Protein Alignment HERC2 and Hectd4

DIOPT Version :9

• Sequence 1: NP_608388.2
• Gene: HERC2 / 33035
• FlyBaseID: FBgn0031107
• Length: 4912
• Species: Drosophila melanogaster
• Sequence 2: XP_006530414.1
• Gene: Hectd4 / 269700
• MGIID: 3647820
• Length: 4525
• Species: Mus musculus
• Alignment Length: 5806
• Identity: 1081/5806 - (18%)
• Similarity: 1743/5806 - (30%)
• Gaps: 2238/5806 - (38%)

  Fly     4 RQASGGAGSSGQGAGSSQTASAAPVSAGVGVGGG-------------------GGASG------A 43
            |...||:.|||:.....:....:| ..|:..|||                   ||..|      |
Mouse    17 RSGRGGSCSSGRRRRRRRRGRGSP-GPGLACGGGWRRGTPRAEPRGRGGRSRRGGRGGRPWVAEA 80

  Fly    44 AAGA--------GSAAGSGSGSGSGSAAPPSHSPDLYLRPLPFLDAKWLRADLIASLRNAADGAV 100
            ||.|        ||:|.:.:.:.:.:||..|              |:||      |::.  :...
Mouse    81 AAAALQRLLLAMGSSAAAAAAAAAAAAAADS--------------AQWL------SVKE--ETIF 123

  Fly   101 LWNHLIQDCELVSSPTAPLLNARGQLSYLGDDGKHYCGAQQLKCSCCQPEYCGPLSACNCDGCRP 165
            |.:.||:..:|...|:..|                  ||                         |
Mouse   124 LHDGLIRVTDLAELPSEIL------------------GA-------------------------P 145

  Fly   166 LDSDTAIKKLTTQAAAQQAAHLSQATDMVLSGWLWSQPPSQQARLDC--QRSMISELQELALRAA 228
            ..:||.::.||.:.        ...|::           :::.|..|  |.:..:.|.|..|.|.
Mouse   146 EAADTDLEILTFET--------KNPTEL-----------AERLRSVCGNQSNAYARLLEYRLNAL 191

  Fly   229 GNCLSAQHLRQQLFIYERYFVALKRERERERKSTTSAQAVASVTTANTTIAATTANAAVESQPAE 293
            ....:||  ||         :||:.:.|||........|:                  ::.|...
Mouse   192 RGLWNAQ--RQ---------LALEEQHEREGSGDEETLAL------------------LKRQGLL 227

  Fly   294 QQAEHGALGLARVATHAALNFSFAFLRRAWRSGEDTEMC---SELLSEALASLQEL-----PEAT 350
            ||.|.     |...:...|...|..::.  :|..|..:|   :|:|...|...|.|     |...
Mouse   228 QQPEQ-----APFTSRVGLLLVFPLIQS--QSRTDPSLCNITAEVLLNCLRDCQPLSLTKEPADC 285

  Fly   351 LFEAAVVSSLWLEVMERSIKFLRLVALGDPMGNRCTAPLNDRHTALCLLLELGVQKGTLAATLEC 415
            |.....:...|||....:.:.:               |...:..|...|:.|...:|:|...:..
Mouse   286 LNGIETLLCSWLEETSDTGRHI---------------PHKQKENAAAALVALACARGSLKTFVHT 335

  Fly   416 VVLLLLLWEKDRAGNDNRDMPRKT---GAPLQRILLRYQKI-GATAKGGGIAGGE---------- 466
            |.||                .|:|   ..|:..:|.|...: |.......:.||:
Mouse   336 VHLL----------------QRQTELGSLPVADVLYRLLLLEGGPGSPSCLLGGKHIVSWGYEDM 384

  Fly   467 -PAPVASATETFLRFLSLPKSSAAIVDLRRAAVVIISHLDRMVQPLMPRCLLRGGQATAASSSSA 530
             |||.::...:         |.....||                   .|||...|.....::|:.
Mouse   385 LPAPDSNTGSS---------SENKDADL-------------------GRCLTADGHYLYTTNSAG 421

  Fly   531 PQQRIYALGWPSLSKDQQGF------SAEPTLSW----SGESAGVPTL-----SCRFQI---KQV 577
              :.:..|| ..|....:||      ..||  .|    :|.....|..     ...||:   ..:
Mouse   422 --RGVSKLG-SGLHGTLRGFVYCRNEELEP--GWVAYGNGHLLHRPVSFDNKPHSLFQVIDQNTL 481

