DRSC/TRiP Functional Genomics Resources

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Protein Alignment HERC2 and Herc1

DIOPT Version :9

Sequence 1:NP_608388.2 Gene:HERC2 / 33035 FlyBaseID:FBgn0031107 Length:4912 Species:Drosophila melanogaster
Sequence 2:XP_017451567.1 Gene:Herc1 / 315771 RGDID:1306366 Length:4876 Species:Rattus norvegicus


Alignment Length:5720 Identity:1311/5720 - (22%)
Similarity:2009/5720 - (35%) Gaps:1769/5720 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    69 PDLYLRPLPFLDAKWLRADLIASLRNAADGAVLWNHLIQDCELVSSPTAPLLNARGQL------S 127
            |.:.|:.|..|::.|:..| ..|:.......||::.|:.:.|:|..|...|.....||      |
  Rat     6 PPVKLKWLEHLNSSWITED-SESIATREGVTVLYSKLVSNKEVVPLPQQVLCLKGPQLPDFERES 69

  Fly   128 YLGDDGKHYCGAQQLKCSCCQPEYCGPLSACNCDGCRPLDSDTAIKKLTTQAAAQQAAHLSQATD 192
            ...|:..||..|.                         |.|..|:.|:.                
  Rat    70 LSSDEQDHYLDAL-------------------------LSSQLALAKMV---------------- 93

  Fly   193 MVLSGWLWSQPPSQQARLDCQRSMISELQELALRAAGNCLSAQHLRQQLFIYERYFVAL------ 251
                               |..|..                |..||::|.:.:|.|.||      
  Rat    94 -------------------CSDSPF----------------AGALRKRLLVLQRVFYALSNKYHD 123

  Fly   252 KRERERERKSTTSAQAVASVTTANTTIAATTANAAVESQPAEQQAEHGALGLARVATHAALNFSF 316
            |.:.::::.|..|:...|.|.:.:....::| :|.:|                 :.....|:..|
  Rat   124 KGKVKQQQHSPESSSGSADVHSVSERPRSST-DALIE-----------------MGVRTGLSLLF 170

  Fly   317 AFLRRAWR---SGEDTEMCSELLSEALASLQELPEATLFEAAVVSSLWLEVMERSIKFLRLVAL- 377
            |.||::|.   ||....:|::::..|:..:..||..:|...:.:..:.|:.:.:...||:.|.: 
  Rat   171 ALLRQSWMMPVSGPGLSLCNDVIHTAIEVVSSLPPLSLANESKIPPMGLDCLSQVTTFLKGVTIP 235

  Fly   378 ---GDPMGNRCTAPLNDRHTALCLLLELGVQKGTLAATLECVVLLL------LLWEKDRAGNDNR 433
               .|.:|.|..:.         |||.|..|:|:|...||.:.:.|      ...||::..:...
  Rat   236 NSGADTLGRRLASE---------LLLGLAAQRGSLRYLLEWIEMALGASAVVYTMEKNKLLSSQE 291

  Fly   434 -------------DMPRKTGAPLQRILLRYQKIGATAKGGGIAGGEPAPVASATETFLRFLSLPK 485
                         .|.|..|:...|...|                ||.                :
  Rat   292 GMISFDCFMAILMQMRRSLGSSADRSQWR----------------EPT----------------R 324

  Fly   486 SSAAIVDLRRAAVVIISHLDRMVQPLMPRCL----LRGGQATAASSSSAPQQRIYALGWPSLSKD 546
            :|..:..|..||:.:...:.||.......|.    ::.|.|...|.:.    .:|.  |.|.|..
  Rat   325 TSEGLCSLYEAALCLFEEVCRMASDYSRTCASPDSIQTGDAPIVSETC----EVYV--WGSNSSH 383

  Fly   547 Q-----QGFSAEPTLSWSGESAGVPTLS----CRFQIK---QVACCETQMLILSQEGKLYTWRLA 599
            |     |....:|.|:.|...|  .|:.    |.|.|.   .|..|          ||....||.
  Rat   384 QLVEGTQEKILQPKLAPSFSDA--QTIEAGQYCTFVISTDGSVRAC----------GKGSYGRLG 436

  Fly   600 KPEA------EPLPMEEVAHDVFISIAGHCEGRHFLAIDSNHNAYSWGTGEDHRLGHGDTHARAV 658
            ..::      :.|..|.......:|.:...:| |.||..:....:|||.|:..:||||::..:..
  Rat   437 LGDSNNQSTLKKLTFEPHRSIKKVSSSKGSDG-HTLAFTTEGEVFSWGDGDYGKLGHGNSSTQKY 500

  Fly   659 PTKI-AALEQHCVQSVYCGCSYSAAITCGGNLLTWGRGTYARLGHGNSDDRSLPTLVVALSDHMV 722
            |..| ..|:...|..|..|..:|||:|..|.|.|||.|.:.|||||:|:.|::||||..:|:  |
  Rat   501 PKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELYTWGEGDFGRLGHGDSNSRNIPTLVKDISN--V 563

