Protein Alignment HERC2 and Hectd4

DIOPT Version :9

• Sequence 1: NP_608388.2
• Gene: HERC2 / 33035
• FlyBaseID: FBgn0031107
• Length: 4912
• Species: Drosophila melanogaster
• Sequence 2: XP_038945800.1
• Gene: Hectd4 / 304503
• RGDID: 1309762
• Length: 4432
• Species: Rattus norvegicus
• Alignment Length: 5727
• Identity: 1055/5727 - (18%)
• Similarity: 1720/5727 - (30%)
• Gaps: 2193/5727 - (38%)

  Fly    39 GASGAAAGAGSAAGSGSGSGSGSAAPPSHSPDLYLRPLPFLDAKWLRADLIASLRNAADGAVLWN 103
            |:|.|||.|.:||.:.|                         |:||      |::.  :...|.:
  Rat     2 GSSAAAAAAAAAAAADS-------------------------AQWL------SVKE--ETIFLHD 33

  Fly   104 HLIQDCELVSSPTAPLLNARGQLSYLGDDGKHYCGAQQLKCSCCQPEYCGPLSACNCDGCRPLDS 168
            .||:..:|...|:..|                  ||                         |..:
  Rat    34 GLIRVTDLAELPSEIL------------------GA-------------------------PEAA 55

  Fly   169 DTAIKKLTTQAAAQQAAHLSQATDMVLSGWLWSQPPSQQARLDC--QRSMISELQELALRAAGNC 231
            ||.::.||.:.        ...|::           :::.|..|  |.:..:.|.|..|.|....
  Rat    56 DTDLEILTFET--------KNPTEL-----------AERLRSVCGNQSNAYARLLEYRLNALRGL 101

  Fly   232 LSAQHLRQQLFIYERYFVALKRERERERKSTTSAQAVASVTTANTTIAATTANAAVESQPAEQQA 296
            .:||  ||         :||:.:.|||........|:                  ::.|...||.
  Rat   102 WNAQ--RQ---------LALEEQHEREGSGDEETLAL------------------LKRQGLLQQP 137

  Fly   297 EHGALGLARVATHAALNFSFAFLRRAWRSGEDTEMC---SELLSEALASLQEL-----PEATLFE 353
            |.     |...:...|...|..::.  :|..|..:|   :|:|...|...|.|     |...|..
  Rat   138 EQ-----APFTSRVGLLLVFPLIQS--QSRTDPSLCNITAEVLLNCLRDCQPLSLTKEPADCLSG 195

  Fly   354 AAVVSSLWLEVMERSIKFLRLVALGDPMGNRCTAPLNDRHTALCLLLELGVQKGTLAATLECVVL 418
            ...:...|||....:.:.:               |...:..|...|:.|...:|:|...:..|.|
  Rat   196 IETLLCSWLEETSDTGRHI---------------PHKQKENAAAALVALACARGSLKTFVHTVHL 245

  Fly   419 LLLLWEKDRAGNDNRDMPRKT---GAPLQRILLRYQKI-GATAKGGGIAGGE-----------PA 468
            |                .|:|   ..|:..:|.|...: |.......:.||:           ||
  Rat   246 L----------------QRQTELGSLPVADVLYRLLLLEGGPGSPSCLLGGKHIVSWGYEDMLPA 294

  Fly   469 PVASATETFLRFLSLPKSSAAIVDLRRAAVVIISHLDRMVQPLMPRCLLRGGQATAASSSSAPQQ 533
            |.::           |.||:...|..                 :.|||...|.....::|:.  :
  Rat   295 PDSN-----------PGSSSENKDAD-----------------LGRCLTADGHYLYTTNSAG--R 329

  Fly   534 RIYALGWPSLSKDQQGF------SAEPTLSW----SGESAGVPTL-----SCRFQI---KQVACC 580
            .:..|| ..|....:||      ..||  .|    ||.....|..     ...||:   ..:..|
  Rat   330 GLSKLG-SGLHGTLRGFVYCRNEELEP--GWVAYGSGHLLHRPVSFDNKPHSLFQVIDQNTLQVC 391

  Fly   581 ET--------------QMLILSQEGKLYTWRLAKPEA--EPLPMEEVAHDVFISI---------- 619
            :|              ..:.||.:|..:.| :..|.:  |..|.   .|.||:.|
  Rat   392 QTVPMPASPLPVGSTMSTVHLSSDGTYFYW-IWSPASLNEKTPK---GHSVFMDIFELVVENGVF 452

  Fly   620 -AGHCEGRHFLAIDSNHNAYSWGTGEDHRLGHGDTHARAVPT-KIAALEQHCVQSVYCGCSYSAA 682
             |...:.|..|......:|.|.......||    :..||.|: .:|||....:.:.... ..:|.
  Rat   453 VANPLQERTILMRKEGESAKSINEMLLSRL----SRYRASPSATLAALTGSTISNTLKE-DQAAN 512

