DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HERC2 and CG8060

DIOPT Version :9

Sequence 1:	NP_608388.2	Gene:	HERC2 / 33035	FlyBaseID:	FBgn0031107	Length:	4912	Species:	Drosophila melanogaster
Sequence 2:	NP_611117.2	Gene:	CG8060 / 36824	FlyBaseID:	FBgn0034113	Length:	1189	Species:	Drosophila melanogaster

Alignment Length:	1420	Identity:	259/1420 - (18%)
Similarity:	437/1420 - (30%)	Gaps:	530/1420 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   567 TLSCRFQIKQVACCETQMLILSQEGKLYTWRLAKPEAEPLPMEEVAHDVFISIAGHCE-----GR 626
            |..||               |.|.|...|..|.|   ..:..:::|..:|.:......     ||
  Fly    12 TAKCR---------------LRQHGNAITAALTK---RSIDNQKLASFIFKTCGNFANILDDLGR 58

  Fly   627 ---HFLAIDS---------NHNAYSWGTGEDHRLGHGDTHARAVPTKI----------AALE--- 666
               |..|..:         ||.||.  .|:|:..|....|.......|          |:||
  Fly    59 SAVHMSASTARYEILEWLLNHGAYI--NGQDYESGSSPLHRALYYGSIDCAVLLLRYGASLELLD 121

  Fly   667 --QHC-VQSVYCGCSYSAAITCGGN-LLTWGRGTYARLGHGNSDDRSLPTLV--VALSDHMVVDV 725
              ..| :|::...|......|...| :|.||......||.||..:.:.|..|  ...|:..:..|
  Fly   122 EDTRCPLQAICRKCDDDDLATDSQNDVLVWGSNKNYNLGIGNEQNTNTPQAVDFFRKSNLWLEQV 186

  Fly   726 ALGSGDAHSLALTSEGLVFAWGDGDYGKLGNGNCNGSLQPILVESLPRVQRVFAGS--------- 781
            |||:  .|||....:|.::|.|.|..|:||.|         |..|||..:||...|
  Fly   187 ALGA--YHSLFCDKKGHLYAVGHGKGGRLGIG---------LENSLPAPKRVKVSSKLSGDSIQC 240

  Fly   782 -----QFSVALSSEGQLYTWGKATCLGHQL-VERSVQGCSVPRLVSSLQHKRIVDVAVSVA---H 837
                 |.|:.|:.:..::..|..|  .||| |..:.:..:..:.|.:|:.|...|:...:|   |
  Fly   241 ISVSRQHSLVLTHQSLVFACGLNT--DHQLGVRDAAEQLTQFKEVVALRDKGASDLVRVIACDQH 303

  Fly   838 CLALSSSGEVFGWGRNDSQQICPASVSSEPLLRTPILVSLPT-----FPASGIACTSAQSLVWTQ 897
            .:|..|.. |:.||.|..|.   ...|:.|.:..|.|:.||.     |    :...:|.::::.:
  Fly   304 SIAYGSRC-VYVWGANQGQF---GINSNTPSITVPTLIKLPAKTTIRF----VEANNAATVIYNE 360

  Fly   898 SSHQGVPRRAPFVVDLGEPTFRLLDQLLGMCSSQDNR--QTPNQESECIAVACLNLFRLQLLALI 960
                                    ::::.:|.:...|  :|||.|.            |:.::::
  Fly   361 ------------------------EKIITLCYADKTRYIKTPNYED------------LKSISVM 389

  Fly   961 ANGVEPRQVGLASGSRLLCSLKTRILGL----------AGGSQV----LRTIQVAAQQAL---QD 1008
            ...::....|.|:..:||...:|.::.|          ...|.:    ::.|.....|.:   :|
  Fly   390 GGNLKNSTKGSAAALKLLMLTETNVVYLWYENTQQFYRCNFSPIRLHQIKKILYKCNQVMVLSED 454

  Fly  1009 GWSVLLPTAAERAQTLTSLLPSEPGQASSAGHRFMTDLLVSSL-----MAEGGLESALQHAIRLE 1068
            |       ...|.:.....|||...|..|.|          ||     ..:...|.:.:|.||:|
  Fly   455 G-------CVYRGKCNQIALPSSALQEKSRG----------SLDNWQDNDQNKTEISREHVIRIE 502

  Fly  1069 SSSCSADCGDGVHLPLLQLITRLLSNNAALSQTRLSPTLGKQQEKEEEEREQQHQEPSTSPSLSL 1133
            ..          .:|.:...|.:..:....|...|               ::.|.:....|||..
  Fly   503 LQ----------RVPNIDRATYIFCDEGFSSFAVL---------------QESHTKYFRKPSLPR 542

  Fly  1134 L-HRFQRLLLSHIHQAQPEEETTGAEALLLQYMHALIPACVATLQKAHELALQCREPGEN----- 1192
            . |.|::||          .||:..:|     :|.::.........||:..:..|.||..
  Fly   543 REHSFKKLL----------HETSDCDA-----VHDVVFHVDGEKFAAHKFIIYSRAPGLRDLIRC 592

  Fly  1193 --------SFGQMVGHLGRVLQADISDALLNELLVGLLLLKRD---RPQCLG------GLRWARL 1240
                    :|..:.|.:        .:.:||.:.......:.|   ..|.||      ..|...:
  Fly   593 YLDKDIYLNFDHLTGKM--------FELILNHIYSSYWPTEDDIDCIQQSLGPANPQQRTRTCEM 649

  Fly  1241 FLPLL---------------------------RVLDRLNRALGEGELRDGDDMGWPGIICRGGP- 1277
            |||.|                           ::.:||.|: ...||.|      ..|:|:.|.
  Fly   650 FLPHLEKFQLVELTKYVQSYVRDHQFPLPNARKLFNRLYRS-DHPELYD------VRIVCKDGKV 707

