DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HERC2 and Rccd1

DIOPT Version :9

Sequence 1:	NP_608388.2	Gene:	HERC2 / 33035	FlyBaseID:	FBgn0031107	Length:	4912	Species:	Drosophila melanogaster
Sequence 2:	XP_006229517.1	Gene:	Rccd1 / 308760	RGDID:	1309901	Length:	378	Species:	Rattus norvegicus

Alignment Length:	274	Identity:	80/274 - (29%)
Similarity:	119/274 - (43%)	Gaps:	81/274 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly  3023 HIAGGSKSLFIVSQDGKVYACGE---GTNGRLGLGVTHNVPLPHQLPVLRQYV------------ 3072
            ::|.|:|            |.||   |:..|:|     .:||   ||..|.|:
  Rat   115 NLASGAK------------AQGEDEPGSEPRMG-----TLPL---LPCARAYMTPQPPFCQPLAP 159

  Fly  3073 ---VKKVAVHSGGKHALALTLDGKVFSWGEGEDGKLGHGNRTTLDKPRLVEALRAKKIRDVACGS 3134
               |:::.:  |.:|||.|...|:|||||.|..|:||||:.....:|||:|||:..::.:||.|.
  Rat   160 ELRVRQLQL--GAEHALLLCEAGQVFSWGGGRHGQLGHGSLEAELEPRLLEALQGLRMAEVAAGG 222

  Fly  3135 SHSAAISSQGELYTWGLGEYGRLG----HG-------DNTTQLK--------------------- 3167
            .||..:|..|::|.||..|.|:|.    .|       :..|:|.
  Rat   223 WHSVCVSETGDIYIWGWNESGQLALPTRSGTEKKTVREEATELNDDGLRGEEAALADVGAPAHFI 287

  Fly  3168 -----PKLVTALAGRRVVQVACGSRDAQTLALTEDGAVFSWGDGDFGKLGRGGSEGSDTPHEIER 3227
                 |.|:....|...|:.:||||  .|..:|..|.:::||.|.:|:||...|..||.|..:|.
  Rat   288 AIQPFPALLDLPLGSDAVKASCGSR--HTAVVTRTGELYTWGWGKYGQLGHKDSTSSDQPCRVEY 350

  Fly  3228 L--SGIGVVQIECG 3239
            .  ..:.|..:.||
  Rat   351 FVERQLEVRAVTCG 364

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HERC2	NP_608388.2	RCC1	638..683	CDD:278826
		RCC1	687..737	CDD:278826
		RCC1	740..787	CDD:278826
		RCC1	790..841	CDD:278826
		RCC1_2	828..857	CDD:290274
		Cyt-b5	1290..1363	CDD:278597
		MIB_HERC2	1928..1987	CDD:284184
		UBA_HERC2	2515..2559	CDD:270585
		Cul7	2624..2699	CDD:288381
		APC10-HERC2	2762..2932	CDD:176485
		RCC1	3037..3088	CDD:278826	17/68 (25%)
		RCC1	3091..3140	CDD:278826	23/48 (48%)
		RCC1	3144..3194	CDD:278826	19/86 (22%)
		RCC1	3197..3246	CDD:278826	15/45 (33%)
		RCC1	3250..3298	CDD:278826
		RCC1	3302..3350	CDD:278826
		RCC1_2	4136..4166	CDD:290274
		RCC1	4154..4203	CDD:278826
		RCC1	4206..4257	CDD:278826
		RCC1	4260..4309	CDD:278826
		RCC1	4312..4360	CDD:278826
		RCC1	4364..4413	CDD:278826
		HECTc	4509..4880	CDD:238033
		HECTc	4553..4878	CDD:214523
Rccd1	XP_006229517.1	RCC1_2	163..192	CDD:290274	13/30 (43%)
		RCC1	180..228	CDD:278826	23/47 (49%)
		RCC1_2	218..244	CDD:290274	11/25 (44%)
		RCC1_2	305..333	CDD:290274	11/29 (38%)
		RCC1	321..368	CDD:278826	15/44 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820