  Fly   683 ITCGGNLLTWGR------GTYARL------GHGNSDDRSLPTLVVALSDHMVVDVALGSGDAHSL 735
            .:||..|.|..|      |||..:      |.|:|..|||               ..|:....||
  Rat   513 TSCGLPLKTLRRTPMYTCGTYLVMLVPPPGGSGSSATRSL---------------FGGTSGLSSL 562

  Fly   736 ALTSEGLVFAWGDGDYGK-------LGNGNCNGSLQPILVESLPRVQRVFAGSQFSVALSSEGQL 793
            .:.:..||:...||.:..       .|:....|:|.|.|......|..:.
  Rat   563 KILASSLVYNISDGQFASRADLIDAAGSSLGRGALVPGLGACYDTVNNML--------------- 612

  Fly   794 YTWGKATCL----------GHQLVERSVQGCSVPRLVSSLQHKRIVDVAVSVAHCLALSSSGEVF 848
              |   ||.          |:|......|...|..::...:.:.|              |:.||.
  Rat   613 --W---TCSNDYIDQWCNPGNQAFHYVCQRLGVSHIIPEPKEEAI--------------STNEVI 658

  Fly   849 GWGRNDSQQICPASVSSEPLLRTPILVSLPTFPASGIACTSAQSLVWTQSSHQGVPRRAPFVVDL 913
            ....:....:|        :.:..:|.:.|..|.:.:          ....|....|....:.|:
  Rat   659 NQLLHHVGAMC--------IHQLNLLATNPNLPITSV----------LGKQHPIEARHLSSICDI 705

  Fly   914 GEPTFRLLDQLLGMCSSQDNRQTPNQESECIAVACLNLFRLQLLALIANGVEPRQVGLASGSRLL 978
            .|             .:..|..|      ||....|.:|::......:...|..:..:.....||
  Rat   706 ME-------------KAMVNGDT------CIVRCILVVFQVVFKFFFSPQTERNRDIIRRSGLLL 751

  Fly   979 CSLKTRILGLAGGSQVLRTIQVAAQQALQDGWSVLLPTAAERAQTLTSLLPSEPGQASSAGHRFM 1043
            ..|.     :|...|:...||.....|:..|.::|.|...| ...|..|:.:| |:.:| |...:
  Rat   752 WQLL-----MAPKDQICPEIQKEVCLAISSGLNILYPGETE-INNLLKLVLTE-GERNS-GLSQL 808

  Fly  1044 TDLLVSSLMAEGGLESALQHAIRLESSSCSADCGDGVHL--PLLQLITRLLSNNAALSQTRLSPT 1106
            .|:::::|            |.:|:::...:|..|...|  .||..|.:::...:.:..|:.
  Rat   809 RDVILTNL------------AEQLQNNRFGSDEDDHYRLNDELLHYILKIVVRESCILITKC--- 858

  Fly  1107 LGKQQEKEEEEREQQHQEPSTSPSLSLLHRFQRLLLSHIHQAQPEE----------ETTGAEAL- 1160
               |...:::.::.....|:.|..|..|...|..|||:....:|::          ||...:.|
  Rat   859 ---QTVSKDDFQKLLSTVPAASSCLRYLMAVQNHLLSNTVLIKPDDNEDSDSSLQGETLKVQELK 920

  Fly  1161 --LLQYMHALIPACVATLQKAHELA-------LQCREPGENSFGQ-----MVGHLGRVLQADI-- 1209
              :|.....::..|...|:...::.       :..||.......|     |:|||..||...:
  Rat   921 TSILALATQVLTGCDEVLEMLQQVTTALINSDMPDREQRLKGLEQVTKATMLGHLLPVLLTSLMH 985

  Fly  1210 --------SDALLNELL-------VGLLLLKRDRP--------QCLGGLRWARLFLPLLRVLDRL 1251
                    :|||:.:|:       ...||||...|        .|....:..||| |..|:|:..
  Rat   986 PNLQTLTMADALMPQLVQLVLYTSQTALLLKTQCPVFAEVGCSPCGTSDQKCRLF-PDERMLEEK 1049

  Fly  1252 NRALGEGELRDGDDMGWPGIICRGGPKGGPPPADPET----HYVRRAD----MENLLLDGSRCII 1308
            ..               ||.:.  |.|...|.|..:|    |.||  |    .|.:.:.|:||:.
  Rat  1050 EE---------------PGFLT--GLKIPAPWAAGKTVETVHPVR--DNYKFKETVHIPGARCLY 1095

