Protein Alignment HERC2 and HECTD4

DIOPT Version :9

• Sequence 1: NP_608388.2
• Gene: HERC2 / 33035
• FlyBaseID: FBgn0031107
• Length: 4912
• Species: Drosophila melanogaster
• Sequence 2: NP_001103132.4
• Gene: HECTD4 / 283450
• HGNCID: 26611
• Length: 4428
• Species: Homo sapiens
• Alignment Length: 5470
• Identity: 1041/5470 - (19%)
• Similarity: 1684/5470 - (30%)
• Gaps: 2009/5470 - (36%)

  Fly   354 AAVVSSLWLEVMERSI----KFLRLVALGDPMGNRCTAP-------------------LNDRHTA 395
            ||..|:.||.|.|.:|    ..:|:..|.:.......||                   |.:|..:
Human    13 AAADSAQWLSVKEETIFLHDGLIRVTDLAELPSEILGAPEAADTDLEILTFETKNPSELAERLRS 77

  Fly   396 LCLLLELGVQKGTLAATLECVVLLLL-LW------------EKDRAGNDNRDMPRKTGAPLQRIL 447
            :|     |.|....|..||..:..|. ||            |::.:|::      :|.|.|:|..
Human    78 VC-----GNQSNAYARLLEYRLNALRGLWNAQRQLALEEQHERESSGDE------ETLALLKRQG 131

  Fly   448 LRYQKIGATAKGGGIAGGEPAPVASATETFLRFLSLPKSSAAIVDLRRAAVVIISHLDRMVQPLM 512
            |..|.             |.||..|.....|.|..:...|.....|......::.:..|..|||.
Human   132 LLQQP-------------EQAPFTSRMGLLLVFPLIQSQSRTDPSLCNITAEVLLNCLRDCQPLS 183

  Fly   513 ----PRCLLRGGQATAASSSSAPQQRIYALGWPSLSKDQQGFSAEPTLSWSGESAGVPTLSC-RF 572
                |...|.|.:....|             |  |.:........|.......:|.:..|:| |.
Human   184 LTKEPADCLNGIETLLCS-------------W--LEETSDTGRHIPHKQKENAAAALVALACARG 233

  Fly   573 QIKQVACCETQMLILSQEGKLYTWRLAKPEAE--PLPMEEVAHDVFISIAG----HC--EGRHFL 629
            .:|..               ::|..|.:.:.:  .||:.:|.:.:.:...|    .|  .|:|.:
Human   234 SLKTF---------------VHTVHLLQKQTDLGSLPVADVLYRLLLLEGGPGSPSCLLGGKHIV 283

  Fly   630 AIDSNHNAYSWG-----TGEDHRLGHGDTHARAVPTKIAALEQHCVQSVYCGCSYSAAITCGGNL 689
                     |||     ...|...|....:..|                    .....:|..|..
Human   284 ---------SWGYEDMLPAPDSNTGSSSENKDA--------------------DLGRCLTADGLY 319

  Fly   690 L----TWGRGTYARLG---HGNSDDRSLPTLVVALSDHMVVD-VALGSGD-----------AHSL 735
            |    :.|||. ::||   ||     :|...|...::.:... ||.|||.           .|||
Human   320 LYTTNSVGRGV-SKLGSGLHG-----TLRGFVYCRNEELEPGWVAFGSGSLLHRPVSFDNKPHSL 378

  Fly   736 ALTSEGLVFAWGDGDYGKLGNGNCNGSLQPILVESLPRVQRVFAGSQFSVALSSEGQLYTW---- 796
            ....:                   ..:||...|..:|........:..:|.|||:|..:.|
Human   379 FQVID-------------------QNTLQVCQVVPMPANHLPIGSTMSTVHLSSDGTYFYWIWSP 424

  Fly   797 ---GKATCLGHQ-------------------LVERSV----QGCSVPRLVSSLQHKRIVDVAVSV 835
               .:.|..||.                   |.||::    :|.|. :.::.:...|:.....|.
Human   425 ASLNEKTPKGHSVFMDIFELVVENGVFVANPLQERTILMRKEGESA-KSINEMLLSRLSRYRASP 488

  Fly   836 AHCLALSSSGEVFGWGRNDSQQICPASVSSEPLLRTPI------LVSL-PTFPASGIACTS---- 889
            :..||..:...:....:.|........:..:.|.:|||      ||.| |....||.:.|.
Human   489 SATLAALTGSTISNTLKEDQAANTSCGLPLKMLRKTPIYTCGTYLVMLVPPPGGSGSSATRSLFG 553

