DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment HERC2 and Ibtk

DIOPT Version :9

Sequence 1:NP_608388.2 Gene:HERC2 / 33035 FlyBaseID:FBgn0031107 Length:4912 Species:Drosophila melanogaster
Sequence 2:XP_038938472.1 Gene:Ibtk / 315858 RGDID:1311697 Length:1352 Species:Rattus norvegicus


Alignment Length:1441 Identity:292/1441 - (20%)
Similarity:461/1441 - (31%) Gaps:517/1441 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly  2977 AAAPEQDLPCTVMVWGLNDKEQLGGL----KGSKVKVPTF-SQTISRLRPIHIAGGSKSLFIVSQ 3036
            :|||:    ||.....|  |..|..|    |||:.::..| |........:..|.|..:|.:||.
  Rat     3 SAAPD----CTAKCRSL--KHALDVLSVITKGSERQIKIFLSSYCYNAATVKDAFGRNALHLVSS 61

  Fly  3037 DGKVYACGEGTNGRLGLGVTHNVPLPHQLPVLRQYVVKK-------------VAVH--------- 3079
            .||                          ..:..::::|             .|:|         
  Rat    62 CGK--------------------------KAVLDWLIEKGVDLLVKDKESGWTALHRSIFYGHIN 100

  Fly  3080 ---SGGKHALALTLDGK--------------------------VFSWGEGEDGKLGHGNRTTLDK 3115
               |..||.::|.:..|                          |::||:..:..||||::.:...
  Rat   101 CVWSLLKHGVSLYMQDKEGLSPLDLLMKDRPAHVVFKNTDPTEVYTWGDNTNFTLGHGSQNSKHH 165

  Fly  3116 PRLVEALRAKK--IRDVACGSSHSAAISSQGELYTWGLGEYGRLGHGDNTTQLKPKLVTALAGRR 3178
            |.|::.....:  ::.|.....||..:|.||::||.|.|..|||||||..|.|.|:||..|:|..
  Rat   166 PELLDLFSRSRVYVKQVVLCKFHSVFLSQQGQVYTCGHGRGGRLGHGDEQTCLVPRLVEGLSGHS 230

  Fly  3179 VVQVACGSRDAQTLALTEDGAVFSWGDGDFGKLGRGGSEGS-DTPHEIER--LSGIGVVQIECGA 3240
            ..||| .::| .|:.|||||.|:::|...|.:||......| :.|.:|:.  |.|..::.:..|.
  Rat   231 CSQVA-AAKD-HTVVLTEDGCVYTFGLNTFHQLGIIPPPSSCNVPRQIQAKYLKGRTIIGVAAGR 293

  Fly  3241 QFSLALTRAGEVWTWG-KGDYYRLGH----GGDQHVRKPQPIGGLRGRRV----IHVAVGALHCL 3296
            ..::..||.. |:|.| .|.  :|||    .|::.|..|:.:..|..:.:    :..:.||..| 
  Rat   294 FHTVLWTREA-VYTLGLNGG--QLGHLLDPNGEKCVTTPRQVSALHHKDIAVSLVAASDGATVC- 354

  Fly  3297 AVTDAGQVYAWGDNDHGQQGSGNTFVNKKPALVIG------------------------LDAVFV 3337
             ||..|.:|...|....:..:..  :|.|..||.|                        :|.  .
  Rat   355 -VTTRGDIYLLADYQCKKMATKQ--LNLKKVLVSGGCMEYKVDPEHLTENGGQKICILAMDG--A 414

  Fly  3338 NRVACGSSHSIA-----WGLPNASSDEE---KRGPVPFSSTRDPLGGSSLGIYEAETMQTLKQEA 3394
            .||.|..|.|.:     |..|...|..:   .|..:.| .|:|..|.......:.......|.:.
  Rat   415 GRVFCWRSLSSSLKQCRWAYPRQVSISDIALNRNEILF-VTQDGEGFKGKWFEDKRKNSEKKADI 478