  Fly  1309 L-------AGYVCDLS-------------GYNCESETL------------RSVLDSGLGKDLT-A 1340
            |       :.|..|.|             |.|..|..:            ||||.:|..|||. .
  Rat  1096 LRFDTRCSSQYDYDKSNGLFSVLKLVIYAGPNTNSRKVAEYGGNTLGYGSRSVLGTGWPKDLVKV 1160

  Fly  1341 EMSSQVHRTAMEHILEHHKLGKYM--------VQASTEEKSS--------APGPSRLTHFSSECA 1389
            |..:......|....||:...|.|        .|.|:|:.|.        |.|.|.|.     |:
  Rat  1161 EGDTVTFSFEMRSGREHNTPDKAMWGFACTVRAQESSEDVSGGLPFLVDLALGLSVLA-----CS 1220

  Fly  1390 LAQLLGLVANLMCSGPALQPAELQCRQLDKSSLL--------SGGL--QLLQPS-NP----FDEE 1439
            :.::|       .:||.:...|..|:.|.:|.||        :.|:  ..|.|| :|    .:|:
  Rat  1221 MLRIL-------YNGPEITKEEEACQDLLRSKLLQRCQWQVEANGVISPALTPSPSPLPLTIEED 1278

  Fly  1440 KGEARSSHSCHSTAGN----TPTELPPPLPMQQQLAPGRGKSQLQLRADAFISGLAEARVSEPPV 1500
            :.....|.......||    ....|||.:.::.:...||.:.|.:    ..|..:.:..|.|..|
  Rat  1279 REFTYPSDVLVPPVGNYFDLPRIRLPPGIMIKLREISGRARPQFR----PSIKEVIQPDVMEEMV 1339

  Fly  1501 AA----WLALTERYCKAHNLMWHQEFATEHPVQELERLLSAVLIRHQYLGGLVLNALETEVPPPR 1561
            .:    .|.|.:......|..:.:|.|.|:.:  |.:::.....:        |||:|      |
  Rat  1340 VSCVIKHLNLVDALQSLINFQYQEEHAEEYDL--LCKIMGETFKK--------LNAME------R 1388

  Fly  1562 QLGEIIRLVHQAKW-----SVVRTRQQLNR--------------------SYKEVC--APILERL 1599
            ||..:..|  :.||     ..::.:.:.|.                    |.|||.  ...||.:
  Rat  1389 QLQSVAEL--EQKWQSEAEDAMQGKLENNMPFFYDYHFNENKMKELELLCSMKEVSFDGNDLENM 1451

  Fly  1600 RFLLYEVRPAISPQQRGLRRLPILQRPP-----RFKMLVRRLLQELRSSRQPAKPEDLLNASIQQ 1659
                     .:|.:::.|:.:..|.:.|     :.|.||:.|:.         :.|.||:.:|
  Rat  1452 ---------VLSLREKFLQEVNSLTQKPSHPLAKTKTLVKSLMN---------RAELLLHVTI-- 1496

  Fly  1660 EQEKKPQSMPKQELEEQEEEETLLRRLNERQIHGEGELDPALMQDI---VDFALQDSCDVETAR- 1720
                ..||...:.:.....|....:..:|.::.......|..::.:   .|..:..:.|:|..|
  Rat  1497 ----AAQSGLTRSISGTPAETPACKSASETKVASHAVRQPVFLRSMSAPSDLEMIGNEDLEFTRA 1557

  Fly  1721 --RAMYCQMQRYQLRLAGLQIVQQLLELHGLLDAAQYSLLNG----FLGLHLKSTSSGG------ 1773
              .:::|:.:......:....:.|.|.:....|...||:|.|    |:|.:.....|..
  Rat  1558 NQSSVFCRRRHVTSHRSSSFTLLQSLAIEDSRDKPTYSVLLGQLFAFIGTNPDQAVSSSSFLLAA 1622

  Fly  1774 ------GSTGS----------------GSSLHVLGQLNMI--------------------SAYQK 1796
                  |:|..                |...|::|.:.|:                    .|:.:
  Rat  1623 QTRWRRGNTRKQALVHMRELLTAAVRVGGVTHLVGPVTMVLQGGPRIEELTCGGMVEQVQEAFGE 1687

  Fly  1797 ---------ARLLLA------------------QSRVLDWAVRELRRLVNQEQQGHARGKDSTNL 1834
                     ||..:|                  :..|....|:.:.||.:...|..:...:...
  Rat  1688 TMTSVVSLCARYPIACANSIGLLCTIPYTRSEEKCLVRSGLVQLMDRLCSLSSQTESSSSEKQT- 1751

  Fly  1835 GTYVLLKRLPRARFLLSVFGLLA--------KELGPNELGFLINSGLLGTVLGLLAQ-------- 1883
                  |:...|....:.|.:||        :|.|..|   .::|||...|..||..
  Rat  1752 ------KKQKVATMAWAAFQVLANRCVEWEKEEGGSTE---AVHSGLARQVSSLLTNHLARATEC 1807