  Fly   890 -----------AQSLVWTQSSHQGVPR------------RAPFVVDLGEPTFRLLDQLLGMCSSQ 931
                       |.|||:..|..|...|            |...|..|| ..:..::.:|..||:.
Human   554 GTSGLSSLKILASSLVYNISDGQFTSRADLIDAAGSSLGRGALVPGLG-ACYDTVNNMLWTCSND 617

  Fly   932 DNRQTPNQESECIAVACLNLFRLQLLALIANGVEPRQVGLAS-----------GSRLLCSLK--- 982
            ...|..|..::.....|.   ||.:..:|   .||::..:.:           |:..:..|.
Human   618 YIDQWCNPGNQAFHYVCQ---RLGVSHII---TEPKEEAITTNEVINQLLHHVGAMCIHQLNLLA 676

  Fly   983 -------TRILG---------------------LAGGSQVLRTIQVAAQ---------------- 1003
                   |.:||                     :.|.:.::|.|.|..|
Human   677 TNPNLPITSVLGKQHPIEAHHLSSICDIMEKAMVNGDTCIIRCILVVFQVVFKFFFSPQTERNRD 741

  Fly  1004 -----------------------------QALQDGWSVLLPTAAERAQTLTSLLPSEPGQASSAG 1039
                                         .|:..|.::|.|...| ...|..|:.:| |:.:| |
Human   742 IIRRSGLLLWQLLMAPKDQICPEIQKEVCLAISSGLNILYPGETE-INNLLKLVLTE-GERNS-G 803

  Fly  1040 HRFMTDLLVSSLMAEGGLESALQHAIRLESSSCSADCGDGVHL--PLLQLITRLLSNNAALSQTR 1102
            ...:.|:::::|            |.:|:::...:|..|...|  .||..|.:::...:.:..|:
Human   804 LSQLRDVILTNL------------AEQLQNNRFGSDEDDHYRLNDELLHYILKIVVRESCILITK 856

  Fly  1103 LSPTLGKQQEKEEEEREQQHQEPSTSPSLSLLHRFQRLLLSHIHQAQPEE----------ETTGA 1157
            .      |...:::.::.....|:.|..|..|...|..|||:....:|:|          ||...
Human   857 C------QTVSKDDFQKLLSTVPAASSCLRYLMAVQNHLLSNTILIKPDENDDSDSSLQGETLKV 915

  Fly  1158 EAL---LLQYMHALIPACVATLQKAHELA-------LQCREPGENSFGQ-----MVGHLGRVLQA 1207
            :.|   :|.....::..|...|:...::.       :..||.......|     |:|||..||..
Human   916 QELKVSILALATQILTGCDEVLEMLQQVTTALINSDIADREQRLKGLEQVTKATMLGHLLPVLLT 980

  Fly  1208 DI----------SDALLNELL-------VGLLLLKRDRP--------QCLGGLRWARLFLPLLRV 1247
            .:          :|||:.:|:       ...||||...|        .|....:..||| |..|:
Human   981 SLMHPNLQTLIMADALMPQLVQLVLYTSQTALLLKTQCPVFAEVGCSPCGAPDQKCRLF-PDERM 1044

  Fly  1248 LDRLNRALGEGELRDGDDMGWPGIICRGGPKGGPPPADPET----HYVRRAD----MENLLLDGS 1304
            |:....               ||.:.  |.|...|.|..:|    |.||  |    .|.:.:.|:
Human  1045 LEEKEE---------------PGFLT--GLKIPAPWAAGKTVETVHPVR--DNYKFKETVHIPGA 1090

  Fly  1305 RCIIL-------AGYVCD----LSGYNCESETL------------RSVLDSGLGKDLT------- 1339
            ||:.|       :.|..|    .:|.|..|..:            ||||.:|..|||.
Human  1091 RCLYLRFDSRCSSQYDYDKLVIYAGPNTNSRKVAEYGGNTLGYGSRSVLGTGWPKDLVKCISPPS 1155

  Fly  1340 ----AEMSSQVHRTAMEHILEHHKLGKYM--------VQASTEEKSS--------APGPSRLTHF 1384
                .|..:......|....||:...|.|        .|.|:|:.|.        |.|.|.|.
Human  1156 LNFKVEGDTVTFSFEMRSGREHNTPDKAMWGFACTVRAQESSEDVSGGLPFLVDLALGLSVLA-- 1218