  Fly  3395 KP-LNQSSLSESLALETPAA----RQAALGHVLRAMS-----------ILQA---RQLIVAALTS 3440
            .| |:.||...|...:|.:.    |...|....||:|           |||:   ..|....:.|
  Rat   479 LPNLHHSSSDVSCVSDTNSVYERIRLEKLPFAHRAVSVSTDPSGCNFAILQSDPKTSLYEIPVVS 543

  Fly  3441 HSKVNFKERGAVGGEEDHL---------IGGPIM---------------------GAPLQLAETI 3475
            .|.. |:|.|.:..|.|.:         :|..:.                     |..|:|.:..
  Rat   544 SSSF-FEEFGKLLRETDEMDSFHDVTFQVGNRLFPAHKYVLAVRSDFFQKLFLSDGTLLELTDVY 607

  Fly  3476 AQGGGEAPADATDAG-----LQEHSPEA-----------AVDALTGGMSGGANTLPPLSAGPLSA 3524
            .:       |...||     :::..|:.           ..|.||.|..      |.:       
  Rat   608 RK-------DEDAAGCHLFVVEKVHPDLFEYLLQFMYTDTCDFLTHGFK------PRM------- 652

  Fly  3525 FQSLTGSLSMSGSLSSSALPQHKHSRMSASAMSVMAATMTQQEEMLSHISHCHGLDDFGGLLGEP 3589
                   :....|..|...|:   ||:                    |..:|| :||        
  Rat   653 -------IMNKKSEDSKGSPE---SRL--------------------HAVNCH-VDD-------- 678

  Fly  3590 EAKSLVELLKLAVCGRCGPPSTSQTIADTLISLGAGTPAVAAMLLETCITELEDLCTSRHCLGKL 3654
            :.||..|:.:           ::|  |.||.......|..:                      |.
  Rat   679 KQKSAFEVYR-----------SNQ--AHTLSERQKSKPKSS----------------------KK 708

  Fly  3655 PKPVMQESSHPYVDNV-------NVTGVVRIPGAEMLRLEFDSQCSTEKRNDPLVIMDGTGRVL- 3711
            .|.|.::.....:.||       |::.  |:.|   :|.|      .||.|   ||...||..| 
  Rat   709 GKGVGEDDPVKMLQNVAKKFGLSNLSS--RLDG---VRYE------NEKIN---VIAKKTGNKLK 759

  Fly  3712 ------------AMRS--GREF-AHWAPEIRVLGDELRWKFSSDSSVNGWGWRFWVHAIMPAATL 3761
                        .|:|  |:|| .|..    ||...|.:..|..|       |.|:.|       
  Rat   760 LSQKKCSFLYDVTMKSVDGKEFPCHKC----VLCARLEYFHSMLS-------RSWIEA------- 806

  Fly  3762 GESGSDRAVLSQPSMALVMSLLDSRLAPRQPSVLLRLASALAACSQLGALTTAQR--IWSLRKLH 3824
                |..|.|..|..|.::.::...|...:..|:....:....||   .|..|.:  |..|:::.
  Rat   807 ----SSCAALEMPIQAEILKVILDYLYTDEAVVIKESQNVDFVCS---VLVVADQLLITRLKEMC 864

  Fly  3825 AVLLLEQAPRPQDPSLSTLLQPLIPELLRQYEYEEPQVRG----GIHLMHSDYFKTLAALACDMQ 3885
            .|.|.|        :|:.....::.|....|..|:.::..    |:::......::|..|:.|:.
  Rat   865 EVALAE--------NLTLKNAAMLLEFASMYNAEQLKLSCLQFIGLNMAALLEARSLDVLSEDVL 921

  Fly  3886 LDAAL------PATS-----------SSSSSSAAPGAISSTGDV-----HKWAWFKRYCIAVRVA 3928
            .|.::      ||..           ..|...|..|.:....::     |....||:        
  Rat   922 KDLSIFYRKMVPAMERRVITPYQDGPDISCVQAEDGEVFLKEEISLEPNHSETMFKK-------- 978

