DRSC/TRiP Functional Genomics Resources

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Protein Alignment HERC2 and Zzef1

DIOPT Version :9

Sequence 1:NP_608388.2 Gene:HERC2 / 33035 FlyBaseID:FBgn0031107 Length:4912 Species:Drosophila melanogaster
Sequence 2:XP_006246919.1 Gene:Zzef1 / 287476 RGDID:1311189 Length:2965 Species:Rattus norvegicus


Alignment Length:2657 Identity:518/2657 - (19%)
Similarity:848/2657 - (31%) Gaps:1009/2657 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly  2738 SQGSSAIGVVSSV--------RSKQLTVDFPDQPAWQGHINEVELVASQPTSATLPSL------- 2787
            |:....:|..||:        |...:.:.:|    ...|.|.:..:.|.....:|..|       
  Rat   173 SESKEGLGTHSSMILRFLHRNRVSSMVIPYP----MLDHCNNMCTMRSSVLKDSLDQLLQKEKES 233

  Fly  2788 -GDSCSQMPPSDLIEDWSRCIRSLTVSSNEAAAKHLLNG-SNQPWQSCSSGPCR-HWIRLELHDR 2849
             || .::.|..|.::..::|...:..|||.|....:.|| ::..||  |.|..| |||||::...
  Rat   234 PGD-LARSPEMDKLKSVTKCYAYIETSSNPADIYRMTNGETSSYWQ--SDGSARSHWIRLKMKPD 295

  Fly  2850 ILVHSLTLKVSPEDHSHMPSLLEIRVGDCVDSLKEYTWIPVPAGAS-RVLLMQQVPTYYPWVEVV 2913
            :::..|::.|:..|.|:||..:.:.||.....|:|...:.:|:..: .|.|::.......:|::.
  Rat   296 VVLRHLSIAVAATDQSYMPQQVTVAVGRSASDLQEVRDVHIPSNVTGYVTLLENANISQLYVQIN 360

  Fly  2914 VKQCQNNGIQCKIHGIKFVGRRQQPD-------------------------------LQHILANA 2947
            :|:|.::|...:|||::.||.::...                               :|.:|.|.
  Rat   361 IKRCLSDGCDTRIHGLRAVGFQRVKKSGVSVSDASAIWYWSLLTSLVTASMETNPAFVQTVLHNT 425

  Fly  2948 Q-FLASEYSAGVGPGSTAGAGAVSTSHEE-----------AAAAPEQDLPCTVMVWGLNDKEQLG 3000
            | .|.......:.||||..:..:|.:..|           ..:.||.:|  |::.:.|       
  Rat   426 QKALQHMPPLSLSPGSTDFSTFLSPNVLEEVDSFLIRITSCCSTPEVEL--TLLAFAL------- 481

  Fly  3001 GLKGSKVKVPTFSQTISRLRPIHIAGGSKSLFIVSQDGKVYACGEGTNGRLGLGVTHNVPLPHQL 3065
             .:||..||.:....||.    |:.....:..::|....|         |..|.:.:..||  ||
  Rat   482 -ARGSIAKVMSSLCAISD----HLDTQYDASSLISSMASV---------RQSLLLKYGKPL--QL 530

  Fly  3066 PVLRQYVVKKVAVHSGGKHALALTLDGKVFSWGEGEDGKL---GHGNRTTLDKPRLVEALRAKKI 3127
             .|:...||.....||.::.|       |..|  ..||.|   |....:|:.......|.:..:|
  Rat   531 -TLQACDVKGKEDKSGPENLL-------VEPW--TRDGFLTETGKTRASTIFSAGTESAFQVTQI 585

  Fly  3128 R--------DVACG----------SSHSAAISSQGELY-TWGLGEYGRLGHGDNTTQLKPKLVTA 3173
            |        ...||          ..|:.....:.|.| .|.|.|.                   
  Rat   586 RIMVRRGGIGAQCGLVFAYNSPSDKFHAEEHFKRFEKYDRWKLQEL------------------- 631

