DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment HERC2 and Ufd4

DIOPT Version :9

Sequence 1:NP_608388.2 Gene:HERC2 / 33035 FlyBaseID:FBgn0031107 Length:4912 Species:Drosophila melanogaster
Sequence 2:NP_609369.1 Gene:Ufd4 / 34378 FlyBaseID:FBgn0032208 Length:2727 Species:Drosophila melanogaster


Alignment Length:2756 Identity:519/2756 - (18%)
Similarity:850/2756 - (30%) Gaps:1033/2756 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly   709 SLPTLVVALSDHMVVDVALGSGDAHSLA----------LTSE-GLVFAWGDGDYGKLGNGNCNGS 762
            |:...:.|:.:|:|| ..|.|..:..||          .|.| |.||   :|     |..||   
  Fly    94 SIDGAIKAICNHLVV-ADLSSRTSRDLAEQCIKVLELICTREAGAVF---EG-----GGLNC--- 146

  Fly   763 LQPILVESLPRVQRVFAGSQ-----FSVALSSEGQLYTWGKATCLGHQLVERS---VQGCSVPRL 819
                 |.|..|    ..|||     ...|:|...:|.|          .||.:   :|.| |..|
  Fly   147 -----VLSFIR----DCGSQVHKDTLHSAMSVVSRLCT----------KVEPNTPCIQNC-VESL 191

  Fly   820 VSSLQHKRIVDVAVS--VAHCLALSSSGEVFGWGRNDSQQICPASVSSEPLLRTPILVSLPTFPA 882
            .:.|||:   |..||  ...|.|..:......|       :.||.: :|..|.|.:|..|.:.  
  Fly   192 STLLQHE---DPMVSDGALKCFASVADRFTRKW-------VDPAPL-AEYGLTTELLKRLQSV-- 243

  Fly   883 SGIACTSAQSLVWTQSSHQGVPRRAPFVVDLGEPTFRLLDQLLGMCSSQDNRQTPNQE--SECIA 945
             |....|:.:...||                  ||           ||.....|.|.:  :|.:|
  Fly   244 -GGNTHSSLTAAGTQ------------------PT-----------SSSQPAATTNSDAINENVA 278

  Fly   946 VACLNLFRLQLLALIANGVEPRQVGLASGSRLLCSLKTRILGLAGGS-----QVLRT-IQVAAQQ 1004
            ..          |.|:|..:.:....|:..:.:.:..:.:..|..||     .:||: :..|.::
  Fly   279 GT----------ATISNSTKVKSSDAAASPQSISTTISLLSTLCRGSPSITHDILRSQLADALER 333

  Fly  1005 ALQDGWSVLLPTAAERAQTLTSLLPSEPGQASSAG-----------------------HRFMTDL 1046
            |||.....:|.  ..|...|..||..|..||.:.|                       ||.:.|.
  Fly   334 ALQGDERCVLD--CMRFADLLLLLLFEGRQALNRGSNNPNQGQLAPRPRRNNTNTDRTHRQLIDC 396

  Fly  1047 LVSSLMAEGGLESALQHAIRLESSSCSADCGDGVHLPL---------LQLITRLLSNNAALSQTR 1102
            :.|.      ...||:.||  ||.....:|.|.|...|         |:::..|....|.:::.:
  Fly   397 IRSK------DSEALREAI--ESGGIDVNCMDDVGQTLLNWASAFGTLEMVEYLCEKGADVNKGQ 453

  Fly  1103 LSPTL----------------------------GKQQ-EKEEEEREQQHQEPST---------SP 1129
            .|.:|                            ||.. :|..|..:..|:|.:.         ||
  Fly   454 RSSSLHYAACFGRPAIAKILLKFGAYPDLRDEDGKTPLDKARERLDDGHREVAAILQSPGEWMSP 518

  Fly  1130 SLSLLHRFQRLLLSHIHQAQPEEETTGAEALLLQYMHALIPACVATLQKAHELALQCREPGENSF 1194
            ..|||::..:.......:..||        :...|:..|:|             :.||    ...
  Fly   519 DHSLLNKDGKKYTLMEPRGDPE--------MAPIYLKVLLP-------------IFCR----TFL 558

