DRSC/TRiP Functional Genomics Resources

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Protein Alignment HERC2 and Arel1

DIOPT Version :9

Sequence 1:NP_608388.2 Gene:HERC2 / 33035 FlyBaseID:FBgn0031107 Length:4912 Species:Drosophila melanogaster
Sequence 2:NP_001100214.1 Gene:Arel1 / 299197 RGDID:1307597 Length:823 Species:Rattus norvegicus


Alignment Length:494 Identity:104/494 - (21%)
Similarity:194/494 - (39%) Gaps:96/494 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly  4436 RDLAPEALHARLILLHHFSELVCP-----CLAMLPISGDLSL---GALKDVLVYNIKEAAFRKVI 4492
            :..:.:..:.::|....::..|||     .|...|:...|:|   ..::..:..:.||   |.::
  Rat   360 KQFSVKEFYLKIIPWRLYTFRVCPGTKFSYLGPDPVHKLLTLVVDDGIQPPVELSCKE---RNIL 421

  Fly  4493 QTTMVR-------------DKQHGPVIELNRIQVKRSRNRCNGLAGIDGMKSVFGQMVQKLPLLT 4544
            ..|.:|             ||.:....||.::.:||..::..       :|      |.:..||.
  Rat   422 AATFIRSLHKNIGGSETFQDKVNFFQRELRQVHMKRPHSKVT-------LK------VSRHALLE 473

  Fly  4545 QEALALPH-------RVWKVKFVGESVDDCGGGYSESIAEMCDELQNGSVPLLIN-TPNGRGEAG 4601
            ....|..:       :.::|.|..|...|.||...|....:|..|.:.:..|... :.|.:....
  Rat   474 SSLKATRNFSISDWSKNFEVVFQDEEALDWGGPRREWFELICKALFDTTSQLFTRFSDNNQALVH 538

  Fly  4602 ANRDCFLLDPTLSSVLQMNMFRFLGVLMGIAVRTGSPLSINLAEPVWRQLTGEVLRPTDLTEVDR 4666
            .|       |...:.|::.|:.|.|.|:|              :.::....|...:........|
  Rat   539 PN-------PNRPAHLRLKMYEFAGRLVG--------------KCLYESSLGGAYKQLVRARFTR 582

  Fly  4667 DYVAGLLCIRN-----MDDDPKLF------------TALELPF-----STSSARGHEVPLST--R 4707
            .::|.::.:|.     ..|||:.:            :.:||.|     :.|......|.|.|  .
  Rat   583 SFLAQIIGLRMHYKYFETDDPEFYKSKVCFILNNDMSEMELVFAEEKYNKSGQLDKIVELMTGGA 647

  Fly  4708 YTHISPRNRAEYVRLALGFRL-HEFDEQVKAVRDGMSKVIPVPLLSLFSAAELQAMVCGSPDIPL 4771
            .|.::..|:..|:.|...:|| .:..|:|:....|:::::|..||::|...||:.::||:.||.:
  Rat   648 QTPVTNANKTFYLNLLAQYRLASQVKEEVEHFLKGLNELVPENLLAIFDENELELLMCGTGDISV 712

  Fly  4772 GLLKSVATYKG--FDPSSALVTWFWEVMEEFTNQERSLFLRFVWGRTRLPRTIADFRGRDFVLQV 4834
            ...|:.|...|  :.....::.|||.|:...|.:|.:..|:|..|.::||.  ..|.......|:
  Rat   713 SDFKAHAVVVGGSWHFREKVMRWFWTVVSSLTQEELARLLQFTTGSSQLPP--GGFAALCPSFQI 775

  Fly  4835 LEKNPPDHFLPESYTCFFLLKMPRYSCKAVLLEKLKYAI 4873
            :.. |....||.::|||..|.:|.|.....:...|:.||
  Rat   776 IAA-PTHSTLPTAHTCFNQLCLPTYDSYEEVHRMLQLAI 813

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HERC2NP_608388.2 RCC1 638..683 CDD:278826
RCC1 687..737 CDD:278826
RCC1 740..787 CDD:278826
RCC1 790..841 CDD:278826
RCC1_2 828..857 CDD:290274
Cyt-b5 1290..1363 CDD:278597
MIB_HERC2 1928..1987 CDD:284184
UBA_HERC2 2515..2559 CDD:270585
Cul7 2624..2699 CDD:288381
APC10-HERC2 2762..2932 CDD:176485
RCC1 3037..3088 CDD:278826
RCC1 3091..3140 CDD:278826
RCC1 3144..3194 CDD:278826
RCC1 3197..3246 CDD:278826
RCC1 3250..3298 CDD:278826
RCC1 3302..3350 CDD:278826
RCC1_2 4136..4166 CDD:290274
RCC1 4154..4203 CDD:278826
RCC1 4206..4257 CDD:278826
RCC1 4260..4309 CDD:278826
RCC1 4312..4360 CDD:278826
RCC1 4364..4413 CDD:278826
HECTc 4509..4880 CDD:238033 87/400 (22%)
HECTc 4553..4878 CDD:214523 80/349 (23%)
Arel1NP_001100214.1 Filamin 56..154 CDD:395505
HECTc 486..820 CDD:214523 80/352 (23%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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