  Fly   723 VDVALGSGDAHSLALTSEG-LVFAWGDGDYGKLGNGNCNGSLQPILVESLPR--VQRVFAGSQFS 784
            .:|:.||  :|::||:.:| .|:::|.||.||||:|:.|...:|.::|:|..  :::|.||||.|
  Rat   564 GEVSCGS--SHTIALSKDGRTVWSFGGGDNGKLGHGDTNRVYKPKVIEALQGMFIRKVCAGSQSS 626

  Fly   785 VALSSEGQLYTWGKATCLGHQLVERSVQGCSVPRLVSSLQHKRIVDVAVSVAHCLALSSSGEVFG 849
            :||:|.||:|.||...|||....|.:...   |:|:..|...||||:::..:|||:||...||:.
  Rat   627 LALTSTGQVYAWGCGACLGCGSSEATALR---PKLIEELAATRIVDISIGDSHCLSLSHDNEVYA 688

  Fly   850 WGRNDSQQICPASVSSEPLLRTPILVSLPTFPASGIACTSAQSLVWT--QSSHQGVPRRAPFVVD 912
            ||.|...| |....|:.|:.:...:..|.......|:..::.||.||  ....|.|....|:.||
  Rat   689 WGNNSMGQ-CGQGNSTGPITKPKKVSGLDGIAIQQISAGTSHSLAWTALPRDRQVVAWHRPYCVD 752

  Fly   913 LGEPTFRLLDQLLGMCSSQDNRQTP------NQESECIAVACLNLFRLQLLALIANGVEPRQVGL 971
            |.|.||..|...|.....:.|.:.|      ::|.......||.|....|...:|.||....:|.
  Rat   753 LEESTFSHLRSFLERYCDKINSEIPPLPFPSSREHHNFLKLCLKLLSNHLALALAGGVATSILGR 817

  Fly   972 ASGSRLLCSLKTRILGLAGGSQVLRTIQVAAQQALQDGWSVLLPTAAERAQTLTSLLPSEPG--Q 1034
            .:|.  |.:|..|::    .|.|...||....:.|..|.::|||...||.:.|.||||..|.  :
  Rat   818 QAGP--LRNLLFRLM----DSTVPDEIQEVVIETLSVGATMLLPPLRERMELLHSLLPQGPDRWE 876

  Fly  1035 ASSAGHRFMTDLLVSSLMAEGGLESALQHAIRLESSSCSADC------GDGVHLP--------LL 1085
            :.|.|.|...|::::||.....:.|.|.::...:::..|..|      .|..:.|        |.
  Rat   877 SLSKGQRMQLDIILTSLQDHTHVASLLGYSSPSDAADLSTVCMGYGNLSDQPYGPQTCHPDTHLA 941

  Fly  1086 QLITRLLSNNAALSQTRLSPTLGKQQEK------EEEEREQQHQEPSTSPSLSLLHRFQRLLLS- 1143
            :::.:.|..|......:....|.|..:|      ..|..:..|..       .||...|:.||: 
  Rat   942 EILMKTLLRNLGFYTDQAFGELEKNSDKYLLGTSSSENSQPAHLH-------ELLCSLQKQLLAF 999

  Fly  1144 -HIHQAQPEEETTGAEALLLQYMHALIPACVATLQKAHELALQCREPGENSFGQMVGHLGRVLQA 1207
             ||:..   .|.:.:.|||.:::..|:|.......::..|..:  .|...|.|:   .|..|:..
  Rat  1000 CHINNI---TENSSSVALLHKHLQLLLPHATDIYSRSANLLKE--SPWNGSVGE---KLRDVIYV 1056

  Fly  1208 DISDALLNELLVGLLLLKRD--RPQCLGGLRWARLFLPLLRVLDRLNRALGEGELRDGDDMGWPG 1270
            ..:.::|.:::..||||...  ||       .....|.||..||.|||.|....|.:..::.|| 
  Rat  1057 SAAGSMLCQIINSLLLLPVSVARP-------LLSYLLDLLPPLDCLNRLLPAAALLEDQELQWP- 1113

  Fly  1271 IICRGGPK----GGPPPADPETHYVRRADMEN--LLLDGSRCIILAGYVCDLSGYNCESETLRSV 1329
              ..|||:    .|.|...|...:|...|:|.  .||.| ||         |.|           
  Rat  1114 --LHGGPEVIDPAGVPLPQPAQSWVWLVDLERTIALLIG-RC---------LGG----------- 1155

  Fly  1330 LDSGLGKDLTAEMSSQVHRTAMEHILEHHKLGKYMVQ---ASTEEKSSAPGPSRLTHFSSECALA 1391
                                              |:|   .|.||:.:|                
  Rat  1156 ----------------------------------MLQGSPVSPEEQDTA---------------- 1170

  Fly  1392 QLLGLVANLMCSGPALQPAELQCRQLDK--SSLLSGGLQLLQPSNPFDEEKGEARSSHSCHSTAG 1454
              ..:...|...|     .|:...||||  |.||...|...:...|||                 
  Rat  1171 --YWMKTPLFSDG-----VEMDTPQLDKCMSCLLEVALSGNEEQKPFD----------------- 1211

