DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment HERC2 and Hace1

DIOPT Version :9

Sequence 1:NP_608388.2 Gene:HERC2 / 33035 FlyBaseID:FBgn0031107 Length:4912 Species:Drosophila melanogaster
Sequence 2:XP_006256657.1 Gene:Hace1 / 361866 RGDID:1306114 Length:916 Species:Rattus norvegicus


Alignment Length:603 Identity:138/603 - (22%)
Similarity:229/603 - (37%) Gaps:154/603 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly  4319 GKGDFHRLGHG---SVDHVRRPKKVAALQGKKIISIATGSLH--------CVACSDSGEVYTWGD 4372
            |.|.:.||..|   |...|...|:.|:...:.:||:....|.        |.:|           
  Rat   419 GPGSYERLSTGPGESKPDVLAGKQEASADCQDVISVTANRLSAVIQAFYMCCSC----------- 472

  Fly  4373 NDEGQLGDGTVTAIQRPRLVAALQGKHIVKVTCGSAHTLALSTSQLSERLRPLPNPPLEYDLVRD 4437
                |:..|..:    ||         .::..|.....|....::         ||.:.:|    
  Rat   473 ----QMPPGMTS----PR---------FIEFVCKHDEVLKCFVNR---------NPKIIFD---- 507

  Fly  4438 LAPEALHARLILLHHFSELV-CPCLAMLPISGDLSLGALKDVLVYNIKEAAFRKVIQTTMVR--- 4498
                          ||..|: ||              .|....::.||...|:...:.....   
  Rat   508 --------------HFHFLLECP--------------ELMSRFMHIIKAQPFKDRCEWFYEHLHS 544

  Fly  4499 -----DKQHGPVIELNRIQVKRS---RNRCNGLAGIDGMKSVFGQMVQKLPLLTQEALALPHRVW 4555
                 |..|.||.|.:.:.|.|.   |:.|..::..:..|             .::.:|      
  Rat   545 GQPDSDMVHRPVSENDILLVHRDSIFRSSCEIVSKANCAK-------------LKQGIA------ 590

  Fly  4556 KVKFVGESVDDCGGGYSESIAE-----MCDELQNGSVPLLINTPNGRGEAGANRDCFLLDPTLSS 4615
             |:|.||.      |..:.:..     :.:|:.|....|...:.:|.          ...|..:|
  Rat   591 -VRFHGEE------GMGQGVVREWFDILSNEIVNPDYALFTQSADGT----------TFQPNSNS 638

  Fly  4616 VL---QMNMFRFLGVLMGIAVRTGSPLSINLAEPVWRQLTGEVLRPTDLTEVDRDYVAGLLCIRN 4677
            .:   .:|.|||.|.::|:|:.....::|......::.:.|..:...|:..:|.:|...|..|  
  Rat   639 YVNPDHLNYFRFAGQILGLALNHRQLVNIYFTRSFYKHILGIPVNYQDVASIDPEYAKNLQWI-- 701

  Fly  4678 MDDDPKLFTALELPFSTSS---ARGHEVPLSTRYTHI--SPRNRAEYVRLALGFRL-HEFDEQVK 4736
            :|:|.. ...|||.||..:   ....||||......|  :..|:||||:|....|: .....|:.
  Rat   702 LDNDIS-DLGLELTFSVETDVFGAMEEVPLKPGGGSILVTQNNKAEYVQLVTELRMTRAIQPQIN 765

  Fly  4737 AVRDGMSKVIPVPLLSLFSAAELQAMVCGSPDIPLG-LLKSVATYKGFDPSSALVTWFWEVMEEF 4800
            |...|....||..|:.||...||:.::.|.|:|.:. .:|:.....|::....::.|||||:|:.
  Rat   766 AFLQGFHMFIPPSLIQLFDEYELELLLSGMPEIDVNDWIKNTEYTSGYEREDPVIQWFWEVVEDM 830

  Fly  4801 TNQERSLFLRFVWGRTRLPR-TIADFRG----RDFVLQVLEKNPPDHFLPESYTCFFLLKMPRYS 4860
            |.:||.|.|:||.|.:|:|. ..|:..|    ::|.:..:...|  :.||.|.||..:||:|.|.
  Rat   831 TQEERVLLLQFVTGSSRVPHGGFANIMGGSGLQNFTIAAVPYTP--NLLPTSSTCINMLKLPEYP 893

  Fly  4861 CKAVLLEKLKYAIHFCKS 4878
            .|.:|.::|..|:| |.|
  Rat   894 SKEILKDRLLVALH-CGS 910

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HERC2NP_608388.2 RCC1 638..683 CDD:278826
RCC1 687..737 CDD:278826
RCC1 740..787 CDD:278826
RCC1 790..841 CDD:278826
RCC1_2 828..857 CDD:290274
Cyt-b5 1290..1363 CDD:278597
MIB_HERC2 1928..1987 CDD:284184
UBA_HERC2 2515..2559 CDD:270585
Cul7 2624..2699 CDD:288381
APC10-HERC2 2762..2932 CDD:176485
RCC1 3037..3088 CDD:278826
RCC1 3091..3140 CDD:278826
RCC1 3144..3194 CDD:278826
RCC1 3197..3246 CDD:278826
RCC1 3250..3298 CDD:278826
RCC1 3302..3350 CDD:278826
RCC1_2 4136..4166 CDD:290274
RCC1 4154..4203 CDD:278826
RCC1 4206..4257 CDD:278826
RCC1 4260..4309 CDD:278826
RCC1 4312..4360 CDD:278826 13/51 (25%)
RCC1 4364..4413 CDD:278826 6/48 (13%)
HECTc 4509..4880 CDD:238033 101/393 (26%)
HECTc 4553..4878 CDD:214523 94/344 (27%)
Hace1XP_006256657.1 ANK repeat 66..95 CDD:293786
ANK 66..93 CDD:197603
Ank_2 69..194 CDD:289560
ANK 92..217 CDD:238125
ANK repeat 97..128 CDD:293786
ANK repeat 130..161 CDD:293786
Ank_2 135..222 CDD:289560
ANK repeat 163..194 CDD:293786
ANK repeat 196..221 CDD:293786
Ank_4 199..249 CDD:290365
HECTc 561..910 CDD:238033 100/390 (26%)
HECTc 586..909 CDD:214523 94/351 (27%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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