Protein Alignment HERC2 and HUWE1

DIOPT Version :9

• Sequence 1: NP_608388.2
• Gene: HERC2 / 33035
• FlyBaseID: FBgn0031107
• Length: 4912
• Species: Drosophila melanogaster
• Sequence 2: NP_001285288.1
• Gene: HUWE1 / 32510
• FlyBaseID: FBgn0030674
• Length: 5151
• Species: Drosophila melanogaster
• Alignment Length: 5939
• Identity: 1052/5939 - (17%)
• Similarity: 1676/5939 - (28%)
• Gaps: 2381/5939 - (40%)

  Fly     6 ASGGAGSSGQGAGSSQTASAAPVSAGVGVGGG----GGASGAAAGAGSAAGSGSGSGS----GSA 62
            :|.||    .||||....:......|.|.|.|    |||..:.:| ||:..||.|:||    |||
  Fly   519 SSDGA----TGAGSIVYRAYHEHIGGAGSGAGLLDIGGARSSLSG-GSSGTSGMGAGSINRDGSA 578

  Fly    63 A-PPS---HSPDLYLRPLPFLDAKWLRADLIASLRNAADGAVLWNHLIQDCELVSSPTAPLLNAR 123
            | ||:   .:...|.|||....|: |.:.|.:||.......|             :..|.||  :
  Fly   579 ARPPAIMYPTNSYYARPLAERKAE-LSSQLPSSLAPKKPSCV-------------TQRAALL--K 627

  Fly   124 GQLSYLG---DDGKHYCG---------AQQLKCSCCQPEYCGPLSACNCDGCRPLDSDTAIKKLT 176
            ..|::|.   .|..|:..         .|.|:......||.||
  Fly   628 SMLNFLKKSIQDHAHFSNMRNIMETSLTQSLRHIIANAEYYGP---------------------- 670

  Fly   177 TQAAAQQAAHLSQATDMVLSGWLWSQPPSQQARLDCQRSMISELQELALRAAGNCLSAQHLRQQL 241
                    :....||| |::.:::::|           |::|.||:|.:.:
  Fly   671 --------SLFLLATD-VVTVYVFNEP-----------SLLSSLQDLGITS-------------- 701

  Fly   242 FIYERYFVALKRERERERKSTTSAQAVASVTTANTTIAATTANAAVESQPAEQQAEHGALG-LAR 305
                   |.||...:::                               .||.::    .|| |..
  Fly   702 -------VMLKALLQKD-------------------------------VPATRE----VLGSLPN 724

  Fly   306 VATHAALNFSFAFLRRAWRSGEDTEMCSELLSEALASLQELPEATLFEAAVVSSLWLEVMERSIK 370
            |.:...||                                  |..|||     .|..:..::.:|
  Fly   725 VFSALCLN----------------------------------ERGLFE-----FLSYDPFDKVLK 750

  Fly   371 FL----RLVAL-----GDPMGNRCTAPLNDRHTALCLLLELGVQKGTL--------AATLECVVL 418
            .|    .|||:     .||:|:..|              .||.....|        |...|.:|.
  Fly   751 VLLSPDYLVAMRRRRSSDPLGDTAT--------------NLGNAMDDLIKHHPYLRADATEAIVR 801

  Fly   419 LL------------LLW--EKDRAGNDNRDMPRKTGAPLQRILLRYQKIGATAKGGG-IAGGEPA 468
            ||            :.|  .|:.:|:.:                     |:.:.||| .....|:
  Fly   802 LLNELVRLGSDPSFICWRANKESSGSGS---------------------GSGSHGGGHHVASTPS 845

  Fly   469 PVASATETFLRFLSLPKSSAAIVDLRRAAVVIISHLDRMVQPLMPRCLLRGGQATAASS------ 527
            |:.....|         .||:.|                         |:|...|..||
  Fly   846 PMVMVAGT---------GSASSV-------------------------LQGAADTNDSSGDDDDD 876

  Fly   528 ----SSAPQQRIYAL-----GWPSLSKDQQGFSAEPTLSWSGESAGVPTLSCRFQIKQVACCETQ 583
                |||.||:....     |.||..:.||   |...:.....:.|.|..:
  Fly   877 DDEMSSASQQQQQPTTPGQGGGPSTPRTQQ---AGGVVGSGAGATGTPAAA-------------- 924

  Fly   584 MLILSQEGKLYTWRLAKPEAEPLPMEEVAHDV--FISI-------AGHCEGRHFLAIDSNHNAYS 639
                ||..|:.|    .||.|.:|:.:...:|  ||..       ..||  |.|:
  Fly   925 ----SQAVKVVT----PPEREAIPLIDYILNVMKFIEAIFSNSPNGDHC--REFV---------- 969

  Fly   640 WGTGEDHRLGHGDTHARAVP-TKIAALEQHCVQSVYCGCSYSAAITCGGNLLTWGRGTYARLGHG 703
                         .|....| .::.:|....|.|.....|.:.|..|
  Fly   970 -------------LHGGLKPILQLLSLPNLPVDSPVSTTSQAVANVC------------------ 1003

