DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment HERC2 and Trip12

DIOPT Version :9

Sequence 1:NP_608388.2 Gene:HERC2 / 33035 FlyBaseID:FBgn0031107 Length:4912 Species:Drosophila melanogaster
Sequence 2:XP_038939619.1 Gene:Trip12 / 316575 RGDID:1306607 Length:2074 Species:Rattus norvegicus


Alignment Length:2419 Identity:468/2419 - (19%)
Similarity:736/2419 - (30%) Gaps:866/2419 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly  2960 PGSTAGAGAVSTSHEEAAAAPEQDLPCTVMVWGLNDKEQLGGLK----------GSKVKVPTF-S 3013
            |.:..|.....:....|.|.|:.|        .:..:..||..|          .|..|.|.. |
  Rat     5 PNNNPGGSLRRSQRNTAGAQPQDD--------SIGGRSHLGQAKRKGYIPPESRKSNFKAPKVQS 61

  Fly  3014 QTISRLRPIHIAG---GSKSLFIV-----------SQDGKVYACGEGTNGRLGLGVTH------- 3057
            .|.|.|...|::.   .|.|..||           |:..|.....:..|.|   ||..       
  Rat    62 NTTSELSRGHLSKRSCSSSSAVIVPQPEDPDRANTSERQKTGQVPKKDNSR---GVKRSASPDYN 123

  Fly  3058 --NVPLPHQLPVLRQYV-----VKKVAVHSGGKHALALTLDGKVFSWGEGEDGKLGHGNRTTLDK 3115
              |.|...:.|...|::     ..|....|..:|     ||                 ....|..
  Rat   124 RTNSPSSAKKPRAFQHIESLSETNKPPSKSKKRH-----LD-----------------QEQQLKS 166

  Fly  3116 PRLVEALRAKKIRDVACGSS--------HSAAISSQGELYTWGLGEYGRLGHGDNTT-----QLK 3167
            .:|....:|...:.||.|||        .|:.:.|               |.|..:|     ..|
  Rat   167 AQLPSTSKAHTRKSVAAGSSRSQKRKRTESSCVKS---------------GSGSESTGAEERSAK 216

  Fly  3168 PKLVTALAGRRVVQVACGS---RDAQTLALTED--------------GAVFSWGDGDFGKLGRGG 3215
            |   |.||.:.......|.   .|:.:.|.|..              ||....|. |..|..|..
  Rat   217 P---TKLASKSATSAKAGCSTITDSSSAASTSSSSSAVASASSTVPAGARVKQGK-DQNKARRSR 277

  Fly  3216 SEGSDTP----HEIERLSGIGVVQIECGAQFS-------LALTRAGEVWTWGKGDYYRLGHGGDQ 3269
            |..|.:|    .|.|:....|..:.:..|:||       ..|:..|.    .|.:..:.|..|.|
  Rat   278 SASSPSPRRSSREKEQSKTGGSSKFDWAARFSPKVSLPKTKLSLPGS----SKSETSKPGPSGLQ 338

  Fly  3270 ----HVRK---------PQPIGGLRGRRVIHVAVGALHCLAVTDAGQVYAWGDNDHGQQGSGNTF 3321
                .:||         |..:..|| |.......|:  |.:.:..|       :..|::|:....
  Rat   339 AKLASLRKSTKKRSESPPAELPSLR-RSTRQKTTGS--CASTSRRG-------SGLGKRGAAEAR 393

  Fly  3322 VNKKPALVIGLDAVFVNRVACGSSHSIAWGLPNASSDEEKRGPVPFSSTRDPLGGSSLGIYEAET 3386
            ..:|.|...|      |:....||        .|.:||..:|....||....:|.::.|..|:: 
  Rat   394 RQEKMADPEG------NQETVNSS--------AARTDEAPQGAAASSSVAGAVGMTTSGESESD- 443

  Fly  3387 MQTLKQEAKPLNQSSLSESLALETPAARQAALGHVLRAMSILQARQLIVAALTSHSKVNFKERGA 3451
                                        .:.:|   |..::|:||                    
  Rat   444 ----------------------------DSEMG---RLQALLEAR-------------------- 457

  Fly  3452 VGGEEDHLIG--GPIMGAPLQLAETIAQGGGEAPADATDAGLQ----EHSPEAAVDALTGGMSGG 3510
              |...||.|  ||.|.   ||.......|..:.|.....|||    ....:|.::.....:.|.
  Rat   458 --GLPPHLFGPLGPRMS---QLFHRTIGSGASSKAQQLLQGLQASDESQQLQAVIEMCQLLVMGN 517