  Fly  3174 LAGRRVV--QVACGSRDAQTLALTEDGAV------FSWGDGDFGKLGRGGSEGSDTPHEIERLSG 3230
               |:.|  ::.|...|     |.||..:      ..|.:.|. ||.:.            |::.
  Rat   632 ---RQFVKSRIGCSPDD-----LGEDDPIGWFELEEEWDEADV-KLQQC------------RVAK 675

  Fly  3231 IGVVQIECGAQFSLALTRAGEVWTWGKGDYYRLGHGGDQHVRKPQPIGGLR-GRRVIHVAVGALH 3294
            ..:|:..|..|.|..                |||      |:.....|.|| .|.....::...|
  Rat   676 FLMVKFLCTRQESAE----------------RLG------VQGLSISGYLRPARAEAEQSILYAH 718

  Fly  3295 CLAVTDAGQVYAWGDNDHG-----------QQGSGNTFVNKKPAL-------VIGLD-AVFVN-- 3338
            |...|         :|.:|           ||.:.:....|:..|       ..||| .:|.|  
  Rat   719 CRRDT---------ENIYGATLLLRTLQFIQQLAHDLVQQKESGLKYKSFLDFAGLDLQIFWNFY 774

  Fly  3339 -------RVAC-----------GSSHSIAWGLPNASSDEEK---RGPVPFSSTR----------D 3372
                   |..|           .|..|:..|.|.|.|:|||   :.|....:.:          |
  Rat   775 SKLKQNPREECICAQTLLLQLLQSCFSVLQGDPQAVSEEEKPAAQRPEGIQAAKELYTHLCDVVD 839

  Fly  3373 PLGGSSLGIYEAETMQTLKQEAKPLNQSSLSESLALETPAARQAALGHVLRAMSIL------QAR 3431
            ...|.|:      .|:.||||.:    ::|....|:..| .||.....:...|..:      |:.
  Rat   840 RADGESM------PMEILKQEVR----NTLLNGAAIFFP-DRQTRRNQLFTMMKNVTEHERKQSL 893

  Fly  3432 QLIVAALTSHSKVNFKERGAVGGEEDHLIGGPIMGAPLQLAETIAQGGGEAPADATDAGLQEHSP 3496
            ||...:|.::    |.::..         ||.::                         |.|.|.
  Rat   894 QLTFRSLCTY----FSDKDP---------GGLLL-------------------------LPEKSD 920

  Fly  3497 EAAVDALTGGMSGGANTLPPLSAGP-----LSAFQSLTGSL------SMSGSLSSSALPQHKHSR 3550
            .|.::  |..:....|||..::|..     |.......||:      |:.|||.|....|.|.:.
  Rat   921 LATMN--TSEVLAVMNTLLSVAARECELLMLGRAHGEVGSVLFSLFWSVQGSLLSWCFLQLKSTD 983

  Fly  3551 MSASAMSV----------MAATMTQQEEMLSHISHCHGLDDFGGLLGEPEAKSLVELLKLAVCGR 3605
            .:|..:::          :|:.....|.:||..|                .|::||.|       
  Rat   984 AAAKELAMDLIEKYVGQFLASMRVILESLLSQYS----------------GKTIVEKL------- 1025

  Fly  3606 CGPPSTSQTIADTLISLGAGTPAVAAMLLETC---------------ITE-LEDLCTS-RHCLGK 3653
                      .:::.|:.|  ..:...||:.|               :|| |:.||:. ...|.|
  Rat  1026 ----------CNSVFSMAA--RQLVIFLLDFCTLDVSHCTLLREFSTLTELLKKLCSDPEGGLSK 1078