  Fly   704 NSDDRSLPTLVVALSDHMVVDVALGSGDAHSLALTSEGLV--FAWGDGDY--------GKLGNGN 758
                   ..::....:..|:||||  .....:....:.|:  |.:..|..        .:|.:|.
  Fly  1004 -------KAILSQAQETKVLDVAL--KQLADIVAQLKPLIKHFTFPGGSVLLAELVCCQRLEDGF 1059

  Fly   759 CNGSLQPIL---------VESLPRVQRVFAGSQFSVALSSEGQLYTWGKATCLGHQLVERSVQGC 814
            .|....|||         |..|..:.|..:....::.|.      .||.....|.||:::.||
  Fly  1060 ANAEYTPILHNMSFVHGYVVMLVHLCRNASNDMRTILLK------RWGVNRETGVQLLQQLVQ-- 1116

  Fly   815 SVPRLVSSLQHKRIVDVAVSVAHCLALSSSGEVFGWGRNDSQQICPASVSSEPLLRTPILVSLPT 879
                            :.:|:.             |.......:|    |.||
  Fly  1117 ----------------LYISLV-------------WESTILLNLC----SDEP------------ 1136

  Fly   880 FPASGIACTSAQSLVWTQSSHQGVPRRAPFVVDLGEP-TFRLLDQLLGMCSSQDNRQTPNQESEC 943
                    |....|:|.:     :..:........:| |...|.:.|...:....:.||.::
  Fly  1137 --------TQHPDLIWDE-----IAAQMSAAAGTADPLTEAELSRKLERAAEFRTKYTPEEQ--- 1185

  Fly   944 IAVACLNLFRLQLLALIANGVEPRQVGLASGSRL---LCSLKTRILGLAGGSQVLRTIQVAAQQA 1005
                    || .:.:|           ||:.|||   |..|...::.|:.||.  :|.|......
  Fly  1186 --------FR-YIKSL-----------LAASSRLGRALAELLGTLVKLSVGSP--QTRQRRINDL 1228

  Fly  1006 LQDGWSVLLPTAAERAQTLTSLLPSEPGQAS----------------SAG---------HRFMTD 1045
            :.:...|..|.|.|.|:.|:|:|.:.....|                |.|         .|....
  Fly  1229 ISNITKVPTPEAREIARILSSILVNGFSHESILPKPVPKLKLTFLICSVGFTGPMLFDDKRSAFH 1293

  Fly  1046 LLVSSLMAEGGLESALQ---HAIRLESSS--------------------CSADCGDGVHLPL--- 1084
            |::|...||.||::..:   .|:.|::.|                    ...||.:|....|
  Fly  1294 LMISQFCAENGLKAFFEMFYWALSLDNVSQKFEFDQWASMEDLMQSHEDDKRDCPEGTGEFLDAW 1358

  Fly  1085 LQLITRLLSNNAAL-SQTRLSPTLGKQQEKEEEEREQQHQEPSTSPSLSLLHRFQRLLLSHIHQA 1148
            |||:.::::..|.| |...:||.|              :..|.:.|...:.:      |.||||
  Fly  1359 LQLLEKMVNPRAMLDSPYTMSPRL--------------NYMPDSVPFEPVFY------LIHIHQ- 1402

  Fly  1149 QPEEETTGAEALLLQYMHALIPACVATLQKAHELALQCREP----GENSFGQMVGHLGRVLQADI 1209
                       |.:|.:.                .:..|.|    |.:.|..|:
  Fly  1403 -----------LAMQALR----------------RIWARRPIPNYGPSMFETMI----------- 1429

  Fly  1210 SDALLNELLVGLLLLKRDRPQCLGGLRWARLFLPLLRVLDRLNRALGEGELRDGDDMGWPGIICR 1274
                        |:||             .|......:|||.:..:.|.:.
  Fly  1430 ------------LILK-------------HLIKSHQTLLDRYHTRMKEIKF-------------- 1455

  Fly  1275 GGPKGGPPPADPETHYVRRADMENLLLDGSRCIILAGYVCDLSGYNCESETLRSVLDSGLGKDLT 1339
                        |..|:|..|      ||                 ..::.::::.|.|
  Fly  1456 ------------ENLYIRSTD------DG-----------------LNADHIKTLTDMG------ 1479

  Fly  1340 AEMSSQVHRTAMEHILEHHKLGKYMVQASTEEKSSAPGPSRLTHFSSECALAQLLGLVANLMCSG 1404
                          .:.:|.:......||.||                 |...||
  Fly  1480 --------------FMHYHVIEALRTNASLEE-----------------ATDYLL---------- 1503