  Fly  3511 ANTL---PPLSAGPL---------------SAFQSLT---GSLSMSGSLSSSALPQHKHSRMSAS 3554
            ..||   |..|..|.               .|.::||   .:|..|.::...|:|..........
  Rat   518 EETLGGFPVKSVVPALITLLQMEHNFDIMNHACRALTYMMEALPRSSAVVVDAIPVFLEKLQVIQ 582

  Fly  3555 AMSVMAATMTQQEEMLSHISHCHGLDDFGGLLGEPEAKSLVEL---------LKLAVCGRCG--- 3607
            .:.|....:|.. ||||. .|...:...|||     |..|:.|         ..||:...|.   
  Rat   583 CIDVAEQALTAL-EMLSR-RHSKAILQAGGL-----ADCLLYLEFFSINAQRNALAIAANCCQSI 640

  Fly  3608 PPSTSQTIADTLISLGAGTPAVAAMLLETCITELEDLCTSRHCLGKL-------PKPVMQESSHP 3665
            .|.....:||:|       |.:...|.......:|..|.   |..:|       ...:.|.:|..
  Rat   641 TPDEFHFVADSL-------PLLTQRLTHQDKKSVESTCL---CFARLVDNFQHEENLLQQVASKD 695

  Fly  3666 YVDNVNVTGVVRIP-------------------GAEMLRLEFDSQCSTEKRNDPLVIMDGTGR-- 3709
            .:.||....||..|                   ....|.::...|..|:.......::.|...  
  Rat   696 LLTNVQQLLVVTPPILSSGMFIMVVRMFSLMCSNCPTLAVQLMKQSFTDIAETLHFLLCGASNGS 760

  Fly  3710 -----VLAMRSGREFAHWA----------PEIRVLGDELRWKFSSDSSVNG--WGWRFWVHAIMP 3757
                 .|..||.:|.....          |:..:...:...|..:..:.:|  |.||        
  Rat   761 CQEQIDLVPRSPQELYELTSLICELMPCLPKEGIFAVDTMLKKGNAQNTDGAIWQWR-------- 817

  Fly  3758 AATLGESGSDRAVLSQPSMALVMSLLDSRLAPRQPSVLLRLASALAACSQLG----ALTTAQRIW 3818
                    .||. |..|     .:.:|||:..             .|..|:|    :|:|..|::
  Rat   818 --------DDRG-LWHP-----YNRIDSRIIE-------------VAAHQVGEDEISLSTLGRVY 855

  Fly  3819 -----SLRKLH----AVLLLEQAPRP-------------QDPSLSTLLQPLIPELLRQYEYEEPQ 3861
                 |:::::    ....:::.|.|             :|.:.:.|::            |:|:
  Rat   856 TIDFNSMQQINEDTGTARAIQRKPNPLANTNTSGYSDLKKDDARAQLMK------------EDPE 908

  Fly  3862 VRGGIHLMHSDYFKTLAALACDMQLDAALPAT------------------------SSSSSSSAA 3902
                   :...:.|||..:..::...:|.||.                        .:.:.||..
  Rat   909 -------LAKSFIKTLFGVLYEVYSSSAGPAVRHKCLRAILRIIYFADAELLKDVLKNHAVSSHI 966

  Fly  3903 PGAISSTGDVHKWAWFKRYCIAVRVAQSLIRRTELPRAFCLEVRKK----FAEMLPSSSSNSNAN 3963
            ...:||..       .|....|:::|:.|:::  ||..|.:..|::    ..:.|..|.|...:.
  Rat   967 ASMLSSQD-------LKIVVGALQMAEILMQK--LPDIFSVYFRREGVMHQVKHLAESESLLTSP 1022

  Fly  3964 PGCQSPGASMLNSTTSLSSSTVSNVSPPPGITGEQPDLHCHAHQLESTSTLLH-EDHTLFQAPHD 4027
            |...:.|:..|.|||..||.|.:      ..|....||        .:.:|.| .|.:|..:| .
  Rat  1023 PKACTNGSGSLGSTTPASSGTAT------AATNASADL--------GSPSLQHSRDDSLDLSP-Q 1072