  Fly  3654 L-------PKPVM-----QESSHPYVDNVNVTGVVRIPGAEMLRLEFDSQCSTEKRNDPLVIMDG 3706
            |       .:||:     :||:|.|.:|.:...|...|||....:|||.:|.||||.|.|...|.
  Rat  1079 LDVETWQQEQPVVLHTWTKESTHNYENNCHEVSVFVSPGATYFEVEFDERCETEKRYDYLEFTDS 1143

  Fly  3707 TGRVLAMRSGREFAHWAPEIRVL-GDELRWKFSSDSSVNGWGWRFWVHAI-MPAATLGESGSDRA 3769
            .|......:......|..::... |..|::.|.||||.|.||::|.|.|. :|         |.|
  Rat  1144 RGGKTRYDTKVGTYKWPKKVTFKDGPRLQFLFHSDSSNNEWGYKFTVTAYGLP---------DVA 1199

  Fly  3770 VLSQPSMALVMSLLDSRLAPRQPSVLLRLAS---ALAACSQLGA-LTTAQRIWSLRKLHAVL--- 3827
            |    |..|.:.||.|||       :.||||   ||.:..|||: |..:|     .||.|||   
  Rat  1200 V----SWGLDLQLLVSRL-------MGRLASQCMALKSVHQLGSNLAISQ-----AKLTAVLNSP 1248

  Fly  3828 ------------------------------------------LLE-------------------- 3830
                                                      ||:                    
  Rat  1249 LWKPVFRHQICPELELEASWPTHPHQDGKEVKNIPDDPCRHFLLDFAQSEPAQNFCGPYSELFKG 1313

  Fly  3831 --QAPRPQDPSL-----STLLQPL----------IPELLRQYEYEEPQVRGGIHLMHSDYFKTLA 3878
              ||.|.|.|..     ||:.|.:          .|:|   ||..:..|..|..:...:.|..:.
  Rat  1314 FIQACRKQAPKTDIVAGSTIDQAVNATFAALVYRTPDL---YEKLQKYVHSGGKIALPEEFSQVY 1375

  Fly  3879 ALACDMQ---LDAALPATSSSSSSSAAPGAISSTGDVHKWAWFKRYCIAVRV------------- 3927
            :||..::   |:....:..|..:.|.....: .|.:|:.....|. ||...:             
  Rat  1376 SLADGIRIWMLEMKQKSLVSMGNDSEEKRGL-ETAEVNPENLAKE-CIQKSLLLLKFLPMSKSSK 1438

  Fly  3928 --AQSLIRRTELPRAFCLEVRKKFAEMLP-----SSSSNSNANPGC--QSPGASMLNSTTSLSSS 3983
              ...|:...|..|...|:.|::.:.::.     |:|....|.|..  :|||..|.......|..
  Rat  1439 ENCDKLVPVDETDRLQPLDRRQRTSSVVEEHFQGSASPTEAATPAADDKSPGLEMQPKLLPSSGP 1503

  Fly  3984 TVSNVSPPPGITGEQPDLHCHAHQLESTSTLLHEDHTLFQAPHDAQLLQWLNRRPDDWALSWGGA 4048
            :.:.||     |.|:|       ...||.|                      |||.         
  Rat  1504 SAAEVS-----TAEEP-------SSPSTPT----------------------RRPP--------- 1525

  Fly  4049 STIYGWGHNHRGQL-----GGLEGSRIKTPTPCEALSLLRPVQLAGGEQSLFAVTPDGKLFATGY 4108
                    ..||:|     ..:|.:| ..||..|...:|:.|.....:|||            .:
  Rat  1526 --------FTRGRLRLLSFRSMEETR-PVPTVKEKYPVLKDVMDFIKDQSL------------SH 1569

  Fly  4109 GSGGR-LGVGGSDSWAIPTLLGSLQHVFVKKVAVNSGGKHCL----------ALTTEGEVYAWGE 4162
            .|..: |.:..:.:.:|..:|..:|:     ...:.|..||.          .||.:.:...:  
  Rat  1570 ESIVKVLSLRKAQAQSILEVLRIIQY-----CTESLGQPHCFHPPYILFLLELLTCQKDFTNY-- 1627