  Fly  1385 SSECALAQLLGLVANLMCSGPALQPAELQCRQLDKSSLL--------SGGL--QLLQPS-NP--- 1435
               |::.::|       .:||.:...|..|::|.:|.||        :.|:  ..|.|| :|
Human  1219 ---CSMLRIL-------YNGPEITKEEEACQELLRSKLLQRCQWQVEANGVISPALTPSPSPLPL 1273

  Fly  1436 -FDEEKGEARSSHSCHSTAGN----TPTELPPPLPMQQQLAPGRGKSQLQLRADAFISGLAEARV 1495
             .:|::.....|.......||    ....|||.:.::.:...||.:.|.:    ..|..:.:..|
Human  1274 TIEEDREFTYPSDVLVPPVGNYFDLPRIRLPPGIMIKLREISGRARPQFR----PSIKEVIQPDV 1334

  Fly  1496 SEPPVAA----WLALTERYCKAHNLMWHQEFATEHPVQELERLLSAVLIRHQYLGGLVLNALETE 1556
            .|..|.:    .|.|.:......|..:.:|.|.|:.:  |.:::.....:        |||:|
Human  1335 MEEMVVSCVIKHLNLVDALQSLINFQYQEEHAEEYDL--LCKIMGETFKK--------LNAME-- 1387

  Fly  1557 VPPPRQLGEIIRLVHQAKW-SVVRTRQQ------------------------LNRSYKEVC--AP 1594
                |||..:..|  :.|| |.|....|                        |..|.|||.  ..
Human  1388 ----RQLQSVAEL--EQKWQSEVDDAMQGKLENNMPFFYDYHFNENKMKELELLCSMKEVSFDGN 1446

  Fly  1595 ILERLRFLLYEVRPAISPQQRGLRRL-PILQRP----PRFKMLVRRLLQ--EL------------ 1640
            .||.:         .:|.:::.|:.: .::|:|    .:.|.||:.|:.  ||
Human  1447 DLENM---------VLSLREKFLQEVNSLIQKPSHPLAKTKTLVKSLMNRAELLLHVTIAAQSGL 1502

  Fly  1641 -RS-SRQPAKPEDLLNAS--------IQQEQEKKPQSMPKQELEEQEEEETLLRRLNERQIHGEG 1695
             || |..||:.....:||        ::|....:..|.| .:||....|:....|.|:|:.|...
Human  1503 TRSISGTPAETPACKSASETKVISHAVRQPVFLRSMSAP-SDLEMIGNEDLEFTRANQRRRHVTS 1566

  Fly  1696 ELDPA--LMQDIVDFALQDSCDVETARRAMYCQMQRYQLRLAGL---------QIV--------- 1740
            ....:  |:|.:   |::||.|..|           |.:.|..|         |.|
Human  1567 HRSSSFTLLQSL---AIEDSRDKPT-----------YSVLLGQLFAFIGTNPDQAVSSSSFLLAA 1617

  Fly  1741 -----------QQLLELHGLLDAA------------QYSLLNGFLGLHLKSTSSGG--------- 1773
                       |.|:.:..||.||            ...:|.|  |..::..:.||
Human  1618 QTRWRRGNTRKQALVHMRELLTAAVRVGGVTHLVGPVTMVLQG--GPRIEELTCGGMVEQVQEAF 1680

  Fly  1774 GSTGSG----------SSLHVLGQLNMISAYQKARLLLAQSRVLDWAVRELRRLVNQEQQGHARG 1828
            |.|.:.          :..:.:|.|..|...:.....|.:|.:    |:.:.||.:...|..:..
Human  1681 GETMTSVVSLCARYPIACANSIGLLCTIPYTRSEEKCLVRSGL----VQLMDRLCSLSNQTESSS 1741

  Fly  1829 KDSTNLGTYVLLKRLPRARFLLSVFGLLA--------KELGPNELGFLINSGLLGTVLGLLAQ-- 1883
            .:...       |:...|....:.|.:||        :|.|..|   .::|||...|..||..
Human  1742 SEKQT-------KKQKVATMAWAAFQVLANRCVEWEKEEGGSTE---AVHSGLARQVSSLLTNHL 1796

  Fly  1884 ------TGGEGATGGQVHGELSILYEDSVLKQKSSKAQLSGPDLA--------------KLMKIG 1928
                  .|.:.|....:...||:|  :.:.:....||.||.|...              ||:.|.
Human  1797 ARATECCGNQAAGNDALQDVLSLL--NDLSRSHIGKAILSQPACVSKLLSLLLDQRPSPKLVLII 1859

  Fly  1929 TRIVRGA---------------DWKWG--------DQDGNP-----------------PGEGRII 1953
            .::.|.|               .|.:.        :...:|                 ||...::
Human  1860 LQLCRAALPLMSVEDCGNVELPPWSYSVPSLNSEQEDPSDPASKIASLLLAKLADYVVPGCQTVL 1924