  Fly  1884 TGGEGATGGQVHGELSILYEDSVLKQKSSKAQLSGPDLA--------------KLMKIGTRIVRG 1934
            .|.:.|....:...||:|  :.:.:....||.||.|...              ||:.|..::.|.
  Rat  1808 CGNQAAGNDALQDVLSLL--NDLSRSHIGKAILSQPACVSKLLSLLLDQRPSPKLVLIILQLCRA 1870

  Fly  1935 A---------------DWKWG--------DQDGNP-----------------PGEGRIISEVGED 1959
            |               .|.:.        :...:|                 ||...::|....:
  Rat  1871 ALPLMSVEDCGNVELPPWSYSVPSLNSEQEDPSDPASKIASLLLAKLADYVVPGCQTVLSPTASE 1935

  Fly  1960 GWVRVEWYTGATNSYRMGKEGQYDLQLADSALNVASPTEPEREDVSGSEA-SP---TSDSHPSKL 2020
            ....:. .|...||.:..|:...:.:..|..|::..   .:|||.|..|. .|   :|:..|.:|
  Rat  1936 PDTTLT-KTSPKNSLKGDKDPGEESEAVDGKLSIFI---HKREDQSSHEVLQPLLSSSEGRPFRL 1996

  Fly  2021 LRHCAAKLLQILAVGTGLH---GAQLDKDALRGMTSMFRTIIYPKPSMSNISYALGWLNLGFIRA 2082
                          |||.:   ..::|:|..:|....    :..:.:.:.:..|..|...|.|.:
  Rat  1997 --------------GTGANMEKVVKMDRDMTKGGCCE----VITEEASAALRKATKWAQSGLIVS 2043

  Fly  2083 ISGDCPRLCLELSTPGWLSHYLSLLEQPAGNEAGVYRQLHCLRLLQLILAQWGAEEEPRMPALVH 2147
            :...     :|...|..:|. ||..::....:..:.|:    |..:|      |..:|..|.:
  Rat  2044 VGPP-----VESINPETVSG-LSTGDKKKTAQTSICRE----RNSEL------ARTDPVRPFI-- 2090

  Fly  2148 QLFATLGRIALHCPGDASLLPTAEGKARVLLTASHSGSVAEELVALLRRLHTLPS------WNPV 2206
                 .|.:|                          .|:|.|::|||..|...|.      |...
  Rat  2091 -----SGHVA--------------------------NSMAAEVIALLHSLLMAPESNAAQIWTTT 2124

  Fly  2207 INSFLAQKLCVA------AELLAEQSHSTA-----LDSEQVFVLGVLGAMGGHDLRPRVG----- 2255
            ....|::.|...      ||.:.|...|:.     |.......:..|.|:||.....::|
  Rat  2125 AEKVLSRALMYIPQLGKYAESILENGSSSGRKLAKLQRIARQAVAALCALGGFKETIKIGSEVQV 2189

  Fly  2256 LHCFHEGSHMVIASFTPKGRCLLAPGGVGSGVGFVKVQLPAV-----MPHLDHTVFSLSR----- 2310
            |.....||..|:||             :....|...|:.|.|     ....|.....|||
  Rat  2190 LGRGISGSIGVVAS-------------INEQEGIATVRFPPVDCRRTSQAADTLTIPLSRLCVPR 2241

  Fly  2311 ---LPMN-----EMLLNAWTVLLYGPAPEL---RELPSSADGRLD-LALLRAQQLQMAVLHTNGV 2363
               ||::     |.::.|...:|......|   ..||::.||... :|::|.    :|.:.|...
  Rat  2242 SEALPLHKLSITEKVVQAVQSMLLPQEGSLSIHTSLPATGDGSAPVMAVVRL----LAEIRTRAC 2302

  Fly  2364 LYRHQVALRRILKQRAPGSIYASPDEPDRSDAESQQPGEQD------QQLSSGSGQEPQLLIQCI 2422
            |         ::.|....|::.       .:...|.|...:      |:.|:|. :...:.:||.
  Rat  2303 L---------VMAQLLEDSLFC-------EEFIQQCPAAVEVLNLVAQECSAGE-RLAVVEVQCE 2350

  Fly  2423 LLR------------ATQAS----------------PVKACYSYMDLATAALNCIQSLATQAHQE 2459
            .||            ..||.                ||:||     :.::.|..:..||     :
  Rat  2351 RLRMLYRDCARPPPPPLQADRRQPKEITWSPSRVFPPVRAC-----MFSSHLTSVTFLA-----D 2405