  Fly  1405 PALQPAELQCRQLDKSSLLSGGLQLLQPSNPFDEEKGEARSSHSCHSTAGNTPTELPPPLPMQQQ 1469
                                        :||         .:.|..:|.|.:.:..|||
  Fly  1504 ----------------------------NNP---------EASSLSTTGGQSSSSAPPP------ 1525

  Fly  1470 LAPGRGKSQLQLRADAFISG-LAEARVSEPPVAAW---------LALTERYC-----KAHNLMWH 1519
             .|....|.:.:..|....| ..:::.|..|.:::         ..:.:|:|     :|...|
  Fly  1526 -PPPPSASTMDIDVDVPADGESTQSKSSTSPNSSYDYKHLKLMPSLIFDRFCDEAISRAFEFM-- 1587

  Fly  1520 QEFATEHPVQELERLLSAVLIRHQYLGGLVLNALETEVPPPRQLGEIIRLVHQAKWSVVRTRQQL 1584
              .|....|.....|::.:..||.:|...|...                       :.||.
  Fly  1588 --EAIPDTVNSAADLIAVLYRRHNHLNKQVFVT-----------------------NFVRN---- 1623

  Fly  1585 NRSYKEVCAPILERLRFLLYEVRPAISPQQRGLRRLPILQRPPRFKMLVRRLLQELRSSRQPAKP 1649
                      |::.:.|.|....||.:...:..|....|.     .|...||...|::|
  Fly  1624 ----------IIQWVDFTLQLFEPAKTTGSKASRLEECLT-----GMTATRLFVRLKTS------ 1667

  Fly  1650 EDLLNASIQQEQEKKPQSMPKQE-LEEQEEEETLLRRLNERQIHGEGELDPALMQDIVDFALQDS 1713
                  ::..|:.......|..| :..|:...:|::                |:..:..:.|:.|
  Fly  1668 ------TLLLEENYSDLHRPLVEAITAQDAMVSLVK----------------LLDCMSQWMLEQS 1710

  Fly  1714 CDVETARRAMYCQMQRYQLRLAGLQIVQQLLELHGLLDAAQYSLLNGFLGLHLKSTSSG-----G 1773
            .:..|.           |.|....:.||.|::|...:|:..:.|..   ..::::.||.     .
  Fly  1711 TETNTG-----------QQRATVPRWVQNLVDLIDAIDSISHILQR---KANMRAVSSDVWRWYD 1761

  Fly  1774 GSTGSGSSLHVLGQLNMISAYQKARLLLAQSRVLDWAVRELRRLVNQEQQGHARGKDSTNLGTYV 1838
            .|||..            :||.:|                     |.|
  Fly  1762 ASTGKW------------NAYSEA---------------------NNE----------------- 1776

  Fly  1839 LLKRLPRARFLLSVFGLLAKELGPNELGFLINSGLLGTVLGLLAQTGGEGATGGQVHGELSILYE 1903
                            |:.......|....||.|.....:.|...|....|:|  .|..:.
  Fly  1777 ----------------LIRNAYAAGERWLYINIGRQRCTVSLNCMTQVSEASG--THRPVC---- 1819

  Fly  1904 DSVLKQKSSKAQLSGP-DLAKLMKIGTRIVRGADWKWGDQDGNPPGEGRIISEVGEDGWVRVEWY 1967
             ..||...:...|:.| .|.|:..|..|:||.|          |.|.|.:.|    |..:.:...
  Fly  1820 -PALKLSEAITSLNNPVALHKVEHILNRVVRTA----------PDGSGTVHS----DELISLRQL 1869

  Fly  1968 TGATNSYRMGKEGQYDLQLADSALNVASPTEPEREDVSGSEASPTSDSHPSKLLRHCAAKLLQIL 2032
            ...|       :||...|..:||......|..:....:.|.:.|.:.:..||..:..||..
  Fly  1870 VNFT-------DGQQPQQSENSANPSEEATSEDGPAAANSGSPPATMTTRSKTRQKSAAAA---- 1923

  Fly  2033 AVGTGLHGAQLDKDALRGMTSMFRTIIYPKPSMSNISYALGWLNLGFIRAISGDCPRL---CLEL 2094
                   .|..:|....|...:      ||.:...|      ||...:.....||.|:   .::|
  Fly  1924 -------AAAKNKSQSGGSPPI------PKRTQKII------LNEEQVGLSKFDCGRIIGSIVDL 1969

  Fly  2095 STPGWLSHYLSLLEQPAGNEAGVYRQLHCLRL------LQLILAQWGAEEEPRMPALVHQLFATL 2153
            ..|   ||.:.       ||..:.....|.||      .|:.:.:.|.    ||...:.|..:.:
  Fly  1970 LQP---SHQML-------NETKLSLLRLCARLTRNYDNAQVFIRRGGV----RMLLHLQQACSFM 2020

  Fly  2154 G---------RIALHCPGDASLLPTAEGKARVLLTASHSGSVA---EELVALLRRLHTLPSWNPV 2206
            |         |..|..|      |..:.....:|....:|.|.   .:|:.:|.::.:..|.||.
  Fly  2021 GFPTYANIILRHVLEAP------PVLQEAMERVLGMRAAGIVPVGHRDLIYVLTQVSSAVSRNPQ 2079