  Fly  1455 NTPTELPPPLPMQQQLAPGRGKSQLQLRADAFISGLAEARVSEPPVAAWLALTERYCKAHNLMWH 1519
               .:|.|.:.:...||.|..|                    ||..:.|:::.: |..:.:  |.
  Rat  1212 ---YKLRPEIAVYVDLALGCSK--------------------EPARSLWISMQD-YAVSKD--WD 1250

  Fly  1520 Q-EFATEHPVQELERLLSAVLIRHQYLGGLVLNALETEVPPPRQLGEIIRLVHQA---------- 1573
            . ..:.|..:..:.|.:.|.|::|..|  |.....|:...|.:.|.|:.|.|::.          
  Rat  1251 SATLSNESLLDTVSRFVLAALLKHTNL--LSQACGESRYQPGKSLSEVYRCVYKVRSRLLACKNL 1313

  Fly  1574 -----------KW---------------------------------------------------- 1575
                       :|                                                    
  Rat  1314 ELIQTRSSSRDRWISDNQDSADVDPQEHSFTRTIDEEAEMEELAERDREDGHPEAEDEEEEREHE 1378

  Fly  1576 ---------------SVVRTR----------------------QQLNR----------SYKEVCA 1593
                           .|.|:|                      ||..|          .|...|.
  Rat  1379 VLTAGKIFQCFLSAREVARSRDRDRMSSGAGPGVRADDPPPQPQQERRVSTDLPEGQDVYTAACN 1443

  Fly  1594 PILERLRFLLYEVRPAISPQQRGLRRLPILQRP---------------------------PRFKM 1631
            .::.|...|:..|.|.|...|: .|....||:|                           |.:::
  Rat  1444 SVIHRCALLILGVSPVIDELQK-RREEGQLQQPSVSASEGTGLMTRSESLTAENRLVHASPSYRL 1507

  Fly  1632 LVRRLLQELRSSRQPAKPED------LLNASIQQEQEKKPQSMPKQELEEQEEEETLLRRLNE-- 1688
            :..|...:|   .||...|:      ..|..:......:.:.....:||...:..|.|:...:  
  Rat  1508 IKSRSESDL---SQPESDEEGYALSGRRNVDLDLVSSHRKRGPMHSQLESLSDSWTRLKHTRDWF 1569

  Fly  1689 --RQIHGEGELD-------PALMQDIVDFALQD--------------SCDVETARRAMYCQMQRY 1730
              .....|.:.|       ..|::::|.|...|              |...:.:..||..|..|.
  Rat  1570 YNSSYSFESDFDLTKSLGVHTLIENVVSFVSGDVGNAPGFKEPEESMSTSPQASIIAMEQQQLRA 1634

  Fly  1731 QLRLAGLQIVQQLLE---------LHG-----------LLDAAQYSLLNGFLGLHLKSTSSGGGS 1775
            :|||..|..:..||.         |.|           ||.:.:...|.|..||   .|....|:
  Rat  1635 ELRLEALHQILTLLSGMEEKGNILLTGSRSSSGFQSSTLLTSVRLQFLAGCFGL---GTVGYTGA 1696

  Fly  1776 TGSGSSLH--------------VLGQLNMISAYQKARLLLAQSRVLDWAVRELRRLVNQEQQ--- 1823
            .|....||              |..|:.:...||:.      |..|:.|::..:..:..:|:   
  Rat  1697 KGESGRLHHYQDGIRAAKRNIQVEIQVAVHKIYQQL------SATLERALQANKHHIEAQQRLLL 1755

  Fly  1824 -------GHARGKD-----STNL--------GTYVL----LKRLPRA-----------------R 1847
                   .|.:..|     ||.|        ||..:    |:.||:.                 :
  Rat  1756 VTVFALSVHYQPVDVSLAISTGLLNVLSQLCGTDTMLGQPLQLLPKTGVSQLSTALKVASTRLLQ 1820

  Fly  1848 FLLSVFGLLAKELGPNELGFLINSGLLGTVLGLLAQTG-------GEGATG-------------- 1891
            .|....|..|.:|.|..:..|::. |...:..||:|||       |||..|              
  Rat  1821 ILAITTGTYADKLSPKVVQSLLDL-LCSQLKNLLSQTGVLFMASFGEGEEGEEEDKKVDSSGEAE 1884

  Fly  1892 -------------GQVHGELSILYEDSVLKQKSSKAQLSGPDLAKLM--------KIGTRIVRGA 1935
                         .::|....:::...|:..|:.:::::.|...:::        ..|..:|   
  Rat  1885 KRDFRAALRKQHAAELHLGDFLVFLRRVVSSKAIQSKMASPKWTEVLLNIASQKCSSGIPLV--- 1946

  Fly  1936 DWKWGDQDGN---------------PPGEGRIISEVGEDGWVRV-----------EWYT---GAT 1971
                    ||               |..|    |.|.:|...:|           .|.|   .|.
  Rat  1947 --------GNLRTRLLALHVLEAVLPACE----SGVEDDQMAQVVERLFSLLSDCMWETPIAQAK 1999

