DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment HERC2 and Hecw2

DIOPT Version :9

Sequence 1:NP_608388.2 Gene:HERC2 / 33035 FlyBaseID:FBgn0031107 Length:4912 Species:Drosophila melanogaster
Sequence 2:NP_001101688.1 Gene:Hecw2 / 316395 RGDID:1593244 Length:1578 Species:Rattus norvegicus


Alignment Length:1804 Identity:344/1804 - (19%)
Similarity:563/1804 - (31%) Gaps:575/1804 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly  3385 ETMQTLKQEAKPLNQSSLSESLALE--------TPAARQAALGHVLRAMSILQARQLIV------ 3435
            |.:|:|      ..|:|:.|::||:        ..:..:::|...:...::.||:.||:      
  Rat    26 ENLQSL------ATQNSMPENMALQRANSDTDLVTSESRSSLTASMYEYTLGQAQNLIIFWDIKE 84

  Fly  3436 ----------AALTSHSKVNF---KERGAVGGEEDHLI----GGPIMGAP-LQLAETIAQGGGEA 3482
                      ..:..:|..||   |.||..|.::..::    .||....| :::......|...|
  Rat    85 EVDPSDWIGLYHIDENSPANFWDSKNRGVTGTQKGQIVWRIEPGPYFMEPEIKICFKYYHGISGA 149

  Fly  3483 PADATDAGLQEHSPEAAVDALTGGMSGGANTLPPLSAGPLSAFQSLTGSLSMSGSLSSSALPQHK 3547
             ..||...:...:|...:.|  .||.|.|                       ||||         
  Rat   150 -LRATTPCITVKNPAVMMGA--EGMEGCA-----------------------SGSL--------- 179

  Fly  3548 HSRMSAS-AMSVMAATMTQQEEMLSHISHCHGLDDFGGLLGEPEAKSLVELLKLAV--------- 3602
            |||...| .:|.:.|.               ||..  |:...|:     ..||:::         
  Rat   180 HSRKLVSFTLSDLRAV---------------GLKK--GMFFNPD-----PYLKMSIQPGKKSSFP 222

  Fly  3603 -CGRCGPPSTSQTIADTLISLGAGTP-------AVAAMLLETCITELED-LCTSR----HCLGKL 3654
             |...|....|..|::|.      .|       :..|:|.:....|::| ...||    ..||||
  Rat   223 TCAHHGQERRSTIISNTT------NPIWHREKYSFFALLTDVLEIEIKDKFAKSRPIIKRFLGKL 281

  Fly  3655 PKPVMQESSHPYVDNVNVTGVVRIPGAEMLRLEFDSQCSTEKRNDPLVIMDGTGRVLAMRSGREF 3719
            ..||.:......|            |.:||....                   ||.|.......:
  Rat   282 TIPVQRLLERQAV------------GDQMLSYNL-------------------GRRLPADHVSGY 315

  Fly  3720 AHWAPEIRVLGDELRWKFSSDSSVNGWGWRFWVHAIMPAATLGESGSDRAVLSQPSMALVMS--- 3781
            ..:..|:.....|       |:|....|....||.:  ...||....|..:......:.:.:   
  Rat   316 LQFRVEVPSSAQE-------DASPEAVGTILGVHTV--NGDLGSPSDDEDMPGSHHDSTICANGP 371

  Fly  3782 LLDSRLAPRQPSVLLRLASALAACSQLGALTTAQRIWSLRKLHAVLLLEQAPRPQDPSLSTLLQ- 3845
            :.:..:|...|....|.:|.|...:: ..::|:.|             ...||.:..||:..|. 
  Rat   372 VSEDSVADGTPKHSFRTSSTLEIDTE-DLISTSSR-------------NSPPRGRQDSLNDYLDA 422

  Fly  3846 -----PLIPELLRQYEY---EEPQVRGGI-------HLMHSDYFKTLAALACDMQLDAALPAT-- 3893
                 |..|......|.   ..|::|...       .::|.|..:.    ..|.|.|...|::  
  Rat   423 IEHNGPSRPGTASSSERPMGASPKLRSSFPTDTRLNAMLHIDSDEE----DHDFQQDLGYPSSLE 483

  Fly  3894 ------SSSSSSSAAPGAISS-------------TGDVHKWAWFKRYCIAVRVAQSLIRRTE--- 3936
                  ..|.:|....|:::|             ...||:.|             ||..|.|   
  Rat   484 EEGGLIMCSRTSRIDDGSLTSQTKPEDDNPVENEDASVHETA-------------SLEERPENLP 535