  Fly  2460 LSEGGGVPPNGRALSSPPQPTMVHG------VPVYNVARKEQKP------SEQVEQKS------- 2505
            .|.|||:|......::.|.|.....      :..|.....:..|      :.:.|::.
  Rat  2406 PSAGGGLPRGTFIYATSPLPVQAPSFYWEIEIVSYGDTDDDTGPIVSFGFATEAEKRDGAWTNPV 2470

  Fly  2506 --------------------KWPAAATDAQLI-GQIMEMGFTRR--------------------- 2528
                                :|.:...|..|. |.:..:|:.|.
  Rat  2471 GTCLFHNNGRAVHYNGSSLLQWKSVRLDVTLCPGDVAGIGWERTEGTPPPPGQPAKGRVYFTYCG 2535

  Fly  2529 ----------------TVELALKQLSLQAEIMPTPEQIVQWILEH--PDVCANTIEE-----DTL 2570
                            .|.:..|....:|.....|....:.....  .|:|.:..||     :.|
  Rat  2536 QRLTPYLEDVSGGMWPVVHIQKKNTKTRANFGSRPFAYAEGQAHRNAADLCTDLAEEISANFEAL 2600

  Fly  2571 PLASSASSHDPEADSDNECPSS----------------NSTTSSSTSSDT-------VEGQPMAV 2612
            |.|.:       :||||:..:|                .:|......|||       :..:....
  Rat  2601 PFAMA-------SDSDNDAGTSIASDPGTHGPPCRIAAVATAQQQYDSDTSCHYKVELSYENFIT 2658

  Fly  2613 SGP---APPVKFESRKDFQTADL-----YALYVR----------------------GL------- 2640
            |||   .||:..:...|....|:     |||.|:                      ||
  Rat  2659 SGPDPHPPPIADDESDDDDDDDIPQEDHYALLVKAWETKVFPTIRRRFRNEAERKSGLDQIKGAL 2723

  Fly  2641 ---------------------------------------------VRPGMT-VRCCRDFEEIKQG 2659
                                                         ||.|:| |....|...:...
  Rat  2724 QLGMVDIARQTVEFLYEENGGIPRDLYLPTIEDIKDEANKFTIDKVRKGLTVVTRSPDSSNVASS 2788

  Fly  2660 DMGTVL-------IVDTEGLHDLNVQVD-----------WRNHG--STYWVCFVHIELVEAAQTH 2704
            .:||.|       ::.|.|||.:.:.||           .|:.|  ..||   ..|:::|
  Rat  2789 AVGTALPKFAIRGMLKTFGLHGVVLDVDSVNELVQVETYLRSEGVLVRYW---YPIDMLE----- 2845

  Fly  2705 HQPRPPP----IAVGARVRLRTSSL---RYGMLCPLRLGRSQGSSAIGVVSSVRSKQLTVDFPDQ 2762
               |||.    .|....|.|..::|   |..:.|...|.|.....|:..:.:.:...|.......
  Rat  2846 ---RPPAGYRRTATNGLVTLDNTNLQIHRELLRCEAALARLYCRMALLNIFAPKLPHLFTRLFHI 2907

  Fly  2763 PAWQG-HINEVELVASQPTSATLPSLGDSCSQMPPSDLIEDWSRCIRSLTVSSNEAAAKHLLNGS 2826
            ||.:. .:..::|:::|..:..||....|.|.:.   |.:....||.|.:.|:.:.    ...|:
  Rat  2908 PAIRDITLEHLQLLSNQLLAPPLPDGTISSSSIL---LAQSLQHCIHSQSCSATDL----FYQGN 2965

  Fly  2827 NQPWQSCSSGPCRHWIRLELHDRILVHSLTLKVSPEDHSHMPSLLEIRVGDCVDSLKEYTWIPVP 2891
            :|        ..|.|             |::.::...|....||||:....|.
  Rat  2966 SQ--------TLREW-------------LSVAITRTLHQGEDSLLELTKQICA------------ 2997

  Fly  2892 AGASRVLLMQQVPTYYPWVEVVVKQCQNNGIQCKIHGIKFVGRRQQPDLQHILANAQFLASEYSA 2956
                   .:|..|..:|..|..|.:                                   |:.|.
  Rat  2998 -------FLQTAPEQFPSEEFPVSE-----------------------------------SKVSM 3020

  Fly  2957 GVGPGSTAGAGAVSTSHEEAAAAPEQDLP------CTVMVWGLNDK-EQLGGLKGSKVKVPTFSQ 3014
            .|   :..||..|..|.:|:.:...:|..      ..|:|:||..| ::.|.|  :.::...:.:
  Rat  3021 DV---NFPGAAFVVVSCKESQSGFRKDSSLYKAPWARVLVYGLGHKVKRTGQL--NLIEAACYPR 3080