  Fly  2207 INSFL-AQKLCVAAELLAEQSHSTALDSEQVFVLGVLG-----AMGG---HDLRPRVGLHCFHEG 2262
            |  |: |.|..:..|.|...:.:|..|..:|.|....|     |.||   |:..|
  Fly  2080 I--FVAAAKEMLKGEYLINTNSTTLADDARVMVKSKFGQQPTAAAGGATPHNQTP---------- 2132

  Fly  2263 SHMVIASFTPKGRCLLAPGGVGSGVGFVKVQLPAVM------PHLDHTVFSLSRLPMNEMLLNAW 2321
                    ||.                     ||..      |.:..:|..|..| ::.::...|
  Fly  2133 --------TPP---------------------PAAKDELKDDPQVQSSVAVLKEL-LHGLVQPCW 2167

  Fly  2322 TVLLYGPAPELRELPSSADGRLDLALLRAQQLQMAVLHTNGVLYRHQVALRRILKQRAPGSIY-A 2385
            .   ||           ..|.||                     |.|.|...:...:.||:.. .
  Fly  2168 H---YG-----------GTGSLD---------------------RGQGAAELLQPDQPPGTAQGC 2197

  Fly  2386 SPDEPDRSDAESQQPGEQDQQLSSG--------SGQEPQLLIQCILL------RATQASPVKACY 2436
            ..||......|:..|....:|.|||        :||..:....|...      ..|.|.|.
  Fly  2198 HDDELYFRFQETPAPVSSKKQSSSGGGAAAAGQTGQATEKFEPCCCTWHIPTSGHTHAKPT---- 2258

  Fly  2437 SYMDLATAALNCIQSLATQAHQELSEGGGVP---------PNGRALSSPPQPTMV---------- 2482
                ::.|.|..:.:.:|:|:|.|     ||         |....|.|.||.|.:
  Fly  2259 ----ISRATLLKLLADSTRAYQSL-----VPRVLLSHVYTPADSPLISAPQQTFLGVLLDRFLPI 2314

  Fly  2483 ---HGVP---------VYNVARKEQKPSEQVEQKSKWPAAATDA-----------------QLIG 2518
               |.||         :.:::...|:|..||....:..||...|                 .|..
  Fly  2315 TQRHHVPEVSTMTRVLICSLSDCYQQPGVQVHVAEELHAAVARALAQPDSAEKHTRLQVLMSLFP 2379

  Fly  2519 QIMEMGFTRRTVEL---ALKQLSLQAEIMPTPEQIVQW--------------------ILEHPDV 2560
            .::|.......|.:   .:.::.|:..:|....::.|:                    ||....|
  Fly  2380 NLIESPMLYDKVHMHRNNMYRVLLRQGVMTYLTKVAQYKDLSNHNTLSTLAAILRPMEILLRFSV 2444

  Fly  2561 CANTIEEDTLPLASSASSHDPEADSDNECPSSNSTTSSSTSSDTVEGQPMAVSGPAPPVKFESRK 2625
            ...|:....: |..|.....|.|..     :.|:|...|:.           :||.
  Fly  2445 STTTLGSKRI-LFGSGGPGGPNASG-----NGNNTAGGSSG-----------NGPG--------- 2483

  Fly  2626 DFQTADLYALYVRGLVRPGMTVRCCRDFEEIKQGDMGTVLIVDTEGLHDL-----NVQVDWRNHG 2685
               :.:.|...:...:.|.:..|........:...||        |.|.|     ||..| |.|.
  Fly  2484 ---SGNTYGTIINRRLYPRLAARTGFGSAMERSNAMG--------GEHVLRDIIRNVLSD-RRHA 2536

  Fly  2686 STYWVCFVHIELV----EAAQTHHQPRPPPIAVGARVRLRTSSLRYGMLCPLRLGRSQGSSAIGV 2746
                     .|.:    :.|........|...||..                  |...||...||
  Fly  2537 ---------FEFIFNSDDMAVDSEDAAAPGSGVGGG------------------GSGAGSVGGGV 2574

  Fly  2747 VSSV--RSKQLTVDFPDQPAWQGHINEVELVASQPTSATLPSLGDSCSQMPPSDLIEDWSRCIRS 2809
            ..||  .|....:|..::.:..|..|:.....|..:|....|........|..:..:.|...::|
  Fly  2575 SGSVSGNSSAAVIDVVEERSNGGDTNDPPANVSSASSGAGQSSTSGGPVRPVVNFDQLWDDFLQS 2639

  Fly  2810 --LTVSSNE------------AAAKHLLNGSNQPWQSCSSGPCRHWIRLELHDRILVHSLTLKVS 2860
              |.::|..            |::....||||....|.:||
  Fly  2640 EGLRLASRSGGGAGSGSGSVGASSSGQQNGSNTTASSTNSG------------------------ 2680

