DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HERC2 and Nedd4l

DIOPT Version :9

Sequence 1:	NP_608388.2	Gene:	HERC2 / 33035	FlyBaseID:	FBgn0031107	Length:	4912	Species:	Drosophila melanogaster
Sequence 2:	XP_038952600.1	Gene:	Nedd4l / 291553	RGDID:	735047	Length:	1259	Species:	Rattus norvegicus

Alignment Length:	1529	Identity:	296/1529 - (19%)
Similarity:	499/1529 - (32%)	Gaps:	484/1529 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly  3513 TLPPLS--------AGPLSAFQSLTGSLSMSGSLSSSALPQHKHSRMSASAMSVMAATMTQQEEM 3569
            |||..|        ||..|..|...|:|..|   ||..:||         .::.:.|..|:...|
  Rat    37 TLPRRSSPHPFTQNAGEDSGLQEGVGALKRS---SSMFIPQ---------LLAGVDARPTRSSSM 89

  Fly  3570 LSHISH--CHGLDDFGGLLGEPEAKSLVELLKLAVCGRCGPPSTSQTIADTLISLGAGTPAVAAM 3632
            ...:..  ..|..|..|....|:.:               |||....:.|.     |....|:|.
  Rat    90 KISLQRKAADGATDSCGPQEGPDDR---------------PPSAQGDLGDQ-----AAATRVSAQ 134

  Fly  3633 LLETCITELEDLCTSRHCLGKLPKPVMQESSHPYVDNVNVTGVVRIPGAEMLRLEFDSQCSTEKR 3697
            :                           .||.|        ..|..||:...|..:
  Rat   135 I---------------------------GSSEP--------SPVDTPGSSPPRAAW--------- 155

  Fly  3698 NDPLVIMDGT--GRVLAMRSGREFAHWAPEIRV----LGDELR----WKFSSDSSVNGWGWRFWV 3752
             ||..:::||  .|..:.|...:.....|.:|:    ...::|    ..|..|.....   |.|.
  Rat   156 -DPGTLVNGTCDHRGPSPRLAEDTEEATPGLRIQHRASSADVRQVRLLPFGPDGQAEP---RRWS 216

  Fly  3753 HAIMPAATLGESGSDRAV--LSQPSMALV----------MSLLDSRLAPRQPSVLLRLASALAAC 3805
            ...:|.|: |.||....|  |.||....|          ......||. |.|.:.|..:::....
  Rat   217 LQHVPDAS-GSSGKRCFVFQLQQPHQGTVGLGSDFNFGFTGTKGDRLV-RYPRIRLERSTSYPTQ 279

  Fly  3806 SQLGALTTAQRIWSLRKLHAVLLLEQAPRPQDPSLSTLLQPLIPELLRQYEYEEPQVRGGIHLMH 3870
            .:.|.::..:...:         .|.:||           .::||:.|......||..|.:..:.
  Rat   280 PRAGRVSPTEDRGT---------PEASPR-----------RMVPEIRRTNSERTPQSPGCMFKIR 324

  Fly  3871 SD------YFKTLAALACDMQLDAALPATSSSSSSSAAPGAISSTGD------------------ 3911
            .|      :|:.|....    .:.|......:..|...||....|.|
  Rat   325 QDQNAGQQHFRILVTRG----PEEAPQNQEETPKSPGHPGTGVPTRDDFLGQVDVPLSHLPTEDP 385

  Fly  3912 -VHKWAWFKRYCIAVRVAQSLIRRTELPRAFCLEVRKKFAEMLPSSSSNSNANPGCQSP---GAS 3972
             :.:...||.:.:..|..:|.:      :.|   :|.|.|.| |.:......|...:..   |..
  Rat   386 TMERPYTFKDFLLRPRSHKSRV------KGF---LRLKMAYM-PKNGGQDEENSEQRDDMEHGWE 440

  Fly  3973 MLNSTTSLSSSTVSNVSPPPGITG--EQPD--------------LHCHAHQLESTSTLLHEDHTL 4021
            :::|..| :|.....:.|||...|  |:.|              ...|...|...|:  ..|:.:
  Rat   441 VVDSNDS-ASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRSTQWHRPSLMDVSS--ESDNNI 502

  Fly  4022 FQAPHDAQLLQWLNRR-------PDDWALSWGGASTIYGWGH-NHRGQLGGLEGSRIKTPTPCEA 4078
            .|...:|...::.:||       |:   .|.||......|.. :....:.|...|....|.|...
  Rat   503 RQINQEAAHRRFRSRRHISEDLEPE---ASEGGGEGPEPWETISEEVNMAGDSLSLALPPPPASP 564

  Fly  4079 LSLLRPVQLAGGEQSLFAVTPD--GKLFAT--GYGSGGRLGVGGSDSWAIPTLLGSLQHV----- 4134
            :|...|.:|:........:|||  |:.|:.  ......||     .|.::...:....|:
  Rat   565 VSRTSPQELSEELSRRLQITPDSNGEQFSALIQREPSSRL-----RSCSVTDTVAEQAHLPPPST 624

  Fly  4135 ---FVKKVAVNSGGKHCLAL----TTEGEVYAWGEGEDGK-----LGHGNR-MSYDRPKLVEHLN 4186
               ..:...|..|.:...::    ||.|....|.|.:|.|     :.|.|| .::.||
  Rat   625 PTRRARSSTVTGGEESTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRP------- 682

  Fly  4187 GMSVADIACGSAHSAAITASGHVLTWGKGRYGRLGHGDSEDQL-RPKLVEALLGYRAIDIAC--- 4247
               :..:|...|..:|..::.|::               |.|: ||:    .|....:.::.
  Rat   683 ---IMQLAEDGASGSATNSNNHLV---------------EPQIRRPR----SLSSPTVTLSAPLE 725

