DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HERC2 and Hectd3

DIOPT Version :9

Sequence 1:	NP_608388.2	Gene:	HERC2 / 33035	FlyBaseID:	FBgn0031107	Length:	4912	Species:	Drosophila melanogaster
Sequence 2:	XP_008762291.1	Gene:	Hectd3 / 313525	RGDID:	1309823	Length:	861	Species:	Rattus norvegicus

Alignment Length:	837	Identity:	227/837 - (27%)
Similarity:	340/837 - (40%)	Gaps:	206/837 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly  4163 GEDGKLGHGNRMSYDRPKLVEHLNGMSVAD---IAC----GSAHSAAITASGH------------ 4208
            ||:...|||..:...:.:|.|||:..|:.:   :.|    |.|....|....|
  Rat   108 GEELCNGHGLWVKLTKEQLAEHLSDCSLDEGWLLVCRPAEGGARLVPIDTPDHLQRQQQLFGVDY 172

  Fly  4209 --VLTWGKG---RYG-RLGHGDSEDQLRPKLVEALLGYRAIDIACGSGDAQTLCITDDDNVWSWG 4267
              ||.|.:.   .|. |||.       ||:..||.           :...|.|.....  .|::.
  Rat   173 RPVLRWEQVVDLTYSHRLGS-------RPQPAEAY-----------TEAVQRLLYVPP--TWTYE 217

  Fly  4268 -DGD-----YGKLGRGGSDGCKLPYKIESLAGLGVVK-----VECGS---QFSVA-LTKSGAVYT 4317
             |.|     |..||:...:             ||.||     ::..|   :|:|: ||.|.|...
  Rat   218 CDEDLIHFLYDHLGKEDEN-------------LGSVKQYVESIDVSSYTEEFNVSCLTDSNADTY 269

  Fly  4318 WGKGDFHRLGHGSVDHVRRPKKVAALQGKKIISIATGSLHCVACSD-----------SGEVYTWG 4371
            | :.|..:..|    .||...|...:..|.::::.|        :|           .||    |
  Rat   270 W-ESDGSQCQH----WVRLTMKKGTIVKKLLLTVDT--------TDDNFMPKRVVVYGGE----G 317

  Fly  4372 DN---------DEGQLGDGTV---TAIQRP----RLV--------AALQGKHIVKVTCGSAHTLA 4412
            ||         ||..:||..|   ..:..|    |:|        ..|:|   ||:.......|.
  Rat   318 DNLKKLSDVNIDETLIGDVCVLEDMTVHLPVIEIRIVECRDDGIDVRLRG---VKIKSSRQRELG 379

  Fly  4413 LSTSQLSERLRPLPNPPLEYDLVRDLAPEALHARLILLHHFSELVCPCLAMLPISGDLSLGALKD 4477
            |:.....      |...:.|..:....||.|:.|.:||..|.:::...|..|..:.|.:||...:
  Rat   380 LNADLFQ------PASLVRYPRLEGTDPEVLYRRAVLLQRFIKILDSVLHHLVPAWDHTLGTFSE 438

  Fly  4478 VLVYNIKE----AAFRKVIQTTMVRDKQHGPVIELNRIQVKR----------SRN-RCNGLAGID 4527
              :..:|:    :..|..:.|..:||.:......:.|:.:.|          ||: .|.
  Rat   439 --IKQVKQFLLLSRQRPSLVTQCLRDSESSKPSFMPRLYINRRLAMEHRACPSRDPACK------ 495

  Fly  4528 GMKSVFGQMVQKLPLLTQEALALPHR-------VWKVKFVGESVDDCGGGYSESIAEMCDELQNG 4585
              .:||.|:.:.|....:....|.:|       .|:.||:.|.:.|.|||:.:|:|:|.:||...
  Rat   496 --NAVFTQVYEGLKPSDKYEKPLDYRWPMRYDQWWECKFIAEGIIDQGGGFRDSLADMSEELCPS 558