  Fly  3015 TIS----RLRPIHIAGGSKSLFIVSQDGKVYACGEGTNGRLGLGVTHNVPLP------HQLPVLR 3069
            ..|    .|.|...|....|: ::|.| ||:         :.|||:   |.|      |.||:
  Rat  3081 DASPANTGLAPPPTADQYPSV-VLSTD-KVH---------IKLGVS---PPPGAVLVLHSLPL-- 3129

  Fly  3070 QYVVKKVAVHSGGKHALALTLDGKVFSW-GEGEDGK-------------------LGHGNRTTLD 3114
                         :..||:....::.|| .|..:||                   ||:...|| |
  Rat  3130 -------------EFPLAMAFAEQLLSWKSEDSEGKSEDEPDSIPTSVLLHVVELLGNFLWTT-D 3180

  Fly  3115 K----PRLVEALRAKKIRDVAC--GSSHSAAISSQGELYTWGLGEYGRLGHGDNTTQLKPKLVTA 3173
            .    ..||..|.|:.:|.|..  ...|.|.:||...|                  ||.|.|
  Rat  3181 MAACVKELVFHLLAELLRTVHTLEQRKHPAGLSSSIAL------------------QLNPCL--- 3224

  Fly  3174 LAGRRVVQVACGSRDAQTLALTEDGAVFSWGDGDFGKLGRGGSEGSDTPHEIERLSGIGVVQIEC 3238
                           |..:||          ..:..||....::|             .|....|
  Rat  3225 ---------------AMLMAL----------QSELHKLYDEETQG-------------WVSSSTC 3251

  Fly  3239 GAQFSLALTRAGEVWTWGKGDYYRLGHGGDQHVRKPQPIGGLRGRRVIHVAVGALHCLAVTDAGQ 3303
            |...:.|:...|...|:    ::.|..|                            ||||.
  Rat  3252 GGSGAAAVGDQGRFSTY----FHALMEG----------------------------CLAVA---- 3280

  Fly  3304 VYAWGDNDHGQQGSGNTFVNKKPALVIGLDAVFVNRVACGSSHSIAWGLPNASSDEEKRGPVPFS 3368
                                         :......::..:|...:...||.|.........|..
  Rat  3281 -----------------------------EVTLPTNISVTASGVTSTTTPNLSDSSSSSSSSPGQ 3316

  Fly  3369 STRDPLGGSSLGIYEAETMQTLKQEAKPLNQSSL---SESLALETPAARQAALGHVLRAMSILQA 3430
            :.:.|   |.|...:...|:..|..:....|||.   ::|..|....::...:....||:::|
  Rat  3317 TPQSP---SLLSKRKKVKMKREKASSSNKRQSSRATDADSTVLSIGGSKPEDMLWFHRALTLL-- 3376

  Fly  3431 RQLIVAALTSHSKVNFKERGAVGGEEDHL------IGGP--------IMGAPLQLAETIAQGG-- 3479
              :|:..||.      |:...:|...|.:      :.||        |.|.|..|.|.:.:|.
  Rat  3377 --IILRHLTK------KDPQGLGVTSDAIADACQALVGPTAHSRLLVISGIPTHLDEAVVRGAIR 3433

  Fly  3480 ------GEAPADATDAGLQEHSPEAAVDALTGGMSGGANTLPPLSAGPLSAFQSLTGSLSMSGSL 3538
                  |....|.....||:..|:...|...||.|       .:.:..|..|.|:.   |:.||.
  Rat  3434 KACNAHGGVFKDEIYIPLQDEDPKRPKDKAEGGDS-------KVESEKLLGFPSVD---SLEGST 3488

  Fly  3539 SSSALPQHKHSRMSASAMSVMAATMTQQEEMLSHISHCHGLDDFGGLLGEPEAKSLVELLKLAVC 3603
            |||..|          |||:.|:..|.|..:.|  |.|
  Rat  3489 SSSLAP----------AMSISASASTSQASVCS--SQC--------------------------- 3514

  Fly  3604 GRCGPPSTSQTIADTLISLGAGTPAVAAMLLETCITELEDLCTSRHCLGKLP-KPVMQESSHPYV 3667
                   .|||.:|..:.     |..:.:                    :|| .||:.|   |:|
  Rat  3515 -------VSQTASDLSVD-----PLPSGL--------------------ELPVPPVLLE---PHV 3544

  Fly  3668 DNVNVTGVVRIPGAEMLRLEFDSQCSTEKRNDPLVIMDGTGRVLAMRSGREFAHWAPEIRVLGDE 3732
                      :...|.|.:   |.|||
  Rat  3545 ----------VSSQESLDI---SLCST-------------------------------------- 3558

  Fly  3733 LRWKFSSDSSVNGWGWRFWVHAIMPAATLGESGSDRAVLSQPSMALVMSLLDSRLAPRQPSVLLR 3797
                                      .:||..||    |.:|        ||:   |...||
  Rat  3559 --------------------------GSLGSLGS----LGEP--------LDN---PETASV--- 3579