  Fly  1954 SEVGEDGWVRVEWYTGATNSYRMGKEGQYDLQLADSALNVASPTEPEREDVSGSEA-SP---TSD 2014
            |....:....:. .|...||.:..|:...:.:..|..|::..   .:|||.|..|. .|   :|:
Human  1925 SPTASEPDTTLT-KTSPKNSLKGDKDPGEESEAVDGKLSIFI---HKREDQSSHEVLQPLLSSSE 1985

  Fly  2015 SHPSKLLRHCAAKLLQILAVGTGLH---GAQLDKDALRGMTSMFRTIIYPKPSMSNISYALGWLN 2076
            ..|.:|              |||.:   ..::|:|..:|....    :..:.:.:.:..|..|..
Human  1986 GRPFRL--------------GTGANMEKVVKMDRDMTKGGCCE----VITEEAAAALRKATKWAQ 2032

  Fly  2077 LGFIRAISGDCPRLCLELSTPGWLSHYLSLLEQPAGNEAGVYRQLHCLRLLQLILAQWGAEEEPR 2141
            .|.|.:|...     :|...|..:|. ||..::....:..:.|:    |..:|      |..:|.
Human  2033 SGLIVSIGPP-----VESINPETVSG-LSTGDKKKTAQTSICRE----RNSEL------ARTDPV 2081

  Fly  2142 MPALVHQLFATLGRIALHCPGDASLLPTAEGKARVLLTASHSGSVAEELVALLRRLHTLPS---- 2202
            .|.:       .|.:|                          .|:|.|::|||..|...|.
Human  2082 RPFI-------SGHVA--------------------------NSMAAEVIALLHSLLMAPESNAA 2113

  Fly  2203 --WNPVINSFLAQKLCVA------AELLAEQSHSTA-----LDSEQVFVLGVLGAMGGHDLRPRV 2254
              |.......|::.|...      ||.:.|...|:.     |.......:..|.|:||.....::
Human  2114 QIWTTTAEKVLSRALMYIPQLGKYAESILENGSSSGRKLAKLQRIARQAVAALCALGGFKETIKI 2178

  Fly  2255 G-----LHCFHEGSHMVIASFTPKGRCLLAPGGVGSGVGFVKVQLPAV----------------- 2297
            |     |.....||..|:||             :....|...|:.|.:
Human  2179 GSEVQVLGRGISGSIGVVAS-------------INEQEGIATVRFPPIDCRKTSQASDTLTIPLS 2230

  Fly  2298 ---MPHLDHTVFSLSRLPMNEMLLNAWTVLLYGPAPEL---RELPSSADGRLD-LALLRAQQLQM 2355
               :|..:  ...|.:|.:.|.::.|...:|......|   ..||::.||... :|::|.    :
Human  2231 RLCVPRSE--ALPLHKLSITEKVVQAVQSMLLPQEGSLSIHTSLPATGDGSAPVMAVVRL----L 2289

  Fly  2356 AVLHTNGVLYRHQVALRRILKQRAPGSIYASPDEPDRSDAESQQPGEQD------QQLSSGSGQE 2414
            |.:.|...|         ::.|....|::.       .:...|.|...:      |:.|:|. :.
Human  2290 AEIRTRACL---------VMAQLLEDSLFC-------EEFIQQCPAAVEVLNLVAQECSAGE-RL 2337

  Fly  2415 PQLLIQCILLR------------ATQAS----------------PVKACYSYMDLATAALNCIQS 2451
            ..:.:||..||            ..||.                ||:||     :.::.|..:..
Human  2338 AVVEVQCERLRMLYRDCARPPPPPLQADRRQPKEITWSPSRVFPPVRAC-----MFSSHLTSVTF 2397

  Fly  2452 LATQAHQELSEGGGVPPNGRALSSPPQPTMVHGVPVYNVARKEQKPS--EQVEQKSKWPAAATDA 2514
            ||     :.|.|||:|......::.|.|.              |.||  .::|..|   ...||.
Human  2398 LA-----DPSAGGGLPRGTFIYATSPLPV--------------QAPSFYWEIEIVS---YGDTDD 2440

  Fly  2515 QLIGQIMEMGFTR----------------------RTVE------LALKQLSLQAEIMP------ 2545
            . .|.|:..|||.                      |.|.      |..|.:.|...:.|
Human  2441 D-TGPIVSFGFTTEAEKRDGAWTNPVGTCLFHNNGRAVHYNGSSLLQWKSVRLDVTLSPGDVAGI 2504

