Protein Alignment HERC2 and smurf1

DIOPT Version :9

• Sequence 1: NP_608388.2
• Gene: HERC2 / 33035
• FlyBaseID: FBgn0031107
• Length: 4912
• Species: Drosophila melanogaster
• Sequence 2: NP_001001943.1
• Gene: smurf1 / 321695
• ZFINID: ZDB-GENE-040426-2744
• Length: 731
• Species: Danio rerio
• Alignment Length: 984
• Identity: 209/984 - (21%)
• Similarity: 331/984 - (33%)
• Gaps: 335/984 - (34%)

  Fly  3962 ANPGCQSPGASMLNSTTSLSSSTVSNVS----PPP----GITGEQPDLHCHAHQLESTSTL---- 4014
            :|||.:..|:|:....|.|.:..::...    |.|    .:.|..   .||     ||.|:
Zfish     2 SNPGTRRNGSSIKIRLTVLCAKNLAKKDFFRLPDPFAKVVVDGSG---QCH-----STDTVKSTL 58

  Fly  4015 ---LHEDHTLFQAPHDAQLLQWLNRRPDDWALSWGGASTIYGWGHN--HRGQLGGLEGSRIKTPT 4074
               .::.:.|:....|                    :.||..|.|.  |:.|..|..|
Zfish    59 DPKWNQHYDLYIGKTD--------------------SITISVWNHKKIHKKQGAGFLG------- 96

  Fly  4075 PCEALSLLRPVQLAGGEQSLFAVTPDGKLFATGYGSGGRLGVGGSDSWAI-PTLLGSLQHVFVKK 4138
             |        |:|.....|        :|..|||.......:..|||.|: ..::.|||    .:
Zfish    97 -C--------VRLLSNAIS--------RLKDTGYQRLDLCKLNPSDSDAVRGQIVVSLQ----TR 140

  Fly  4139 VAVNSGGK--HCLALT-TEGEVYA-WGEGE---------------DGKLGHGNRMSYDRPKLVEH 4184
            ..:.|||.  .|..|. .||.|:. .|.|.               .|..|.||..:.:.|...:.
Zfish   141 DRIGSGGPVVDCRGLVENEGPVFEDSGPGRPLSCFMEEPMPYTDPTGAAGGGNCRALESPNQEQR 205

  Fly  4185 LNGMSVAD-IACGSAHSAAITASGHVLTWGKGRYGRLGHGDSEDQLRPKLVEALLGYRAIDIACG 4248
            |....:.: .:.|..|:......||                    ..|.|.|   ||.......|
Zfish   206 LQAQRIRNQDSRGHTHTPQNRPHGH--------------------QSPDLPE---GYEQRTTVQG 247

  Fly  4249 SGDAQTLCITDDDNVWSWGDGDYGKLGRGGSDGCKLPYKIESLAGLGVVKVECGSQFSVALTKSG 4313
                |...:.....|.:|.|.             ::|..:.|::...:..:..|.:  :..|.||
Zfish   248 ----QVYFLHTQTGVSTWHDP-------------RIPRDLNSVSCEELGPLPPGRE--IRSTVSG 293

  Fly  4314 AVYTWGKGDFHRLGHGSVDHVRRPKKVAALQGKKIISIATGSLHCVACSDSGEVYTWGDNDEGQL 4378
            .:|             .|||..|
Zfish   294 RIY-------------FVDHNNR------------------------------------------ 303

  Fly  4379 GDGTVTAIQRPRLVAALQGKHIVKVTCGSAHTLALSTSQLSERLRPLP------------NPPLE 4431
                .|....|||      .||:     |.|      ||:.|..:.||            ..|:.
Zfish   304 ----TTQFTDPRL------HHIM-----SQH------SQVKESSQALPVQMEVGMEEGDGELPVR 347

  Fly  4432 YDLVRDLAPEALHARLILLHHFSELVCPCLAMLPISGDLSLGALKDVLVYNIKEAAFRKVIQTTM 4496
            |:  |||.     .:|.:|.|                :|||
Zfish   348 YE--RDLV-----QKLKVLRH----------------ELSL------------------------ 365