  Fly  1195 GQMVGHLGRVLQADISDALLNELLVGLLLLKRDRPQCLGGLRWARLFLPLLRVLDRLNRALGEGE 1259
            |.|:|.:.|.     |.||:.:      :::...|..|..|                      .|
  Fly   559 GSMLGSVRRA-----SLALIKK------IVQYAYPTVLQSL----------------------SE 590

  Fly  1260 LRDGDDMGWPGIICRGGPKGGPPPADPETHYVRRADMENLLLDGSRCIILAGYVCDLSGYNCESE 1324
            ....:|..     ...|..||                 |||:                      |
  Fly   591 TSFSEDAA-----STSGQNGG-----------------NLLI----------------------E 611

  Fly  1325 TLRSVLDS---GLGKDLTAEMSSQVHRTAMEHILEHH-KLGKY-MVQA-----STEEKSSAPGPS 1379
            .:.||||:   |.|..:...:..::.....|..|:|. :||.: .|||     :.|.....||. 
  Fly   612 VIASVLDNEDDGDGHLIVLNIIEEIMCKTQEEFLDHFARLGVFAKVQALMDTDAEELYVQLPGT- 675

  Fly  1380 RLTHFSSECALAQLLG---LVANLMCSGPALQPAE--LQ-----------CRQLDKSSLLSG--G 1426
                 ..|.|.||...   :||....|...::.|:  ||           ||..|...:.|.  .
  Fly   676 -----VEEPAAAQRSSTSVVVAPRPTSDDPMEDAKEILQGKPYHWREWSICRGRDCLYVWSDSVA 735

  Fly  1427 LQLLQPSNPF-----DEEKGEARSSHSCHSTAGNTPTELPPPLPMQQQLAPGRGKSQLQLRADAF 1486
            |:|...||.:     |.:.....||.|..:  ||..:|             .||:         |
  Fly   736 LELSNGSNGWFRFIIDGKLATMYSSGSPEN--GNDSSE-------------NRGE---------F 776

  Fly  1487 ISGLAEAR-------VSEP--PVAA--------WLALTERYCKAHNLMWHQEFATE-HPVQELER 1533
            :..|..||       ||:|  |.|:        |:..::   |.:.|..|.   || |.|..|:.
  Fly   777 LEKLMRARSCVIAGVVSQPILPTASALRLVVGNWVLQSQ---KTNQLQIHN---TEGHQVTVLQD 835

  Fly  1534 LLSAVLI------RHQYLGGLVL---------------NALETE--------------------- 1556
            .|...:.      :|.:....||               |..:||                     
  Fly   836 DLPGFIFESNRGTKHTFSAETVLGPDFASGWSTAKKKRNKSKTEGQKFQVRNLSREIYNKYFKSA 900

  Fly  1557 -VPPPRQLGEIIRLVHQAKWSVVRTRQQLNRSYKEVCAPILERLRFLLYE--VRPAISPQQRGL- 1617
             :.|...:..:..:|.|.:.|........|.:::......|.:|..|::|  |..|......|| 
  Fly   901 QIIPRGAVAILTDIVKQIELSFEEQHMAPNGNWETTLTDALMKLSQLIHEDGVVSAYEMHSSGLV 965

  Fly  1618 --------------------------RRLPILQR------------PPRFKMLVRRLLQELRSSR 1644
                                      :|:.:.::            .||.|.....|:|:|    
  Fly   966 QALVAVLSVNHWETNSPRCKRNKMQKQRVSVFKKCILEDNVESATNKPRTKSTASILIQKL---- 1026

  Fly  1645 QPAKPEDLLNASIQQEQEKKP-------------QSMPKQ---ELEEQEEEETLL----RRLNER 1689
                      .|:.:..||.|             |.:.|:   .||..|.|.||.    |.|...
  Fly  1027 ----------VSVLESTEKLPVYLYDSPCTGYSLQILQKRLRFRLERAECESTLFDRSGRTLKME 1081

