DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HERC2 and CG4238

DIOPT Version :9

Sequence 1:	NP_608388.2	Gene:	HERC2 / 33035	FlyBaseID:	FBgn0031107	Length:	4912	Species:	Drosophila melanogaster
Sequence 2:	NP_001259896.1	Gene:	CG4238 / 33377	FlyBaseID:	FBgn0031384	Length:	977	Species:	Drosophila melanogaster

Alignment Length:	939	Identity:	185/939 - (19%)
Similarity:	308/939 - (32%)	Gaps:	297/939 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly  4131 LQHVFVKKVAVNSGGKHCLALTTEGEVYAWGE--------GEDGKLGHGNRMSYDRPKLVEHLNG 4187
            |||.:.:.:||.        :.:..:|| |.|        |:|.:|..|.|.:....|
  Fly   121 LQHHYQRLLAVE--------VASLEDVY-WLEDSRASKILGKDWQLWSGARQNLPTSK------- 169

  Fly  4188 MSVADIACGSAHSAAITASGH--VLTWGKGRYGRLGHGDS-----------EDQLRPKLVEALLG 4239
             :..|.......|..:.:|.|  ..|||    |.|....|           :..|.|:...:||.
  Fly   170 -AQLDALKAQLWSTVVKSSQHQDAWTWG----GMLVVSVSVAGLVTLAAMTQPSLAPEARHSLLQ 229

  Fly  4240 YRAIDIACGSGDAQTLCITDDDNVWSWGDGDYGKLG-----------RGGSDGCKLPY------- 4286
            |     ..|.......|...    |.|.|.  ..:|           |.|.     ||
  Fly   230 Y-----VTGKYLLPANCKVQ----WDWKDP--ASVGGTMCFVVRFFQRNGQ-----PYPICDTDH 278

  Fly  4287 ----------KIESLAGLG---------VVKVE----CGSQFSVALTKSGAVYTWGKGDFHRLGH 4328
                      |:.:::.||         :.||:    ...|:.:::. .||.:..|.........
  Fly   279 FFVEVTEGTRKVVTISELGSSTDPNNANIAKVKFTVRTAGQYKISVL-IGASHIAGSPFLRSFLP 342

  Fly  4329 GSVDHVRRPKKVAALQGKKIISIATGSLHCVACSDSGEVYTWGDNDEGQLGDGTVTAIQRPRLVA 4393
            |::| .||.:.:.........:.|...:|.....:.|....:..|...:...|...||.
  Fly   343 GAID-ARRSRFIRPASTVICCAGAPTLMHIEPRDEFGNSCLFDQNQSDEALQGYQVAIY------ 400

  Fly  4394 ALQGKHIVKVTCGSAHTLALSTSQLSERL--------------------RPLPNPPLEYDLVRDL 4438
            .|.|..:.|:    .|.:..:..:::.|:                    :.|||...:..::...
  Fly   401 DLHGVPVEKL----QHAIVFAYDKVNSRVSVTALFPEPTCLRAVISYRDQQLPNGDFDIIVLSSS 461

  Fly  4439 APEALHARLILLHHFSELVCPCLAMLPISGDLSLGALKDVLVY------------NIKE------ 4485
            ....:|..:....|   .:|....:|.|.| :|....:.||.|            .|||
  Fly   462 DTTLVHKNIASRKH---NICYEAKLLSIFG-VSKNKPRKVLCYVGPKQNSLIFQVTIKEMILKFI 522

  Fly  4486 ----AAFRKVIQT-----TMVRDKQHGPV----------IEL-----NRIQVKRSRNRCNGLAGI 4526
                |.||....|     ..:..:.||||          |||     |.|....:......:.|.
  Fly   523 PKRIATFRLCPSTKFHFLPQLVSQLHGPVFIIDDGAQPKIELASKDRNIIAATFTHFLLKNIGGS 587

  Fly  4527 DGMK---SVFGQMVQKL-PLLTQEALALPHRVWKVKFVGESVDDCGGGYSESIAEMCDELQNGSV 4587
            :..|   ..|...|:|. .....|.:||  :|.:.|.:..|:....|   .|:::.|     |:.
  Fly   588 ETFKDKQDFFYHEVRKFHASYYHEKMAL--KVQREKILESSMKAVKG---FSVSDWC-----GNF 642

