DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HERC2 and yki

DIOPT Version :9

Sequence 1:	NP_608388.2	Gene:	HERC2 / 33035	FlyBaseID:	FBgn0031107	Length:	4912	Species:	Drosophila melanogaster
Sequence 2:	NP_001350857.1	Gene:	yki / 37851	FlyBaseID:	FBgn0034970	Length:	418	Species:	Drosophila melanogaster

Alignment Length:	353	Identity:	64/353 - (18%)
Similarity:	123/353 - (34%)	Gaps:	89/353 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly  2292 VQLPAVMPHLDHTVF-----SLSRLPMNEMLLNA--WTVLLYGPAPELRELPSSADGRLDLALLR 2349
            :|||..|..|.::.|     |.||....:...:|  .:.:..|....:.:.|   ||:..:|.:.
  Fly    85 LQLPLRMRKLPNSFFTPPAPSHSRANSADSTYDAGSQSSINIGNKASIVQQP---DGQSPIAAIP 146

  Fly  2350 AQQLQMAVLHTNGVLYRHQVALRRILKQRAPGSIYASPDEPDRSDA----------ESQQ----- 2399
            ..|:|.:..|:       ::|:.....:.:|.|:..:.:...||||          .|||
  Fly   147 QLQIQPSPQHS-------RLAIHHSRARSSPASLQQNYNVRARSDAAAANNPNANPSSQQQPAGP 204

  Fly  2400 --PGEQDQQLSSGSGQEPQLLIQCILLRATQASPV------KACYSYMDLATAALNCIQSLATQA 2456
              |....|:..||:.....:.:..:....:|..|:      |...||..::...||
  Fly   205 TFPENSAQEFPSGAPASSAIDLDAMNTCMSQDIPMSMQTVHKKQRSYDVISPIQLN--------- 260

  Fly  2457 HQELSEGGGVPP---------------NGRALSSPPQPTMVHGVPVYNVARKEQKPSEQVEQKSK 2506
             ::|   |.:||               |....|:..:...:.......:...|:.....|.|.:|
  Fly   261 -RQL---GALPPGWEQAKTNDGQIYYLNHTTKSTQWEDPRIQYRQQQQILMAERIKQNDVLQTTK 321

  Fly  2507 -----------------WPAAATDAQLIGQIMEMGFTRRTVELALKQLSLQAEIMPTPEQIVQWI 2554
                             |..|.|::   |.:..:....||......::.....::..|:.:|..:
  Fly   322 QTTTSTIANNLGPLPDGWEQAVTES---GDLYFINHIDRTTSWNDPRMQSGLSVLDCPDNLVSSL 383

  Fly  2555 LEHPDVCANTIEEDTLPLASSASSHDPE 2582
            ....::|:| :..|...:.:..|||.|:
  Fly   384 QIEDNLCSN-LFNDAQAIVNPPSSHKPD 410

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HERC2	NP_608388.2	RCC1	638..683	CDD:278826
		RCC1	687..737	CDD:278826
		RCC1	740..787	CDD:278826
		RCC1	790..841	CDD:278826
		RCC1_2	828..857	CDD:290274
		Cyt-b5	1290..1363	CDD:278597
		MIB_HERC2	1928..1987	CDD:284184
		UBA_HERC2	2515..2559	CDD:270585	5/43 (12%)
		Cul7	2624..2699	CDD:288381
		APC10-HERC2	2762..2932	CDD:176485
		RCC1	3037..3088	CDD:278826
		RCC1	3091..3140	CDD:278826
		RCC1	3144..3194	CDD:278826
		RCC1	3197..3246	CDD:278826
		RCC1	3250..3298	CDD:278826
		RCC1	3302..3350	CDD:278826
		RCC1_2	4136..4166	CDD:290274
		RCC1	4154..4203	CDD:278826
		RCC1	4206..4257	CDD:278826
		RCC1	4260..4309	CDD:278826
		RCC1	4312..4360	CDD:278826
		RCC1	4364..4413	CDD:278826
		HECTc	4509..4880	CDD:238033
		HECTc	4553..4878	CDD:214523
yki	NP_001350857.1	HUL4	<261..>404	CDD:227354	21/149 (14%)
		WW	266..295	CDD:395320	4/28 (14%)
		WW	335..364	CDD:395320	6/31 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900