  Fly   578 ACCET--------------QMLILSQEGKLYTWRLAKPEA--EPLPMEEVAHDVFISI------- 619
            ..|:|              ..:.||.:|..:.| :..|.:  |..|.   .|.||:.|
Mouse   482 QVCQTVPMPASPLPVGSTMSTVHLSSDGTYFYW-IWSPASLNEKTPK---GHSVFMDIFELVVEN 542

  Fly   620 ----AGHCEGRHFLAIDSNHNAYSWGTGEDHRLGHGDTHARAVPTKIAA----------LEQHCV 670
                |...:.|..|......:|.|.......||    :..||.|:...|          |::...
Mouse   543 GVFVANPLQERTILMRKEGESAKSINEMLLSRL----SRYRASPSATLAALTGSTISNTLKEDQA 603

  Fly   671 QSVYCGCSY-----SAAITCGGNLLTWGRGTYARL------GHGNSDDRSLPTLVVALSDHMVVD 724
            .:..||...     :...||         |||..:      |.|:|..|||
Mouse   604 ANTSCGLPLKMLRKTPMYTC---------GTYLVMLVPPPGGSGSSATRSL-------------- 645

  Fly   725 VALGSGDAHSLALTSEGLVFAWGDGDYGK-------LGNGNCNGSLQPILVESLPRVQRVFAGSQ 782
             ..|:....||.:.:..||:...||.:..       .|:....|:|.|.|            |:.
Mouse   646 -FGGTSGLSSLKILASSLVYNISDGQFASRADLIDAAGSSLGRGALVPGL------------GAC 697

  Fly   783 FSVALSSEGQLYT--------WGKATCLGHQLVERSVQGCSVPRLVSSLQHKRIVDVAVSVAHCL 839
            :.   :....|:|        |...   |:|......|...|..:::..:.:.|
Mouse   698 YD---TMNNMLWTCSNDYIDQWCNP---GNQAFHYVCQRLGVSHIITEPKEEAI----------- 745

  Fly   840 ALSSSGEVFGWGRNDSQQICPASVSSEPLLRTPILVSLPTFPASGIACTSAQSLVWTQSSHQGVP 904
               |:.||.....:....:|        :.:..:|.:.|..|.:.:          ....|....
Mouse   746 ---STNEVINQLLHHVGAMC--------IHQLNLLATNPNLPITSV----------LGKQHPIEA 789

  Fly   905 RRAPFVVDLGEPTFRLLDQLLGMCSSQDNRQTPNQESECIAVACLNLFRLQLLALIANGVEPRQV 969
            |....:.|:.|             .:..|..|      ||....|.:|::......:...|..:.
Mouse   790 RHLSSICDIME-------------KAMVNGDT------CIVRCILVVFQVVFKFFFSPQTERNRD 835

  Fly   970 GLASGSRLLCSLKTRILGLAGGSQVLRTIQVAAQQALQDGWSVLLPTAAERAQTLTSLLPSEPGQ 1034
            .:.....||..|.     :|...|:...||.....|:..|.::|.|...| ...|..|:.:| |:
Mouse   836 IIRRSGLLLWQLL-----MAPKDQICPEIQKEVCLAISSGLNILYPGETE-INNLLKLVLTE-GE 893

  Fly  1035 ASSAGHRFMTDLLVSSLMAEGGLESALQHAIRLESSSCSADCGDGVHL--PLLQLITRLLSNNAA 1097
            .:| |...:.|:::::|            |.:|:::...:|..|...|  .||..|.:::...:.
Mouse   894 RNS-GLSQLRDVILTNL------------AEQLQNNRFGSDEDDHYRLNDELLHYILKIVVRESC 945

  Fly  1098 LSQTRLSPTLGKQQEKEEEEREQQHQEPSTSPSLSLLHRFQRLLLSHIHQAQPEE---------- 1152
            :..|:.      |...:::.::.....|:.|..|..|...|..|||:....:|:|
Mouse   946 ILITKC------QTVSKDDFQKLLSTVPAASSCLRYLMAVQNHLLSNTVLIKPDENEDSDSSLQG 1004

  Fly  1153 ETTGAEAL---LLQYMHALIPACVATLQKAHELA-------LQCREPGENSFGQ-----MVGHLG 1202
            ||...:.|   :|.....::..|...|:...::.       :..||.......|     |:|||.
Mouse  1005 ETLKVQELKTSILALATQILTGCDEVLEMLQQVTTALINSDIPDREQRLKGLEQVTKATMLGHLL 1069