  Fly  1690 QIHGEGELDPALMQDIVDFALQDSCDVETARRAMYCQMQRYQLRLAGLQIVQQL-LELHGLL--- 1750
            .:...|:|...|::.:.    :...|::   |:.|..:::.:............ .:..|||   
  Fly  1082 PLATIGQLSKYLLKMVA----KQWYDLD---RSTYFYLKKIREHRTATVFTHSFDFDEEGLLFYI 1139

  Fly  1751 ----------DAAQYSLLNGFLGLHLKSTSSGGGSTGSGSSLHVLGQ----LNMISAYQKARLLL 1801
                      :.|||.|        ::.|||.|.:...|....:|.:    ||..:...|.....
  Fly  1140 GSNAKTCDWVNPAQYGL--------VQVTSSEGKTLPYGKLEDILSRDSISLNCHTKDNKKAWFA 1196

  Fly  1802 AQSRV----LDWAVRELR-----RLVNQEQQGHARGKDSTNLGTYV----LLKRLPRARFLL--- 1850
            ....|    ..:.:|..|     .|.|...||...|...|.|.|:|    |::....|.:.:   
  Fly  1197 IDLGVYIIPTAYTLRHARGYGRSALRNWLLQGSKDGSTWTTLSTHVDDKSLVEPGSTATWPINCA 1261

  Fly  1851 ---SVF--GLLAKELGPNELG---FLINSG--LLGTVLGLLAQTG-----GEGATGGQVHGELSI 1900
               ||:  .:..::.|.|..|   :|..||  :.|.|:|:....|     .|..|..:       
  Fly  1262 TDDSVWYRHIRIQQNGRNASGQTHYLSLSGFEIYGRVVGVADDIGKSVKEAEAKTRRE------- 1319

  Fly  1901 LYEDSVLKQKSSKAQLSGPDLAKLMKIGTRIVRGADWKWGDQDGNPPGEGRIISEVGEDGWVRVE 1965
                    ::..:|||      |.|..|.|::||.||:|.:|||  ..||.|..|: .:||:.|:
  Fly  1320 --------RRQIRAQL------KHMTTGARVIRGVDWRWEEQDG--CAEGTITGEI-HNGWIDVK 1367

  Fly  1966 WYTGATNSYRMGKEGQYDLQLAD--------------SALNVASPTE--------------PERE 2002
            |..|..||||||.||:|||:|||              ||...|.|:|              |...
  Fly  1368 WDHGVRNSYRMGAEGKYDLKLADCEYLSAFDGNQSMGSASTAAKPSEKGGNTLTSRKSSSTPSLP 1432

  Fly  2003 DVSGSEASPTSDSHPSKLLRHCAAK------------------LLQILAVGTGLHGAQLDKDALR 2049
            :.:....:|...|:.:....:.|.|                  :...||:.|........|....
  Fly  1433 EATEKNQNPEGASNQTVSADNLAWKQTVETIAENVFASAKTQIISNQLAMNTSSSREARAKHKES 1497

  Fly  2050 GMTSMFR-TIIYPKPSMSNISYALGWLNLGFIRAISGDCPRL----CLELSTPGWLSHYLSLLEQ 2109
            |...|.: .|..|.|....:.:      :..:.||:...|.:    ..:|:|   :|..|||.|.
  Fly  1498 GTNQMHKDNISGPSPLSRELEH------ISDLSAINNSMPAINSSNVSDLAT---ISENLSLTEL 1553

  Fly  2110 PAGNEAGVYRQLHCLRLLQLILAQWGAEEEPRMPALVHQLFATLGRIALH------CPGDASLLP 2168
            ...|            :.:::...:...|.           .|..:.:.|      .|.:..:..
  Fly  1554 SKEN------------ICRVLTPSYKPAES-----------VTASQSSSHPDVQSSSPRENDIKN 1595

