Protein Alignment HERC2 and Wwc1

DIOPT Version :9

• Sequence 1: NP_608388.2
• Gene: HERC2 / 33035
• FlyBaseID: FBgn0031107
• Length: 4912
• Species: Drosophila melanogaster
• Sequence 2: XP_002727807.1
• Gene: Wwc1 / 303039
• RGDID: 1308329
• Length: 1108
• Species: Rattus norvegicus
• Alignment Length: 1039
• Identity: 207/1039 - (19%)
• Similarity: 340/1039 - (32%)
• Gaps: 370/1039 - (35%)

  Fly  1719 ARRAMYCQMQRYQLRLAGLQIVQQ-LLELHGLLD---AAQYSLLNGFLGLHLKSTSSGGGSTGSG 1779
            |:.|:..|.:.||::...|::.|| ..:||.:.:   .:|.||::|       |:||
  Rat   103 AQEALSAQKEIYQVKQQRLELAQQEYQQLHAVWEHKLGSQVSLVSG-------SSSS-------- 152

  Fly  1780 SSLHVLGQLNMISAYQ----KARLLLAQSRVLDWAVRELRRLVNQEQQGHARGKDSTNLGTYVLL 1840
                        |.|.    ||.:..|:||     |.:|:|     :..|
  Rat   153 ------------SKYDPEILKAEIATAKSR-----VNKLKR-----EMVH--------------- 180

  Fly  1841 KRLPRARFLLSVFGLLAKELGPNELGFLINSGLLGTVLGLLAQTGGEGATGGQVHGELSILYEDS 1905
                           |..||...|.||        ..|..:.:...:...|.::....::|.|..
  Rat   181 ---------------LQHELQFKERGF--------QTLKKIDERMSDAQGGYKLDEAQAVLRETK 222

  Fly  1906 VLKQKSSKAQLSGPDLAK---LMKIGTRIVRGADWKWGDQDGNPPGEGRIISEVGEDGWVRVEWY 1967
            .:|:..:..:....||.|   ::|.|.|..||:.                 |::         |.
  Rat   223 AIKKAITCGEKEKQDLIKSLAMLKDGFRTDRGSH-----------------SDL---------WS 261

  Fly  1968 TGA---TNSYRMGKEGQYDLQLADSALNVASPTEPEREDVSGSEASPTSDSHPSKL---LRHCAA 2026
            :.:   ::|:.:.|:          .|:|:|.|     |:|||.::.:|:....|:   ||:..|
  Rat   262 SSSSLESSSFPVPKQ----------FLDVSSQT-----DISGSFSTSSSNQLAEKVRLRLRYEEA 311

  Fly  2027 K------LLQILAVGTGLHGAQLDKDALRGMTSMFR---TIIYPKPSMSNISYALGWLNLGFIRA 2082
            |      .:|:         |:||.:|..|:....|   .:|..|..:           |..:|.
  Rat   312 KRRIANLKIQL---------AKLDSEAWPGVLDSERDRLILINEKEEL-----------LKEMRF 356

  Fly  2083 ISGDCPRLCLELSTPGWLSHYLSLLEQ---------PAGNEAGVYRQLHCLRL----LQLILAQW 2134
            ||   ||        .|....:..||.         .|..:.........|:|    .||:..
  Rat   357 IS---PR--------KWTQGEVEQLEMARRRLEKDLQAARDTQSKALTERLKLNSKRNQLVRE-- 408

  Fly  2135 GAEEEPRMPALVHQLFATLGRIALHCPGDASLLPTAEGKARVLLTASHSGSVAEELVALLRRLHT 2199
             .||..|..|.:|....:|         .:|:...:.|.:...||:|.....|..|.:......|
  Rat   409 -LEEATRQVAALHSQLKSL---------SSSMQSLSSGSSPGSLTSSRGSLAASSLDSSTSASFT 463

  Fly  2200 LPSWNPVINSFLAQKLCVAAELLAEQSHSTALDSE---QVFVLGVLGAMGGHDLRPRVGLHCFHE 2261
            ...::|.                 ||     ||||   :|.:|.:.||.|   .||...:...||
  Rat   464 DLYYDPF-----------------EQ-----LDSELPSKVELLFLEGATG---FRPSGCITTIHE 503

