DRSC/TRiP Functional Genomics Resources

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Protein Alignment HERC2 and Smurf

DIOPT Version :9

Sequence 1:NP_608388.2 Gene:HERC2 / 33035 FlyBaseID:FBgn0031107 Length:4912 Species:Drosophila melanogaster
Sequence 2:NP_001261061.1 Gene:Smurf / 36999 FlyBaseID:FBgn0029006 Length:1061 Species:Drosophila melanogaster


Alignment Length:990 Identity:194/990 - (19%)
Similarity:312/990 - (31%) Gaps:375/990 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly  3955 SSSSNSN---ANPGCQSPGASMLNSTTSLSSSTVS------------NVSPPPGITGEQPDLHCH 4004
            |:|.|.:   |.|...|.|.:..::.|:.|.||.:            |:|||..:|   |..:.:
  Fly   367 STSGNGSGQAAQPQSASNGWTQEDAATTTSPSTTTSPPRHSQSPPTPNISPPASVT---PSANGN 428

  Fly  4005 AHQLESTSTLLHEDHTLFQAPHDAQLLQWLNRRPDDWALSWGGASTIYGWGHNHRGQLGGLEGSR 4069
            .|...:.||                                                        
  Fly   429 VHSPNANST-------------------------------------------------------- 437

  Fly  4070 IKTPTPCEALSLLRPVQLAGGEQSLFAVTP-----------DGKLFAT------GYGSGGRLGVG 4117
                          |....||.:|..|.||           .|:..:|      |..:||..|.|
  Fly   438 --------------PAGSGGGSRSYTAATPGQRSQRRSSRQQGEESSTRRRSSRGTRNGGTSGGG 488

  Fly  4118 GSDSWAIPTLLGSLQ-HVFVKKVAVNSGGKHCLAL--------TTEGEVYAWGEGEDGKLGHGNR 4173
            |..        ||.| :......|.|...:..|.|        |.:|:||.:             
  Fly   489 GGG--------GSGQRYASAAIAAANQAARPFLDLPPGYEMRTTQQGQVYFY------------- 532

  Fly  4174 MSYDRPKLVEHL-NGMSVADIACGSAHSAAITASGHVLTWGKGRYGRLGHGDSEDQLRPKLVEAL 4237
                      |: .|:|                     ||...|..|                  
  Fly   533 ----------HIPTGVS---------------------TWHDPRIPR------------------ 548

  Fly  4238 LGYRAIDIACGSGDAQTLCITDDDNVWSWGDGDYGKLGRGGSDGCKLPYKIESLAGLGVVKVECG 4302
                         |..|..:|.|            .:|       .||                 
  Fly   549 -------------DFDTQHLTLD------------AIG-------PLP----------------- 564

  Fly  4303 SQFSVALTKSGAVYTWGKGDFHRLGHGSVDHVRRPKKVA--ALQGKKIISIATGSLHCVACSDSG 4365
            |.:....|.||.||             .|||..|..:..  .|.|..:..|..|::...:.:::|
  Fly   565 SGWEQRKTASGRVY-------------FVDHNNRTTQFTDPRLSGSILQMIRRGTVPPTSAANAG 616

  Fly  4366 EVYTWGDNDEGQLGDGTVTAIQRPRLVAALQGKHIVKVTCGSAHTLALSTSQLSERLRPLPNPPL 4430
            .             ....:|.......||.........:..:..||..:|           ||| 
  Fly   617 T-------------PAPPSATPATPSAAAAVPPQATPASNATPTTLTTTT-----------NPP- 656

  Fly  4431 EYDLVRDLAPEALHARLILLHHFSELVCPCLAMLPISGDLSLGALKDVLVYNIKEAAFRKVIQTT 4495
             :.:|.||....|....:|..:..:||               |.|:          |.|..:|| 
  Fly   657 -HRIVPDLPQGLLEGADLLPKYRRDLV---------------GKLR----------ALRTELQT- 694

  Fly  4496 MVRDKQHGPVIELNRIQVKRSRNRCNGLAGIDGMKSVFGQMVQKLPLLTQEALALPHRVWKVKFV 4560
              ...|.|..    |::|.|:              .:|.:..:.  ::...|..:..|: .|||.
  Fly   695 --MQPQSGHC----RLEVSRN--------------EIFEESYRL--IMKMRAKDMRKRL-MVKFK 736