  Fly  4163 GEDGKLGHGNRMSYDRPK------------LVEHLNGM-SVADIACGSAHSAAITASGHVLTWG- 4213
                 .||......|..|            ||:.:.|. |:.|.:...|.|...||..|:|..| 
  Rat  1628 -----FGHLEGCGADLHKEIRDTYYQLVLFLVKAIKGFSSINDRSLLPAVSCVQTALLHLLDMGW 1687

  Fly  4214 -----------------------------------------------------------KGRYGR 4219
                                                                       :..|.:
  Rat  1688 EPSDLAFFVDIQLPDLLMNMSQENISIHDSVISQWSEEDELADAKQNSEWMDECQDGMFEAWYEK 1752

  Fly  4220 LGHGDSEDQLRPKLVEA----LLGYRAIDIACGSGDAQTLCITDDDNVWSWGDGDYGKLGRGGSD 4280
            :...|.|.|.:..:..|    ||.   :||:|..      |    |.:..|  ..|..|.....|
  Rat  1753 IAQEDPEKQRKMHMFIARYCDLLN---VDISCDG------C----DEIAPW--HRYRCLQCSDMD 1802

  Fly  4281 GCKLPYKIESLAGLGVVKVECGSQFSVALTKSGAVYTWGKGDFHRLGH--GSVDHVRRPKKVAAL 4343
            .||..:       ||.||.|                  |.||.|.:.:  .:.||.:     ..:
  Rat  1803 LCKTCF-------LGGVKPE------------------GHGDDHEMVNMEFTCDHCQ-----GLI 1837

  Fly  4344 QGKKIISIATGSLHCVACSD--------SGEVYTWGDNDEGQLGDGTVTAIQRPRLVAALQGKHI 4400
            .|::        ::|..|.|        :.:.|::     |.|...::|                
  Rat  1838 IGRR--------MNCNVCDDFDLCYGCYAAKKYSY-----GHLPTHSIT---------------- 1873

  Fly  4401 VKVTCGSAHTLALSTSQLSERLRPLPNPPLEYDLVRDLAPEALHARLILLHHFSELVCPCLAMLP 4465
                   ||.:.  |.::|:|             .|.:.|        .:|::|.|:...||:  
  Rat  1874 -------AHPMV--TIRISDR-------------QRFIQP--------YIHNYSWLLFAALAL-- 1906

  Fly  4466 ISGDLSLGALKDVLVYNIKEAAFRKVIQTTMVRDKQHGPVIELNRIQVKRS----RNRCNGLAGI 4526
            .|..|:                     .|..|..:|..|       |.:.|    |::|..|.|.
  Rat  1907 YSAHLT---------------------STEHVDGEQLDP-------QARGSAATLRSQCMQLVGD 1943

  Fly  4527 DGMKSVFGQMVQKLPLL--------TQEALALPHRVWKVKFVGESVD-----------------D 4566
            ..||:..|:.::.|.||        |.|..|||..| .::...|.::                 .
  Rat  1944 CLMKAHQGKGLKALALLGVLPDGDSTSENQALPVTV-SIQASEEQLEKKTAQPAEGPADAGLFVP 2007

  Fly  4567 CGGGYS-----------------ESIAEMCD---ELQNGSVPLLINTPNGRGEA-------GANR 4604
            |.|..:                 |.::.|.|   ::|....|...:.|.|..:|       .|..
  Rat  2008 CNGKRATDKEVGPLDCKQKKKAGEDLSIMKDPSCQIQVSDPPASDHVPPGLPDAEHPDRSSQAPM 2072