  Fly  3937 ------LPRAFCLEVRKKFAEMLPSSSSNSNANPGCQSPGASMLNSTTSLSSSTVSNVSPPPGIT 3995
                  ||.....:..:  |.:.|..|::..:...|.|.......|.|...:|..|..|......
  Rat   536 EVEDGSLPSGTAPDENE--ASVEPQPSADQGSTELCSSQEVDQPTSGTDAGASDTSVGSRRAASE 598

  Fly  3996 GEQPDLHCHAHQLESTSTLLHEDHTLFQAPHDAQLLQWLNRRPDDWALSWGGASTIYG----WGH 4056
            .|..|......|:.|        .|....|...:.:...:.||:       |.|.:.|    ...
  Rat   599 TESLDQGSEPSQVSS--------ETEPSDPARTESVSEASTRPE-------GESDLEGADSSCNE 648

  Fly  4057 NHRGQLGGLEGSRIKTPTPCEALSLLRPVQLAGGEQSLFAVTP--------DGKLFATGYGSGGR 4113
            :...||..:|       |.|.:|           |.:.|..||        ||...|....||..
  Rat   649 SVTTQLSSVE-------TRCSSL-----------ESARFPETPAFSSQEEEDGACAAEPTSSGPT 695

  Fly  4114 LGVGGSDSWAIPTLLGSLQHVFVKKVAVNSGGKHCLALTTEGEV-YAWG-----EG--------- 4163
              .|..:|...|   |||..|.|........|....||:.:||: ..|.     ||         
  Rat   696 --EGSQESVCTP---GSLPAVQVPSREEEGSGAEATALSEQGELGEVWQRRGSLEGAAAAATAAA 755

  Fly  4164 ------EDGKLG----------------------HGNRMSYDRPKLVEHLNGMSVADIACGSAHS 4200
                  |||..|                      :|::.....|.:.:.::.....|.|......
  Rat   756 TDSQPQEDGDPGDTQGACEGATAQEEGATGGSQTNGHQPLRSLPSVRQDVSRYQRVDEALPPNWE 820

  Fly  4201 AAITASGHVL---------TWGK----------GRYGRLGHGDSEDQLRPKLVEALLGYR----- 4241
            |.|.:.|.:.         ||.:          .|...:...:..::....:...:...|     
  Rat   821 ARIDSHGRIFYVDHVNRTTTWQRPTAPPAPQVLQRSNSIQQMEQLNRRYQSIRRTMTNERPEENT 885

  Fly  4242 -AIDIACGSGDAQTLCITDDDNVWSWGDGDYGKLGRGGSDGCKLPY-----KIESLAGLGVVKVE 4300
             |||   |:|:                :.|:.:..........||:     ::..|.....||..
  Rat   886 SAID---GAGE----------------EADFHQASADFRRENVLPHSTSRSRLTLLLQSPPVKFL 931

  Fly  4301 CGSQFSVALTKSGAVY-------------TWGKGDFHRLGHGSVDHVRRPKKVAALQG------K 4346
            ...:|...|..:.:.|             |..:.|.|        |..|.:....|.|      .
  Rat   932 ISPEFFTVLHSNPSAYRMFTNNTCLKHMITKVRRDTH--------HFERYQHNRDLVGFLNMFAN 988

  Fly  4347 KIISIATG--SLHCVACSDSGEVYTWGDNDEGQLGDGTVTAIQRPRL--------VAALQGKHIV 4401
            |.:.:..|  ..|    ...|:.:....|..      |.|.|. |||        .|.:..:|:.
  Rat   989 KQLELPRGWEMKH----DHQGKAFFVDHNSR------TTTFID-PRLPLQSSRPTSALVHRQHLT 1042

  Fly  4402 KVTCGSAHTLALSTSQLSERLR-----PLPNPPLEYDLV-----RDLAPEALHARLILL------ 4450
            :....||       .::.|..|     .||.|...::.|     :|:.|.|.:.:::..      
  Rat  1043 RQRSHSA-------GEVGEDSRHAGPPVLPRPASTFNTVSRPQYQDMVPVAYNDKIVAFLRQPNI 1100

  Fly  4451 --------------HHFSELV-------CPCLAMLPISGDLSLGALKDVLVYNIKEAAF------ 4488
                          |...|.:       .|.|..|....||       |::.::.|...      
  Rat  1101 LEILQERQPDLARNHSLREKIQFIRTEGTPGLVRLSSDADL-------VMLLSLFEEEIMSYVPP 1158

  Fly  4489 RKVIQTTMVRDKQHGPVIELNRIQVKRSRNRCNGLAGIDGMKSV---------------FGQMVQ 4538
            ..::..:..:..:..||   :..|......|.|..|.....:..               :||...
  Rat  1159 HALLHPSYCQSPRGSPV---SSPQNSPGTQRANARAPAPYKRDFEAKLRNFYRKLETKGYGQGPG 1220

