DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment HERC2 and Herc4

DIOPT Version :9

Sequence 1:NP_608388.2 Gene:HERC2 / 33035 FlyBaseID:FBgn0031107 Length:4912 Species:Drosophila melanogaster
Sequence 2:NP_001261249.1 Gene:Herc4 / 38151 FlyBaseID:FBgn0035207 Length:1062 Species:Drosophila melanogaster


Alignment Length:1094 Identity:263/1094 - (24%)
Similarity:415/1094 - (37%) Gaps:322/1094 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly  4051 IYGWGHNHRGQ--LGGLEGSRIKTP-----TPCEALSLLRPVQLAGGEQSLFAVTPDGKLFATGY 4108
            :|.||....||  |||:|..:|.||     ||..|:.     |:|.|.:....:|..||::|.|.
  Fly     7 LYCWGSTSHGQLGLGGIEDEQILTPSQIPWTPDTAVQ-----QVACGHRHTLFLTATGKVYACGS 66

  Fly  4109 GSGGRLGVGGSDSWAIPT---------LLGSLQHVFVKKVAVNSGGKHCLALTTEGEVYAWGEGE 4164
            ....:||      ..:||         |:..||...:  :.:..|.:|.|||:..|:|.:||:.:
  Fly    67 NDYSQLG------HDLPTKRPRMSPFLLIPELQDYVI--IQICCGSRHSLALSDWGQVLSWGDND 123

  Fly  4165 DGKLGHG-NRMSYDRPKLVEHLNGMSVADIACGSAHSAAITASGHVLTWGKGRYGRLGHGDSEDQ 4228
            .|:|||. ::.....||:|..|...:|..||||:.||.|:|:.|.:.:||...||:||.....|.
  Fly   124 CGQLGHATDKEIVQLPKVVRQLVTKTVVQIACGNNHSLALTSCGELYSWGSNIYGQLGVNSPNDL 188

  Fly  4229 LR---PKLVEALLGYRAIDIACGSGDAQTLCITDDDNVWSWGDGDYGKLGRGGSDGCKLPYKIES 4290
            ..   |..:..|||.....||||..  .:..|:....|:.||..:.|:||.........|.::::
  Fly   189 THCNYPLRLTTLLGIPLAAIACGGN--HSFLISKSGAVFGWGRNNCGQLGLNDETNRSYPTQLKT 251

  Fly  4291 LAGLGVVKVECGSQFSVALTKSGAVYTWGKGDFHRLGHGSVDHVRRPKKVAALQGKKIISIATGS 4355
            |..|||..|.||.:|||.||..|.|:|.|.|.:.:||||...:...|:.|..|.|..|..:|.|:
  Fly   252 LRTLGVRFVACGDEFSVFLTNEGGVFTCGAGAYGQLGHGFSSNEMLPRMVMELMGSTITQVACGN 316

  Fly  4356 LHCVACSDS-GEVYTWGDNDEGQLGDGTVTAIQRPRLV----------AALQG------------ 4397
            .|.:|...| |.||.:|....||||..:..::..|::|          |.||.            
  Fly   317 RHTLALVPSRGRVYAFGLGSSGQLGTRSTKSLMLPQVVIGPWVSPSGSALLQSNDSQVSLVIRQI 381

  Fly  4398 -----KHIVKVT------------------------------CGSA------------------- 4408
                 :.||..|                              |...                   
  Fly   382 FSGGDQSIVTTTLFVDKVPPEDFRNYNPKSQILTLTAEVTKQCAQCKQGLQSDMDLLSSIELIFR 446

  Fly  4409 -----------------------HTLALSTSQLS-ERLRPLPNPPLEY--------DLV------ 4435
                                   |.|.|..:||: :.||.:.|..:..        :||      
  Fly   447 SQACWNGSFLLDHDRHFGCSVRNHGLDLKAAQLAFDNLRAVENESIRQVIWDNITKELVGSLVCS 511

  Fly  4436 -RDLAPEALHARLILLH------HFSELVCP------------------CLAMLP---------- 4465
             .|:....|:..|.|.|      |:..|..|                  .||..|          
  Fly   512 PADVESMRLYLLLPLYHEFVNSKHYKSLQVPFANAIFKLAENPRKVLNKWLAQTPAEYFEHLVQN 576

  Fly  4466 --------ISGDLSLGAL-------KDVLVYNIKEAAFRKVIQT-TMVRDKQH------------ 4502
                    ||..:.|.|.       :.:|.||.:.....|:::| ..:.:::|            
  Fly   577 FLHVVIHIISFKMGLAAASPSAERRQQLLPYNTELEIILKLMKTLCQINNERHDRLNYQIFYWPD 641