  Fly  1972 NSYRMGKEGQYDLQLADSALNVASPTEPEREDVSGSEASPTSD-SHPSKLLRHCAAKLLQILAVG 2035
            ::.:: ||.:.:::|....       |.|.||    |..|..: |...:..:.|..:..|||..|
  Rat  2000 HAIQI-KEKEQEIKLQKQG-------ELEEED----ENLPIQEVSFDPEKAQCCIVENGQILTHG 2052

  Fly  2036 TGLHGAQLDKDALRGMTS-MFRTIIY-PKPSMSNISYALG-----------------WLNLGFIR 2081
            :|..|..|   |..|:|| .::...| .|.:..|....:|                 ||    .|
  Rat  2053 SGGKGYGL---ASTGVTSGCYQWKFYIVKENRGNEGTCVGVSRWPVHDFNHRTTSDMWL----YR 2110

  Fly  2082 AISGDCPRLCLELSTPGWLSHYLSLLEQPAGNEAGVYRQLHCLRLLQLILAQWGAE-EEPRMPAL 2145
            |.||:       |...|..:..||...|      |.:  :.|:..::.....:|.. |||::   
  Rat  2111 AYSGN-------LYHNGEQTLTLSSFTQ------GDF--ITCVLDMEARTISFGKNGEEPKL--- 2157

  Fly  2146 VHQLFATLGRIALH-C-------PGDASLLPTAE--GKARVLLTASH-----SGSVAEELVALLR 2195
               .|..:....|: |       ||:...:...:  |..|.||....     :..:||..:.|:|
  Rat  2158 ---AFEDVDAAELYPCVMFYSSNPGEKVKICDMQMRGTPRDLLPGDPICSPVAAVLAEATIQLIR 2219

  Fly  2196 RLHTLPSWNPVINSFLAQ-----KLCVAA-----------------ELLAEQS-----------H 2227
            .||....|...||..:.:     |:|:..                 |:..|:.           |
  Rat  2220 ILHRTDRWTYCINKKMMERLHKIKICIRESGQKLKKSRSVQSREENEMREEKENKEEEKGKHNRH 2284

  Fly  2228 STALDSEQ------VFVLGVLGAMGGHDLRPRVGLHCFHE--GSHMVIASFTPKGRCLLAPGGVG 2284
            ..|..||.      :.|..||..:||.|...|||..|.|:  |.|..:..       ::..|...
  Rat  2285 GLADLSEPQLRTLCIEVWPVLAVIGGVDAGLRVGGRCVHKQTGRHATLLG-------VVKEGSTS 2342

  Fly  2285 SGVGFVKVQLPAVMPHLDHTVFSLSRLPMNEMLLNAWTVLLYGPAPELRELPSSADGRLDLALLR 2349
            :.|.:.:.::....|    |.:|.|..|:..  |.....||:..| ..|.|.:|.  .|||..|.
  Rat  2343 AKVQWDEAEITISFP----TFWSPSDTPLYN--LEPCEPLLFDVA-RFRGLTASV--LLDLTYLT 2398

  Fly  2350 AQQLQMAVLHTN---GVLYRHQVALRRILKQRAPGSIYASPDEPDRSDA---------------- 2395
            .       :|.:   ..:.||:...|...:::  |.|...|:.....|.                
  Rat  2399 G-------IHEDIGKQSIKRHEKKHRHESEEK--GDIEQKPESESILDVRTGLISDDVKSQGTTS 2454

  Fly  2396 ------------ESQQPG-EQDQQLSSGSGQEPQLLIQCILLRATQASPVKACYSYMDLATAALN 2447
                        ||..|| |...|::.|..:..:.:.:...:..::...|:..|.|:. |..:|:
  Rat  2455 SKSENEIASFSLESTLPGVESQHQITEGKRKNHEHISKTHDIAQSEIRAVQLSYLYLG-AMKSLS 2518

  Fly  2448 CIQSLATQAH-----QELSEGGGVPPNGRALSSPPQPTMVHGVPVYNVARKEQKPSEQVEQKSKW 2507
            .:...:..|.     :.|:|.|   .|....|||    :||               |.||.:   
  Rat  2519 ALLGCSKYAELLLIPKVLAENG---HNSDCASSP----VVH---------------EDVEMR--- 2558

  Fly  2508 PAAATDAQLIGQIMEMGFTRRTVELALKQLSLQAEIMPTPEQIVQWILE-------HPDVCANTI 2565
               |....|:..:::....|..::.||....|:.......:.:|..:||       ..::.....
  Rat  2559 ---AALQFLMRHMVKRAVMRSPIKRALGLADLERAQAMIYKLVVHGLLEDQFGGKIKQEIDQQAE 2620

  Fly  2566 EEDTLPLASSASSHDPEADSDNECPSSN--STTSSSTSSDTVEGQPMAVSGPAPPVKFESRKDFQ 2628
            |.|....|.:..:..|.|.|.....||:  .||:::|.....|..|.:.|....|:....:....
  Rat  2621 ESDQAQQAQTPVTTSPSASSTTSFMSSSLEDTTTATTPVTDTETVPASESPGVMPLSLLRQMFSS 2685