  Fly  2861 PEDHSHMPSLLEIRVGDCVDSLKEYTWIPVPAGASRVLLMQQVPTYYPWVEVVVKQCQNNGIQCK 2925
                                                                      ||.
  Fly  2681 ----------------------------------------------------------NNS---- 2683

  Fly  2926 IHGIKFVGRRQQPDLQHILANAQFLASEYSAGV-------GPGSTAGA----------------- 2966
              ||..:..|..||:.....|.....|..:|||       |.|.:.||
  Fly  2684 --GIGNLRLRTNPDVDVGSGNGSGSGSGSNAGVVNDNGISGGGGSDGASTSSDTGAPGGARDLNA 2746

  Fly  2967 ---GAVSTSHEEAAAAPEQDLPCTVMVWGLNDKEQLGGLKGSKVKVPTFSQT----------ISR 3018
               |.||||..::..:.|.|        ..|::::..........|...|:|          |..
  Fly  2747 SLLGDVSTSESDSDPSTEND--------ERNEEDEDEDDDAPDEDVDEHSETDVDEERSRQFIEV 2803

  Fly  3019 LRPIHIAGGSKSLFIVSQDGKV----------------------YACGEGTNGRLGLGVTHNVPL 3061
            ...|:....|::   .|.|..|                      ....|.....:...:.:.:.:
  Fly  2804 FDHIYEPESSET---ASNDADVDNDDDDDEDDVDDDDDDDEDNDDDVREEVQSVMDAEIENRIDI 2865

  Fly  3062 PHQLPVLRQYVVKKVAVHSGGKHALALTLDGKVFSWGEGEDGKLGHGNRTTLD------------ 3114
            ...|........:..||::.|.                      |..|||..|
  Fly  2866 ALALVSSNNRPRRSAAVNASGD----------------------GSANRTNPDDEVDDEDDDVDA 2908

  Fly  3115 ----KPRLVEALRAKKIRDVACGSSHSAAISSQGELYTWGLGEYGRLGHGDNTTQLKPKLVTALA 3175
                .|            ||...|..|||   |.|.|.     |.|||.|     |.|   |...
  Fly  2909 DPDGDP------------DVDPISGPSAA---QAEAYL-----YERLGSG-----LMP---TPPV 2945

  Fly  3176 GRRVVQVACGSRDAQTLALTEDGAVFSWGDG-DFGKLGRGGSEGSDTPHEIERLSGIGVVQIECG 3239
            |.|   |...|..||.|.:..:|.  :.|.| :.|..|..|..|        :.|..|......|
  Fly  2946 GFR---VRMNSSIAQPLDIDVNGG--NAGSGSNAGATGSSGGSG--------QRSSTGGTTASIG 2997

  Fly  3240 AQFSLALTRAGEVWTWGKGDYYRLGHGGDQHVRKPQPIGGLRGRRVIHVAVGALHCLAVTDAGQV 3304
            |..|.||..:...|.....::.|:. |||..:.....|||......::|.:  ...:::..||
  Fly  2998 AIASAALRPSSGSWMAPDFNFIRIS-GGDSSMGSGPAIGGNANGGDMNVFI--TPSMSLERAG-- 3057

  Fly  3305 YAWGDNDHGQQGSGNT---FVNKKP---------ALVIGLDAVFVNRVACGSSHSIAWGLPNAS- 3356
                    |..|||.|   .:|::|         ....|:..|..|....|..       |||:
  Fly  3058 --------GAPGSGQTMSELLNEQPTGAGGGGGGGSASGVGGVGANGGTTGQH-------PNATL 3107

  Fly  3357 -----------SDEEKRGPVPFSSTRDPLGGSSLGIYEAETMQTLKQEAKPLNQSSLSESLALET 3410
                       .|::....:|  :.::|...:.:..:..:.:....:||..|:..|       :|
  Fly  3108 CTNGVRRRLLYLDQQYCVCMP--THQNPTEETQMETFTQDALHWWLEEATLLDMES-------QT 3163

  Fly  3411 PAARQAA---LGHVLRAMSIL-QARQLIVAALTSHSKVNFKERGAVGGEEDHLIGGPIMGAPLQ- 3470
            .|...||   |.|:::.:... |.|:...||..|.:..:.....|.......::|   ..||..
  Fly  3164 DACLYAAHFLLPHLIKELKAAHQQRKQEEAARQSTTPASGSNASATSSSTTSVVG---TAAPTAT 3225

  Fly  3471 -------LAETIAQGGGEA-----PADATDAGLQEHS-----------PEAAVDALTGGMSGGAN 3512
                   ||..::.|.|.:     |..|:..|....|           |.:|..|.:...:|..:
  Fly  3226 SSIASGLLANAVSAGSGSSSLVVPPVAASATGGTRRSSIPVLISSTLGPSSASSATSATGNGATS 3290