  Fly  4028 AQLLQWLN---------RRP-----------DDWALS-------------------WGGAST--- 4050
            .:|...|.         |||           |:.|.|                   ||..|.   
  Rat  1073 GRLSDVLKRKRLPKRGPRRPKYSPPRDDDKVDNQAKSPTTTQSPKSSFLASLNPKTWGRLSAQSN 1137

  Fly  4051 -----------IYGWGH--------NHRGQLGG------------------LEGSRIKTPTPCEA 4078
                       :.|...        |:|.::.|                  ::||.       .|
  Rat  1138 SNNIEPARTAGVSGLARAASKDTISNNREKIKGWIKEQAHKFVERYFSSENMDGSN-------PA 1195

  Fly  4079 LSLLR---------PVQLAGGEQSLFAVTPDGKLFATGYGSGGRLGVGGSDSWAIPTLLGSLQHV 4134
            |::|:         .:|:.||.:.|..:               |..|..||..:.     .:||.
  Rat  1196 LNVLQRLCAATEQLNLQVDGGAECLVEI---------------RSIVSESDVSSF-----EIQHS 1240

  Fly  4135 -FVKKVAVNSGGKHCLALTTEGEVYAW-------------------GEGEDGK---LGHGNRMSY 4176
             |||::        .|.||::.|..|.                   ||...|:   :||...:: 
  Rat  1241 GFVKQL--------LLYLTSKSEKDAVSREIRLKRFLHVFFSSPLPGEEPVGRVEPVGHAPLLA- 1296

  Fly  4177 DRPKLVEHLNG---------MSVADIACGSAHSAAITASGHVLTWGKGRYGRLGHGDSEDQLRPK 4232
                ||..:|.         :.|.|...|:               |.|....|..|.        
  Rat  1297 ----LVHKMNNCLSQMEQFPVKVHDFPSGN---------------GSGGSFSLNRGS-------- 1334

  Fly  4233 LVEALLGYRAIDIACGSGDAQTLCITDDDNVWSWGDGDYGKLGRGGSDGCKLPYKIESLAGLGVV 4297
              :||..:....:.|     |.....|..||..|         :||      |.||:.||.:..:
  Rat  1335 --QALKFFNTHQLKC-----QLQRHPDCANVKQW---------KGG------PVKIDPLALVQAI 1377

  Fly  4298 K---------------------------VECGSQFSVALTKSGAVYTWGKGDFHRLGHGSVDHVR 4335
            :                           .|.....:.....||.|.       |||.....:|: 
  Rat  1378 ERYLVVRGIFRYGRVREDDEDSDDDGSDEEIDESLAAQFLNSGNVR-------HRLQFYIGEHL- 1434

  Fly  4336 RPKKVAALQGKKIISIATGSLHCVACSDSGEVYTWGDNDEGQLG--DGTVTAIQRPRLVAALQGK 4398
            .|..:...|..:..|        |...|..|......|..|:.|  ..|.|...:|........|
  Rat  1435 LPYNMTVYQAVRQFS--------VQAEDERESTDDESNPLGRAGIWTKTHTIWYKPVREDEESSK 1491

  Fly  4399 HIVKVTCGSAHTLALSTSQLSER---------LRPLPNPPLEYDLVRDLAPE-------ALHARL 4447
            ..|....|.|.|....||..:.:         :.|....|||..|: ...||       :|...|
  Rat  1492 DCVGGKRGRAQTAPTKTSPRNAKKHDELWHDGVCPSVANPLEVYLI-PTPPENITFEDPSLDVIL 1555

  Fly  4448 IL--LHHFSEL------VCPCLAMLP----ISGDLSLGA---LKDVLVY---NI----------- 4483
            :|  ||..|..      ...|..::|    |:..|:..|   |:|.||.   ||           
  Rat  1556 LLRVLHAISRYWYYLYDNAMCKEIIPTSEFINSKLTAKANRQLQDPLVIMTGNIPTWLTELGKTC 1620

  Fly  4484 -------------------KEAAFRKVIQT------TMVRDKQHGPVIE-----LNRIQ-VKRSR 4517
                               ::.|.::::.|      :..:|.:..|.::     :||.: :|::.
  Rat  1621 PFFFPFDTRQMLFYVTAFDRDRAMQRLLDTNPEINQSDSQDSRVAPRLDRKKRTVNREELLKQAE 1685