  Fly  2629 TADLYALYVRGLVRPGMTVRCCRDFEEIKQGDMGTVLIVDTEGLHDLN--VQVDWRNHGSTYWVC 2691
            ......|..|....|.::.......:|:  |...::...|::.....|  ...|..:..||    
  Rat  2686 YPTTTVLPTRRAQTPPISSLPASPSDEV--GRRQSLTSPDSQSTRPANRTALSDPSSRLST---- 2744

  Fly  2692 FVHIELVEAAQTHHQPRPPPIAVGARVRLRTSSLRYGMLCPLRLGRS-----QGSSAIGVVSSVR 2751
                          .|.||.|||..                |.:|.|     :...|.|......
  Rat  2745 --------------SPPPPAIAVPL----------------LEMGFSLRQIAKAMEATGARGEAD 2779

  Fly  2752 SKQLTVDFPDQPAWQ----GHINEVELVASQPT-----SATLPSLG---DSCSQMPPSD------ 2798
            ::.:||    ...|.    ||.:|.|..:|...     :|.|.|.|   |.|....|.|      
  Rat  2780 AQNITV----LAMWMIEHPGHEDEEEPQSSSTADSRHGTAVLGSGGKSNDPCYLQSPGDIPSADA 2840

  Fly  2799 --LIEDWSRCIRSLTVSSNEAAAKHLLNGSNQPWQSCSSGPCRHWIRLELHDRILVHSLTLKVSP 2861
              :.|.:|....:|..:.|.|      :||..|.:..|:...||...|                 
  Rat  2841 AEMEEGFSESPDNLDHTENAA------SGSGPPTRGRSTVTRRHKFDL----------------- 2882

  Fly  2862 EDHSHMPSLLEIRVGDCVDSLKEYTWIPVPAGASRVLLMQQVPTYYPWVEVVVKQCQNNGIQCKI 2926
                                            |:|.||.:....|        :..|.:..|.:.
  Rat  2883 --------------------------------AARTLLARAAGLY--------RSVQAHRNQSRR 2907

  Fly  2927 HGIKFVGRRQQP--------------DLQHILANAQFLASEYSAGVGPGSTAGAGAVSTSHEEAA 2977
            .||..   :|.|              ||......|.|                 |...||..:..
  Rat  2908 EGISL---QQDPGALYDFNLDEELEIDLDDEAMEAMF-----------------GQDLTSDNDIL 2952

  Fly  2978 A--APE-QDLPCTVMVWGLNDKEQLGGLKGSKVKVPTFSQTISRLRPIHIAGGSKSLFIVSQDGK 3039
            .  .|| .|.| |..|....|:|::...:..:..|.:|:|.:.|..|                  
  Rat  2953 GMWIPEVLDWP-TWHVCESEDREEVVVCELCECNVVSFNQHMKRNHP------------------ 2998

  Fly  3040 VYACGEGTNGRLGLGVTHNVPLPHQLPVLRQYVVKKVAVHSGGKHALALTLDGKVFSWGEGEDGK 3104
              .||...|                    ||      ...|.|.:     :||    |..||   
  Rat  2999 --GCGRSAN--------------------RQ------GYRSNGSY-----VDG----WFGGE--- 3023

  Fly  3105 LGHGNRTTLDKPRLVEALRAKKIRDVACGSSHSAAISSQGELYTWGLGEYGRLGHGDNTTQLK-- 3167
            .|.||...|                 .|||.....::.:.:..|            .|:.:.|  
  Rat  3024 CGSGNPYYL-----------------LCGSCREKYLALKTKTKT------------TNSERYKGQ 3059

  Fly  3168 -PKLVTALAGRRVVQVACGSRDAQTLALTEDGAVFSWGDGDF----GKLGRGGSEGSDTPHEIER 3227
             |.|:    |:   |.:....|...|.:.||..:  .|:.:|    |.||.........|.:...
  Rat  3060 APDLI----GK---QDSVYEEDWDMLDVDEDEKL--TGEEEFELLAGPLGLNDRRIVPEPVQFPD 3115

  Fly  3228 LSGIG---------------VVQIECGAQFSLALTRAGEVWTWGKGDYYRLGHGGDQHVRKPQPI 3277
            ...:|               ::||.|..  |:..:.:|.|..            |:|......| 
  Rat  3116 SDPLGASVAMVTATNSMEETLMQIGCHG--SVEKSSSGRVTL------------GEQAAALANP- 3165

  Fly  3278 GGLRGRRVIHVAVGALHCLAVTDAGQVYAWGDNDHGQQGSGNTFVNKKPALVIGLDAVFVNRVAC 3342
                     |..|.||.  .||.|.||..           ..|.|.:..:|:          ...
  Rat  3166 ---------HDRVVALR--RVTAAAQVLL-----------ARTMVMRALSLL----------SVS 3198

  Fly  3343 GSSHSIAWGLPN------------------------------ASSDEEKRGPVPFSSTRDPLG-- 3375
            |||.|:|.||.:                              ||:.|..||  ..|....|:.  
  Rat  3199 GSSCSLAAGLESLGLTDIRTLVRLMCLAAAGRAGLSTSPSAIASTSERSRG--GHSKASKPISCL 3261