  Fly  3513 TLPPLSAGPLSAFQS-------------------------------------LTGSLSMSGSLSS 3540
            .....:.||...|.|                                     ||......|..|:
  Fly  3291 DATTTTGGPTRNFSSVDSNVSSETQTTTRPPRQRGGLRQQSQLPFNIYAEIDLTNEQDSEGDRST 3355

  Fly  3541 S-------------------------ALPQHK-----------------HSRMSASAMSVMAATM 3563
            |                         |:|||:                 |:|:..:.:.::..|.
  Fly  3356 STTTGTAADGAESQSQHNSSSTAAQVAVPQHQRHPPVPLLPSSGRPSRPHTRLDETELLLLQLTD 3420

  Fly  3564 TQQEEMLSHIS-HCHGLDDFGGLL--GEPEAKSLVELLKLAVC--------GRCGP-PSTSQTIA 3616
            .|....|...| |.:.....|..|  ..|..       .|..|        |...| ||.::|.|
  Fly  3421 RQIRNRLQGSSGHTNSSRTSGSALINARPNR-------DLPACLQRHDHPAGSIFPRPSANRTPA 3478

  Fly  3617 DTLISLGAGTPAVAAMLLETCITELEDLCTSRHCLGKLPKPVMQESSHPYVDNVNVTGVVRIPGA 3681
            .||:|:  .||...|.|.:..:|..:.:.|.|:.  .||       |...||...:.|:|.:|
  Fly  3479 PTLVSM--PTPMSNAALEQLNVTAPDVVRTDRNF--ALP-------SSLEVDVDVLPGIVDLP-- 3530

  Fly  3682 EMLRLEFDSQCSTEKRNDPLVI--------MDGT-----------GRVLAMRSGREFAHWAPEIR 3727
                     |...:..:|.|::        .|.|           |.|::..:..|.:  ||.:.
  Fly  3531 ---------QQEAQPEDDQLLLPPPPPPPPSDTTPLVHAEDDLWPGTVVSAGTREESS--APAVA 3584

  Fly  3728 VLGDELRWKFSSDSSVNGWGWRFWVHAIMPAATLGESGS----DRAVLSQPSMALVMSLLDSRLA 3788
            .         .|..:||        .:..|..|...|.|    .:|..::|:.....:.:|:.:.
  Fly  3585 T---------ESTEAVN--------ESNQPEPTPESSESTSPNPQAPSAEPTPLEPGAAVDASVG 3632

  Fly  3789 PRQPSVLLRLASALAACSQLGALTTAQRIWSLR-KLHAVLLLEQAPRPQDPSL-----STLLQPL 3847
            .:.|      |:...|.|..||..|...|..:. ::.|.|...:.|...|||.     |.:.:.:
  Fly  3633 AQTP------ATTEEAASTAGASGTTATITDMSPEVRAALGDLEVPEGVDPSFLAALPSEMREEV 3691

  Fly  3848 IPELLRQYEYEEPQVRGGIHLMHSDYFKT----LAALACDMQLDAALPATSSSSSSSAAPGAISS 3908
            |.|.||.....:...:..|.:.|....:.    ||||..::|.:..:.........:|.  ..:.
  Fly  3692 IQEHLRMQRIRQRAQQNAIQIAHDSLVEVNPEFLAALPLNIQSEVLMQQRIEQQRQAAQ--TANP 3754

  Fly  3909 TGDVHKWAWFK------RYCIAVRVAQSLIRRTELPRAFCLEVRKKFAEMLPSSSSNSNANPGCQ 3967
            ...|...|:|:      |..|...:.:|.|  ..||.....|.:....:....:.:..:|:|
  Fly  3755 EDPVDTAAFFQNLPENLRQAILTDMEESQI--ASLPPELAAEAQFLRRDWESRNGARMDAHP--- 3814

  Fly  3968 SPGASMLNSTTSLSS-------STV-----SNVSPP----PGITGEQPDLHCHAHQL-ESTSTLL 4015
             |..::....|:|.|       |::     .|..|.    ..|..:.|..| ||..: :..:.|:
  Fly  3815 -PSNALSRFQTTLQSLDDTRWHSSIWYDASGNAQPQHHQHTTIVHQHPHAH-HAPNMGKPLALLM 3877

  Fly  4016 HEDHTLFQAPHD-AQLLQWL--------------------NRRPD-DWALSWGGASTIYGWGHNH 4058
            .||..:...|.. |.||.:|                    :..|. ||.:| ...|.|.....::
  Fly  3878 MEDENILLDPDSLATLLLFLFVEDQKVNSMRLHRVIRNLCHHEPTRDWIIS-ALISIIQKTNEDN 3941

  Fly  4059 ----RGQLGG-------------------------LEGS-RIKTPTPCEA-------LSLL---- 4082
                .||.||                         .||| |..:..|..|       |.||
  Fly  3942 ANFGAGQAGGKPEWLKLRVDAAFGYKSNIFLINRLYEGSARSISINPQAAQMIVRNCLDLLFVLA 4006

