Protein Alignment HERC2 and rcbtb1

DIOPT Version :9

• Sequence 1: NP_608388.2
• Gene: HERC2 / 33035
• FlyBaseID: FBgn0031107
• Length: 4912
• Species: Drosophila melanogaster
• Sequence 2: NP_956285.1
• Gene: rcbtb1 / 336007
• ZFINID: ZDB-GENE-030131-7951
• Length: 531
• Species: Danio rerio
• Alignment Length: 362
• Identity: 114/362 - (31%)
• Similarity: 175/362 - (48%)
• Gaps: 25/362 - (6%)

  Fly  3008 KVPTF----SQTISRLRPIHIAGGSKSLFI-VSQDGKVYACGEGTNGRLGLGVTHNVPLPHQLPV 3067
            |.|.|    :|.:|.:|...|.|.|.:..| ::.|.:||..|...:..||.|.:.:...|.:|..
Zfish     6 KWPLFTLLSAQELSSIRQACIFGASANEAIYITHDDEVYVLGLNCSNCLGTGDSQSTIAPKKLDC 70

  Fly  3068 LRQYVVKKV--AVHSGGKHALALTLDGKVFSWGEGEDGKLGHGNRTTLDKPRLVEA-LRAKKIRD 3129
            |..   ||:  ..:..|.|.|.:|.||::::||.....:||:|.......|.||.. |:.|::.:
Zfish    71 LSG---KKLISLSYGSGPHVLLVTEDGELYAWGHNGYSQLGNGTTNQGVSPILVSTNLQGKRVTE 132

  Fly  3130 VACGSSHSAAISSQGELYTWGLGEYGRLGHGDNTTQLKPKLVT-ALAGRRVVQVACGSRDAQTLA 3193
            |:|||.||.|::.:||::.||....|::|.|....|..|:.|: .|..:.:|.:|||  ...::|
Zfish   133 VSCGSHHSLALTHEGEVFAWGYNNCGQVGSGSTANQPTPRKVSNCLQNKVIVNIACG--QTSSMA 195

  Fly  3194 LTEDGAVFSWGDGDFGKLGRGGSEGSDTPHEIERLSGIGVVQIECGAQFSLALTRAGEVWTWGKG 3258
            :|::|.|:.||....|:||.|.:....||..:..|.|..|:||..|...|||||..|.::.||..
Zfish   196 VTDNGEVYGWGYNGNGQLGLGNNGNQLTPCRLIALQGFCVLQIASGYAHSLALTDEGLLYAWGAN 260

  Fly  3259 DYYRLGHGGDQHVRKPQPIGGLRGRRVIHVAVGALHCLAV-TDAGQVYAWGDNDHGQQGSGNTFV 3322
            .|.:||.|...:...|..:...:.|.|...|..:.|..|. |.:||||.||      |..|...|
Zfish   261 TYGQLGTGNKSNQLSPVQVMTEKERIVEIAACHSTHTSAAKTQSGQVYMWG------QCRGQAIV 319

  Fly  3323 NKKPALVIGLDAVFVNRVACGSSHSIAWGLPNASSDE 3359
            ..........|.||    ||.::.|:.|.:.:...|:
Zfish   320 LPHLTHFASTDDVF----ACFATPSVMWRMLSMEHDD 352

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HERC2	NP_608388.2	RCC1	638..683	CDD:278826
		RCC1	687..737	CDD:278826
		RCC1	740..787	CDD:278826
		RCC1	790..841	CDD:278826
		RCC1_2	828..857	CDD:290274
		Cyt-b5	1290..1363	CDD:278597
		MIB_HERC2	1928..1987	CDD:284184
		UBA_HERC2	2515..2559	CDD:270585
		Cul7	2624..2699	CDD:288381
		APC10-HERC2	2762..2932	CDD:176485
		RCC1	3037..3088	CDD:278826	15/52 (29%)
		RCC1	3091..3140	CDD:278826	18/49 (37%)
		RCC1	3144..3194	CDD:278826	15/50 (30%)
		RCC1	3197..3246	CDD:278826	18/48 (38%)
		RCC1	3250..3298	CDD:278826	12/47 (26%)
		RCC1	3302..3350	CDD:278826	15/47 (32%)
		RCC1_2	4136..4166	CDD:290274
		RCC1	4154..4203	CDD:278826
		RCC1	4206..4257	CDD:278826
		RCC1	4260..4309	CDD:278826
		RCC1	4312..4360	CDD:278826
		RCC1	4364..4413	CDD:278826
		HECTc	4509..4880	CDD:238033
		HECTc	4553..4878	CDD:214523
rcbtb1	NP_956285.1	RCC1	40..90	CDD:278826	15/52 (29%)
		RCC1_2	77..106	CDD:290274	8/28 (29%)
		RCC1	93..143	CDD:278826	18/49 (37%)
		RCC1	146..196	CDD:278826	15/51 (29%)
		RCC1	199..248	CDD:278826	18/48 (38%)
		RCC1	251..299	CDD:278826	12/47 (26%)
		BTB	360..464	CDD:279045
		BTB	371..467	CDD:197585
		SPOP_C_like	467..525	CDD:269810

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820