DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HERC2 and Herc3

DIOPT Version :9

Sequence 1:	NP_608388.2	Gene:	HERC2 / 33035	FlyBaseID:	FBgn0031107	Length:	4912	Species:	Drosophila melanogaster
Sequence 2:	NP_001102101.1	Gene:	Herc3 / 362377	RGDID:	1307803	Length:	1050	Species:	Rattus norvegicus

Alignment Length:	1078	Identity:	244/1078 - (22%)
Similarity:	410/1078 - (38%)	Gaps:	298/1078 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly  4054 WGHNHRGQLG---GLEGSRIKTPTPCEALSLLRPVQLA-GGEQSLFAVTPDGKLFATGYGSGGRL 4114
            ||:...||.|   .|:|. :..|..|..:|.....::| ||..|:| :..||:::..|..:.|:|
  Rat     4 WGYWSLGQPGISSNLQGI-VAEPQVCRFVSDRSIKEVACGGNHSVF-LLEDGEVYTCGVNTKGQL 66

  Fly  4115 G---VGGSDSWAIPTLLGSL--QHVFVKKVAVNSGGKHCLALTTEGEVYAWGEGEDGKLG-HGNR 4173
            |   .|..     |..:|:|  ||:    :.|..|..|.|||:..|::::||.|.||:|| ....
  Rat    67 GHEREGNK-----PEQIGALADQHI----IHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTE 122

  Fly  4174 MSYDRPKLVEHLNGMSVADIACGSAHSAAITASGHVLTWGKGRYGRLGHG-DSEDQLRPKLVEAL 4237
            .|...|:|::.||..::..::||:.|..|:.|.|...||||..:|:||.| :...|..|:.|.:|
  Rat   123 DSVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQTSPQRVRSL 187

  Fly  4238 LGYRAIDIACGSGDAQTLCITDDDNVWSWGDGDYGKLGRGGSDGCKLPYKIESLAGLGVVKVECG 4302
            .|.....:|  :|.|.:..::....|:.||..:.|:||.......:.|..::.|....||.:.||
  Rat   188 EGIPLAQVA--AGGAHSFALSLSGAVFGWGMNNAGQLGLSDEKDRESPCHVKLLRTQKVVYISCG 250

  Fly  4303 SQFSVALTKSGAVYTWGKGDFHRLGHGSVDHVRRPKKVAALQGKKIISIATGSLHCVA-CSDSGE 4366
            .:.:..|||||.|:|:|.|...:|||.||:....|::|..|.|.::..||.|..|.:| ...||.
  Rat   251 EEHTAVLTKSGGVFTFGAGSCGQLGHDSVNDEVNPRRVLELMGSEVTQIACGRQHTLALVPSSGL 315

  Fly  4367 VYTWGDNDEGQLGDGTVTAIQRPRLV----AALQGK----------HIVK----------VTCGS 4407
            :|.:|...:||||.|....::.|..|    ||..|:          .:||          |.|.:
  Rat   316 IYAFGCGAKGQLGTGHTCNVKCPSPVKGHWAAHSGQLSARADRFKYRVVKQIFSGGDQTFVLCST 380

  Fly  4408 ---------------AH--------TLA---------------------LSTS----------QL 4418
                           ||        |:|                     ||::          ::
  Rat   381 YENSSPAVDFRTVNQAHYTNLINDETIAVWRQKLTEHNNANTVNGVVQILSSAACWNGSFLEKKI 445

  Fly  4419 SERLRPLPN-PPLEYDLVRDLAPEALHAR--LIL---LHHFSELVCPCLAMLP------------ 4465
            .|..:..|. |.::.:..|.|..:.:|::  :||   |:.|...:.|.|:..|
  Rat   446 DEHFKTSPKIPGIDLNSTRVLFEKLMHSQHSMILEQILNSFESCLIPQLSSSPPDVEAMRIYLIL 510

  Fly  4466 --------------ISGDLSLGAL-----------------------------KDVLVYNIK--- 4484
                          ::..|::..|                             |..::|.::
  Rat   511 PEFPLLQDSKYYITLTIPLAMAILRLETNPSKVLDNWWSQACPKYFMKLVTLYKSAVLYLLRGRK 575

  Fly  4485 ----EAAFRKVIQTTM-VRDKQHGPVIELNRIQV-KRSRNRCNGLAGI-----------DGMK-- 4530
                ...|...:..|: :.:|.:...:::..::. |......:.|..|           .|||
  Rat   576 TFLIPVLFNNYMTATLKLLEKLYKVNLKVKHVEYDKFYIPEISSLVDIQEDYLMWFLHQSGMKAR 640

