DRSC/TRiP Functional Genomics Resources

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Protein Alignment HERC2 and Wwp1

DIOPT Version :9

Sequence 1:NP_608388.2 Gene:HERC2 / 33035 FlyBaseID:FBgn0031107 Length:4912 Species:Drosophila melanogaster
Sequence 2:XP_006237992.1 Gene:Wwp1 / 297930 RGDID:1311734 Length:968 Species:Rattus norvegicus


Alignment Length:437 Identity:114/437 - (26%)
Similarity:188/437 - (43%) Gaps:64/437 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly  4493 QTTMVRDKQH--------GPVIELNRI---QVKRSRNRCNGLAGIDGMK------SVFGQMVQKL 4540
            :||..:|.::        ||.|...|.   ::...|..|...|....:|      ::|....|::
  Rat   566 RTTTFKDPRNGKSSVTKGGPQIAYERSFRWKLAHFRYLCQSNALPSHVKINVSRQTLFEDSFQQI 630

  Fly  4541 PLLTQEALALPHRVWKVKFVGESVDDCGGGYSESIAEMCDELQNGSVPLLINTPNGRGEAGANRD 4605
            ..|  :...|..|:: |.|.||...|.||...|....:..|:.|....|.       ..||.|..
  Rat   631 MAL--KPYDLRRRLY-VIFRGEEGLDYGGLAREWFFLLSHEVLNPMYCLF-------EYAGKNNY 685

  Fly  4606 CFLLDPTLSSVL---QMNMFRFLGVLMGIAVRTGSPLSINLAEPVWRQLTGEVLRPTDLTEVDRD 4667
            |..::|  :|.:   .::.|.|:|..:.:|:..|..:....:.|.::::..:.|...||..:|.:
  Rat   686 CLQINP--ASTINPDHLSYFCFIGRFIAMALFHGKFIDTGFSLPFYKRMLSKKLTIKDLESIDTE 748

  Fly  4668 YVAGLLCIR--NMDDDPKLFTALELPFST-----SSARGHEVPLSTRYTHISPRNRAEYVRLALG 4725
            :...|:.||  |:::     ..||:.||.     .....|::.|......::..|:.||:.|...
  Rat   749 FYNSLIWIRDNNIEE-----CGLEMYFSVDMEILGKVTSHDLKLGGSNILVTEENKDEYIGLMTE 808

  Fly  4726 FRLHE-FDEQVKAVRDGMSKVIPVPLLSLFSAAELQAMVCGSPDIPLGLLKSVATYKGFDPSSAL 4789
            :|... ..||.||..||.::|:|:..|..|...||:.|:||..::.|...:....|:.:..:|..
  Rat   809 WRFSRGVQEQTKAFLDGFNEVVPLQWLQYFDEKELEVMLCGMQEVDLADWQRNTVYRHYTRNSKQ 873

  Fly  4790 VTWFWEVMEEFTNQERSLFLRFVWGRTRLP-RTIADFRGRDFVLQ-VLEKNPPDHFLPESYTCFF 4852
            :.|||:.::|..|:.|...|:||.|..||| ...|:..|.:...: .:||...|.:||.|:|||.
  Rat   874 IIWFWQFVKETDNEVRMRLLQFVTGTCRLPLGGFAELMGSNGPQKFCIEKVGKDTWLPRSHTCFN 938

  Fly  4853 LLKMPRYSCKAVLLEKLKYAIHFCKSIDTDEYARVAMGEPTEATGSE 4899
            .|.:|.|.....|.|||.:||                 |.||..|.|
  Rat   939 RLDLPPYKSYEQLKEKLLFAI-----------------EETEGFGQE 968

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HERC2NP_608388.2 RCC1 638..683 CDD:278826
RCC1 687..737 CDD:278826
RCC1 740..787 CDD:278826
RCC1 790..841 CDD:278826
RCC1_2 828..857 CDD:290274
Cyt-b5 1290..1363 CDD:278597
MIB_HERC2 1928..1987 CDD:284184
UBA_HERC2 2515..2559 CDD:270585
Cul7 2624..2699 CDD:288381
APC10-HERC2 2762..2932 CDD:176485
RCC1 3037..3088 CDD:278826
RCC1 3091..3140 CDD:278826
RCC1 3144..3194 CDD:278826
RCC1 3197..3246 CDD:278826
RCC1 3250..3298 CDD:278826
RCC1 3302..3350 CDD:278826
RCC1_2 4136..4166 CDD:290274
RCC1 4154..4203 CDD:278826
RCC1 4206..4257 CDD:278826
RCC1 4260..4309 CDD:278826
RCC1 4312..4360 CDD:278826
RCC1 4364..4413 CDD:278826
HECTc 4509..4880 CDD:238033 103/392 (26%)
HECTc 4553..4878 CDD:214523 94/337 (28%)
Wwp1XP_006237992.1 C2_E3_ubiquitin_ligase 67..190 CDD:175988
PARM 243..>400 CDD:293666
WW 397..426 CDD:278809
WW 429..458 CDD:278809
WW 504..533 CDD:278809
WW 545..574 CDD:238122 3/7 (43%)
HECTc 614..966 CDD:238033 102/385 (26%)
HECTc 637..965 CDD:214523 98/359 (27%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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