  Fly  4588 PLLINTPNGRGEAGANRDCFLL--------------------------DPTLSSVLQMNMFRFLG 4626
            .:......|....|..|:.|.|                          :||..:.|::..|.|.|
  Fly   643 EVTFQGEQGIDWGGLRREWFELVCSALFDARGGLFCTFHDKHQALVHPNPTRPAHLKLKHFEFAG 707

  Fly  4627 VLMGIAVRTGSPLSINLAEPVWRQLTGEVLRPTDLTEVDRDYVAGLLCIR-----NMDDDPKLFT 4686
            .::|              :.::....|...|........|.::|.|:.:|     ...|||.|:.
  Fly   708 KMVG--------------KCLFESALGGTYRQLVRARFSRSFLAQLIGLRVHYKYFEQDDPDLYL 758

  Fly  4687 A---------------LELPF------STSSARGHEVPL-----STRYTHISPRNRAEYVRLALG 4725
            :               |||.|      |:|......:.|     .||.|:.:   :.:|:.....
  Fly   759 SKIKYILDTDLDATDTLELYFVEEMYDSSSGQLSKTIELIPNGAKTRVTNAT---KNQYLDALAQ 820

  Fly  4726 FRL-HEFDEQVKAVRDGMSKVIPVPLLSLFSAAELQAMVCGSPDIPLGLLKSVATYKGFDPSSA- 4788
            .|| :...::|.:...|::.:||..|||:|...||:.::||:.:..:...|:.....|   :||
  Fly   821 QRLCNNVKDEVDSFLKGLNSIIPDNLLSIFDENELELLMCGTGEYSISDFKAHHIANG---NSAE 882

  Fly  4789 ---LVTWFWEVMEEFTNQERSLFLRFVWGRTRLPRTIADFRGRDFVLQVLEKNPPDHF------- 4843
               ::.|||..:..|:..|.:..|:|..|.::||.  ..|:         |.||....
  Fly   883 FRRVLAWFWAGVSNFSQTEMARLLQFTTGCSQLPP--GGFQ---------ELNPQFQITAAPTFG 936

  Fly  4844 -LPESYTCFFLLKMPRYSC-----KAVLL 4866
             ||.::|||..|.:|.|..     |::||
  Fly   937 NLPTAHTCFNQLCLPDYESYEQFEKSLLL 965

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HERC2	NP_608388.2	RCC1	638..683	CDD:278826
		RCC1	687..737	CDD:278826
		RCC1	740..787	CDD:278826
		RCC1	790..841	CDD:278826
		RCC1_2	828..857	CDD:290274
		Cyt-b5	1290..1363	CDD:278597
		MIB_HERC2	1928..1987	CDD:284184
		UBA_HERC2	2515..2559	CDD:270585
		Cul7	2624..2699	CDD:288381
		APC10-HERC2	2762..2932	CDD:176485
		RCC1	3037..3088	CDD:278826
		RCC1	3091..3140	CDD:278826
		RCC1	3144..3194	CDD:278826
		RCC1	3197..3246	CDD:278826
		RCC1	3250..3298	CDD:278826
		RCC1	3302..3350	CDD:278826
		RCC1_2	4136..4166	CDD:290274	7/37 (19%)
		RCC1	4154..4203	CDD:278826	12/56 (21%)
		RCC1	4206..4257	CDD:278826	14/63 (22%)
		RCC1	4260..4309	CDD:278826	14/89 (16%)
		RCC1	4312..4360	CDD:278826	9/47 (19%)
		RCC1	4364..4413	CDD:278826	9/48 (19%)
		HECTc	4509..4880	CDD:238033	93/437 (21%)
		HECTc	4553..4878	CDD:214523	83/389 (21%)
CG4238	NP_001259896.1	IG_FLMN	238..336	CDD:214720	18/109 (17%)
		Filamin	238..336	CDD:279024	18/109 (17%)
		HECTc	615..975	CDD:238033	84/392 (21%)
		HECTc	642..974	CDD:214523	76/355 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446948
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.830