  Fly  2262 -----------GSHMVI---ASFTPKGRCLLAPGG----------------VGSGVGFVKVQLPA 2296
                       ||.:..   .|.||:....|:|..                :.:|..|: ..|..
  Rat   504 DEVAKTQKAEGGSRLQALRSLSGTPRSMTSLSPRSSLSSPSPPCSPLIADPLLAGDAFL-TPLEF 567

  Fly  2297 VMPHLDHTVFSLS--------RLPMNEMLLNAWTVLLYGPAPE---LRELPSSADG-RLDLALLR 2349
            ....|..|:..||        |..:.|            |.||   |.:..|.|.| .|.:|.:.
  Rat   568 EDTELSPTLCELSLGTDGARERFRLEE------------PGPEGKPLGQAASVAPGCGLKVACVS 620

  Fly  2350 AQQLQMAVLHTNGVLYRHQVALRRILKQRAPGSIYASPDEPDRSDA--------------ESQQP 2400
            |.....:|...:||   ::.:::|:      |:..|:..:.|.|:|              :|:|.
  Rat   621 AAVSDESVAGDSGV---YEASMQRL------GTSEAAAFDSDESEAVGVTQVQIALKYDEKSKQF 676

  Fly  2401 GEQDQQLSSGSG----QEPQLLIQCILLRATQAS-------PVKAC------------YSYMDLA 2442
            .....|||:.|.    |:.::.|:..:|..:::|       |:.:.            .||..|.
  Rat   677 AILVIQLSNLSALLLQQDQKVNIRVAILPCSESSTCLFRTRPLDSADSLVFNEAFWVSMSYPALH 741

  Fly  2443 TAALNCIQSLATQAHQELSEGGGVPPNGRALSSPPQPTMVHGVPVYNVARKEQKPSEQVEQKSKW 2507
            ...|........::|.|...||..........|..:.|..:.:..|...:|:.:..:..|.....
  Rat   742 QKTLRVDVCTTDRSHTEECLGGAQISLAEVCRSGERSTRWYNLLSYKYLKKQGREPQPAEAPGPD 806

  Fly  2508 PAAATDAQLIGQIMEMGFTRRTVELALKQLSLQAEIMPTPEQIVQ--WILEHPDVCANTI----- 2565
            ...|..|.|         .:..|||..:|....:      .|.::  |..|. :...|..
  Rat   807 HVDAVSALL---------EQTAVELEKRQEGRSS------SQTLEGSWTYEE-EASENEAVAEEE 855

  Fly  2566 -------EEDTLPLASSASSHDPEADSDNECPS----SNSTTSSSTSSDT-VEGQPMAVSGPAP 2617
                   |||..     |....|||:   |||:    ..:.|.|.|.|.| |..:...|..|:|
  Rat   856 EREEEEGEEDVF-----AEKVSPEAE---ECPALKVDRETNTDSVTPSPTVVRPKDRRVGAPSP 911

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HERC2	NP_608388.2	RCC1	638..683	CDD:278826
		RCC1	687..737	CDD:278826
		RCC1	740..787	CDD:278826
		RCC1	790..841	CDD:278826
		RCC1_2	828..857	CDD:290274
		Cyt-b5	1290..1363	CDD:278597
		MIB_HERC2	1928..1987	CDD:284184	8/61 (13%)
		UBA_HERC2	2515..2559	CDD:270585	8/45 (18%)
		Cul7	2624..2699	CDD:288381
		APC10-HERC2	2762..2932	CDD:176485
		RCC1	3037..3088	CDD:278826
		RCC1	3091..3140	CDD:278826
		RCC1	3144..3194	CDD:278826
		RCC1	3197..3246	CDD:278826
		RCC1	3250..3298	CDD:278826
		RCC1	3302..3350	CDD:278826
		RCC1_2	4136..4166	CDD:290274
		RCC1	4154..4203	CDD:278826
		RCC1	4206..4257	CDD:278826
		RCC1	4260..4309	CDD:278826
		RCC1	4312..4360	CDD:278826
		RCC1	4364..4413	CDD:278826
		HECTc	4509..4880	CDD:238033
		HECTc	4553..4878	CDD:214523
Wwc1	XP_002727807.1	WW	9..39	CDD:238122
		WW	55..84	CDD:278809
		ALDH-SF	378..>420	CDD:299846	9/44 (20%)
		C2_Kibra	661..784	CDD:176062	21/122 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900