  Fly  2169 TAEGKARVLLTASHS-GSVAEELVALLRRLHTLPSWNPVINSFLAQKLCVAAELLAEQSHSTALD 2232
            .:..:....:.|::| ..::::|:|.| |...:....||                      |.|.
  Fly  1596 ISNIEENNKMNANNSVNKISKDLLANL-RTSNIAGCPPV----------------------TQLS 1637

  Fly  2233 SEQVFVLGVLGAMGGHDLRPRVGLHCFHEGSHMVIASFTPKGRCLLAP-GGVGSGVGFVKVQLPA 2296
            :|.:.::.          :.|.|:......|:.::::.|....|...| ||              
  Fly  1638 TEALEMID----------KMRDGVDMIRNMSNSILSTDTFPVPCTNVPVGG-------------- 1678

  Fly  2297 VMPHLDHTVFSLSRLPMNEMLLNAWTVLLYGPAPE----------LRELPSSADGRLDLALLRAQ 2351
                        .:.|..:.|:|          |:          ..|.|:.:..:..:.|..||
  Fly  1679 ------------KKTPKAQALIN----------PDNANQKQIIVTSEEFPTKSSKKPSVTLKPAQ 1721

  Fly  2352 QLQMAVLHTNGVLYRHQVALRRILKQRAPGSIYASPDEPDRSDAESQQPGEQDQQLSSGSGQEP- 2415
            |                           |.::.:..|             .::|.:|:.:...| 
  Fly  1722 Q---------------------------PNAVLSIVD-------------IKEQPISNENVSVPS 1746

  Fly  2416 QLLIQCILLRATQASPVKACYSYMDLATAALNCIQSLATQAHQELSEGGGVPPNGRALSSPPQPT 2480
            |:.|....|..|.||.|.   |..::||.. ..:::.|..|.:..|:|..:..|           
  Fly  1747 QMSISVPNLTTTSASEVP---STSEVATHT-GLLETFAAIARRRTSQGTNIQDN----------- 1796

  Fly  2481 MVHGVPVYNVARKEQKPSEQVEQKSKWPAAATDAQLIGQIMEMGFTRRTVELALKQLSLQAEIMP 2545
                    .:...|...:|..:|.:.           |..:....| ..|:|||.. :..:.::.
  Fly  1797 --------QIMNAEANVNEHGDQNAS-----------GSFLGHSVT-SLVKLALSS-NFHSGLLS 1840

  Fly  2546 TPEQIVQWILEHPDVCANTIEEDTLPLASSASSHDPEADSDNECPSSNSTTSSSTSSDTVEGQPM 2610
            |.:       .:|.:.:|. .|:..|...|.:|...::.|......:.|.||:|:.|:.|..:..
  Fly  1841 TAQ-------SYPSLSSNN-SENIAPSNPSNTSAGQQSASTINHTLTMSLTSTSSDSEQVSLEDF 1897

  Fly  2611 AVSGPAPPV---------KFESRKDFQTADLYALYVRGLVRPGMTVRCCRDFEEIKQGDMGTVLI 2666
            ..|..||.:         ..|...:.:..|                    ::||:     |..|:
  Fly  1898 LESCRAPALLGDLDDEDDMDEDNDEEENED--------------------EYEEV-----GNTLL 1937

  Fly  2667 -----------VDTEGLHDLNVQV----DWRNHGSTYWVCFVHIELVEAAQTHHQPRPPPIAVGA 2716
                       :|.|.:.:..|.|    .|.:.       ||......|......|||       
  Fly  1938 QVMVSRNLLTFMDDEAMENRLVGVTKRKSWDDE-------FVLKRQFSALIPAFDPRP------- 1988

  Fly  2717 RVRLRTSSLRYGMLCPLRLGRSQGSSAIGVVSSVRSKQLTVDFPDQPAWQGHINEVELVASQPTS 2781
                                   |.:.:...|.:....|..:.| :|...|....:|    ||..
  Fly  1989 -----------------------GRTNVNQTSDLEISPLGAELP-KPQQSGGPETIE----QPLL 2025