  Fly  3376 ---GSSLGIYEAETMQTLKQEAKPLNQSSLSES-----LALETPAARQAALGHVLRAMS------ 3426
               .:::|...:.|....|...:...|:.:|.:     ..::.|..|: .|...||.::      
  Rat  3262 AYLSTAVGCLASNTPSAAKLLVQLCTQNLISAATGVNLTTVDDPIQRK-FLPSFLRGIAEENKLV 3325

  Fly  3427 ------ILQARQLIVAALT--------SHSKVNFKERGAVGGEEDHLIGGPIMGAPLQLAETIA- 3476
                  :.||   :||.|.        ::.|...:::|.:.....|....|....||:||..:| 
  Rat  3326 TSPNFVVTQA---LVALLADKGAKLRPNYDKTEIEKKGFIAQLYAHPSYDPSAVGPLELANALAA 3387

  Fly  3477 ---------------------------QGGGEAPADATDAG----------LQEHSPEAAVDA-- 3502
                                       :....||....|.|          |:.|........  
  Rat  3388 CCLSSRLSSQHRQWAAQQLVRTLAAHDRDNQTAPQTLADMGGDLRKCSFIKLEAHQNRVMTCVWC 3452

  Fly  3503 ------LTGGMSGGAN----TLPPLSAGPLSAFQSLTGSLSMSGSLSSSALPQHKHSRMSASAMS 3557
                  .|.|..|...    |....|......|..|.|  ....||.|.:.|.     .|..:.|
  Rat  3453 NKKGLLATSGNDGTIRVWNVTKKQYSLQQTCVFNRLEG--DAEESLGSPSDPS-----FSPVSWS 3510

  Fly  3558 VMAATMTQQEEMLSHISHCHGLDDFGGLLGEPEAKSLVELLKLAVCGRCGP---PST--SQTIAD 3617
            :....:....|.:.:|...:|            .|.||::....|.....|   |:|  |....:
  Rat  3511 ISGKYLAGALEKMVNIWQVNG------------GKGLVDIQPHWVSALAWPEEGPATAWSGESPE 3563

  Fly  3618 TLI------SLGAGTPAVAAMLLETCITELEDLCTSRHCLGKLPKPVMQESSHPYVDNVNVT--- 3673
            .|:      |||              :.|:.|:.|...          :|..|.|..:|:||   
  Rat  3564 LLLVGRMDGSLG--------------LIEVVDVSTMHR----------RELEHCYRKDVSVTCIA 3604

  Fly  3674 --------GVVRIPGAEML----RLEFDSQCSTEKRNDPLVIM--DGTGRVLAMRSGREFAH-WA 3723
                    .|....|..::    .||.......:...:.||.|  |.||.:|...:..|... |.
  Rat  3605 WFSEDRPFAVGYFDGKLLMGTKEPLEKGGIVLIDAHKETLVSMKWDPTGHILMTCAKEENVKLWG 3669

  Fly  3724 PEIRVLGDELRWK----FSSDSSVNGWGWRFWVHAIMPAATLGESGSDRAVL------------- 3771
            |   |.|   .|:    ....|:|||..|          .:|...||...:|             
  Rat  3670 P---VSG---CWRCLHSLCHPSTVNGIAW----------CSLPGKGSKMQLLMATGCQNGLVCVW 3718

  Fly  3772 ------SQPSM----------------------ALVMSLLDSRLAPRQPSVLLRLASALAACSQL 3808
                  :|.||                      |..:..|...:.|.:.........||.:    
  Rat  3719 CIPQDTTQTSMTSSEGWWDQESNCQDGFKKSAGAKCVYQLRGHITPVRTVAFSSDGLALVS---- 3779

  Fly  3809 GALTTAQRIWSLR---------------------------------------------------- 3821
            |.|.....|||||                                                    
  Rat  3780 GGLGGLMNIWSLRDGSVLQTVVIGSGAIQTTVWIPEVGVAACSNRSKDVLVVNCTAEWASANHIL 3844

  Fly  3822 -------KLHAVLLLEQAPRPQDPSLSTLLQPLIPELLRQYEYEEPQVRGGIHLMHSDYFKTLAA 3879
                   |...||.|..|     |.:...|:.|...|..||.||:|.|..|..|:||.|.:.||:
  Rat  3845 ATCRTALKQQGVLGLNMA-----PCMRAFLERLPMMLQEQYAYEKPHVVCGDQLVHSPYMQCLAS 3904

  Fly  3880 LACDMQLDAAL---PATSSSSSSSAAPGAISSTGDVHKWAWFKRYCIAVRVAQSLIRRTELPRAF 3941
            ||..:.||..|   |......:....|    ::.:.::|||.:.:...::.|::|....:.|.:|
  Rat  3905 LAVGLHLDQLLCSPPVPPHHQNCPPDP----ASWNPNEWAWLECFSTTIKAAEALTNGAQFPESF 3965

  Fly  3942 CLEVRKKFAEMLPSSSSNSNANPGCQSPGASMLNSTTSLSSSTVSNVSPPPGITGEQPDLHCHAH 4006
                                                      ||.::.|.|              
  Rat  3966 ------------------------------------------TVPDLEPVP-------------- 3974

