DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment HERC2 and Magix

DIOPT Version :9

Sequence 1:NP_608388.2 Gene:HERC2 / 33035 FlyBaseID:FBgn0031107 Length:4912 Species:Drosophila melanogaster
Sequence 2:NP_001014131.1 Gene:Magix / 317379 RGDID:1549729 Length:326 Species:Rattus norvegicus


Alignment Length:363 Identity:76/363 - (20%)
Similarity:108/363 - (29%) Gaps:153/363 - (42%)


- Green bases have known domain annotations that are detailed below.


  Fly  3213 RG-GSEGSDTPHE---IERLSGIGVVQIECGAQFSLALTRAGEVWTWGKGDYYRLGHGGDQHVRK 3273
            || |.:||.:|..   :|||.. ..:.....|..|..:.:||..        .||.|        
  Rat    16 RGVGLQGSGSPRARQLL
ERLDA-RPLAARAAADLSALVRKAGAT--------LRLRH-------- 63

  Fly  3274 PQPIGGLRGRRVIHVAVGAL-HCLAVTDAGQVYAWGDNDHGQQGSGNTFVNKKPALVIGLDAVFV 3337
            .:.|.||.... |.||...| |...|....|          .|.|.......:|..||...|.:.
  Rat    64 KEAISGLDSAD-IEVADSRLPHATLVEHRPQ----------HQRSDTQGPRMEPLPVIQNKASYA 117

  Fly  3338 NRVACGSSHSIAWGLPNAS---SDEEKRGPVPFSSTRD---------PL---------------- 3374
            :|            ||.|:   |.|..|||..|..|..         ||                
  Rat   118 SR------------LPQATGRFSVELVRGPAGFGLTLSGGRNVSGNVPLAVCGLLKDGPAQRCGH 170

  Fly  3375 -----------GGSSLGIYEAETMQTLK----------QEAKPLNQSSLSE-------------- 3404
                       |.|:.|:..|:.::.::          |..:.:|.|...|              
  Rat   171 LQAGDLVLYINGQSTRGLTHAQAVEWIRTGGPRLCLVLQRPQEMNGSRSKEVGGGHQKTDRIPDP 235

  Fly  3405 --SLALET------------------PAARQAALGHVLRAMSILQARQLIVAALTSHSKVNFKER 3449
              ...:|:                  |:....|.|||:||              ..|...:.::|
  Rat   236 RGGRMMESRGTISPVHHRPKTRTGPGPSPESVATGHVVRA--------------AEHPAEDLEDR 286

  Fly  3450 --GAVG----GEEDHL---IGGPIMGAPLQLAETIAQG 3478
              |:.|    ..||.|   :|  |.|..:|||:.:|.|
  Rat   287 IPGSPGPWLVPSEDRLSRALG--IRGGGVQLAQEMAAG 322

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HERC2NP_608388.2 RCC1 638..683 CDD:278826
RCC1 687..737 CDD:278826
RCC1 740..787 CDD:278826
RCC1 790..841 CDD:278826
RCC1_2 828..857 CDD:290274
Cyt-b5 1290..1363 CDD:278597
MIB_HERC2 1928..1987 CDD:284184
UBA_HERC2 2515..2559 CDD:270585
Cul7 2624..2699 CDD:288381
APC10-HERC2 2762..2932 CDD:176485
RCC1 3037..3088 CDD:278826
RCC1 3091..3140 CDD:278826
RCC1 3144..3194 CDD:278826
RCC1 3197..3246 CDD:278826 11/36 (31%)
RCC1 3250..3298 CDD:278826 12/48 (25%)
RCC1 3302..3350 CDD:278826 8/47 (17%)
RCC1_2 4136..4166 CDD:290274
RCC1 4154..4203 CDD:278826
RCC1 4206..4257 CDD:278826
RCC1 4260..4309 CDD:278826
RCC1 4312..4360 CDD:278826
RCC1 4364..4413 CDD:278826
HECTc 4509..4880 CDD:238033
HECTc 4553..4878 CDD:214523
MagixNP_001014131.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..32 6/15 (40%)
PDZ_signaling 127..209 CDD:238492 13/81 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 214..267 5/52 (10%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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