  Fly  4531 ------------------------------------SVFGQMVQKL-------PLLTQEALALPH 4552
                                                :|.|..:|.:       |||.:....:.|
  Rat   641 PSIMQDAVTLCSYPFIFDAQAKTKMLQTDAELQMQVAVNGANLQNVFMLLTLEPLLARSPFLVLH 705

  Fly  4553 -----------------------RVWKVKFVGESVDDCGGGYSESIAEMCDELQNGSVPLLINTP 4594
                                   :..||.|.||...|.||...|....:..||.|   |:.
  Rat   706 VRRNHLVGDALRELSIHSDIDLKKPLKVIFDGEEGVDAGGVTKEFFLLLLKELLN---PIY---- 763

  Fly  4595 NGRGEAGANRDCFLLDPTLSSVLQMNMFRFLGVLMGIAVRTGSPLSINLAEPVWRQLTG------ 4653
               |.....:|..||..:.:..::.|.|..:|:..|:|:...:.:.::....::::|..
  Rat   764 ---GMFTYYQDSNLLWFSDTCFVEHNWFHLIGITCGLAIYNSTVVDLHFPLALYKKLLNVKPSLE 825

  Fly  4654 --EVLRPT------DLTEVDRDYVAGLLCIRNMDDDPKLFTALELPFSTSSARGHEVPLSTRYTH 4710
              :.|.||      :|.:...:.:....|:.        ||.....:.....: ..:|...|..
  Rat   826 DLKELSPTEGRSLQELLDYPGEDIEETFCLN--------FTVCRESYGVIEQK-KLIPGGDRVA- 880

  Fly  4711 ISPRNRAE----YVRLALGFRLHEFDEQVKAVRDGMSKVIPVPLLSLFSAAELQAMVCGSPDIPL 4771
            :...||.|    ||.......:||:   ..|...|..||....:|.||..|||:||:.|:.:...
  Rat   881 VCKDNRQEFVDAYVNYIFQISVHEW---YTAFSSGFLKVCGGKVLELFQPAELRAMMVGNSNYNW 942

  Fly  4772 GLLKSVATYKG-FDPSSALVTWFWEVMEEFTNQERSLFLRFVWGRTRLPRTIADFRGRDFVLQVL 4835
            ..|:..|.||| :..:...|..|||...||..:::..||.|:.|..|:|  |........|:|..
  Rat   943 EELEETAVYKGDYSSTHPTVKLFWETFHEFPLEKKKRFLLFLTGSDRIP--IYGMASLQIVIQST 1005

  Fly  4836 EKNPPDHFLPESYTCFFLLKMPRYSCKAVLLEKLKYAI 4873
            ...  :.:||.::||:.||.:|:||.|.::..:|..|:
  Rat  1006 ATG--EDYLPVAHTCYNLLDLPKYSSKEIMKARLTQAL 1041

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HERC2	NP_608388.2	RCC1	638..683	CDD:278826
		RCC1	687..737	CDD:278826
		RCC1	740..787	CDD:278826
		RCC1	790..841	CDD:278826
		RCC1_2	828..857	CDD:290274
		Cyt-b5	1290..1363	CDD:278597
		MIB_HERC2	1928..1987	CDD:284184
		UBA_HERC2	2515..2559	CDD:270585
		Cul7	2624..2699	CDD:288381
		APC10-HERC2	2762..2932	CDD:176485
		RCC1	3037..3088	CDD:278826
		RCC1	3091..3140	CDD:278826
		RCC1	3144..3194	CDD:278826
		RCC1	3197..3246	CDD:278826
		RCC1	3250..3298	CDD:278826
		RCC1	3302..3350	CDD:278826
		RCC1_2	4136..4166	CDD:290274	10/29 (34%)
		RCC1	4154..4203	CDD:278826	16/49 (33%)
		RCC1	4206..4257	CDD:278826	17/51 (33%)
		RCC1	4260..4309	CDD:278826	12/48 (25%)
		RCC1	4312..4360	CDD:278826	19/47 (40%)
		RCC1	4364..4413	CDD:278826	22/116 (19%)
		HECTc	4509..4880	CDD:238033	97/464 (21%)
		HECTc	4553..4878	CDD:214523	84/340 (25%)
Herc3	NP_001102101.1	ATS1	2..331	CDD:227511	111/339 (33%)
		RCC1	313..377	CDD:395335	16/63 (25%)
		HECTc	702..1048	CDD:238033	85/367 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820