  Fly  4007 QLESTSTLLHEDHTLFQAPHDAQLLQWLNRRPDDWALSWGGASTIYGWGHNHRGQLGGLEGSRIK 4071
              |....|| .|::.:....|.|::.|...||:||.|  ||...:|.||....|||.  |..| .
  Rat  3975 --EDELVLL-MDNSKWINGMDEQIMSWATSRPEDWHL--GGKCDVYLWGAGRHGQLA--EAGR-N 4031

  Fly  4072 TPTPCEALSLLRPVQLAGGEQSLFAVTPDGKLFATGYGSGGRLGVGGSDSWAIPTLLGSLQHVFV 4136
            ...|..|.|..:..|:..|:...|.:..:|.:.|.|.||.||||.|.||...:.|::.:||...|
  Rat  4032 VMVPATAPSFSQAQQVICGQNCTFVIQANGTVLACGEGSYGRLGQGNSDDLHVLTVISALQGFVV 4096

  Fly  4137 KKVAVNSGGK-HCLALTTEGEVYAWGEGEDGKLGHGNRMSYDRPKLVEHLNGMSVADIACGSAHS 4200
            .::..:.|.. |.:|||..|||::||:|:.|||||||.....||:.:|.|.|..|..::||..||
  Rat  4097 TQLVTSCGSDGHSMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHS 4161

  Fly  4201 AAITASGHVLTWGKGRYGRLGHGDSEDQLRPKLVEALLGYRAIDIACGSGDAQTLCITDDDN-VW 4264
            |.:|:.|.:.|:|.|.|||||.|::.::..|:.|.||.||:...:|||..  .||.::.|.: ||
  Rat  4162 AVVTSDGKLFTFGNGDYGRLGLGNTSNKKLPERVTALEGYQIGQVACGLN--HTLAVSADGSMVW 4224

  Fly  4265 SWGDGDYGKLGRGGSDGCKLPYKIESLAGLGVVKVECGSQFSVALTKSGAVYTWGKGDFHRLGHG 4329
            ::|||||||||.|.|.....|.|::.|.|:|:.||.||:||||||||.|.|||:|:.....|..|
  Rat  4225 AFGDGDYGKLGLGNSTAKSSPQKVDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEG 4289

  Fly  4330 SVDHVRRPKKVAALQGKKIISIATGSLHCVACSDSGEVYTWGDNDEGQLGDGTVTAIQRPRLVAA 4394
            ...:..||:::..|.|..|..:|.|:.|.:|.:.:|:||.||.|.|||||.|....::.|.||..
  Rat  4290 RARNHNRPQQIPVLAGVVIEDVAVGAEHTLALASTGDVYAWGSNSEGQLGLGHTNHVREPTLVTV 4354

  Fly  4395 LQGKHIVKVTCGSAHTLALSTSQLSERLRPLPNP---------PLEYDLVRDLAPEALHARLILL 4450
            ||||:|.:::.|..|:.|.:...:..|...:..|         |.:|..:|:::...:.|||.||
  Rat  4355 LQGKNIRQISAGRCHSAAWTAPPVPPRAPGVSVPLQLGLPDAVPPQYGALREVSIHTVRARLRLL 4419

  Fly  4451 HHFSELVCPCLAMLPISGD--------------LSLGALKDVLVYNIKEAAFRKVIQTTMVRDKQ 4501
            :|||:|:.....:|.:|.:              :..|.|:.:|...:......:.|..|||:.|.
  Rat  4420 YHFSDLMYSSWRLLNLSPNNQNSTSHYNAGTWGIVQGQLRPLLAPRVYTLPMVRSIGKTMVQGKN 4484

  Fly  4502 HGPVIELNRIQVKRSRNRCNGLAGIDGMKSVFGQMVQKLPLLTQEALALPHRVWKVKFVGESVDD 4566
            :||.|.:.||.. |.| :|         |.:|.|:.:::..|....|.||.|.||||.|||..||
  Rat  4485 YGPQITVKRIST-RGR-KC---------KPIFVQIARQVVKLNASDLRLPSRAWKVKLVGEGADD 4538

  Fly  4567 CGGGYSESIAEMCDELQNGSVPLLINTPNGRGEAGANRDCFLLDPTLSSVLQMNMFRFLGVLMGI 4631
            .||.:.::|.|||.||:.|.|.|||.:||...|.|.|||.||..|:......:..|:|||:|||:
  Rat  4539 AGGVFDDTITEMCQELETGIVDLLIPSPNATAEVGYNRDRFLFSPSACLDEHLMQFKFLGILMGV 4603

  Fly  4632 AVRTGSPLSINLAEPVWRQLTGEVLRPTDLTEVDRDYVAGLLCIRNMDD----DPKLFTALEL-P 4691
            |:||..||.::||..||:||....|...||.|||..||..|..|.:::|    :......:.| .
  Rat  4604 AIRTKKPLDLHLAPLVWKQLCCVPLTLEDLEEVDLLYVQTLNSILHIEDSGITEESFHEMIPLDS 4668

