DRSC/TRiP Functional Genomics Resources

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Protein Alignment HERC2 and CG42797

DIOPT Version :9

Sequence 1:NP_608388.2 Gene:HERC2 / 33035 FlyBaseID:FBgn0031107 Length:4912 Species:Drosophila melanogaster
Sequence 2:NP_572574.2 Gene:CG42797 / 31905 FlyBaseID:FBgn0261931 Length:1426 Species:Drosophila melanogaster


Alignment Length:1674 Identity:335/1674 - (20%)
Similarity:538/1674 - (32%) Gaps:523/1674 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly  3463 PIMGAPLQ-LAETIAQGGGEAPADATDAGLQEH----------------------SPEAAVDALT 3504
            |....||| ||.:.|.....:|.|.....||:.                      ..||..:|..
  Fly     4 PAAPVPLQPLAASSACLADRSPVDPIAVRLQQEEQAEGDDEEEEEEEEDDDDDPKEEEAFYEARN 68

  Fly  3505 GGMSGGANTLPPLSAGPLSAFQSLTGSLSMSGSLSSSALPQHKHSRMSASAMSVMAATMTQQEEM 3569
            |..|....          .||||   :|:::..:..|.....:|....||....:|....||:: 
  Fly    69 GNESDELE----------QAFQS---ALTLTNDVHVSVSEVEEHEPPLASRNQEVAEVEEQQQQ- 119

  Fly  3570 LSHISHCHGLDDFGGLLGEPEAKSLVELLKLAVCGRCGPPSTSQTIADTLISLGAGTPAVAAMLL 3634
               :..|        .|.:|...||....:..      .|...||:..|   ....|||..|.|.
  Fly   120 ---LGAC--------ALPQPSEASLTGSKETR------EPRHHQTLLST---KSCETPANNATLS 164

  Fly  3635 ETCITELEDLCTSRHCLGKLPKPVMQESSHPYVDNVNVTGVVRIPGAEMLR---LEFDSQCSTEK 3696
            .|                           :.|..::...|...:.|....:   |...|..||  
  Fly   165 PT---------------------------NSYNGSIGSDGGSSVGGGARRKSWTLSPQSGGST-- 200

  Fly  3697 RNDPLVIMDGTGRVLAMRSGREFAHWAPEIRVLGDELRWKFSSDSSVNGWGWRFWV----HAIMP 3757
               ||     :|.....::|      ||...:            |:.||.|:..||    ...:|
  Fly   201 ---PL-----SGAKKKTKTG------APTTTL------------SNANGDGFNLWVARECFETVP 239

  Fly  3758 AATLGESGSDRAVLSQPSMALVMSLLDSRLAPRQPSVLLRLASALAACSQLGALTTAQRIWSLRK 3822
            |..:.              .|.|:.:|..:...:......:.|.|.|.:.|.|....||      
  Fly   240 AEMVD--------------TLSMAEVDEEVDEEEDEEAAAVESLLGAAAALQASAHVQR------ 284

  Fly  3823 LHAVLLLEQAPRPQDPSLSTLLQPLIPE---LLRQYEYEEPQVRGGIHLMHSDYFKTLAALACDM 3884
                       |.|......|.||..|:   |.|.:   .|:..|....:..|.|: ...|..|.
  Fly   285 -----------RQQQQHHQHLRQPSPPQHRPLERSW---PPRAVGRDLKLQGDVFQ-FDILDTDE 334

  Fly  3885 QLDAALPATSSSSSSS--AAP------------------GAISSTG-DVHKWAWFKRYCIAVRVA 3928
            :|...:...|.||::|  |.|                  ..||:.. .||:...|..:..:..|.
  Fly   335 RLAEEMAQGSGSSNNSPLATPPVRFKPLLKKKIGPDSYINTISTQKVPVHQSYEFPTFPSSSAVG 399

  Fly  3929 QSLIRRTELPRAFCLEVRKKFAEML---PSSSSNSNANP--------------GCQSPGASMLNS 3976
            .|......|...: |...:.....|   .:|||...|:|              ||.:..||.|: 
  Fly   400 SSSSSPNSLQFPY-LRQHRPLTRALSNGKASSSEEQASPRLLLSPKRPRSPPSGCSTRSASPLD- 462