  Fly  4605 DCFLLDPTLSSVL-QMNMFRFLGVLMGI--AVRTGS--PLSINLAE--PVWRQ------------ 4650
            :...:.|:...|. :.:..|.||:|..:  .:::|.  || |:|..  |:..|            
  Rat  2073 EEKAITPSPEQVFAECSQKRILGLLAAMLPPIKSGPTVPL-IDLEHVLPLMFQVVISNAGHLNET 2136

  Fly  4651 ------LTGEVLRPTDLTEVDRDYVAGLLCIRNMDDDPKLFTALELPFSTSSARGHEVPLSTRYT 4709
                  |.|:::......|||    |.::         |:.:|....|:|  |....||...:.|
  Rat  2137 YHLTLGLLGQLIIRLQPAEVD----AAVM---------KVLSAKHNLFAT--ADNAVVPDGWKTT 2186

  Fly  4710 H---------ISPR-------NRAEYVRLALGFRLHEFDEQVKAVRDGMSKVIPVPL--LSLFSA 4756
            |         :..|       :.||.:|......|  :.:.:....|...|.:|..|  .::|:.
  Rat  2187 HLLFSLGAVCLDSRVGLDWACSMAEILRSLNNAPL--WRDVIATFTDHCIKQLPFQLKHTNIFTL 2249

  Fly  4757 AELQAMVCGSPDIPLGLLKSVATYKGFDPSSALVTWFWEVMEEFTNQERSLFLRFVWGRTRLPRT 4821
                .::.|.|.:.....:.|......:|.:.:      :::.||.:.|::.:..   :||..:|
  Rat  2250 ----LVLVGFPQVLCVGTRCVYMDNANEPHNVI------ILKHFTEKNRAVIVDV---KTRKRKT 2301

  Fly  4822 IADFR------GRD----------------FVLQVLEKNPPDHFLPESYTCFFLLKM 4856
            :.|::      |::                |:...|.:...|...||:....::|.:
  Rat  2302 VKDYQLVQKGGGQECGTSQAQLSQYSQHFAFIASHLLQTSMDSHCPEAVEATWVLSL 2358

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HERC2NP_608388.2 RCC1 638..683 CDD:278826
RCC1 687..737 CDD:278826
RCC1 740..787 CDD:278826
RCC1 790..841 CDD:278826
RCC1_2 828..857 CDD:290274
Cyt-b5 1290..1363 CDD:278597
MIB_HERC2 1928..1987 CDD:284184
UBA_HERC2 2515..2559 CDD:270585
Cul7 2624..2699 CDD:288381
APC10-HERC2 2762..2932 CDD:176485 46/180 (26%)
RCC1 3037..3088 CDD:278826 13/50 (26%)
RCC1 3091..3140 CDD:278826 13/69 (19%)
RCC1 3144..3194 CDD:278826 9/52 (17%)
RCC1 3197..3246 CDD:278826 10/54 (19%)
RCC1 3250..3298 CDD:278826 10/48 (21%)
RCC1 3302..3350 CDD:278826 15/86 (17%)
RCC1_2 4136..4166 CDD:290274 5/39 (13%)
RCC1 4154..4203 CDD:278826 11/61 (18%)
RCC1 4206..4257 CDD:278826 13/114 (11%)
RCC1 4260..4309 CDD:278826 12/48 (25%)
RCC1 4312..4360 CDD:278826 8/49 (16%)
RCC1 4364..4413 CDD:278826 6/48 (13%)
HECTc 4509..4880 CDD:238033 86/469 (18%)
HECTc 4553..4878 CDD:214523 69/413 (17%)
Zzef1XP_006246919.1 EFh <94..141 CDD:238008
APC10-ZZEF1 250..380 CDD:176488 37/131 (28%)
CUB <1119..1189 CDD:294042 23/69 (33%)
ZZ_EF 1779..1826 CDD:239083 19/83 (23%)
ZZ 1828..1875 CDD:239069 10/87 (11%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5184
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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