  Fly  1203 RVLQADI----------SDALLNELL-------VGLLLLKRDRP--------QCLGGLRWARLFL 1242
            .||...:          :|||:.:|:       ...||||...|        .|....:..|||
Mouse  1070 PVLLTSLMHPNLQTLTMADALMPQLVQLVLYTSQTALLLKTQCPAFAEMSCSPCGTSDQKCRLF- 1133

  Fly  1243 PLLRVLDRLNRALGEGELRDGDDMGWPGIICRGGPKGGPPPADPET----HYVRRAD----MENL 1299
            |..|:|:....               ||.:.  |.|...|.|..:|    |.||  |    .|.:
Mouse  1134 PDERMLEEKEE---------------PGFLT--GLKIPAPWAAGKTVETVHPVR--DNYKFKETV 1179

  Fly  1300 LLDGSRCIIL-------AGYVCDLS-------------GYNCESETL------------RSVLDS 1332
            .:.|:||:.|       :.|..|.|             |.|..|..:            ||||.:
Mouse  1180 HIPGARCLYLRFDTRCSSQYDYDKSNGLFSVLKLVIYAGPNTNSRKVAEYGGNTLGYGSRSVLGT 1244

  Fly  1333 GLGKDLT-AEMSSQVHRTAMEHILEHHKLGKYM--------VQASTEEKSS--------APGPSR 1380
            |..|||. .|..:......|....||:...|.|        .|.|:|:.|.        |.|.|.
Mouse  1245 GWPKDLVKVEGDTVTFSFEMRSGREHNTPDKAMWGFACTVRAQESSEDVSGGLPFLVDLALGLSV 1309

  Fly  1381 LTHFSSECALAQLLGLVANLMCSGPALQPAELQCRQLDKSSLL--------SGGL--QLLQPS-N 1434
            |.     |::.::|       .:||.:...|..|:.|.:|.||        :.|:  ..|.|| :
Mouse  1310 LA-----CSMLRIL-------YNGPEITKEEEACQDLLRSKLLQRCQWQVEANGVISPALTPSPS 1362

  Fly  1435 P----FDEEKGEARSSHSCHSTAGN----TPTELPPPLPMQQQLAPGRGKSQLQLRADAFISGLA 1491
            |    .:|::.....:.......||    ....|||.:.::.:...||.:.|.:    ..|..:.
Mouse  1363 PLPLTIEEDREFTYPADVLVPPVGNYFDLPRIRLPPGIMIKLREISGRARPQFR----PSIKEVI 1423

  Fly  1492 EARVSEPPVAA----WLALTERYCKAHNLMWHQEFATEHPVQELERLLSAVLIRHQYLGGLVLNA 1552
            :..|.|..|.:    .|.|.:......|..:.:|.|.|:.:  |.:::.....:        |||
Mouse  1424 QPDVMEEMVVSCVIKHLNLVDALQSLINFQYQEEHAEEYDL--LCKIMGETFKK--------LNA 1478

  Fly  1553 LETEVPPPRQLGEIIRLVHQAKW-----SVVRTRQQLNR--------------------SYKEVC 1592
            :|      |||..:..|  :.||     ..::.:.:.|.                    |.|||.
Mouse  1479 ME------RQLQSVAEL--EQKWQSEAEDAMQGKLENNMPFFYDYHFNENKMKELELLCSMKEVS 1535

  Fly  1593 --APILERLRFLLYEVRPAISPQQRGLRRLPILQRPP-----RFKMLVRRLLQ--EL-------- 1640
              ...||.:         .:|.:::.|:.:..|.:.|     :.|.|||.|:.  ||
Mouse  1536 FDGNDLENM---------VLSLREKFLQEVNSLAQKPSHPLAKTKTLVRSLMNRAELLLHVTIAA 1591

  Fly  1641 -----RS-SRQPAKPEDLLNAS--------IQQEQEKKPQSMPKQELEEQEEEETLLRRLNE--- 1688
                 || |..||:.....:||        ::|....:..|.| .:||....|:....|.|:
Mouse  1592 QAGLTRSISGTPAETPACKSASETKVASHAVRQPVFLRSMSAP-SDLEMIGNEDLEFTRANQSLV 1655

  Fly  1689 ----RQIHGEGELDPALMQDIVDFALQDSCDVETARRAMYCQMQRYQLRLAGL---------QIV 1740
                |.:.........|:|.:   |::||.|..|           |.:.|..|         |.|
Mouse  1656 FCRRRHVTSHRSSSFTLLQSL---AIEDSRDKPT-----------YSVLLGQLFAFIGTNPDQAV 1706