  Fly  4083 -----------RPVQLAGGEQSLFAV-TPDGKLFATGYGSGGRLGVGGSDSWAIP---------- 4125
                       |.|:......::|.: :|..       ||||..|.|.:.|..:.
  Fly  4007 KHYPSSFVPFNRDVKARRILSAVFGMPSPTA-------GSGGGAGSGSAASGGLTGYDDVPPGGT 4064

  Fly  4126 ----------TLLGSLQHVF-----------------------------VKKVAVNSGGKHCLAL 4151
                      .::..|:.:|                             .|.....|..||.:..
  Fly  4065 LDFRSRFCRYQVVNRLRSIFDDHPAPKPSVPLDEAPSTSKAAAAKAAATAKVSTAGSQNKHSVPY 4129

  Fly  4152 TTEGEVY---------------------------AW------------GEGEDGKL--------- 4168
            .|..:.:                           ||            .|...|:|
  Fly  4130 QTNAKNFWDVVLNIDQQTQVRLANVAQFPLTSQPAWEWQPNTADFLSFSESPFGQLLEMLPYKVI 4194

  Fly  4169 ---GHGNRM--------SYDRPKLVEHL------------NGMSVADIACGSAH----------S 4200
               .|...|        |.:.||..|.|            ..:..|..|..:||          :
  Fly  4195 CRSPHLTDMLVKLLASLSTELPKEEELLPLSDQMPPLVPIGPVQRAGAAAAAAHPPPPQPPAENT 4259

  Fly  4201 AAITASGHVL----------TWGKGRYGRLGHGDSEDQLRPKLVEAL------------------ 4237
            |..|..|..|          ..|....|....|....|| |.|..||
  Fly  4260 ATATEIGDGLAANIEEQASPASGNPASGDSNAGAKRTQL-PTLSVALPVTPSKPRRKIYSKNFSQ 4323

  Fly  4238 --LGYRAIDIACGSGDAQTLCITDDDNVWSWGDGDYGKL------GRGGSDGCKLPYKIESLAGL 4294
              |....:...||:.:..       |||        .||      ....|....:.|...::.||
  Fly  4324 LQLVIEVLTHQCGTTEGL-------DNV--------AKLIVNLTQCSQASSAIFIQYLTAAILGL 4373

  Fly  4295 -------------------------GVVKVECGSQFSVALTKSG-------------AVYTWGKG 4321
                                     |.......:..:.|.|.|.             ||:.....
  Fly  4374 AEEVRQAIQMLLNEIRMYNIHQGGAGTTSQAASTSGAAAATASYVPTVSGASLLPNLAVHEGIMQ 4438

  Fly  4322 DFHRLGHGSVDHVRRPKKVAALQ---GKKIIS---------------------------IATGSL 4356
            |.....|..:...:..|....||   .||::|                           ::||.
  Fly  4439 DRFTAEHVIISAPKNAKPTCELQLPSMKKLMSNSSAQPYFLRTLKIFMQVRDMYEAQNGLSTGG- 4502

  Fly  4357 HCVACSDSGEVYTWGDNDEGQL---GDGTVTAIQRPRLVAALQGKHIVKVTCGSAHTLA----LS 4414
             .|||..       ||||:..:   |||            ...|.....:..|||.|::    :.
  Fly  4503 -GVACGA-------GDNDDDIIDIEGDG------------GASGGSSSDMAPGSASTISPPPPME 4547

  Fly  4415 TSQLS----------ERLRPLP--------------NPPLEYDLVRDLAPEALHARLILLH---- 4451
            |:|::          :..|..|              .|.|...|..|:....|...|:.|.
  Fly  4548 TNQIAQDGDDDEEDDDEARSFPGVGNHAVASASKSTKPTLSQILCLDVLWNTLSECLVALEESKD 4612

  Fly  4452 HFSELVC-PCL-------------------AMLPISGDLSLGA---------------------- 4474
            .|:.||. |.:                   :.:|.:....|.|
  Fly  4613 EFAVLVLQPTVEAFFLIHASHRGASKKSGRSFMPNAAGFGLRAAAGAGAIGGLGAAAPSAQEYSP 4677

  Fly  4475 -LKDVLVYNIKEAAF--------RKVIQTTMVRDKQHGPVIELNRIQVKRSRNRCNGLAGIDGMK 4530
             :.||...|...:|.        .....|.:|.:......:..:..|:::.|.:.  |...:..:
  Fly  4678 FMDDVSSANTPSSASFDDEPRMQDASTNTPLVTNPSTSTAMSAHEAQLRQDRQKF--LQFAEKHR 4740

  Fly  4531 SVFGQMVQKLPLLTQE---ALALPH---------------------------------------- 4552
            :|..|::::.|....:   |:.:.|
  Fly  4741 TVLNQILRQSPTHLSDGPFAVLVDHTRILDFDVKRKYFQTELERLDEGIRREEHTVSVRRVTVFE 4805

