DRSC/TRiP Functional Genomics Resources

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Protein Alignment HERC2 and Sergef

DIOPT Version :9

Sequence 1:NP_608388.2 Gene:HERC2 / 33035 FlyBaseID:FBgn0031107 Length:4912 Species:Drosophila melanogaster
Sequence 2:XP_006541006.1 Gene:Sergef / 27414 MGIID:1351630 Length:465 Species:Mus musculus


Alignment Length:511 Identity:136/511 - (26%)
Similarity:200/511 - (39%) Gaps:128/511 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly  2952 SEYSAGVGPGSTAGA---GAVSTSHEEAAAAPEQDLPCTVMVWGLNDKEQLGGLKGSKVKVPTFS 3013
            |.:.|..|..:..||   |.:...|:|....|:|          |:|..|.|.:|.         
Mouse     9 SPWGASCGCEACGGANSYGQLGLGHKEDVFLPQQ----------LSDFCQAGCIKS--------- 54

  Fly  3014 QTISRLRPIHIAGGSKSLFIVSQDGKVYACGEGTNGRLGLGVTHNVPLPHQLPVLRQYVVKKVAV 3078
                      :.||.....:|:..|.::.||...:|:||||.|..|........||...:::|| 
Mouse    55 ----------VTGGGGHSAVVTDGGDLFVCGLNKDGQLGLGHTEEVLRFTICKPLRGCPIRQVA- 108

  Fly  3079 HSGGKHALALTLDGKVFSWGEGEDGKLG--HGNRTTLDKPRLVEALRAKKIRDVACGSSHSAAIS 3141
             .|....:.||..|:|.|.|....|:||  ||.|..: .|:.:|.|| :|:..||.|..|:.|.:
Mouse   109 -CGWDFTIMLTEKGQVLSCGSNAFGQLGVPHGPRKCV-VPQAIECLR-EKVVCVAAGLRHALATT 170

  Fly  3142 SQGELYTWGLG---EYGRLGHGDN----TTQLKPKLVTALAGRRVVQVACGSRDAQTLALTEDGA 3199
            :.|.::.||.|   ...||..|.|    .|..:|..||.|.....|....||  ..:.:||:.|.
Mouse   171 ATGSVFQWGTGLASSGRRLCPGQNLPLFLTAKEPSRVTGLENSTAVCAVAGS--DHSASLTDTGE 233

  Fly  3200 VFSWGDGDFGKLGRGGSEGSDTPHEIER--LSGIGVVQIECGAQFSLALTRAGEVWTWGKGDYYR 3262
            ::.||....|:|. ..:.....|..||.  .....|..:..|....:|.|..|:|:|||:.||.:
Mouse   234 LYVWGRNKHGQLA-SRAVFLPLPQRIEAHYFQDEKVTAVWSGWTHLVAKTETGKVFTWGRADYGQ 297

  Fly  3263 LGH-------------------GGDQHVRKPQPIGGLRGRRVIHVAVGALHCLAVTDAGQVYAWG 3308
            ||.                   .|.|: ..|.|:..|.|  ...::.|:.|.|||. ..:..:||
Mouse   298 LGRRLEPPEAQKPVEQDSSLAFQGPQN-SVPSPLHCLTG--ATEISCGSEHNLAVI-RDKCCSWG 358

  Fly  3309 DNDHGQQGSGN-------TFVNKKP-----ALVIGLDAVFVNRVACGSSHSIA------------ 3349
            .|:||..|.|.       |.|...|     .|::|          ||:.||:|            
Mouse   359 WNEHGMCGDGTESNVWTPTPVQALPPSPSRLLLVG----------CGAGHSLAVCQLPAHPVPCQ 413

  Fly  3350 -----WGLPNASSDEEKRGPVPFSSTRDPLGGSSL------------GIYEAETMQ 3388
                 ..||:.:.:.|.:|.|    .||.|.|.::            |..|:||:|
Mouse   414 DLKVTCPLPDDTENTESQGAV----DRDRLEGETISDLNPDRTRNGGGGCESETVQ 465

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HERC2NP_608388.2 RCC1 638..683 CDD:278826
RCC1 687..737 CDD:278826
RCC1 740..787 CDD:278826
RCC1 790..841 CDD:278826
RCC1_2 828..857 CDD:290274
Cyt-b5 1290..1363 CDD:278597
MIB_HERC2 1928..1987 CDD:284184
UBA_HERC2 2515..2559 CDD:270585
Cul7 2624..2699 CDD:288381
APC10-HERC2 2762..2932 CDD:176485
RCC1 3037..3088 CDD:278826 15/50 (30%)
RCC1 3091..3140 CDD:278826 19/50 (38%)
RCC1 3144..3194 CDD:278826 16/56 (29%)
RCC1 3197..3246 CDD:278826 10/50 (20%)
RCC1 3250..3298 CDD:278826 18/66 (27%)
RCC1 3302..3350 CDD:278826 17/76 (22%)
RCC1_2 4136..4166 CDD:290274
RCC1 4154..4203 CDD:278826
RCC1 4206..4257 CDD:278826
RCC1 4260..4309 CDD:278826
RCC1 4312..4360 CDD:278826
RCC1 4364..4413 CDD:278826
HECTc 4509..4880 CDD:238033
HECTc 4553..4878 CDD:214523
SergefXP_006541006.1 ATS1 22..370 CDD:227511 109/387 (28%)
RCC1 356..402 CDD:366085 16/55 (29%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5184
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1062377at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.820

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