  Fly  1741 --------------------QQLLELHGLLDAA------------QYSLLNGFLGLHLKSTSSGG 1773
                                |.|:.:..||.||            ...:|.|  |..::..:.||
Mouse  1707 SSSSFLLAAQTRWRRGNTRKQALVHMRELLTAAVRVGGVTHLVGPVTMVLQG--GPRIEELTCGG 1769

  Fly  1774 ---------GSTGSG----------SSLHVLGQLNMISAYQKARLLLAQSRVLDWAVRELRRLVN 1819
                     |.|.:.          :..:.:|.|..|...:.....|.:|.:    |:.:.||.:
Mouse  1770 MVEQVQEAFGETMTSVVSLCARYPIACANSIGLLCTIPYTRSEEKCLVRSGL----VQLMDRLCS 1830

  Fly  1820 QEQQGHARGKDSTNLGTYVLLKRLPRARFLLSVFGLLA--------KELGPNELGFLINSGLLGT 1876
            ...|..:...:...       |:...|....:.|.:||        :|.|..|   .::|||...
Mouse  1831 LSSQTESSSSEKQT-------KKQKVATMAWAAFQVLANRCVEWEKEEGGSTE---AVHSGLARQ 1885

  Fly  1877 VLGLLAQ--------TGGEGATGGQVHGELSILYEDSVLKQKSSKAQLSGPDLA----------- 1922
            |..||..        .|.:.|....:...||:|  :.:.:....||.||.|...
Mouse  1886 VSSLLTNHLARATECCGNQAAGNDALQDVLSLL--NDLSRSHIGKAILSQPACVSKLLSLLLDQR 1948

  Fly  1923 ---KLMKIGTRIVRGA---------------DWKWG--------DQDGNP--------------- 1946
               ||:.|..::.|.|               .|.:.        :...:|
Mouse  1949 PSPKLVLIILQLCRAALPLMSVEDCGNVELPPWSYSVPSLNSEQEDPSDPASKIASLLLAKLADY 2013

  Fly  1947 --PGEGRIISEVGEDGWVRVEWYTGATNSYRMGKEGQYDLQLADSALNVASPTEPEREDVSGSEA 2009
              ||...::|....:....:. .|...||.:..|:...:.:..|..|::..   .:|||.|..|.
Mouse  2014 VVPGCQTVLSPTASEPDTTLT-KTSPKNSLKGDKDPGEESEAVDGKLSIFI---HKREDQSSHEV 2074

  Fly  2010 -SP---TSDSHPSKLLRHCAAKLLQILAVGTGLH---GAQLDKDALRGMTSMFRTIIYPKPSMSN 2067
             .|   :|:..|.:|              |||.:   ..::|:|..:|....    :..:.:.:.
Mouse  2075 LQPLLSSSEGRPFRL--------------GTGANMEKVVKMDRDMTKGGCCE----VITEEASAA 2121

  Fly  2068 ISYALGWLNLGFIRAISGDCPRLCLELSTPGWLSHYLSLLEQPAGNEAGVYRQLHCLRLLQLILA 2132
            :..|..|...|.|.::...     :|...|..:|. ||..::....:..:.|:    |..:|
Mouse  2122 LRKATKWAQSGLIVSVGPP-----VESINPETVSG-LSTGDKKKTAQTSICRE----RNSEL--- 2173

  Fly  2133 QWGAEEEPRMPALVHQLFATLGRIALHCPGDASLLPTAEGKARVLLTASHSGSVAEELVALLRRL 2197
               |..:|..|.:       .|.:|                          .|:|.|::|||..|
Mouse  2174 ---ARTDPVRPFI-------SGHVA--------------------------NSMAAEVIALLHSL 2202

  Fly  2198 HTLPS------WNPVINSFLAQKLCVA------AELLAEQSHSTA-----LDSEQVFVLGVLGAM 2245
            ...|.      |.......|::.|...      ||.:.|...|:.     |.......:..|.|:
Mouse  2203 LMAPESNAAQIWTTTAEKVLSRALMYIPQLGKYAESILENGSSSGRKLAKLQRIARQAVAALCAL 2267