  Fly  2546 -------TPEQIVQ--------------------------WILEH-------------------- 2557
                   ||....|                          |.:.|
Human  2505 GWERTEGTPPPPGQPAKGRVYFTYCGQRLSPYLEDVSGGMWPVVHIQKKNTKTRANFGSRPFAYA 2569

  Fly  2558 --------PDVCANTIEE-----DTLPLASSASSHDPEADSDNECPSSNSTTSSSTSSDT-VEGQ 2608
                    .|:|.:..||     :.||.|.:       :||||:       ..:|.:||. ..|.
Human  2570 EGQAHRNAADLCTDLAEEISANFEALPFAMA-------SDSDND-------AGTSIASDPGTHGP 2620

  Fly  2609 PMAVSGPAPPVKFESRKDFQTADLYALYVRGLVRPGMTVRCCRDFEE-IKQG-DMGTVLIVDTEG 2671
            |..::..|..   :.:.|..|:..|.:.:              .:|. |..| |.....|.|.|.
Human  2621 PCRIAAVATA---QQQYDSDTSCHYKVEL--------------SYENFITSGPDPHPPPIADDES 2668

  Fly  2672 LHDLNVQVDWRNHGSTYWVCFVHIELVEAAQTHHQPRPPPIAVGARVRLRTSSLRYGMLCPLRLG 2736
            ..|.:..:...:|         :..||:|.:|...|.       .|.|.|..:.|..     .|.
Human  2669 DDDDDDDIPQEDH---------YALLVKAWETKVFPT-------IRRRFRNEAERKS-----GLD 2712

  Fly  2737 RSQGSSAIGVVSSVRSKQLTVDFPDQPAWQGHINEVELVASQPTSATLPSLGDSCSQMPPSDLIE 2801
            :.:|:..:|:|...|.   ||:|..:.  .|.|         |....||::.|          |:
Human  2713 QIKGALQLGMVDIARQ---TVEFLYEE--NGGI---------PRDLYLPTIED----------IK 2753

  Fly  2802 DWS------RCIRSLTV-----SSNEAAAKHLLNGSNQPWQSCSSGPCRHWIR-----LELHDRI 2850
            |.:      :..:.|||     .||..|:..:  |:..|         :..||     ..||..:
Human  2754 DEANKFTIDKVRKGLTVVTRSPDSNNVASSAV--GTALP---------KFAIRGMLKTFGLHGVV 2807

  Fly  2851 L-VHSLTLKVSPEDHSHMPSLLEIRVGDCVDSLKEYTWIPVPAGASRVLLMQQVPTYYPWVEVVV 2914
            | |.|:...|..|.:.....:| :|.           |.|:.       ::::.|..|
Human  2808 LDVDSVNELVQVETYLRSEGVL-VRY-----------WYPID-------MLERPPAGY------- 2846

  Fly  2915 KQCQNNG---------------IQCKIHGIKFVGRRQ-----QPDLQHI--------------LA 2945
            ::...||               ::|:....:...|..     .|.|.|:              |.
Human  2847 RRTATNGLVTLDNTNLQIHRELLRCEAALARLYCRMALLNIFAPKLPHLFTRLFHIPAIRDITLE 2911

  Fly  2946 NAQFLASEYSAGVGPGSTAGAGAVSTS-------HEEAAAAPE---QDLPCTVMVWGLNDKEQLG 3000
            :.|.|:::..|...|..|..:.::..:       |.:..:|.:   |....||..| ||
Human  2912 HLQLLSNQLLAPPLPDGTISSSSILLAQSLQHCIHSQNCSATDLFYQGNSQTVREW-LN------ 2969

  Fly  3001 GLKGSKVKVPTFSQTISRLRPIHIAGGSKSLFIVSQDGKVYACGEGTNGRLGLGVTHNV-----P 3060
                           ::..|.:|  .|.:||                     |.:|..:     .
Human  2970 ---------------VAITRTLH--QGEESL---------------------LELTKQICSFLQT 2996

  Fly  3061 LPHQLPVLRQYVVKKVAVHSGGKHALALTLDGKVFSWGEGEDGKLGHGNRTTLDKPRLVEALRAK 3125
            .|.|.| ..::.:.:..|:      :.:...|..|.....::.:.|....::|.|        |.
Human  2997 APEQFP-SEEFPISESKVN------MDVNFPGAAFVVVSCKESQSGFRKDSSLYK--------AP 3046