  Fly  2782 ATLPSLGDSCSQMPPSDL---IEDWS--RCIRSLTVSSNEAAAKHLLNGSNQPWQSCSSGPCRHW 2841
            . |...|.....:|..::   ..||:  |.::.|.                         .|...
  Fly  2026 G-LKLRGPGIGGIPEVEIDLSNTDWTIFRAVQELL-------------------------QCSQL 2064

  Fly  2842 IRLELHDRILVHSLTL---KVSPEDHSHMPSLLEIRVGDCVDSLKEYTWIP---VPAGASRVLLM 2900
            .:|:...:|...:.|:   :|||          |.:...|::| :|:...|   ..:|||  .|.
  Fly  2065 NKLDKFRKIWEPTYTIVYREVSP----------EAQESTCLES-EEFPQTPDVSSKSGAS--TLS 2116

  Fly  2901 QQVPTYYPW----------VEVVVKQCQNNGI-------QCKIHGIK------FVGRRQQPDLQH 2942
            ...|.:..:          .:|:....|.||:       ..|.||:.      |:.::....||.
  Fly  2117 PNSPMHIGFNVADNNLCSVDDVLELLTQINGLNQSEIDSDVKEHGVSVLSEDLFISKKITNKLQQ 2181

  Fly  2943 ILANAQFLAS-----------EYSAGVGPGST-----------AGAGAVSTSHEEAAAAPEQDLP 2985
            .:.:...|||           :....:.|..|           |....|....:.......|.:|
  Fly  2182 QIQDPLVLASNALPNWCENLNQSCPFLFPFETRQLYFNCTSFGASRSIVCLQSQRDVTVERQRIP 2246

  Fly  2986 CTVMVWGLNDKE-QLGGLKGSKVKVP 3010
              :|....:|.| ::|.||..:||||
  Fly  2247 --IMSPRRDDHEFRIGRLKHERVKVP 2270

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HERC2NP_608388.2 RCC1 638..683 CDD:278826
RCC1 687..737 CDD:278826 9/37 (24%)
RCC1 740..787 CDD:278826 14/52 (27%)
RCC1 790..841 CDD:278826 15/55 (27%)
RCC1_2 828..857 CDD:290274 6/30 (20%)
Cyt-b5 1290..1363 CDD:278597 15/76 (20%)
MIB_HERC2 1928..1987 CDD:284184 30/58 (52%)
UBA_HERC2 2515..2559 CDD:270585 7/43 (16%)
Cul7 2624..2699 CDD:288381 12/89 (13%)
APC10-HERC2 2762..2932 CDD:176485 36/203 (18%)
RCC1 3037..3088 CDD:278826
RCC1 3091..3140 CDD:278826
RCC1 3144..3194 CDD:278826
RCC1 3197..3246 CDD:278826
RCC1 3250..3298 CDD:278826
RCC1 3302..3350 CDD:278826
RCC1_2 4136..4166 CDD:290274
RCC1 4154..4203 CDD:278826
RCC1 4206..4257 CDD:278826
RCC1 4260..4309 CDD:278826
RCC1 4312..4360 CDD:278826
RCC1 4364..4413 CDD:278826
HECTc 4509..4880 CDD:238033
HECTc 4553..4878 CDD:214523
Ufd4NP_609369.1 ANK repeat 393..420 CDD:293786 9/34 (26%)
ANK 396..509 CDD:238125 22/120 (18%)
ANK repeat 422..453 CDD:293786 5/30 (17%)
ANK repeat 455..484 CDD:293786 2/28 (7%)
F5_F8_type_C 1173..1298 CDD:329041 27/124 (22%)
MIB_HERC2 1333..1389 CDD:310955 30/58 (52%)
DamX 1576..>1725 CDD:330571 32/244 (13%)
HECTc 2265..2725 CDD:238033 4/6 (67%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45446991
Domainoid 1 1.000 69 1.000 Domainoid score I6289
eggNOG 1 0.900 - - E1_COG5021
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
32.830

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