DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment HERC2 and Magi

DIOPT Version :9

Sequence 1:NP_608388.2 Gene:HERC2 / 33035 FlyBaseID:FBgn0031107 Length:4912 Species:Drosophila melanogaster
Sequence 2:NP_001286661.1 Gene:Magi / 37403 FlyBaseID:FBgn0034590 Length:1202 Species:Drosophila melanogaster


Alignment Length:1615 Identity:272/1615 - (16%)
Similarity:467/1615 - (28%) Gaps:693/1615 - (42%)


- Green bases have known domain annotations that are detailed below.


  Fly  1101 TRLSPT--LGKQQEKEEEEREQQH---------QEPSTSPSLSLLHRFQRLLLSHIHQAQPEEET 1154
            |..|||  |..||::::::::|||         |:|.....|:..|:.|.   ||.|        
  Fly    25 TAKSPTDYLMLQQQQQQQQQQQQHFNSNHFYQQQQPQQLAPLNASHQHQH---SHPH-------- 78

  Fly  1155 TGAEALLLQYMHALIPACVATLQKAHELALQCREPGENSFGQMVGHLGRVLQADISDALLNELLV 1219
                    .:.|   |...||                 ||....|:                   
  Fly    79 --------PHPH---PVAAAT-----------------SFATFNGN------------------- 96

  Fly  1220 GLLLLKRDRPQCLGGLRWARLFLPLLRVLDRLNRALGEGELR----------DGDDMG------- 1267
                                         ..||.:|..|..|          ||.|.|       
  Fly    97 -----------------------------SNLNSSLANGSSRKFNCSRDNVDDGGDAGEMAAASQ 132

  Fly  1268 ----------------WPGIICRGGPK-GGPPPADPETHYVRRADMENLLLDGSRCIILAGYVCD 1315
                            ..|.:...|.| ||..|  |..|::|......|....|..|        
  Fly   133 TLSSAGTDVVGNGSGHGNGTVTGNGEKSGGLAP--PGGHHLRPPPPPALKKSASAVI-------- 187

  Fly  1316 LSGYNCESETLRSVLDSGLGKDLTAEMSSQ--VHRTAMEHILEHHKLGKYMVQASTEEKSSAPGP 1378
              |.:...|.:.|:  ||     |:.::||  ||...:..:                       |
  Fly   188 --GNSASREDVASL--SG-----TSSLNSQMSVHNQFISGL-----------------------P 220

  Fly  1379 SRLTHFSSECALAQLLGLVANLMCSGPALQPAELQCRQLDKSSLLSGGLQLLQPSNPFDEEKGEA 1443
            |.              |:.:|.:..|.|..      |....:|:|.|..:.|..:..::.|.|::
  Fly   221 SN--------------GIGSNGVHGGAATG------RGGPPNSILKGSKENLLQNTYYNGETGDS 265

  Fly  1444 ------------RSSHSCHSTAGNTPTELPPPLPMQQQLAPGRGKSQLQLRADAFISGLAEARVS 1496
                        ..:|..|...|:....|||                                  
  Fly   266 SLGSECGVGDVQHQNHESHDDPGDGLGPLPP---------------------------------- 296

  Fly  1497 EPPVAAW-LALTER---YCKAHNL---MWHQEFATEHPVQELERLLSAVLIRHQYLGGLVLNALE 1554
                 .| .|.|||   |...||.   .|.....:::..:.||                  :..|
  Fly   297 -----KWETAYTERGELYFIDHNTGTSHWLDPRLSKYQKKSLE------------------DCCE 338

  Fly  1555 TEVPPPRQLGEIIRLVHQAKWSVVRTR-------QQLNR--SYKEVCAPILERLRFLLYEVRPAI 1610
            .|:|              ..|..:...       ..:||  .|:.   |:||..|      |.|.
  Fly   339 DELP--------------YGWEKIEDSMYGMYFIDHVNRRTQYEN---PVLEAKR------RAAE 380