  Fly  4561 GESVDDCGGGYSESIAEMCDELQNGSVPLL-----------INTPNGRGEAGANRDCFLLDPTLS 4614
            ||...|.||...|.:..:..|:.|....|.           ||.     ::|.|.|         
  Fly   737 GEEGLDYGGVAREWLHLLSREMLNPQYGLFQYSRDDHYTLQINP-----DSGVNPD--------- 787

  Fly  4615 SVLQMNMFRFLGVLMGIAVRTGSPLSINLAEPVWRQLTGEVLRPTDLTEVDRDYVAGLLCIRNMD 4679
               .::.|.|:|..:||||..|..|......|.::||..:.:...|:..||.|....|..:.   
  Fly   788 ---HLSYFHFVGRTLGIAVFHGHCLDGGFTTPFYKQLLNKPITLGDIEGVDPDLHRSLTWML--- 846

  Fly  4680 DDPKLFTALELPFST-SSARG----HEVPLSTRYTHISPRNRAEYVRLALGFR-LHEFDEQVKAV 4738
             :..:...:|..||. :::.|    ||:........::..|:.|||:|.:.:| :...::|..|:
  Fly   847 -ESNISGIIESTFSVENNSFGALVVHELKPGGASIPVTEENKREYVKLYVNYRFMRGIEQQFLAL 910

  Fly  4739 RDGMSKVIPVPLLSLFSAAELQAMVCGSPDIPLGLLKSVATYKGFDPSSALVTWFWEVMEEFTNQ 4803
            :.|..::||..||..|...||:.::.|...|.:...::....|.....:..|.|||:|:|.::::
  Fly   911 QKGFCELIPSHLLRPFDERELELVIGGISSIDVNDWRNNTRLKHCTNETTQVLWFWQVVESYSSE 975

  Fly  4804 ERSLFLRFVWGRTRLPRTIADFRG----------RDFVLQVLEKNPPDHFLPESYTCFFLLKMPR 4858
            .|:..|:||.|.:|:|  :..||.          |.|.:. |..:.|...||:::|||..:.:|.
  Fly   976 MRARLLQFVTGSSRVP--LQGFRALQGSTGAVGPRLFTIH-LTADVPTQNLPKAHTCFNRIDLPP 1037

  Fly  4859 YSCKAVLLEKLKYAI 4873
            |....:|.:||..|:
  Fly  1038 YETYQLLCDKLTQAV 1052

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HERC2NP_608388.2 RCC1 638..683 CDD:278826
RCC1 687..737 CDD:278826
RCC1 740..787 CDD:278826
RCC1 790..841 CDD:278826
RCC1_2 828..857 CDD:290274
Cyt-b5 1290..1363 CDD:278597
MIB_HERC2 1928..1987 CDD:284184
UBA_HERC2 2515..2559 CDD:270585
Cul7 2624..2699 CDD:288381
APC10-HERC2 2762..2932 CDD:176485
RCC1 3037..3088 CDD:278826
RCC1 3091..3140 CDD:278826
RCC1 3144..3194 CDD:278826
RCC1 3197..3246 CDD:278826
RCC1 3250..3298 CDD:278826
RCC1 3302..3350 CDD:278826
RCC1_2 4136..4166 CDD:290274 8/37 (22%)
RCC1 4154..4203 CDD:278826 6/49 (12%)
RCC1 4206..4257 CDD:278826 6/50 (12%)
RCC1 4260..4309 CDD:278826 5/48 (10%)
RCC1 4312..4360 CDD:278826 12/49 (24%)
RCC1 4364..4413 CDD:278826 6/48 (13%)
HECTc 4509..4880 CDD:238033 95/392 (24%)
HECTc 4553..4878 CDD:214523 90/348 (26%)
SmurfNP_001261061.1 C2_Smurf-like 14..135 CDD:176028
WW 169..198 CDD:278809
WW 514..546 CDD:197736 10/75 (13%)
WW 562..594 CDD:197736 12/61 (20%)
HECTc 702..1058 CDD:238033 95/396 (24%)
HECTc 726..1058 CDD:214523 90/352 (26%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45446958
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
32.740

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