  Fly  3798 LASALAACSQLGALTTAQRIWSLRKLHAVLLLEQAPRPQDPSLSTLLQPLIPELLRQYEYEEPQV 3862
                    |.:|::.|.                       .||.|  |||....::.:...|.:.
  Rat  3580 --------SDVGSMYTV-----------------------TSLDT--QPLTTRPIKGFAVVEIRS 3611

  Fly  3863 RGGIHLMHSDYFKT-----LAAL-----ACDMQLDAALPATSSSSS---SSAAPGAISSTGDVHK 3914
            |..|..:.:..|..     |::|     ..:|..:..|..:..:.|   :..:||......|
  Rat  3612 RAKIEKVRASLFNNNDLIGLSSLDGEEELMEMSTEEILTVSVVNQSLFDTQGSPGLEDYFND--- 3673

  Fly  3915 WAWFKRYCIAVRVAQSLIRRTELPRAFCLEVRKKFAEMLPSSSSNSNANPGCQSPGASMLNSTTS 3979
                          :|:.....:|.|     |:...|:..|.:.:               ..|.|
  Rat  3674 --------------KSIKGEKLVPGA-----REVLTEIFKSCAHS---------------EQTLS 3704

  Fly  3980 LSSSTVSNVSPPPGITGEQPDLHCHAHQLESTS--TLLHEDHTLFQAPH---DAQLLQWLNRRPD 4039
            |:.:....||          |::....|:.|.:  .|||...|..:.|.   :.||.|.|.:
  Rat  3705 LTPAKPIRVS----------DIYLSKEQINSQTPGNLLHLFFTNVRPPKKVLEDQLTQILRK--- 3756

  Fly  4040 DWALSWGGASTIYGWGHNHRGQLGGLEGSRIKTPTPCEALSLLRPVQLAGGEQSLFAVTPDGKLF 4104
                        ||                                            .|..||.
  Rat  3757 ------------YG--------------------------------------------VPKPKLD 3765

  Fly  4105 ATGYGSGGRLGVGGSDSWAIPTLLGSLQHVFVKKVAVNSGGKHCLALTTEGEVYAWGEGEDGKLG 4169
            .:.|...|:                 .||. ||.|
  Rat  3766 KSKYSKAGK-----------------EQHP-VKVV------------------------------ 3782

  Fly  4170 HGNRMSYDRPKLVEHLNGMSVADIACGSAHSAAITASGHVLTWGKGRYGRLGHGDSEDQLRPKLV 4234
                 |..||             :....|...|:.:|          ..|....:.:..::||..
  Rat  3783 -----STKRP-------------VTKPPAKDKAVLSS----------LSRTALSEKKPTVKPKSP 3819

  Fly  4235 EALLGYRAIDIACGSGDAQTLCITDDDNVWSWGDGDYGKLGRGGSDGCKLPYKIESLAGLGVVKV 4299
            |                                     |......|..|.|.|.:.:.....:.:
  Rat  3820 E-------------------------------------KSKPDEKDPEKSPTKKQEVPEEKYLTL 3847

  Fly  4300 ECGSQFSVALTKSG------AVYTWGKG-DFHRLGHGSVDHVRRPKKVAALQGK----------- 4346
            |...:|.:...|..      |:.:.|.. .|.|.....|.|.::..:..||:..
  Rat  3848 EGFHKFVIDRAKQDIRSVWRAILSCGYDLHFERCACIDVRHAQKASRKWALEMDVALVQYINRLC 3912

  Fly  4347 KIISIATGSLHCVACSDSGEVYTWGDNDEGQLGDGTVTAIQRPRLVAALQGKHIVKVTCGSAHTL 4411
            :.::|....||      ..|||.    |.....|        ||:..
  Rat  3913 RHLAITPARLH------PHEVYL----DPADATD--------PRMAC------------------ 3941

  Fly  4412 ALSTSQLSERLRPLPNPPLEYDLVRDLAPEALHARLILLH--------HFSELVCPCLAMLPISG 4468
                         |.|.|:          |:|..|..||.        .|..||  .|...|:..
  Rat  3942 -------------LSNVPI----------ESLRLRFALLQSLNTTLETFFLPLV--ELRQTPMYA 3981

  Fly  4469 DLSLGAL----KDVLVYNIKEAAFRKVIQTTMVRDKQH-GPVIELNRI-----QVKRSRNRCNGL 4523
            . |:.||    |.::.|:.|.....:|:..|:.|...| .|.|.|:.:     :::.|.|
  Rat  3982 H-SIAALLKEAKGLIFYDTKVTVMNRVLNATVQRTADHAAPEITLDPLETVGGEIRASEN----- 4040

