DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HERC2 and Rcbtb1

DIOPT Version :9

Sequence 1:	NP_608388.2	Gene:	HERC2 / 33035	FlyBaseID:	FBgn0031107	Length:	4912	Species:	Drosophila melanogaster
Sequence 2:	NP_001101850.1	Gene:	Rcbtb1 / 361050	RGDID:	1308467	Length:	531	Species:	Rattus norvegicus

Alignment Length:	364	Identity:	111/364 - (30%)
Similarity:	174/364 - (47%)	Gaps:	29/364 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly  3008 KVPTFS----QTISRLRPIHIAG--GSKSLFIVSQDGKVYACGEGTNGRLGLGVTHNVPLPHQLP 3066
            |.|.|:    |....:|...:.|  .|:::::...| :|:..|...:..||.|...:..:|.:|.
  Rat     6 KWPIFTLLSPQETGSIRKACVFGISASEAIYVTDSD-EVFVFGLNYSNCLGTGDNQSTLVPKKLE 69

  Fly  3067 VLRQYVVKKVAVHSGGKHALALTLDGKVFSWGEGEDGKLGHGNRTTLDKP-RLVEALRAKKIRDV 3130
            .|....:|.:: :..|.|.|..|.||.|::||.....:||:|.......| ::...|..|::.:|
  Rat    70 ALCGKRIKSLS-YGSGPHVLLSTEDGVVYAWGHNGYSQLGNGTTNQGIAPIQVCTNLLVKQVVEV 133

  Fly  3131 ACGSSHSAAISSQGELYTWGLGEYGRLGHGDNTTQLKPKLVT-ALAGRRVVQVACGSRDAQTLAL 3194
            ||||.||.|:::.|||:.||....|::|.|....|..|:.|| .|..::||.:|||  ...::|:
  Rat   134 ACGSHHSMALAADGELFAWGYNNCGQVGSGSTANQPTPRKVTNCLHTKKVVNIACG--QTSSMAV 196

  Fly  3195 TEDGAVFSWGDGDFGKLGRGGSEGSDTPHEIERLSGIGVVQIECGAQFSLALTRAGEVWTWGKGD 3259
            .:.|.|:.||....|:||.|.:....||..:..|.|:.|.||.||...:||||..|.::.||...
  Rat   197 LDSGEVYGWGYNGNGQLGLGNNGNQLTPVRVAALHGVCVNQIVCGYAHTLALTDEGLLYAWGANT 261

  Fly  3260 YYRLGHGGDQHVRKPQPIGGLRGRRVIHVAVGALH----CLAVTDAGQVYAWGDNDHGQQGSGNT 3320
            |.:||.|...::..|..| .:...|||.:|  |.|    ..|.|..|.||.||      |..|.:
  Rat   262 YGQLGTGSKNNLLSPTQI-MVEKERVIEIA--ACHSTHTSAAKTQGGHVYMWG------QCRGQS 317

  Fly  3321 FVNKKPALVIGLDAVFVNRVACGSSHSIAWGLPNASSDE 3359
            .:..........|.||    ||..:.:::|.|.:...::
  Rat   318 VILPHLTHFSCTDDVF----ACFGTPAVSWRLLSVEHED 352

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HERC2	NP_608388.2	RCC1	638..683	CDD:278826
		RCC1	687..737	CDD:278826
		RCC1	740..787	CDD:278826
		RCC1	790..841	CDD:278826
		RCC1_2	828..857	CDD:290274
		Cyt-b5	1290..1363	CDD:278597
		MIB_HERC2	1928..1987	CDD:284184
		UBA_HERC2	2515..2559	CDD:270585
		Cul7	2624..2699	CDD:288381
		APC10-HERC2	2762..2932	CDD:176485
		RCC1	3037..3088	CDD:278826	13/50 (26%)
		RCC1	3091..3140	CDD:278826	18/49 (37%)
		RCC1	3144..3194	CDD:278826	18/50 (36%)
		RCC1	3197..3246	CDD:278826	18/48 (38%)
		RCC1	3250..3298	CDD:278826	15/51 (29%)
		RCC1	3302..3350	CDD:278826	12/47 (26%)
		RCC1_2	4136..4166	CDD:290274
		RCC1	4154..4203	CDD:278826
		RCC1	4206..4257	CDD:278826
		RCC1	4260..4309	CDD:278826
		RCC1	4312..4360	CDD:278826
		RCC1	4364..4413	CDD:278826
		HECTc	4509..4880	CDD:238033
		HECTc	4553..4878	CDD:214523
Rcbtb1	NP_001101850.1	RCC1	42..89	CDD:395335	11/47 (23%)
		ATS1	<91..363	CDD:227511	91/277 (33%)
		BTB_POZ_RCBTB1_CLLD7	350..466	CDD:349662	0/3 (0%)
		BACK_RCBTB1	466..531	CDD:350603
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820