  Fly  3977 TTSLSSSTVSNV-----------SPPPGITGEQPDLHCHAHQLESTSTLLHEDHTLFQAPHDAQL 4030
             .|||....|..           :.|||    .|..|                            
  Fly   463 -ISLSPEQHSPTRGRGVGGALQDAVPPG----TPTFH---------------------------- 494

  Fly  4031 LQWLNRRPDDWALS--WGGASTIYGWGHNHRGQLGGLEGSRIKTPTPCEALSLLRPVQLAGGEQS 4093
                .:||....|.  .|||..         |..||..||.:..|.        .|...|.....
  Fly   495 ----GQRPQQRLLKRVGGGAGA---------GATGGATGSPLVCPP--------TPTHHARRHAR 538

  Fly  4094 LFAVTPDGKLFATGYGSGGRLGVGGSDSWAIPTLLGSLQHVFVKKVAVNSGGKHCLALTTEGEVY 4158
            |.|||.:..|     .|||.:   .||.   |.:...|.::::                      
  Fly   539 LQAVTANSSL-----ASGGAI---PSDP---PAVSSQLDYIYL---------------------- 570

  Fly  4159 AWGEGEDGKLGHGNRMSYDRPKLVEHLNGMSVADI----ACGSAHSAAITASGHVLTWGKGRY-G 4218
                 :||    |.....::...|.|::...:..|    |..:|.:||..|...::..|.|.. |
  Fly   571 -----QDG----GQEQGQEQSDEVVHISSTRLPSIPERSAAAAAAAAAAAAGAALMEPGTGTVSG 626

  Fly  4219 RLGHGDSEDQLRPKLVEALLGYRAIDIACGSGDAQTLCITDDDNVWSW----GDGDYGKLGRGGS 4279
            ..|.|.:.:...|...||.:          ....:...|.......||    .....|..||...
  Fly   627 SSGAGAAGEPPLPPAWEARM----------DSHGRIFYIDHTTRTTSWQRPGAAPSGGPAGREQH 681

  Fly  4280 DGCKLPYKIESLAGLGVVKVECGSQFSVALTKSG------------------AVYTWGKGDFHRL 4326
            ...:|..:.:|:......:......:::..:.:.                  |:....:.||:.|
  Fly   682 HRQQLDRRYQSIRRTITNESRAAQLYNLPTSANSNANSTAPAAPPPATAIHPAILMLCRPDFYSL 746

  Fly  4327 GHGS----------------VDHVRRP----------KKVAALQGKKIISIATGSLHCVAC---- 4361
            .|.:                |..:||.          |.:.||    :.:.|..|....:|    
  Fly   747 LHTNEAALAIYNRNAALKHMVMRIRRDPPCFQRYQYNKDLVAL----VNTFAQMSRELPSCWETK 807

  Fly  4362 -SDSGEVYTWGDNDEGQLGDGTVTAIQRPRL------VAALQGKH-------------IVKVTCG 4406
             ..||:.: :.|:...:      |:...|||      |...:.:|             :|...|.
  Fly   808 LDQSGKQF-FIDHQHRR------TSFMDPRLPVECPRVVRHRQQHSQQQSSVGYYYPDLVDGNCL 865

  Fly  4407 SA---HTLALSTSQLSERLRPLPNPPLEYDLVRDLAPEALHARLILLHHFSELVCPCLA---MLP 4465
            ||   |..|...|.:| .:.||| ||....  ...:..:.|......:..|.:.|...|   ...
  Fly   866 SATSGHINASPASSVS-GVPPLP-PPRPSS--SSSSSRSSHGHGHNCNTTSAISCALNADRSAYG 926

  Fly  4466 ISGDLSLGA----LKDV-LVYNIKEAAFRK---VIQTTMVRDKQHGPVIELNRIQVKRSRN--RC 4520
            .:|..|.||    .:|| :.||.|..||.:   :::....|..||    .::| |::...|  |.
  Fly   927 AAGMASAGATAAGYEDVPIAYNEKVIAFLRQPNILEILRERQGQH----TMSR-QLREKINILRV 986

  Fly  4521 NGLAGIDG---------MKSVFGQMV-----------QKLPLLTQEALALPHRV---------WK 4556
            .|:..::.         :.|:|.|.:           |..|:|...   :|.|.         .|
  Fly   987 EGVPALERLGHDLQLTILLSLFEQEIMGFVPIEERSPQGSPVLNSR---MPQRAPPPFRRDFEAK 1048