  Fly  4503 -GPVIELNRIQVK-------RSRNRCNGLAGID-GMKSVFGQMVQKLPL---------------- 4542
             ....::.:..||       |..|.||.....| ..|:...|..|.|.:                
  Fly   642 LSDYADVQQEYVKWIMADTARDFNICNYSFIFDQSAKTALLQADQALQMHSAMANAATMAFSFFN 706

  Fly  4543 -----------------LTQEAL-ALPH-------RVWKVKFVGESVDDCGGGYSESIAEMCDEL 4582
                             |.|::| .|.|       :..|:||.||..:|.||...|....:..:|
  Fly   707 YGMPISQFIVLNVTRENLVQDSLRELQHYSQSDLKKPLKIKFHGEEAEDAGGVRKEFFMLLLKDL 771

  Fly  4583 QNGSVPLLINTPNGRGEAGANRDCFLLDPTLSSVLQMNMFRFLGVLMGIAVRTGSPLSINLAEPV 4647
            .:....:.       .|...:|..:..|.|..:   .||:..:|||.|:|:...:.:::.....:
  Fly   772 LDPKYGMF-------KEYEQSRLLWFADLTFET---ENMYFLIGVLCGLAIYNFTIINLPFPLAL 826

  Fly  4648 WRQLTGEVLRPTDLTEV------DRDYVAGLLCIRNMDDDPKLFTALELPFSTS----------- 4695
            :::|.|   :|.||:::      :.:.:..||..:. ||..::|   :|.|..|           
  Fly   827 FKKLLG---KPVDLSDLRQLSPPEANSMQSLLDYQG-DDFKEVF---DLTFEISRDVFGEAETKC 884

  Fly  4696 -SARGHEVPLSTRYTHISPRNRAEYVRLALGFRLHEFDEQVK----AVRDGMSKVIPVPLLSLFS 4755
             ...|:|:.       ::..||.|:|.|.:.|   .|::.|:    |...|..||....::.:|.
  Fly   885 LKPNGNEIA-------VTLENRQEFVDLYVDF---VFNKSVELHYNAFHKGFMKVCSGRVIHIFQ 939

  Fly  4756 AAELQAMVCGSPDIPLGLLKSVATYK-GFDPSSALVTWFWEVMEEFTNQERSLFLRFVWGRTRLP 4819
            ..||.|:|.|:.|.....|:....|: |:......:.|||||:.:.:..|:..||.|:.|..|:|
  Fly   940 PEELMAVVVGNEDYDWQALQDNCEYREGYTSVDDTIKWFWEVIHDMSEAEKKSFLLFLTGSDRIP 1004

  Fly  4820 RTIADFRGRDFVLQVLEKNPPDHFLPESYTCFFLLKMPRYSCKAVLLEKLKYAI 4873
                 .:|...:...::..|.:.|||.::|||.||.:|||..|    |:|||.:
  Fly  1005 -----IQGMKALKLTIQPTPDERFLPVAHTCFNLLDLPRYKTK----ERLKYKL 1049

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HERC2NP_608388.2 RCC1 638..683 CDD:278826
RCC1 687..737 CDD:278826
RCC1 740..787 CDD:278826
RCC1 790..841 CDD:278826
RCC1_2 828..857 CDD:290274
Cyt-b5 1290..1363 CDD:278597
MIB_HERC2 1928..1987 CDD:284184
UBA_HERC2 2515..2559 CDD:270585
Cul7 2624..2699 CDD:288381
APC10-HERC2 2762..2932 CDD:176485
RCC1 3037..3088 CDD:278826
RCC1 3091..3140 CDD:278826
RCC1 3144..3194 CDD:278826
RCC1 3197..3246 CDD:278826
RCC1 3250..3298 CDD:278826
RCC1 3302..3350 CDD:278826
RCC1_2 4136..4166 CDD:290274 9/29 (31%)
RCC1 4154..4203 CDD:278826 19/49 (39%)
RCC1 4206..4257 CDD:278826 16/53 (30%)
RCC1 4260..4309 CDD:278826 17/48 (35%)
RCC1 4312..4360 CDD:278826 17/47 (36%)
RCC1 4364..4413 CDD:278826 20/148 (14%)
HECTc 4509..4880 CDD:238033 104/437 (24%)
HECTc 4553..4878 CDD:214523 88/344 (26%)
Herc4NP_001261249.1 RCC1 6..55 CDD:278826 18/52 (35%)
RCC1 59..110 CDD:278826 14/58 (24%)
RCC1 114..163 CDD:278826 19/48 (40%)
RCC1 167..218 CDD:278826 16/52 (31%)
RCC1 221..270 CDD:278826 17/48 (35%)
RCC1 273..322 CDD:278826 17/48 (35%)
RCC1_2 309..339 CDD:290274 10/29 (34%)
RCC1 327..390 CDD:278826 13/62 (21%)
HECTc 715..1060 CDD:238033 93/371 (25%)
HECTc 739..1059 CDD:214523 88/347 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45446937
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1062377at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm3500
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
54.750

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