  Fly  3126 KIRDVACGSSHSAAISSQGELYTWGLGEYGRLGHGDNTTQLKPKLVTALAGRRVVQVACGSRDAQ 3190
            ..|.:..|..|.  :...|:|                               .:::.||..|||.
Human  3047 WARVLVYGLGHK--VKRNGQL-------------------------------NLIEAACYPRDAS 3078

  Fly  3191 TLALTEDGAVFSWGDGDFGKLGRGGSEGSDTPHEIERLSGIGVVQIECGAQFSLALTRAGEVWTW 3255
            .                                     :..|:.......|:...:.....|
Human  3079 P-------------------------------------ANTGLAPPPTADQYPSVVLSTDRV--- 3103

  Fly  3256 GKGDYYRLGHGGDQHVRKPQPIGGLRGRRVIHVAVGALHC------LAVTDAGQVYAWGDNDHGQ 3314
                :.:||       ..|.|           .||..||.      ||:..|.|:.:|...|  .
Human  3104 ----HIKLG-------VSPPP-----------GAVLVLHSLPLEFPLAMAFAEQLLSWKSED--S 3144

  Fly  3315 QGSGNTFVNKKPALVIGLDAVFVNRVACGSSHSIAWGLPNASSDEEKRGPVPFSSTRDPLGGSSL 3379
            :|......:..|..|: |..|.:       ..:..|....|:..:|    :.|....:.|
Human  3145 EGKSEDEPDTIPTSVL-LQVVEL-------LGNFLWTTDMAACVKE----LVFHLLAELL----- 3192

  Fly  3380 GIYEAETMQTLKQEAKPLNQSSLSESLALE-TPAARQAALGHVLRAMSILQARQLIVAALTSHSK 3443
                 .|:.||:|...|   :.||.|:||: .|            .:::|.|.|..:..|.....
Human  3193 -----RTVHTLEQRRHP---AGLSSSIALQLNP------------CLAMLMALQSELHKLYDEET 3237

  Fly  3444 VNFKERGAVGGEEDHLIGGPIMGAPLQLAETIAQGGGEAPADATDAGLQEHSPEAAVDALTGGMS 3508
            .|:...||.||                       .||.|..|........|:      .:.|.::
Human  3238 QNWVSGGACGG-----------------------SGGAAAGDQGRFSTYFHA------LMEGCLA 3273

  Fly  3509 GGANTLPPLSAGPLSAFQSLTG-SLSMSGSLSSSA---LPQH------------KHSRMSASAMS 3557
            ....|||...:...|...|.|. :||.|.|.|||:   .||.            |..:.|:|...
Human  3274 VAEVTLPTNMSVTASGVTSATAPNLSDSSSSSSSSPGQTPQSPSLLSKRKKVKMKREKASSSGKR 3338

  Fly  3558 VMAATMTQQEEMLSHISHCHGLDDFGGLLGEPE-----AKSLVELLKLAVCGRCGPPS---TSQT 3614
            ..:.|:.....:||          .||  .:||     .::|..|:.|....|..|..   ||..
Human  3339 QSSRTVDSDPTVLS----------IGG--SKPEDMLWFHRALTLLIILRHLTRKDPQGLGVTSDA 3391

  Fly  3615 IADTLISLGAGTPAVAAMLLETCITELEDLCTSRHCLGKLPKPVMQESSHPYVDNVNVTGVVRIP 3679
            |||...:|...|.....:::....|.|::                              ||||
Human  3392 IADACQALVGPTAHSRLLVISGIPTHLDE------------------------------GVVR-- 3424

  Fly  3680 GAEMLRLEFDSQCSTEKRNDPLVIMDGTGRVLAMRSGREFAH---WAPEIRVLGDELRWKFSSDS 3741
            ||      ....|:                          ||   :..||.:...|...|...|.
Human  3425 GA------IRKACN--------------------------AHGGVFKDEIYIPLQEEDTKKPKDK 3457

  Fly  3742 SVNGWGWRFWVHAIMPAATLGESGSDRAVLSQPSMALVMSLLDSRLAPRQPSVLLRLASALAACS 3806
            :..|.|      .:.|..||...|:|...:|..|.......:.:..:..|.|:          ||
Human  3458 AEGGDG------KVEPEKTLAFPGTDSMEVSTSSSLTPAMSISASASTSQASI----------CS 3506

  Fly  3807 QLGALTTAQRIWSLRKLHAVLLLEQAPRPQDPSLSTLLQPLIPELLRQYEYEEPQVRGGIHLMHS 3871
            ..|...|...:                 ..||..:.|..|:.|.||      ||.
Human  3507 SQGISQTVSDL-----------------SVDPLPAGLELPIPPGLL------EPH---------- 3538