  Fly  4497 VRDKQHGPVIELNRIQVKRSRNRCNGLAGIDGMKSVFGQMVQKLPLLTQEALALPHRVWKVKFVG 4561
             :..|.|..    ||:|.|.          :..:..:.|:::..|...::.|       .|||.|
Zfish   366 -QQPQAGHC----RIEVSRE----------EIFEESYRQIMKMRPKDLKKRL-------MVKFRG 408

  Fly  4562 ESVDDCGGGYSESIAEMCDELQNGSVPLL------INTPNGRGEAGANRDCFLLDPTLSSVLQMN 4620
            |...|.||...|.:..:|.|:.|....|.      |.|.....::..|.|            .::
Zfish   409 EEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYTLQINPDSSINPD------------HLS 461

  Fly  4621 MFRFLGVLMGIAVRTGSPLSINLAEPVWRQLTGEVLRPTDLTEVDRDYVAGLLCIRNMDDDPKLF 4685
            .|.|:|.:||:||..|..::.....|.::||.|:.::..||..||.:....|:.|...|    :.
Zfish   462 YFHFVGRIMGLAVFHGHYINGGFTLPFYKQLLGKPIQLCDLETVDPELHKSLVWILEND----IT 522

  Fly  4686 TALELPFSTS-SARG----HEVPLSTRYTHISPRNRAEYVRLALGFR-LHEFDEQVKAVRDGMSK 4744
            :.|:..|... :|.|    ||:..:.:...::..|:.|||||.:.:| :...:.|..|::.|.::
Zfish   523 SVLDHTFCVEHNAFGKFLQHELKPNGKNIPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNE 587

  Fly  4745 VIPVPLLSLFSAAELQAMVCGSPDIPLGLLKSVATYKGFDPSSALVTWFWEVMEEFTNQERSLFL 4809
            :||..||..|...||:.::.|...|.|...|:....|.....|.:|.|||:.:|.|..:.|...|
Zfish   588 LIPQHLLKPFDNKELELIIGGLGKIDLNDWKANTRLKHCVADSNIVKWFWQAVESFDEERRGRLL 652

  Fly  4810 RFVWGRTRLPRTIADFRG----------RDFVLQVLEKNPPDHFLPESYTCFFLLKMPRYSCKAV 4864
            :||.|.||:|  :..|:.          |.|.:.:::.|..:  ||:::|||..:.:|.|.....
Zfish   653 QFVTGSTRVP--LQGFKALQGSTGSAGPRLFTIHLIDANTDN--LPKAHTCFNRIDIPPYESYEK 713

  Fly  4865 LLEKLKYAI 4873
            |.|||..|:
Zfish   714 LYEKLLTAV 722

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HERC2	NP_608388.2	RCC1	638..683	CDD:278826
		RCC1	687..737	CDD:278826
		RCC1	740..787	CDD:278826
		RCC1	790..841	CDD:278826
		RCC1_2	828..857	CDD:290274
		Cyt-b5	1290..1363	CDD:278597
		MIB_HERC2	1928..1987	CDD:284184
		UBA_HERC2	2515..2559	CDD:270585
		Cul7	2624..2699	CDD:288381
		APC10-HERC2	2762..2932	CDD:176485
		RCC1	3037..3088	CDD:278826
		RCC1	3091..3140	CDD:278826
		RCC1	3144..3194	CDD:278826
		RCC1	3197..3246	CDD:278826
		RCC1	3250..3298	CDD:278826
		RCC1	3302..3350	CDD:278826
		RCC1_2	4136..4166	CDD:290274	10/48 (21%)
		RCC1	4154..4203	CDD:278826	13/65 (20%)
		RCC1	4206..4257	CDD:278826	9/50 (18%)
		RCC1	4260..4309	CDD:278826	6/48 (13%)
		RCC1	4312..4360	CDD:278826	7/47 (15%)
		RCC1	4364..4413	CDD:278826	8/48 (17%)
		HECTc	4509..4880	CDD:238033	102/387 (26%)
		HECTc	4553..4878	CDD:214523	95/343 (28%)
smurf1	NP_001001943.1	C2_Smurf-like	14..138	CDD:176028	33/175 (19%)
		WW	234..266	CDD:197736	9/51 (18%)
		WW	280..312	CDD:197736	11/92 (12%)
		HECTc	373..728	CDD:238033	102/391 (26%)
		HECTc	397..728	CDD:214523	96/353 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810