DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HERC2 and Bag3

DIOPT Version :9

Sequence 1:	NP_608388.2	Gene:	HERC2 / 33035	FlyBaseID:	FBgn0031107	Length:	4912	Species:	Drosophila melanogaster
Sequence 2:	NP_038891.4	Gene:	Bag3 / 29810	MGIID:	1352493	Length:	577	Species:	Mus musculus

Alignment Length:	318	Identity:	67/318 - (21%)
Similarity:	104/318 - (32%)	Gaps:	78/318 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly  2327 GPAPELRELPSSADGRLDLALLRAQQLQMAVLHTNGVLYRHQVALRRILKQRAPG--SIYASPD- 2388
            ||:.:...|....:|......||...:.:.|||...             :.|.|.  ..|:.|.
Mouse    70 GPSRDGSRLLPIREGHPIYPQLRPGYIPIPVLHEGS-------------ENRQPHLFHAYSQPGV 121

  Fly  2389 EPDRSDAESQQPGEQDQQLSSGSGQEPQLLIQCILLRAT----QASPVKACYSYMDLATAALNCI 2449
            :..|::|.:..|......|..|..:..|...||..:.||    .|.|..|.......:.||.:|.
Mouse   122 QRFRTEAAAATPQRSQSPLRGGMTEAAQTDKQCGQMPATATTAAAQPPTAHGPERSQSPAASDCS 186

  Fly  2450 QSLATQAHQELSEGGGVPPNGR-ALSSPPQPTMVHGVPV---YNVARKEQKPSEQVEQKSKWPAA 2510
            .|         |....:|.:|| :|.|...|.....:||   .|:.|...:||....||:.:||.
Mouse   187 SS---------SSSASLPSSGRSSLGSHQLPRGYIPIPVIHEQNITRPAAQPSFHQAQKTHYPAQ 242

  Fly  2511 ATDAQLIGQIMEMGFTRRTVELALKQLSLQAEIMPTPEQIVQWILEHPDVCANTIEEDTLPLASS 2575
            ..:.|                               |:|.|...::..|       .:..||.::
Mouse   243 QGEYQ-------------------------------PQQPVYHKIQGDD-------WEPRPLRAA 269

  Fly  2576 ASSHDP--EADSDNECPSSNSTTSSSTSSDTV-----EGQPMAVSGPAPPVKFESRKD 2626
            :....|  .|.|....|:.:.|.....|...|     ..|||....|.|..:.|::.:
Mouse   270 SPFRSPVRGASSREGSPARSGTPVHCPSPIRVHTVVDRPQPMTHREPPPVTQPENKPE 327

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HERC2	NP_608388.2	RCC1	638..683	CDD:278826
		RCC1	687..737	CDD:278826
		RCC1	740..787	CDD:278826
		RCC1	790..841	CDD:278826
		RCC1_2	828..857	CDD:290274
		Cyt-b5	1290..1363	CDD:278597
		MIB_HERC2	1928..1987	CDD:284184
		UBA_HERC2	2515..2559	CDD:270585	4/43 (9%)
		Cul7	2624..2699	CDD:288381	0/3 (0%)
		APC10-HERC2	2762..2932	CDD:176485
		RCC1	3037..3088	CDD:278826
		RCC1	3091..3140	CDD:278826
		RCC1	3144..3194	CDD:278826
		RCC1	3197..3246	CDD:278826
		RCC1	3250..3298	CDD:278826
		RCC1	3302..3350	CDD:278826
		RCC1_2	4136..4166	CDD:290274
		RCC1	4154..4203	CDD:278826
		RCC1	4206..4257	CDD:278826
		RCC1	4260..4309	CDD:278826
		RCC1	4312..4360	CDD:278826
		RCC1	4364..4413	CDD:278826
		HECTc	4509..4880	CDD:238033
		HECTc	4553..4878	CDD:214523
Bag3	NP_038891.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..81		3/10 (30%)
		WW	23..55	CDD:197736
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	126..207		22/89 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	229..427		26/137 (19%)
		BAG	426..503	CDD:214591
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	524..577
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900