  Fly  4557 VKFVGESVDDCGGG-------------------YSESIAEMCDELQNGSVPLLINTPNGRGEAGA 4602
            ::.....::..|.|                   :...::....:||.|.:.:|.:|..|....|.
  Fly  1049 LRSFYRKLESKGYGQGPHKLKLHIRRSHLLEDAFRRIMSANKKDLQRGRLAVLWDTEEGLDYGGP 1113

  Fly  4603 NRDCF------LLDP------------------TLSSVLQ--MNMFRFLGVLMGIAVRTGSPLSI 4641
            :|:.|      |.:|                  .||:.:.  .:.|||.|.::|:|:.....|..
  Fly  1114 SREFFFLLSRELFNPYYGLFEYSANDTYTVQVSPLSAFVDNCHDWFRFSGRVLGLALVHQYLLDA 1178

  Fly  4642 NLAEPVWRQLTGEVLRPTDLTEVDRDYVAGLLCIRNMDDDPKLFTALELPFSTS-----SARGHE 4701
            ....|.::.|....:..:||..:|.::...|..||  |:|......|.|.|..:     |....|
  Fly  1179 FFTRPFYKALLRLPVALSDLESLDNEFHQSLQWIR--DNDIGTGVDLGLTFCVTEELLGSVVDRE 1241

  Fly  4702 VPLSTRYTHISPRNRAEYVRLALGFRLHE-FDEQVKAVRDGMSKVIPVPLLSLFSAAELQAMVCG 4765
            :....:...|:.:|:.||:...:.:||.. ..||.:::..|..:||...|:|:|.|.||:.::.|
  Fly  1242 LKPGGKNIIINEKNKKEYLERMIKWRLERGVQEQTESLVRGFYEVIDSRLVSVFDARELELVIAG 1306

  Fly  4766 SPDIPLGLLKSVATYK-GFDPSSALVTWFWEVMEEFTNQERSLFLRFVWGRTRLP-RTIADFRG- 4827
            :.:|.....:....|: |:..:..::.|||:|:|.|:|::|...|:||.|.:.:| ...:..|| 
  Fly  1307 TAEIDTNDWRLNTEYRSGYHDNHQVIVWFWQVIERFSNEQRLRLLQFVTGTSSIPYEGFSALRGS 1371

  Fly  4828 ---RDFVLQVLEKNPPDHFLPESYTCFFLLKMPRYSCKAVLLEKLKYAI 4873
               |.|   .:||....:.||.::|||..|.:|.|....:|.|||..|:
  Fly  1372 TGPRRF---CIEKWGKPNALPRAHTCFNRLDLPPYPTPELLYEKLLLAV 1417

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HERC2NP_608388.2 RCC1 638..683 CDD:278826
RCC1 687..737 CDD:278826
RCC1 740..787 CDD:278826
RCC1 790..841 CDD:278826
RCC1_2 828..857 CDD:290274
Cyt-b5 1290..1363 CDD:278597
MIB_HERC2 1928..1987 CDD:284184
UBA_HERC2 2515..2559 CDD:270585
Cul7 2624..2699 CDD:288381
APC10-HERC2 2762..2932 CDD:176485
RCC1 3037..3088 CDD:278826
RCC1 3091..3140 CDD:278826
RCC1 3144..3194 CDD:278826
RCC1 3197..3246 CDD:278826
RCC1 3250..3298 CDD:278826
RCC1 3302..3350 CDD:278826
RCC1_2 4136..4166 CDD:290274 0/29 (0%)
RCC1 4154..4203 CDD:278826 9/52 (17%)
RCC1 4206..4257 CDD:278826 8/51 (16%)
RCC1 4260..4309 CDD:278826 7/52 (13%)
RCC1 4312..4360 CDD:278826 13/91 (14%)
RCC1 4364..4413 CDD:278826 14/70 (20%)
HECTc 4509..4880 CDD:238033 104/453 (23%)
HECTc 4553..4878 CDD:214523 92/387 (24%)
CG42797NP_572574.2 WW 638..667 CDD:278809 6/38 (16%)
HECTc 1068..1424 CDD:238033 88/355 (25%)
HECTc 1092..1423 CDD:214523 88/331 (27%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45446990
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
32.740

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