  Fly  2246 GGHDLRPRVG-----LHCFHEGSHMVIASFTPKGRCLLAPGGVGSGVGFVKVQLPAV-----MPH 2300
            ||.....::|     |.....||..|:||             :....|...|:.|.|     ...
Mouse  2268 GGFKETIKIGSEVQVLGRGISGSIGVVAS-------------INEQEGIATVRFPPVDCRRTSQA 2319

  Fly  2301 LDHTVFSLSR--------LPMN-----EMLLNAWTVLLYGPAPEL---RELPSSADGRLD-LALL 2348
            .|.....|||        ||::     |.::.|...:|......|   ..||::.||... :|::
Mouse  2320 ADTLTIPLSRLCVPRSEALPLHKLSITEKVVQAVQSMLLPQEGSLSIHTSLPATGDGSAPVMAVV 2384

  Fly  2349 RAQQLQMAVLHTNGVLYRHQVALRRILKQRAPGSIYASPDEPDRSDAESQQPGEQD------QQL 2407
            |.    :|.:.|...|         ::.|....|::.       .:...|.|...:      |:.
Mouse  2385 RL----LAEIRTRACL---------VMAQLLEDSLFC-------EEFIQQCPAAVEVLNLVAQEC 2429

  Fly  2408 SSGSGQEPQLLI---QCILLR------------ATQAS----------------PVKACYSYMDL 2441
            |:|.    :|.:   ||..||            ..||.                ||:||     :
Mouse  2430 SAGE----RLAVVEMQCERLRMLYRDCARPPPPPLQADRRQPKEITWSPSRVFPPVRAC-----M 2485

  Fly  2442 ATAALNCIQSLATQAHQELSEGGGVPPNGRALSSPPQPTMVHG------VPVYNVARKEQKP--- 2497
            .::.|..:..||     :.|.|||:|......::.|.|.....      :..|.....:..|
Mouse  2486 FSSHLTSVTFLA-----DPSAGGGLPRGTFIYATSPLPVQAPSFYWEIEIVSYGDTDDDTGPIVS 2545

  Fly  2498 ---SEQVEQKS---------------------------KWPAAATDAQLI-GQIMEMGFTRR--- 2528
               :.:.|::.                           :|.:...|..|. |.:..:|:.|.
Mouse  2546 FGFATEAEKRDGAWTNPVGTCLFHNNGRAVHYNGSSLLQWKSVRLDVTLSPGDVAGIGWERTEGT 2610

  Fly  2529 ----------------------------------TVELALKQLSLQAEIMPTPEQIVQWILEH-- 2557
                                              .|.:..|....:|.....|....:.....
Mouse  2611 PPPPGQPAKGRVYFTYCGQRLTPYLEDVSGGMWPVVHIQKKNTKTRANFGSRPFAYAEGQAHRNA 2675

  Fly  2558 PDVCANTIEE-----DTLPLASSASSHDPEADSDNECPSS----------------NSTTSSSTS 2601
            .|:|.:..||     :.||.|.:       :||||:..:|                .:|......
Mouse  2676 ADLCTDLAEEISANFEALPFAMA-------SDSDNDAGTSIASDPGTHGPPCRIAAVATAQQQYD 2733

  Fly  2602 SDT-------VEGQPMAVSGP---APPVKFESRKDFQTADL-----YALYVR------------- 2638
            |||       :..:....|||   .||:..:...|....|:     |||.|:
Mouse  2734 SDTSCHYKVELSYENFITSGPDPHPPPIADDESDDDDDDDIPQEDHYALLVKAWETKVFPTIRRR 2798

  Fly  2639 ---------GL----------------------------------------------------VR 2642
                     ||                                                    ||
Mouse  2799 FRNEAERKSGLDQIKGALQLGMVDIARQTVEFLYEENGGIPRDLYLPTIEDIKDEANKFTIDKVR 2863

  Fly  2643 PGMT-VRCCRDFEEIKQGDMGTVL-----------------IVDTEGLHDLNVQVD--WRNHG-- 2685
            .|:| |....|...:....:||.|                 ::|.:.:::| |||:  .|:.|
Mouse  2864 KGLTVVTRSPDSSNVASSTVGTALPKFAIRGMLKTFSLHGVVLDVDSVNEL-VQVETYLRSEGVL 2927

  Fly  2686 STYWVCFVHIELVEAAQTHHQPRPPP----IAVGARVRLRTSSL---RYGMLCPLRLGRSQGSSA 2743
            ..||   ..|:::|        |||.    .|....|.|..::|   |..:.|...|.|.....|
Mouse  2928 VRYW---YPIDMLE--------RPPAGYRRTATNGLVTLDNTNLQIHRELLRCEAALARLYCRMA 2981