  Fly  3872 DYFKTLAALACDMQLDAALPATSSSSS--------SSAAPGAISSTGDVHKWAWFKRYCIAVRVA 3928
                   |::....||.:|.:|.|..|        .:|...::|..|.::.........:|.|..
Human  3539 -------AVSSQESLDISLCSTGSLGSLGSLGEPLDNAETASVSDMGSMYTVTSLDNQPLAARPI 3596

  Fly  3929 QSLIRRTELPRAFCLEVRKKF-AEMLPSSSSNSNANPGCQS-PGASMLNS-------TTSLSSST 3984
            :...         .:|:|.:. .|.:.:|..|:|...|..| .|...|..       |.|:.:.:
Human  3597 KGFA---------VVEIRSRAKIEKIRASLFNNNDLIGLSSLDGEDELMEMSTEEILTVSVVNQS 3652

  Fly  3985 VSNVSPPPGITGEQPDLHCHAHQL---------ESTSTLLHEDHTLFQAPHDAQLLQWLNRRPDD 4040
            :.:....||:.....|......:|         |...:..|.:.||...|  |:.::
Human  3653 LFDTQGSPGLEDYFNDKSIKGEKLVPGAREVLTEIFKSCAHSEQTLSLTP--AKPIR-------- 3707

  Fly  4041 WALSWGGASTIYGWGHNHRGQLGGLEGSRIKTPTPCEALSL----LRPVQLAGGEQSLFAV---- 4097
                   .|.||            |...:|.:.||...|.|    :||.:....:|....:
Human  3708 -------VSDIY------------LSKEQINSQTPGNLLHLFFTNVRPPKKVLEDQLTQILRKYG 3753

  Fly  4098 TPDGKLFATGYGSGGRLGVGGSDSWAIPTLLGSLQHVFVKKVAVNSGGKHCLALTTEGEVYAWGE 4162
            .|..|...:.|...|:                 .||. ||.|
Human  3754 VPKPKFDKSKYSKAGK-----------------EQHP-VKVV----------------------- 3777

  Fly  4163 GEDGKLGHGNRMSYDRPKLVEHLNGMSVADIACGSAHSAAITASGHVLTWGKGRYGRLGHGDSED 4227
                        |..||             |....|...|:..|          ..|....:.:.
Human  3778 ------------STKRP-------------ITKPPAKDKAVLNS----------VSRTALSEKKP 3807

  Fly  4228 QLRPKLVEALLGYRAIDIACGSGDAQTLCITDDDNVWSWGDGDYGKLGRGGSDGCKLPYKIESLA 4292
            .::||..|                                     |......|..|.|.|.:.:.
Human  3808 TVKPKSPE-------------------------------------KSKPDEKDPEKSPTKKQEVP 3835

  Fly  4293 GLGVVKVECGSQFSVALTKSG------AVYTWGKG-DFHRLGHGSVDHVRRPKK-------VAAL 4343
            ....:.:|...:|.:...:..      |:.:.|.. .|.|.....|.|.::..:       ||.:
Human  3836 EEKYLTLEGFHKFVIDRARQDIRSVWRAILSCGYDLHFERCACIDVRHAQKASRKWTLEMDVALV 3900

  Fly  4344 QG----KKIISIATGSLHCVACSDSGEVYTWGDNDEGQLGDGTVTAIQRPRLVAALQGKHIVKVT 4404
            |.    .:.::|....||      ..|||.    |.....|        ||            |.
Human  3901 QYINQLCRHLAITPARLH------PHEVYL----DPADAAD--------PR------------VA 3935

  Fly  4405 CGSAHTLALSTSQLSERLRPLPNPPLEYDLVRDLAPEALHARLILLH--------HFSELVCPCL 4461
            |                   |.|.|:          |:|..|..||.        .|..||  .|
Human  3936 C-------------------LLNVPI----------ESLRLRFALLQSLNTTLETFFLPLV--EL 3969

  Fly  4462 AMLPISGDLSLGAL----KDVLVYNIKEAAFRKVIQTTMVRDKQH-GPVIELNRIQVKRSRNRCN 4521
            ...|:... |:.||    |.::.|:.|.....:|:..|:.|...| .|.|.|:.:::.....|.:
Human  3970 RQTPMYTH-SIAALLKEAKGLIFYDTKVTVMNRVLNATVQRTADHAAPEITLDPLEIVGGEIRAS 4033