  Fly  4524 AGIDGMKSVFGQMVQKLPLLTQEALAL-------PHRVWKVKFVGESVDDCGGGYSESIAEMCDE 4581
                   |.|.|..::|..:....|.:       |...:.::|.||.|....|.:...:.::|.|
  Rat  4041 -------SYFCQAARQLASVPSSQLCVKLASGGDPTYAFNIRFTGEEVHGTSGSFRHFLWQVCKE 4098

  Fly  4582 LQNGSVPLLINTPNGRGEAGANRDCFLLDPTLSSVLQMNMFRFLGVLMGIAVRTGSPLSINLAEP 4646
            ||:.|:.||:..|:  .....|:..::|.|:..:..:..:..|||.|:|||:|...||.::|...
  Rat  4099 LQSSSLSLLLLCPS--SAVNKNKGKYILTPSPITYGEEQLLHFLGQLLGIAIRADVPLPLDLLPS 4161

  Fly  4647 VWRQLTGEVLRP-TDLTEVD---RDYVAGLLCIRNMDDDPKL----------FTALELP------ 4691
            .|:.|.||.|.| .||.|.|   .:||..   ..:::|:.:|          ..|.:.|
  Rat  4162 FWKTLVGEPLDPDQDLQEADILTYNYVKK---FESINDESELEALCAEIASQHLATDSPEGPKPC 4223

  Fly  4692 --FSTSSARGHEVPLSTRYTHI--SPRNRAEYVRLALGFRLHEFD--EQVKAVRDGMSKVIPVPL 4750
              |:..:..|.||.|.:|..||  :..|:..|.......||.|..  |.|.|||.|:..:||:.|
  Rat  4224 CRFTYLTMTGEEVELCSRGRHIPVAWENKDIYAAAIRSLRLRELQNMECVTAVRAGLGSIIPLQL 4288

  Fly  4751 LSLFSAAELQAMVCGSPDIPLGLLKSVATYK-GFDPSSALVTWFWEVMEEFTNQERSLFLRFVWG 4814
            |:..|..|::...||.|.:.|..||:...|: |...:...:..||..:|.||.:|...|::|...
  Rat  4289 LTTLSPLEMELRTCGLPYVNLEFLKAHTMYQVGLMETDQHIELFWGALETFTQEELCKFIKFACN 4353

  Fly  4815 RTRLPRTIADFRGRDFVLQV----LEKNPPDHFL--PES-----YTCFFLLKMPRYSCKAVLLEK 4868
            :.|:|.|.....|......|    ::..|||...  |:|     .||.|::|:|:||...::|||
  Rat  4354 QERIPFTCPCKDGGPDTAHVPPYPMKIAPPDGTAGPPDSRYIRVETCMFMIKLPQYSSLEIMLEK 4418

  Fly  4869 LKYAIHF 4875
            |:.|||:
  Rat  4419 LRCAIHY 4425

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HERC2	NP_608388.2	RCC1	638..683	CDD:278826	10/45 (22%)
		RCC1	687..737	CDD:278826	15/61 (25%)
		RCC1	740..787	CDD:278826	10/53 (19%)
		RCC1	790..841	CDD:278826	8/60 (13%)
		RCC1_2	828..857	CDD:290274	4/28 (14%)
		Cyt-b5	1290..1363	CDD:278597	26/109 (24%)
		MIB_HERC2	1928..1987	CDD:284184	11/98 (11%)
		UBA_HERC2	2515..2559	CDD:270585	8/83 (10%)
		Cul7	2624..2699	CDD:288381	28/174 (16%)
		APC10-HERC2	2762..2932	CDD:176485	29/170 (17%)
		RCC1	3037..3088	CDD:278826	12/56 (21%)
		RCC1	3091..3140	CDD:278826	18/74 (24%)
		RCC1	3144..3194	CDD:278826	6/49 (12%)
		RCC1	3197..3246	CDD:278826	6/48 (13%)
		RCC1	3250..3298	CDD:278826	6/47 (13%)
		RCC1	3302..3350	CDD:278826	1/47 (2%)
		RCC1_2	4136..4166	CDD:290274	3/29 (10%)
		RCC1	4154..4203	CDD:278826	4/48 (8%)
		RCC1	4206..4257	CDD:278826	5/50 (10%)
		RCC1	4260..4309	CDD:278826	7/48 (15%)
		RCC1	4312..4360	CDD:278826	11/65 (17%)
		RCC1	4364..4413	CDD:278826	7/48 (15%)
		HECTc	4509..4880	CDD:238033	116/417 (28%)
		HECTc	4553..4878	CDD:214523	108/361 (30%)
Hectd4	XP_038945800.1	SPRY_HECT_like	2414..2569	CDD:293970	14/154 (9%)
		HECTc	4034..4427	CDD:421431	116/409 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910