TTEGEVYAW 4160
            .|.|  :.|..|||.....| |.|....|||     ::..||.|    ||      |.|||    
  Fly   211 HAIGVVFSSVDRLGKSFIRS-AEPAASSSLQ-----ELLANSPG----ALNKEQLRTLEGE---- 261

  Fly  4161 GEGEDGKLGHGNRMSYDRPKLVEHLNGMSVADIACGSAHSAAITASGHVLTWGKGRYGRLGHGDS 4225
                           :|:.:     :.....|....||.:|..||.                 ..
  Fly   262 ---------------HDKDE-----DSTQQVDEQSESAANATATAE-----------------SV 289

  Fly  4226 EDQLRPKLVEALLGYRAIDIACGSGDAQTLCITDDDNVWSWGDGDYGKLGRGGS--DGCKLPYKI 4288
            |.:..|:..:        |..|.|..:.||.             |...|.|...  .||::....
  Fly   290 ESEAEPEEED--------DDVCSSQSSDTLV-------------DLPGLRRVQRLLFGCQIRAIT 333

  Fly  4289 ESLAGLGVVKVECGSQFSVALTKSGAVYTWGKGDFHRLGHGSV----------------DHVRR- 4336
            |.|..            ||.......:|.  :.|:.|:.|..|                |::.| 
  Fly   334 EKLTS------------SVIQLSDWVIYM--RTDWERVIHCLVICFDLATNTNNSVVDMDYLDRV 384

  Fly  4337 -PKKVAALQGKKIISIA----TGSLHC--------VACSDSGEVYTWGDNDEGQLGDGTVTA--- 4385
             ||...|.....:.:.|    ..:.||        .||.....:....|.:..:..:..::.   
  Fly   385 LPKLCQAASAMPVPAQARLARIWAAHCSDQLHSLIAACQQQITLQVLLDEESMRENESIISVTKV 449

  Fly  4386 -------------IQRPRLVAALQGKHIVKVTCGSA---------------HTLALSTSQLSERL 4422
                         ::||.....|:.:.......|||               |....:..|..:.|
  Fly   450 LKIVFYANILASELERPSCRVPLEDRTEAATASGSAAVEDDLFVYNSLLEPHMPKFAEDQFEKEL 514

  Fly  4423 --------RPLPNPPLEYDLVRDLAPEALHARLILLHHFSELVCPCLAMLPISGD---------- 4469
                    :||  .|||     :...||| :..|.:|| ..|....|||....|.          
  Fly   515 QVSAIDCRKPL--IPLE-----EFYNEAL-SENIQMHH-DYLSYKTLAMESEIGSGHANYFSFML 570

  Fly  4470 ----LSLGALKDVL-------VYNIKEAAFRKVIQTTMVRDKQHGPVIELNRIQVKRSRNRCNGL 4523
                |:.....|.|       :|:.:.::...::.......::..|..:| ::.|:|.:...:.|
  Fly   571 YAFILTPSTKVDALYYDSRMRMYSERYSSLHSILNNIGQVGQEDNPRPDL-KLTVRRDQLINDAL 634

  Fly  4524 AGIDGMKSVFGQMVQKLPLLTQEALALPHRVWK---VKFVGESVDDCGGGYSESIAEMCDELQNG 4585
            .|:        :||         |::.|..:.|   |:||||...|.||...|....:.:|:.|.
  Fly   635 IGL--------EMV---------AMSNPKDLKKQLVVEFVGEQGIDEGGVSKEFFQLIVEEIFNP 682

  Fly  4586 SVPLLINTPNGRGEAGANRDCFLLDPTLSSVLQMNMFRFLGVLMGIAVRTGSPLSINLAEPVWRQ 4650
            :..:.|.      :...|...|...|..:..    .|..:|:::|:|:.....|::|....|:|:
  Fly   683 AFGMFIQ------QEETNNMWFNATPFENGA----QFTLIGIIIGLAIYNNVTLAVNFPMVVYRK 737

  Fly  4651 LTGEVLRPTDLTEVDRDYVAGLLCIRNMDDDPKLFTALE-----------------LPFSTSSAR 4698
            |.|......||:                |..|.|:.:|:                 ...|.|...
  Fly   738 LIGYCGTFADLS----------------DWSPALYKSLKSMLDYQGQDMEEVFEQTFKISYSDVF 786

  Fly  4699 G----HEVPLSTRYTHISPRNRAEYVRLALGFRLH-EFDEQVKAVRDGMSKVI-PVPLLSLFSAA 4757
            |    ||:..:.:...:...|:..:|.|...|.|: ..::|..|.|.|...|. ..||..||...
  Fly   787 GDVVQHELVPNGQDVLVGQHNKELFVNLYSDFLLNTNIEQQFNAFRKGFEMVTDESPLKLLFRPE 851

  Fly  4758 ELQAMVCGSPDIPLGLLKSVATYK-GFDPSSALVTWFWEVMEEFTNQERSLFLRFVWGRTRLPRT 4821
            |::.:||||.:.....|::...|: |:...|..:..||.::....::::...|.|..|..|:|  
  Fly   852 EIEMLVCGSREFDFVELENSTVYEGGYTEKSQYIQDFWSIVHAMPSEDKHKLLEFTTGSARVP-- 914

  Fly  4822 IADFRGRDFVLQVLEKNPPD-HFLPESYTCFFLLKMPRYSCKAVLLEKLKYAIHFCK 4877
               ..|...:..::.::.|| ..||.|:|||.:|.:|.||.:..|.|:|..||::.|
  Fly   915 ---VGGLKCLRLLITRHGPDSDRLPTSHTCFNVLLLPEYSSREKLEERLMKAINYSK 968

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HERC2NP_608388.2 RCC1 638..683 CDD:278826
RCC1 687..737 CDD:278826
RCC1 740..787 CDD:278826
RCC1 790..841 CDD:278826
RCC1_2 828..857 CDD:290274
Cyt-b5 1290..1363 CDD:278597
MIB_HERC2 1928..1987 CDD:284184
UBA_HERC2 2515..2559 CDD:270585
Cul7 2624..2699 CDD:288381
APC10-HERC2 2762..2932 CDD:176485
RCC1 3037..3088 CDD:278826
RCC1 3091..3140 CDD:278826
RCC1 3144..3194 CDD:278826
RCC1 3197..3246 CDD:278826
RCC1 3250..3298 CDD:278826
RCC1 3302..3350 CDD:278826
RCC1_2 4136..4166 CDD:290274 9/35 (26%)
RCC1 4154..4203 CDD:278826 8/48 (17%)
RCC1 4206..4257 CDD:278826 7/50 (14%)
RCC1 4260..4309 CDD:278826 9/50 (18%)
RCC1 4312..4360 CDD:278826 13/77 (17%)
RCC1 4364..4413 CDD:278826 8/79 (10%)
HECTc 4509..4880 CDD:238033 94/397 (24%)
HECTc 4553..4878 CDD:214523 86/353 (24%)
Ube3aNP_648452.1 AZUL 40..94 CDD:293166 15/74 (20%)
HECTc 620..971 CDD:238033 95/398 (24%)
HECTc 647..970 CDD:214523 86/353 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45446967
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm3500
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
43.740

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