  Fly  4692 FSTSSARGHEVPL--STRYTHISPRNRAEYVRLALGFRLHEFDEQVKAVRDGMSKVIPVPLLSLF 4754
            |...||.|..||:  ......::..||.|||..|:.:||||.|.||.|||:|||.::|||||||.
  Rat  4669 FVGQSADGKMVPIIPGGNSIPLTFSNRKEYVERAIEYRLHEMDRQVAAVREGMSWIVPVPLLSLL 4733

  Fly  4755 SAAELQAMVCGSPDIPLGLLKSVATYKGFDPSSALVTWFWEVMEEFTNQERSLFLRFVWGRTRLP 4819
            :|.:|:.||||.|:|.:.:||.|..|:..|....||.|.|..:|||:|:||.||:|||.||:|||
  Rat  4734 TAKQLEQMVCGMPEICVDVLKKVVRYREVDEQHQLVQWLWRTLEEFSNEERVLFMRFVSGRSRLP 4798

  Fly  4820 RTIADFRGRDFVLQVLEKNPPDHFLPESYTCFFLLKMPRYSCKAVLLEKLKYAIHFCKSIDTDEY 4884
            ...||...|   .|:::.:.|...||.|.||||.|::|.||.:.|:.|:|:|||:.|:|||.|.|
  Rat  4799 ANTADISQR---FQIMKVDRPYDSLPTSQTCFFQLRLPPYSSQLVMAERLRYAINNCRSIDMDNY 4860

  Fly  4885  4884
              Rat  4861  4860

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HERC2NP_608388.2 RCC1 638..683 CDD:278826 16/45 (36%)
RCC1 687..737 CDD:278826 23/49 (47%)
RCC1 740..787 CDD:278826 20/49 (41%)
RCC1 790..841 CDD:278826 19/50 (38%)
RCC1_2 828..857 CDD:290274 13/28 (46%)
Cyt-b5 1290..1363 CDD:278597 10/74 (14%)
MIB_HERC2 1928..1987 CDD:284184 15/87 (17%)
UBA_HERC2 2515..2559 CDD:270585 8/50 (16%)
Cul7 2624..2699 CDD:288381 10/76 (13%)
APC10-HERC2 2762..2932 CDD:176485 35/189 (19%)
RCC1 3037..3088 CDD:278826 7/50 (14%)
RCC1 3091..3140 CDD:278826 12/48 (25%)
RCC1 3144..3194 CDD:278826 9/52 (17%)
RCC1 3197..3246 CDD:278826 12/67 (18%)
RCC1 3250..3298 CDD:278826 9/47 (19%)
RCC1 3302..3350 CDD:278826 9/47 (19%)
RCC1_2 4136..4166 CDD:290274 12/30 (40%)
RCC1 4154..4203 CDD:278826 24/48 (50%)
RCC1 4206..4257 CDD:278826 21/50 (42%)
RCC1 4260..4309 CDD:278826 27/49 (55%)
RCC1 4312..4360 CDD:278826 15/47 (32%)
RCC1 4364..4413 CDD:278826 22/48 (46%)
HECTc 4509..4880 CDD:238033 164/377 (44%)
HECTc 4553..4878 CDD:214523 151/331 (46%)
Herc1XP_017451567.1 RCC1 421..472 CDD:278826 11/61 (18%)
RCC1 476..526 CDD:278826 16/49 (33%)
RCC1 529..576 CDD:278826 23/50 (46%)
RCC1 579..629 CDD:278826 20/49 (41%)
RCC1 633..680 CDD:278826 19/49 (39%)
RCC1_2 667..696 CDD:290274 13/28 (46%)
RCC1 683..733 CDD:278826 13/50 (26%)
SPRY_HERC1 2030..2187 CDD:293939 39/184 (21%)
UBA_HERC1 2751..2794 CDD:270584 11/62 (18%)
WD40 3409..3793 CDD:225201 84/446 (19%)
WD40 3439..3790 CDD:295369 77/413 (19%)
WD40 repeat 3447..3490 CDD:293791 7/42 (17%)
WD40 repeat 3504..3539 CDD:293791 8/46 (17%)
WD40 repeat 3544..3591 CDD:293791 12/70 (17%)
WD40 repeat 3600..3638 CDD:293791 6/37 (16%)
WD40 repeat 3644..3679 CDD:293791 13/40 (33%)
WD40 repeat 3687..3718 CDD:293791 8/40 (20%)
WD40 repeat 3765..3801 CDD:293791 9/39 (23%)
RCC1 4060..4112 CDD:278826 18/51 (35%)
RCC1 4115..4164 CDD:278826 24/48 (50%)
RCC1 4167..4216 CDD:278826 21/50 (42%)
RCC1 4219..4269 CDD:278826 27/49 (55%)
RCC1 4272..4321 CDD:278826 15/48 (31%)
RCC1_2 4308..4337 CDD:290274 12/28 (43%)
RCC1 4325..4373 CDD:278826 22/47 (47%)
HECTc 4488..4856 CDD:238033 165/381 (43%)
HECTc 4519..4852 CDD:214523 153/335 (46%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1062377at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_102650
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.820

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