  Fly  4518 NRCNGLAGIDGMKSV---------FGQMVQKLPLLTQEALALPHRVWKVKFVGESVDDCGGGYSE 4573
            :....|.....|..:         .|..::...|::||.......:|:    ||.|.......|:
  Rat  1686 SVMQDLGSSRAMLEIQYENEVGTGLGPTLEFYALVSQELQRADLGLWR----GEEVTLSNPKGSQ 1746

  Fly  4574 SIAEMCDELQNGSVPLLINTPNGRGEAGANRDCFLLDPTLSSVLQMNM-FRFLGVLMGIAVR--- 4634
            ...:....||.     |...|.||....|:            :.::.| |||||.||..|:.   
  Rat  1747 EGTKYIQNLQG-----LFALPFGRTAKPAH------------IAKVKMKFRFLGKLMAKAIMDFR 1794

  Fly  4635 -TGSPLSINLAEPVWRQLTGEVLRPTDLTEVDRDYVAGLLCIRNM--------DDDPKLFTALEL 4690
             ...||.:...:.:.||.|.  |...||.::|......:..:.::        .|..:...:|:.
  Rat  1795 LVDLPLGLPFYKWMLRQETS--LTSHDLFDIDPVVARSVYHLEDIVRQKKRLEQDKSQTKESLQY 1857

  Fly  4691 PFSTSSARGHEV-PLSTRYT----------------HISPRNRAEYVRLALGFRLHE-FDEQVKA 4737
            ...|.:..|..| .|...:|                .::..|..||:||.:.:.|:| ...|..:
  Rat  1858 ALETLTMNGCSVEDLGLDFTLPGFPNIELKKGGKDIPVTIHNLEEYLRLVIFWALNEGVCRQFDS 1922

  Fly  4738 VRDGMSKVIPVPLLSLFSAAELQAMVCGSP----DIPLGLLKSVATYKGFDPSSALVTWFWEVME 4798
            .|||...|.|:..|..|...||..::|||.    |... |::......|:...|..|.:.:|::.
  Rat  1923 FRDGFESVFPLSHLQYFYPEELDQLLCGSKADTWDAKT-LMECCRPDHGYTHDSRAVKFLFEILS 1986

  Fly  4799 EFTNQERSLFLRFVWGRTRLPRTIADFRGRDFVLQVLEK-----NPPDHFLPESYTCFFLLKMPR 4858
            .|.|:::.|||:||.|..|||  :..||..:..|.::.|     ..||.|||...||...||:|.
  Rat  1987 SFDNEQQRLFLQFVTGSPRLP--VGGFRSLNPPLTIVRKTFESTENPDDFLPSVMTCVNYLKLPD 2049

  Fly  4859 YSCKAVLLEKLKYA 4872
            ||...::.:||..|
  Rat  2050 YSSIEIMRDKLLIA 2063

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HERC2NP_608388.2 RCC1 638..683 CDD:278826
RCC1 687..737 CDD:278826
RCC1 740..787 CDD:278826
RCC1 790..841 CDD:278826
RCC1_2 828..857 CDD:290274
Cyt-b5 1290..1363 CDD:278597
MIB_HERC2 1928..1987 CDD:284184
UBA_HERC2 2515..2559 CDD:270585
Cul7 2624..2699 CDD:288381
APC10-HERC2 2762..2932 CDD:176485
RCC1 3037..3088 CDD:278826 12/64 (19%)
RCC1 3091..3140 CDD:278826 10/56 (18%)
RCC1 3144..3194 CDD:278826 10/57 (18%)
RCC1 3197..3246 CDD:278826 15/73 (21%)
RCC1 3250..3298 CDD:278826 13/60 (22%)
RCC1 3302..3350 CDD:278826 9/47 (19%)
RCC1_2 4136..4166 CDD:290274 9/48 (19%)
RCC1 4154..4203 CDD:278826 13/79 (16%)
RCC1 4206..4257 CDD:278826 8/50 (16%)
RCC1 4260..4309 CDD:278826 11/75 (15%)
RCC1 4312..4360 CDD:278826 10/47 (21%)
RCC1 4364..4413 CDD:278826 12/50 (24%)
HECTc 4509..4880 CDD:238033 102/414 (25%)
HECTc 4553..4878 CDD:214523 93/360 (26%)
Trip12XP_038939619.1 SRP1 489..>714 CDD:227396 50/241 (21%)
WWE 814..876 CDD:397111 17/96 (18%)
HECTc 1672..2072 CDD:238033 102/418 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.900

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