  Fly  3929 QSLIRRTELPRAFCLEVRKKFAEMLPSSSSNSNANPGCQS-PGASMLNST------------TSL 3980
             :..|..:.|       ||:     ..||...|.:...|| |.|.:|.|.            ||.
  Rat   979 -AKTRAKKKP-------RKR-----SDSSGGYNLSDIIQSPPSAGLLKSAKTNSVESLPELLTSD 1030

  Fly  3981 SSSTVSNVSPPPGITGEQPDLHCHAHQLESTSTLLHEDHTLFQAPHDAQLLQWLNRRPDDWALSW 4045
            |..:.:.|..|..:  :.||.          :...|.|..      :.:...::|..|..|.   
  Rat  1031 SEGSYAGVGSPRDL--QSPDF----------TAGFHSDKV------EGKAKPYVNGTPLPWT--- 1074

  Fly  4046 GGASTIYGWGHNHRGQLGGLEGSRIKTPTPCEALSLLRPVQLAGGEQSLFAVTPDGKLFATGYGS 4110
                         |..|...|    |:||...|...:                           .
  Rat  1075 -------------REDLKPWE----KSPTTKSAPQFI---------------------------P 1095

  Fly  4111 GGRLGVGGSDSWAIPTLLGSLQHVFVKKVAVNSGGKHCLALTTEGEVYAWGEGEDGKLG----HG 4171
            ..|:...||.||    :.||...|....|.:.:      .:.||.....:|......||    ||
  Rat  1096 SSRVDTSGSSSW----VAGSCSPVSPPVVDLRT------IMETEANRQKYGAAPKSNLGKIISHG 1150

  Fly  4172 NRMSYDRPKLV 4182
            .::|..:.|::
  Rat  1151 IKLSQKQRKMM 1161

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HERC2NP_608388.2 RCC1 638..683 CDD:278826
RCC1 687..737 CDD:278826
RCC1 740..787 CDD:278826
RCC1 790..841 CDD:278826
RCC1_2 828..857 CDD:290274
Cyt-b5 1290..1363 CDD:278597
MIB_HERC2 1928..1987 CDD:284184
UBA_HERC2 2515..2559 CDD:270585
Cul7 2624..2699 CDD:288381
APC10-HERC2 2762..2932 CDD:176485
RCC1 3037..3088 CDD:278826 8/75 (11%)
RCC1 3091..3140 CDD:278826 13/76 (17%)
RCC1 3144..3194 CDD:278826 24/49 (49%)
RCC1 3197..3246 CDD:278826 13/51 (25%)
RCC1 3250..3298 CDD:278826 14/56 (25%)
RCC1 3302..3350 CDD:278826 14/76 (18%)
RCC1_2 4136..4166 CDD:290274 4/29 (14%)
RCC1 4154..4203 CDD:278826 8/33 (24%)
RCC1 4206..4257 CDD:278826
RCC1 4260..4309 CDD:278826
RCC1 4312..4360 CDD:278826
RCC1 4364..4413 CDD:278826
HECTc 4509..4880 CDD:238033
HECTc 4553..4878 CDD:214523
IbtkXP_038938472.1 Ank_2 <45..116 CDD:403870 14/96 (15%)
ANK repeat 51..82 CDD:293786 7/56 (13%)
ANK repeat 84..116 CDD:293786 6/31 (19%)
ATS1 139..>341 CDD:227511 67/206 (33%)
RCC1 247..299 CDD:395335 13/51 (25%)
BTB1_POZ_IBtk 547..652 CDD:349610 18/118 (15%)
BTB2_POZ_IBtk 764..876 CDD:349611 31/144 (22%)
BACK_IBtk 872..931 CDD:350575 9/58 (16%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
11.000

Return to query results.
Submit another query.