  Fly  1611 SPQQRGLRRLPILQRPPRFKMLVRRLLQELRSSRQPAKPEDLLNASIQQEQEKKP----QSMPKQ 1671
            ..||:                      |:::..:|          .:|:::.|.|    ::||.:
  Fly   381 QSQQQ----------------------QQMQQQQQ----------QMQEQRSKTPTALSETMPTE 413

  Fly  1672 --ELEEQEEEETLLR-----RLNERQIHGEGELDPALMQDIVDFALQDSCDVETARRAMYCQMQR 1729
              |..||||:|:.::     ..|..::.|: .::..|::                          
  Fly   414 AAEAHEQEEDESPMKLPYKFTRNPAELQGQ-RINTTLLK-------------------------- 451

  Fly  1730 YQLRLAGLQIVQQLLELHGLLDAAQYSLLNGFLGLHLKSTSSGG-----GSTGSGSSL------H 1783
             ..|..|..||.......|  |..::        |.:|:....|     |...:|..|      .
  Fly   452 -SSRGLGFTIVGSDGSAGG--DVEEF--------LQIKTVVPNGPAWLDGQLQTGDVLVYVNDTC 505

  Fly  1784 VLGQL--NMISAYQ------KARLLLAQ-----------------SRVLDWAVRELRRLVNQ--- 1820
            |||..  :|::.:|      :|.|.:.:                 :..:|....:.:|.:|.   
  Fly   506 VLGYTHHDMVNIFQSILPGERAALEVCRGYPLPFDPNDPNTEVVTTMAVDGRESDKQRRLNMDGN 570

  Fly  1821 ----EQQGHARGKDSTNLGTYVLLKRLPRARFLLSVFGLLAKELGPNELGFLINSGLLGTVLGLL 1881
                :..|....|.|.:...::|:|: |.    :..|.::...:|   .||.|.....|.::..:
  Fly   571 YNFLDLSGEGAKKTSGSGSGFILMKK-PE----IYTFSIMKGSMG---FGFTIADSACGQIVKKI 627

  Fly  1882 AQTG-----GEGATGGQVHGELSI-----LYEDSVLKQKSS------KAQLSGPDLAKLMKIGTR 1930
            ....     .||....:::| |::     .|...:||:.|.      |.|.:.||          
  Fly   628 LDRNCCTQLMEGDVLLEING-LNVRNKPHFYVVELLKECSQTTPTAVKIQRTPPD---------- 681

  Fly  1931 IVRGADWKWGDQDGNPPGEGRI--ISEVGEDGWVRVEWYTGATNSYRMGKEGQYDLQLAD----- 1988
                           ||....:  :::||....:|..:........:......|..|:.:     
  Fly   682 ---------------PPANNTLAQLNQVGNVAKLRKNFVGSGLFRSKTPTADLYSTQVKEVLPMR 731

  Fly  1989 ----------SALNVASPTEPEREDVSGSEAS-----------------------PTSDSHPSKL 2020
                      |.:.:.||.....::..|:.|:                       |..|.:|.  
  Fly   732 PKTPLVDTRRSRVQIQSPNNEVDDEGDGAAAAERKPLQLQTQGKSNSSLQELDDIPYMDPYPK-- 794

  Fly  2021 LRHCAAKLLQILAVGTGLHGAQLDKDALRGMTSMFRTIIYPKPSMSNISYALGWLNLGFIRAISG 2085
                .::|.:.||..|      |..||..|:..|       .|||..:...|         |...
  Fly   795 ----ISRLSERLAEVT------LQGDANGGIYGM-------PPSMQPLPLPL---------AHHE 833

  Fly  2086 DCPRLCLELSTPGWLSHYLSLLEQPA-GNEAGVYRQLHCLRLLQLILAQWGAEEEPRMPALVHQL 2149
            .|  .|.:.....:...|....:|.| ....|.|..|....|           :..|:...|::|
  Fly   834 SC--YCYDCQAQRYRPGYFVQAQQAAMSGTTGQYSPLQTAHL-----------QNERIQRRVNEL 885