  Fly  4539 KLPL------LTQEAL---------ALPHRVWKVKFVGESVDDCGGGYSESIAEMCDELQNGSVP 4588
            ||.|      |.::|.         .|......|.||||...|..|...|....:..|       
  Rat  1221 KLKLIIRRDHLLEDAFNQIMGYSRKDLQRNKLYVTFVGEEGLDYSGPSREFFFLVSRE------- 1278

  Fly  4589 LLINTPNGRGEAGANRDCFLLDPTLSSVLQMN---MFRFLGVLMGIAVRTGSPLSINLAEPVWRQ 4650
             |.|...|..|..|| |.:.:..:..|....|   .|||.|.::|:|:.....|......|.::.
  Rat  1279 -LFNPYYGLFEYSAN-DTYTVQISPMSAFVDNHHEWFRFSGRILGLALIHQYLLDAFFTRPFYKA 1341

  Fly  4651 LTGEVLRPTDLTEVDRDYVAGLLCIRNMDDDPKL---FTALELPFSTSSAR-----GHEVPLSTR 4707
            |...:...:||..:|.::...|..:::.|....|   ||..|..|...:.|     |..:|    
  Rat  1342 LLRILCDLSDLEYLDEEFHQSLQWMKDNDIHDILDLTFTVNEEVFGQITERELKPGGANIP---- 1402

  Fly  4708 YTHISPRNRAEYVRLALGFRLHE-FDEQVKAVRDGMSKVIPVPLLSLFSAAELQAMVCGSPDIPL 4771
               ::.:|:.||:...:.:|:.. ..:|.:::..|..:|:...|:|:|.|.||:.::.|:.:|.|
  Rat  1403 ---VTEKNKKEYIERMVKWRIERGVVQQTESLVRGFYEVVDARLVSVFDARELELVIAGTAEIDL 1464

  Fly  4772 GLLKSVATYK-GFDPSSALVTWFWEVMEEFTNQERSLFLRFVWGRTRLP-RTIADFRGRDFVLQV 4834
            ...::...|: |:..:..::.|||..:|.|.|::|...|:||.|.:.:| ...|..||       
  Rat  1465 NDWRNNTEYRGGYHDNHIVIRWFWAAVERFNNEQRLRLLQFVTGTSSIPYEGFASLRG------- 1522

  Fly  4835 LEKNPPDHF----------LPESYTCFFLLKMPRYSCKAVLLEKLKYAI 4873
              .|.|..|          ||.::|||..|.:|.|...::|.|||..|:
  Rat  1523 --SNGPRRFCVEKWGKITALPRAHTCFNRLDLPPYPSFSMLYEKLLTAV 1569

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HERC2NP_608388.2 RCC1 638..683 CDD:278826
RCC1 687..737 CDD:278826
RCC1 740..787 CDD:278826
RCC1 790..841 CDD:278826
RCC1_2 828..857 CDD:290274
Cyt-b5 1290..1363 CDD:278597
MIB_HERC2 1928..1987 CDD:284184
UBA_HERC2 2515..2559 CDD:270585
Cul7 2624..2699 CDD:288381
APC10-HERC2 2762..2932 CDD:176485
RCC1 3037..3088 CDD:278826
RCC1 3091..3140 CDD:278826
RCC1 3144..3194 CDD:278826
RCC1 3197..3246 CDD:278826
RCC1 3250..3298 CDD:278826
RCC1 3302..3350 CDD:278826
RCC1_2 4136..4166 CDD:290274 10/50 (20%)
RCC1 4154..4203 CDD:278826 14/91 (15%)
RCC1 4206..4257 CDD:278826 10/75 (13%)
RCC1 4260..4309 CDD:278826 7/53 (13%)
RCC1 4312..4360 CDD:278826 11/68 (16%)
RCC1 4364..4413 CDD:278826 12/56 (21%)
HECTc 4509..4880 CDD:238033 101/419 (24%)
HECTc 4553..4878 CDD:214523 89/345 (26%)
Hecw2NP_001101688.1 HECW_N 45..162 CDD:406866 19/117 (16%)
C2_NEDL1-like 185..321 CDD:176073 34/194 (18%)
MDN1 <396..741 CDD:227596 81/415 (20%)
NESP55 <464..632 CDD:115071 34/194 (18%)
WW 815..844 CDD:395320 5/28 (18%)
HECW1_helix 921..987 CDD:408233 13/73 (18%)
WW 993..1024 CDD:197736 8/41 (20%)
HECTc 1222..1576 CDD:238033 94/373 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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