  Fly  4553 ---RV--------WK----VKFVGESVDDCGGGYSESIAEMCDELQNGSVPLLINTPNGRGEAGA 4602
               ||        ||    :.|..|...|.||...|....:..|:.|....|...:|       .
  Fly  4806 DSFRVLYRLGPEEWKNRFYIVFEDEEGQDAGGLLREWYVIISREIFNPMYALFCVSP-------G 4863

  Fly  4603 NRDCFLLDPTL-SSVLQMNMFRFLGVLMGIAVRTGSPLSINLAEPVWRQLTGEVLRPTDLTEVDR 4666
            :|..::::|:. ::...::.|:|:|.::..||.....|........::.:.|:.::.||:...|.
  Fly  4864 DRVTYMINPSSHANPNHLSYFKFVGRVIAKAVHDNKLLECYFTRSFYKHILGKQVKHTDMESQDY 4928

  Fly  4667 DYVAGLLCIRNMDDDPKLFTALELPFST-----SSARGHEVPLSTRYTHISPRNRAEYVRLALGF 4726
            ::..||..:...|...   ...||.|||     ...:..::..:.|.|.::..|:.|||:|....
  Fly  4929 EFYKGLDYLMKNDIST---LGYELTFSTEVQEFGVTQIRDLKPNGRDTAVTEENKFEYVQLVCQL 4990

  Fly  4727 RLH-EFDEQVKAVRDGMSKVIPVPLLSLFSAAELQAMVCGSPDIPLGLLKSVATYKGFDPSSALV 4790
            ::. ...:|:.|..:|...:||..|:|:|:..||:.::.|.|||.:..||:...|..:...||.:
  Fly  4991 KMSGSIRQQLDAFLEGFYDIIPKHLISIFNEQELELLISGLPDIDIEDLKANTEYHKYTSKSAQI 5055

  Fly  4791 TWFWEVMEEFTNQERSLFLRFVWGRTRLP-RTIADFRGRDFV--LQVLEKNPPDHFLPESYTCFF 4852
            .|||..:..|...:|:.||:||.|.:::| :......|.:.:  .|:...:.....||.::|||.
  Fly  5056 QWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFGSLEGMNGIQKFQIHRDDRSTDRLPCAHTCFN 5120

  Fly  4853 LLKMPRYSCKAVLLEKLKYAIHFC 4876
            .|.:|.|.....|...|..|||.|
  Fly  5121 QLDLPMYKSYDKLRSCLLKAIHEC 5144

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HERC2	NP_608388.2	RCC1	638..683	CDD:278826	6/45 (13%)
		RCC1	687..737	CDD:278826	5/49 (10%)
		RCC1	740..787	CDD:278826	12/65 (18%)
		RCC1	790..841	CDD:278826	8/50 (16%)
		RCC1_2	828..857	CDD:290274	2/28 (7%)
		Cyt-b5	1290..1363	CDD:278597	8/72 (11%)
		MIB_HERC2	1928..1987	CDD:284184	13/58 (22%)
		UBA_HERC2	2515..2559	CDD:270585	8/66 (12%)
		Cul7	2624..2699	CDD:288381	14/83 (17%)
		APC10-HERC2	2762..2932	CDD:176485	22/183 (12%)
		RCC1	3037..3088	CDD:278826	7/72 (10%)
		RCC1	3091..3140	CDD:278826	11/64 (17%)
		RCC1	3144..3194	CDD:278826	17/49 (35%)
		RCC1	3197..3246	CDD:278826	12/49 (24%)
		RCC1	3250..3298	CDD:278826	9/47 (19%)
		RCC1	3302..3350	CDD:278826	12/59 (20%)
		RCC1_2	4136..4166	CDD:290274	8/68 (12%)
		RCC1	4154..4203	CDD:278826	17/129 (13%)
		RCC1	4206..4257	CDD:278826	14/80 (18%)
		RCC1	4260..4309	CDD:278826	10/79 (13%)
		RCC1	4312..4360	CDD:278826	13/90 (14%)
		RCC1	4364..4413	CDD:278826	12/55 (22%)
		HECTc	4509..4880	CDD:238033	95/436 (22%)
		HECTc	4553..4878	CDD:214523	87/346 (25%)
HUWE1	NP_001285288.1	DUF908	90..326	CDD:283630
		DUF913	621..989	CDD:283642	105/625 (17%)
		UBA_like_SF	1467..1506	CDD:304366	10/113 (9%)
		WWE	1756..1828	CDD:128922	20/144 (14%)
		40S_SA_C	3575..3651	CDD:292740	19/100 (19%)
		DUF4414	3675..3779	CDD:291075	21/105 (20%)
		HECTc	4796..5149	CDD:238033	87/359 (24%)
		HECTc	4820..5148	CDD:214523	84/335 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446982
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740