  Fly  4248 GSGDAQTLCITDD--DNVWSWGDGDYGKLGRGGSDGCKLPYKI-ESLAGLGVVKVECGSQFSVAL 4309
            |:.|:.......|  .|..|.....|        :..|..:|: :|....|         :.:.:
  Rat   726 GAKDSPIRRAVKDTLSNPQSPQPSPY--------NSPKPQHKVTQSFLPPG---------WEMRI 773

  Fly  4310 TKSGAVYTWGKGDFHRLGHGSVDHVRRPKKVAALQGKKIISIATGSLHCVACSDSGEVYTWGD-- 4372
            ..:|..:             .:||                              :.:..||.|
  Rat   774 APNGRPF-------------FIDH------------------------------NTKTTTWEDPR 795

  Fly  4373 ---------------NDEGQLGDGTVTAIQRPRLVAALQGK-----HIVKVTCGSAHT---LALS 4414
                           ||.|.|..|....|.       |.|:     |..:|.||...|   :.|.
  Rat   796 LKFPVHMRSKASLNPNDLGPLPPGWEERIH-------LDGRTFYIDHSSQVLCGENDTRESVPLY 853

  Fly  4415 TSQLSERLRP-LPNPPLEYDLVRDLAPEALHARLILLHHFSELVCPCLAMLPISGDLSLGALKDV 4478
            .|::::...| |.||.:       ..|...::|     .|.:
  Rat   854 DSKITQWEDPRLQNPAI-------TGPAVPYSR-----EFKQ----------------------- 883

  Fly  4479 LVYNIKEAAFRKVIQTTMVRDKQHGPVIELNRIQVKRSRNRCNGLAGIDGMKSVFGQMVQKLPLL 4543
                 |...|||         |...|....||.::|..||            ::|.:..::: :.
  Rat   884 -----KYDYFRK---------KLKKPADIPNRFEMKLHRN------------NIFEESYRRI-MS 921

  Fly  4544 TQEALALPHRVWKVKFVGESVDDCGGGYSESIAEMCDELQN-----------GSVPLLINTPNGR 4597
            .:....|..|:| ::|..|...|.||...|....:..|:.|           .:..|.||..:|.
  Rat   922 VKRPDVLKARLW-IEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGL 985

  Fly  4598 GEAGANRDCFLLDPTLSSVLQMNMFRFLGVLMGIAVRTGSPLSINLAEPVWRQLTGEVLRPTDLT 4662
                .|.|            .::.|.|:|.:.|:||..|..|......|.::.:.|:.:...|:.
  Rat   986 ----CNED------------HLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDME 1034

  Fly  4663 EVDRDYVAGLLCIRNMDDDPKLFTALELPF---STSSARGHEVPLSTRYTHI--SPRNRAEYVRL 4722
            .||.:|...|..|  :::||   |.|:|.|   ..:..:.::|.|....:.|  :..|:.||:.|
  Rat  1035 SVDSEYYNSLKWI--LENDP---TELDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDL 1094

  Fly  4723 ALGFR-LHEFDEQVKAVRDGMSKVIPVPLLSLFSAAELQAMVCGSPDIPLGLLKSVATYK-GFDP 4785
            .:.:| ::...:|:.|..:|.::::|:.|:.:|...||:.::||..|:.:...:..:.|| |:.|
  Rat  1095 VIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCP 1159

  Fly  4786 SSALVTWFWEVMEEFTNQERSLFLRFVWGRTRLPRT-IADFRGRDFVLQVLEKNPPDHF------ 4843
            :..::.|||:.:.....::|...|:||.|.:|:|.. .|:..|         .|.|..|
  Rat  1160 NHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYG---------SNGPQLFTIEQWG 1215

  Fly  4844 ----LPESYTCFFLLKMPRYSCKAVLLEKLKYAI 4873
                ||.::|||..|.:|.|.....|.|||..|:
  Rat  1216 SPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAV 1249

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HERC2	NP_608388.2	RCC1	638..683	CDD:278826
		RCC1	687..737	CDD:278826
		RCC1	740..787	CDD:278826
		RCC1	790..841	CDD:278826
		RCC1_2	828..857	CDD:290274
		Cyt-b5	1290..1363	CDD:278597
		MIB_HERC2	1928..1987	CDD:284184
		UBA_HERC2	2515..2559	CDD:270585
		Cul7	2624..2699	CDD:288381
		APC10-HERC2	2762..2932	CDD:176485
		RCC1	3037..3088	CDD:278826
		RCC1	3091..3140	CDD:278826
		RCC1	3144..3194	CDD:278826
		RCC1	3197..3246	CDD:278826
		RCC1	3250..3298	CDD:278826
		RCC1	3302..3350	CDD:278826
		RCC1_2	4136..4166	CDD:290274	7/33 (21%)
		RCC1	4154..4203	CDD:278826	12/54 (22%)
		RCC1	4206..4257	CDD:278826	8/54 (15%)
		RCC1	4260..4309	CDD:278826	8/51 (16%)
		RCC1	4312..4360	CDD:278826	3/47 (6%)
		RCC1	4364..4413	CDD:278826	16/73 (22%)
		HECTc	4509..4880	CDD:238033	96/394 (24%)
		HECTc	4553..4878	CDD:214523	89/350 (25%)
Nedd4l	XP_038952600.1	C2	<365..418	CDD:417471	10/61 (16%)
		WW	463..489	CDD:395320	4/25 (16%)
		WW	653..682	CDD:395320	7/28 (25%)
		WW	766..796	CDD:238122	7/81 (9%)
		WW	815..865	CDD:197736	13/56 (23%)
		HECTc	926..1255	CDD:214523	90/355 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900