  Fly  1278 -------------------------------KGGPPP-ADPETHYVRRAD--------------- 1295
                                           :|.|.. .:|...|:...|
  Fly   708 LGAHKCMLVARLEYFEMMFMHLWAERSSVTMEGVPAEYMEPVLDYLYSLDNEAFCKQGYLETFLY 772

  Fly  1296 -----------------MENLLLD-------GSR--------------------CIILAGYVCDL 1316
                             .|:|:||       |..                    |..|:..:|..
  Fly   773 NMITICDQYFIESLQNVCESLILDKISIRKCGEMLEFAAMYNCKILQKGCMDFICQNLSRVLCYR 837

  Fly  1317 SGYNCESETLRSVLDSGLGKDLTAEMSSQVHRTAMEHILEHHKLGKYMVQASTEEKSSAPGPSRL 1381
            |...|:.|||:.:.|.              :|...:.:.::.                     ::
  Fly   838 SIEQCDGETLKCLNDH--------------YRKMFKRVFDYR---------------------QI 867

  Fly  1382 THFSSECALAQLLGLVANLMCSGPALQPAELQCRQLDKSSLLSGGLQLLQPSNPFDEEKGEARSS 1446
            |.||.......||..|..  |.      .:|..| :|..|.|....:..|.    |..|.:||..
  Fly   868 TPFSEAIEDELLLSFVDG--CD------VDLNYR-MDAESKLKQAAKHKQK----DLRKQDARHQ 919

  Fly  1447 HS-------------CHSTAGNTPTELPPPLPMQQQLAPGRGKSQLQLRADAFISGLAEARVSEP 1498
            :.             ..||.|   ||:|.. |.....:..:..|::..:.|       :.|
  Fly   920 YEQQAISSMMRSLSISESTQG---TEVPSS-PQDSARSEDKNWSRVVDKKD-------QKR---- 969

  Fly  1499 PVAAWLALTERYCKAHNLMWHQEFATEHPVQEL---ERLLSAVLIRHQYLGGLVLNALETEVPPP 1560
                  .|.|...|.:|.:.|:    :.|.|||   ||                 ..|:.:.|||
  Fly   970 ------KLAETALKVNNTLKHE----DPPTQELVPIER-----------------KPLKEQTPPP 1007

  Fly  1561 RQLGEIIRLVHQAKWSVVRTRQQLNRSYKEVCAPILERLRFLLYEVRPAISPQQRGLRRLPILQR 1625
            ..        |:.:     ....|::||....:.:..:.:.|..:.|..:|.:.:..|    ...
  Fly  1008 PS--------HETE-----PTTPLSKSYNLDFSSLTPQSQKLSQKQRKRLSSESKSWR----TNN 1055

  Fly  1626 PPRFKMLVRRLLQELR-------------------------SSRQPAKPEDLL--NASIQQEQEK 1663
            ||    ||.:....:.                         ||..|....:::  :|:.......
  Fly  1056 PP----LVEQSSTPVAVPNAWGVTTTPSGSFNDSFTSPTTGSSTDPTSFANMMRGHATSSTTPTD 1116

  Fly  1664 KPQSMPKQELEEQEEEETLLRRLNERQIHGEGELDPALMQDIVDFALQDSCDVET 1718
            :.||..:...:|:.:.|:..|..|:..:|  .:::...:.::.:|...|:.|.||
  Fly  1117 QSQSFSRILADEKRQRESYERMRNKSLVH--TQIEERAIAELREFYNVDNIDDET 1169

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HERC2	NP_608388.2	RCC1	638..683	CDD:278826	12/60 (20%)
		RCC1	687..737	CDD:278826	18/52 (35%)
		RCC1	740..787	CDD:278826	17/60 (28%)
		RCC1	790..841	CDD:278826	12/54 (22%)
		RCC1_2	828..857	CDD:290274	9/31 (29%)
		Cyt-b5	1290..1363	CDD:278597	17/131 (13%)
		MIB_HERC2	1928..1987	CDD:284184
		UBA_HERC2	2515..2559	CDD:270585
		Cul7	2624..2699	CDD:288381
		APC10-HERC2	2762..2932	CDD:176485
		RCC1	3037..3088	CDD:278826
		RCC1	3091..3140	CDD:278826
		RCC1	3144..3194	CDD:278826
		RCC1	3197..3246	CDD:278826
		RCC1	3250..3298	CDD:278826
		RCC1	3302..3350	CDD:278826
		RCC1_2	4136..4166	CDD:290274
		RCC1	4154..4203	CDD:278826
		RCC1	4206..4257	CDD:278826
		RCC1	4260..4309	CDD:278826
		RCC1	4312..4360	CDD:278826
		RCC1	4364..4413	CDD:278826
		HECTc	4509..4880	CDD:238033
		HECTc	4553..4878	CDD:214523
CG8060	NP_611117.2	ANK	<46..138	CDD:238125	19/93 (20%)
		ANK repeat	56..87	CDD:293786	9/32 (28%)
		Ank_4	57..111	CDD:290365	13/55 (24%)
		ANK repeat	89..121	CDD:293786	6/31 (19%)
		Ank_2	95..>138	CDD:289560	8/42 (19%)
		RCC1	147..195	CDD:278826	16/49 (33%)
		RCC1	199..251	CDD:278826	17/60 (28%)
		BTB	547..>635	CDD:295341	18/110 (16%)
		BTB	684..795	CDD:279045	16/117 (14%)
		BTB	697..798	CDD:197585	13/106 (12%)
		SPOP_C_like	798..>834	CDD:269810	3/35 (9%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900