DRSC/TRiP Functional Genomics Resources

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Protein Alignment HERC2 and Wwp2

DIOPT Version :9

Sequence 1:NP_608388.2 Gene:HERC2 / 33035 FlyBaseID:FBgn0031107 Length:4912 Species:Drosophila melanogaster
Sequence 2:NP_001099654.1 Gene:Wwp2 / 291999 RGDID:1310091 Length:870 Species:Rattus norvegicus


Alignment Length:322 Identity:93/322 - (28%)
Similarity:145/322 - (45%) Gaps:55/322 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly  4600 AGANRDCFLLDPTLSSVL--QMNMFRFLGVLMGIAVRTGSPLSINLAEPVWRQLTGEVLRPT--D 4660
            ||.|..|..::|. ||:.  .:..|||:|..:.:|:..|..:......|.::::..:  |||  |
  Rat   582 AGKNNYCLQINPA-SSINPDHLTYFRFIGRFIAMALYHGKFIDTGFTLPFYKRMLNK--RPTLRD 643

  Fly  4661 LTEVDRDYVAGLLCIR--NMDDDPKLFTALELPF-----STSSARGHEVPLSTRYTHISPRNRAE 4718
            |..:|.::...::.|:  |:|:     ..|||.|     .......||:........::..|:.|
  Rat   644 LESIDPEFYNSIIWIKENNLDE-----CGLELFFIQDMEILGKVTTHELKEGGENIRVTEENKEE 703

  Fly  4719 YVRLALGFRL-HEFDEQVKAVRDGMSKVIPVPLLSLFSAAELQAMVCGSPDIPLGLLKSVATYKG 4782
            |:.|...:|. ...:||.||..||.::|.|:..|..|...||:.|:||..:|.:...:..|.|:.
  Rat   704 YIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDEKELELMLCGMQEIDMSDWQKNAIYRH 768

  Fly  4783 FDPSSALVTWFWEVMEEFTNQERSLFLRFVWGRTRLPRTIADFRGRDFVLQVLEKNPPDHF---- 4843
            :..||..:.|||:|::|..|::|...|:||.|..|||  :..|      .:::..|.|..|    
  Rat   769 YTKSSKQIQWFWQVVKEMDNEKRIRLLQFVTGTCRLP--VGGF------AELIGSNGPQKFCIDR 825

  Fly  4844 ------LPESYTCFFLLKMPRYSCKAVLLEKLKYAIHFCKSIDTDEYARVAMGEPTEATGSE 4899
                  ||.|:|||..|.:|.|.....|.|||.|||                 |.||..|.|
  Rat   826 VGKETWLPRSHTCFNRLDLPPYKSYEQLKEKLLYAI-----------------EETEGFGQE 870

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HERC2NP_608388.2 RCC1 638..683 CDD:278826
RCC1 687..737 CDD:278826
RCC1 740..787 CDD:278826
RCC1 790..841 CDD:278826
RCC1_2 828..857 CDD:290274
Cyt-b5 1290..1363 CDD:278597
MIB_HERC2 1928..1987 CDD:284184
UBA_HERC2 2515..2559 CDD:270585
Cul7 2624..2699 CDD:288381
APC10-HERC2 2762..2932 CDD:176485
RCC1 3037..3088 CDD:278826
RCC1 3091..3140 CDD:278826
RCC1 3144..3194 CDD:278826
RCC1 3197..3246 CDD:278826
RCC1 3250..3298 CDD:278826
RCC1 3302..3350 CDD:278826
RCC1_2 4136..4166 CDD:290274
RCC1 4154..4203 CDD:278826
RCC1 4206..4257 CDD:278826
RCC1 4260..4309 CDD:278826
RCC1 4312..4360 CDD:278826
RCC1 4364..4413 CDD:278826
HECTc 4509..4880 CDD:238033 88/301 (29%)
HECTc 4553..4878 CDD:214523 88/299 (29%)
Wwp2NP_001099654.1 C2_E3_ubiquitin_ligase 17..142 CDD:175988
WW 302..331 CDD:278809
WW 332..361 CDD:278809
WW 407..435 CDD:278809
WW 447..477 CDD:238122
HECTc 516..868 CDD:238033 91/318 (29%)
HECTc 539..867 CDD:214523 91/317 (29%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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