  Fly  4522 GLAGIDGMKSVFGQMVQKLPLLTQEALAL-------PHRVWKVKFVGESVDDCGGGYSESIAEMC 4579
                   ..|.|.|..::|..:....|.:       |...:.::|.||.|....|.:...:.::|
Human  4034 -------ENSYFCQAARQLASVPSSQLCVKLASGGDPTYAFNIRFTGEEVHGTSGSFRHFLWQVC 4091

  Fly  4580 DELQNGSVPLLINTPNGRGEAGANRDCFLLDPTLSSVLQMNMFRFLGVLMGIAVRTGSPLSINLA 4644
            .|||:.|:.||:..|:  .....|:..::|.|:..:..:..:..|||.|:|||:|...||.::|.
Human  4092 KELQSSSLSLLLLCPS--SAVNKNKGKYILTPSPITYGEEQLLHFLGQLLGIAIRADVPLPLDLL 4154

  Fly  4645 EPVWRQLTGEVLRP-TDLTEVD---RDYVAGLLCIRNMDDDPKL----------FTALELP---- 4691
            ...|:.|.||.|.| .||.|.|   .:||..   ..:::|:.:|          ..|.|.|
Human  4155 PSFWKTLVGEPLDPEQDLQEADILTYNYVKK---FESINDETELEALCAEIASQHLATESPDSPN 4216

  Fly  4692 -----FSTSSARGHEVPLSTRYTHI--SPRNRAEYVRLALGFRLHEFD--EQVKAVRDGMSKVIP 4747
                 |:..:..|.||.|.:|..||  :..|:..|.......||.|..  |.|.|||.|:..:||
Human  4217 KPCCRFTYLTMTGEEVELCSRGRHILVAWENKDIYAAAIRSLRLRELQNVECVTAVRAGLGSIIP 4281

  Fly  4748 VPLLSLFSAAELQAMVCGSPDIPLGLLKSVATYK-GFDPSSALVTWFWEVMEEFTNQERSLFLRF 4811
            :.||::.|..|::...||.|.|.|..||:...|: |...:...:.:||..:|.||.:|...|::|
Human  4282 LQLLTMLSPLEMELRTCGLPYINLEFLKAHTMYQVGLMETDQHIEFFWGALEMFTQEELCKFIKF 4346

  Fly  4812 VWGRTRLPRTIADFRGRDFVLQV----LEKNPPDHFL--PES-----YTCFFLLKMPRYSCKAVL 4865
            ...:.|:|.|.....|......|    ::..|||...  |:|     .||.|::|:|:||...::
Human  4347 ACNQERIPFTCPCKDGGPDTAHVPPYPMKIAPPDGTAGSPDSRYIRVETCMFMIKLPQYSSLEIM 4411

  Fly  4866 LEKLKYAIHF 4875
            ||||:.|||:
Human  4412 LEKLRCAIHY 4421

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HERC2	NP_608388.2	RCC1	638..683	CDD:278826	6/49 (12%)
		RCC1	687..737	CDD:278826	19/68 (28%)
		RCC1	740..787	CDD:278826	5/46 (11%)
		RCC1	790..841	CDD:278826	13/80 (16%)
		RCC1_2	828..857	CDD:290274	4/28 (14%)
		Cyt-b5	1290..1363	CDD:278597	25/110 (23%)
		MIB_HERC2	1928..1987	CDD:284184	11/98 (11%)
		UBA_HERC2	2515..2559	CDD:270585	16/138 (12%)
		Cul7	2624..2699	CDD:288381	13/76 (17%)
		APC10-HERC2	2762..2932	CDD:176485	34/201 (17%)
		RCC1	3037..3088	CDD:278826	6/55 (11%)
		RCC1	3091..3140	CDD:278826	9/48 (19%)
		RCC1	3144..3194	CDD:278826	7/49 (14%)
		RCC1	3197..3246	CDD:278826	2/48 (4%)
		RCC1	3250..3298	CDD:278826	10/53 (19%)
		RCC1	3302..3350	CDD:278826	8/47 (17%)
		RCC1_2	4136..4166	CDD:290274	3/29 (10%)
		RCC1	4154..4203	CDD:278826	5/48 (10%)
		RCC1	4206..4257	CDD:278826	5/50 (10%)
		RCC1	4260..4309	CDD:278826	7/48 (15%)
		RCC1	4312..4360	CDD:278826	12/65 (18%)
		RCC1	4364..4413	CDD:278826	9/48 (19%)
		HECTc	4509..4880	CDD:238033	117/413 (28%)
		HECTc	4553..4878	CDD:214523	110/362 (30%)
HECTD4	NP_001103132.4	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810