  Fly  4586 S----VPL-----LINTPNGRGEAGANRDCFLLDPTLSSVLQMNMFRFLGVLMGIAVRTGSPLSI 4641
            |    |||     ..|..||.|||   ||.::.:|   |......:.::|.|||.|:|....|.:
  Rat   559 SADTPVPLPFFVRTANQGNGTGEA---RDMYVPNP---SCRDFAKYEWIGQLMGAALRGKEFLVL 617

  Fly  4642 NLAEPVWRQLTG-EVLRPTDLTEVDRDYVAGLLCIRNMDDDPKLFT-ALELPFSTSSARGHEVPL 4704
            .|...||:||:| ||....|...||...|..|..:..:|.:...|. ..||.|:|..:....|.|
  Rat   618 ALPGFVWKQLSGEEVSWSKDFPAVDSVLVKLLEVMEGVDKETFEFKFGKELTFTTVLSDQQVVEL 682

  Fly  4705 STRYTHI--SPRNRAEYVRLALGFRLHEFDEQVKAVRDGMSKVIPVPLLSLFSAAELQAMVCGSP 4767
            ....|.|  ...:|..:::|....||.|..|||.|::.|:.||:|..:|.|.:..||:..|||.|
  Rat   683 IPGGTGIVVGYEDRLRFIQLVQKARLEESKEQVAAMQAGLLKVVPQAVLDLLTWQELEKKVCGDP 747

  Fly  4768 DIPLGLLKSVATYKGFDPSSALVTWFWEVMEEFTNQERSLFLRFVWGRTRLPRTIADFRGRDFVL 4832
            ::.:..|:.:..::.|:||...|.:|||.:..|||::||.|||||.||:|||..|..:
  Rat   748 EVTVDALRKLTRFEDFEPSDTRVQYFWEALNNFTNEDRSRFLRFVTGRSRLPARIYIY------- 805

  Fly  4833 QVLEKNPPDHF-------LPESYTCFFLLKMPRYSCKAVLLEKLKYAIHFCKSIDTD 4882
                   ||..       ||||.||...|.:|.|:...|..|||:||.:.|.:||||
  Rat   806 -------PDKLGYETTDALPESSTCSSTLFLPHYASAKVCEEKLRYAAYNCVAIDTD 855

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HERC2	NP_608388.2	RCC1	638..683	CDD:278826
		RCC1	687..737	CDD:278826
		RCC1	740..787	CDD:278826
		RCC1	790..841	CDD:278826
		RCC1_2	828..857	CDD:290274
		Cyt-b5	1290..1363	CDD:278597
		MIB_HERC2	1928..1987	CDD:284184
		UBA_HERC2	2515..2559	CDD:270585
		Cul7	2624..2699	CDD:288381
		APC10-HERC2	2762..2932	CDD:176485
		RCC1	3037..3088	CDD:278826
		RCC1	3091..3140	CDD:278826
		RCC1	3144..3194	CDD:278826
		RCC1	3197..3246	CDD:278826
		RCC1	3250..3298	CDD:278826
		RCC1	3302..3350	CDD:278826
		RCC1_2	4136..4166	CDD:290274	2/2 (100%)
		RCC1	4154..4203	CDD:278826	13/46 (28%)
		RCC1	4206..4257	CDD:278826	14/68 (21%)
		RCC1	4260..4309	CDD:278826	13/63 (21%)
		RCC1	4312..4360	CDD:278826	10/47 (21%)
		RCC1	4364..4413	CDD:278826	18/72 (25%)
		HECTc	4509..4880	CDD:238033	131/408 (32%)
		HECTc	4553..4878	CDD:214523	121/351 (34%)
Hectd3	XP_008762291.1	APC10-HECTD3	238..371	CDD:176487	36/152 (24%)
Hectd3	XP_008762291.1	HECT	579..845	CDD:395507	97/285 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820