  Fly  2150 FATLGRIALHCPGDASLLPTAEGKARVLLTASHSGSVAEELVALLRRLHTLPSWNPVINSFLAQK 2214
            .:...|:     |.|:|.|..:        ..||                 |||.   |..|   
  Fly   886 LSDRRRV-----GFANLDPPQQ--------MQHS-----------------PSWR---NGAL--- 914

  Fly  2215 LCVAAELLAEQSHSTALDSEQVFVLGVLGAMGGHDLRPRVGLHCFHEGSHMVIASFTPKGRCLLA 2279
            |.|:.:  |:|...|.:..|:..:......:||.:           |||.:.:..        :.
  Fly   915 LDVSED--ADQCELTEVTLERQALGFGFRIVGGTE-----------EGSQVTVGH--------IV 958

  Fly  2280 PGG-------VGSGVGFVKVQLPAVMPHLDHTVFSLSRLPMNEMLLNAWT--VLLYGPAPELREL 2335
            |||       :.:|...:.:....|:....|.|.||    :.|..|....  :|.....|.|::.
  Fly   959 PGGAADQDQRINTGDEILSIDGINVLNSSHHKVVSL----VGESALRGQVTMILRRRRTPLLQQA 1019

  Fly  2336 PSSADGR---LDLALLRAQQ--LQMAVLHTNGVLYRHQVALRRILKQRAPGSIYASPDEPDRSDA 2395
            |.|...|   .|:.:.|.:.  ....::.::...|...:.      :..|||             
  Fly  1020 PVSTQLRRYPYDVIVSRHENEGFGFVIISSSNHYYGSTIG------KLIPGS------------- 1065

  Fly  2396 ESQQPGEQDQQLSSGSGQEPQLLIQCILLRATQASPVK-ACYSYMDLATAALNCIQSLATQAHQE 2459
                |.::..:|..|.             |....:.:: |..|:.|:    :|.|:.  :..|..
  Fly  1066 ----PADRCGELKVGD-------------RIVAVNRIEIAGMSHGDV----VNLIKE--SGLHVR 1107

  Fly  2460 LSEG-----GGVPPNGRAL---SSPP---QPTMVHGVPVYNVARKEQKPSEQVEQ 2503
            |:.|     ||..|.|.::   |:.|   .|:::..    .::.::|.|.:.::|
  Fly  1108 LTIGVPLKEGGPSPGGSSVGVSSNTPLQASPSLLKA----QLSHQQQLPQQHLQQ 1158

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HERC2NP_608388.2 RCC1 638..683 CDD:278826
RCC1 687..737 CDD:278826
RCC1 740..787 CDD:278826
RCC1 790..841 CDD:278826
RCC1_2 828..857 CDD:290274
Cyt-b5 1290..1363 CDD:278597 14/74 (19%)
MIB_HERC2 1928..1987 CDD:284184 7/60 (12%)
UBA_HERC2 2515..2559 CDD:270585
Cul7 2624..2699 CDD:288381
APC10-HERC2 2762..2932 CDD:176485
RCC1 3037..3088 CDD:278826
RCC1 3091..3140 CDD:278826
RCC1 3144..3194 CDD:278826
RCC1 3197..3246 CDD:278826
RCC1 3250..3298 CDD:278826
RCC1 3302..3350 CDD:278826
RCC1_2 4136..4166 CDD:290274
RCC1 4154..4203 CDD:278826
RCC1 4206..4257 CDD:278826
RCC1 4260..4309 CDD:278826
RCC1 4312..4360 CDD:278826
RCC1 4364..4413 CDD:278826
HECTc 4509..4880 CDD:238033
HECTc 4553..4878 CDD:214523
MagiNP_001286661.1 WW 294..323 CDD:278809 12/67 (18%)
WW 342..372 CDD:238122 6/46 (13%)
PDZ 443..534 CDD:214570 20/128 (16%)
DegQ <455..534 CDD:223343 18/88 (20%)
PDZ_signaling 606..668 CDD:238492 13/65 (20%)
PDZ 925..1011 CDD:214570 19/108 (18%)
PDZ_signaling 1029..1110 CDD:238492 17/122 (14%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
10.900

Return to query results.
Submit another query.