  Fly  2744 IGVVSSVRSKQLTVDFPDQPAWQG-HINEVELVASQPTSATLPSLGDSCSQMPPSDLIEDWSRCI 2807
            :..:.:.:...|.......||.:. .:..::|:::|..:..||....|.|.:.   |.:....||
Mouse  2982 LLNIFAPKLPHLFTRLFHIPAIRDITLEHLQLLSNQLLAPPLPDGTISSSSIL---LAQSLQHCI 3043

  Fly  2808 RSLTVSSNEAAAKHLLNGSNQPWQSCSSGPCRHWIRLELHDRILVHSLTLKVSPEDHSHMPSLLE 2872
            .|.:.|:.:.    ...||:|        ..|.|             |::.::...|....||||
Mouse  3044 HSQSCSATDL----FYQGSSQ--------TLREW-------------LSVAITRTLHQGEDSLLE 3083

  Fly  2873 IRVGDCVDSLKEYTWIPVPAGASRVLLMQQVPTYYPWVEVVVKQCQNNGIQCKIHGIKFVGRRQQ 2937
            :....|.                   .:|..|..:|..|..|.:
Mouse  3084 LTKQICA-------------------FLQTAPEQFPSEEFPVSE--------------------- 3108

  Fly  2938 PDLQHILANAQFLASEYSAGVGPGSTAGAGAVSTSHEEAAAAPEQDLP------CTVMVWGLNDK 2996
                          |:.|..|   :..||..|..|.:|:.:...:|..      ..|:|:||..|
Mouse  3109 --------------SKVSMDV---NFPGAAFVVVSCKESQSGFRKDSSLYKAPWARVLVYGLGHK 3156

  Fly  2997 -EQLGGLKGSKVKVPTFSQTIS----RLRPIHIAGGSKSLFIVSQDGKVYACGEGTNGRLGLGVT 3056
             ::.|.|  :.::...:.:..|    .|.|...|....|: ::|.| ||:         :.|||:
Mouse  3157 VKRTGQL--NLIEAACYPRDASPANTGLAPPPTADQYPSV-VLSTD-KVH---------IKLGVS 3208

  Fly  3057 HNVPLP------HQLPVLRQYVVKKVAVHSGGKHALALTLDGKVFSW-GEGEDGK---------- 3104
               |.|      |.||:               :..||:....::.|| .|..|||
Mouse  3209 ---PPPGAVLVLHSLPL---------------EFPLAMAFAEQLLSWKSEDSDGKSEDEPDSIPA 3255

  Fly  3105 ---------LGHGNRTTLDK----PRLVEALRAKKIRDVAC--GSSHSAAISSQGELYTWGLGEY 3154
                     ||:...|| |.    ..||..|.|:.:|.|..  ...|.|.:||...|
Mouse  3256 SVLLHVVELLGNFLWTT-DMAACVKELVFHLLAELLRTVHTLEQRKHPAGLSSSIAL-------- 3311

  Fly  3155 GRLGHGDNTTQLKPKLVTALAGRRVVQVACGSRDAQTLALTEDGAVFSWGDGDFGKLGRGGSEGS 3219
                      ||.|.|...:|.:            ..|....|....||
Mouse  3312 ----------QLNPCLAMLMALQ------------SELHKLYDEETQSW---------------- 3338

  Fly  3220 DTPHEIERLSGIGVVQIECGAQFSLALTRAGEVWTWGKGDYYRLGHGGDQHVRKPQPIGGLRGRR 3284
                         |....||...:.|:...|...|:    ::.|..|
Mouse  3339 -------------VSSSACGGSGAAAVGDQGRFSTY----FHALMEG------------------ 3368

  Fly  3285 VIHVAVGALHCLAVTDAGQVYAWGDNDHGQQGSGNTFVNKKPALVIGLDAVFVNRVACGSSHSIA 3349
                      ||||.                                 :......::..:|...:
Mouse  3369 ----------CLAVA---------------------------------EVTLPTNISVTASGVTS 3390

  Fly  3350 WGLPNASSDEEKRGPVPFSSTRDPLGGSSLGIYEAETMQTLKQEAKPLNQSSL---SESLALETP 3411
            ...||.|.........|..:.:.|   |.|...:...|:..|..:....|||.   ::|..|...
Mouse  3391 TTTPNLSDSSSSSSSSPGQTPQSP---SLLSKRKKVKMKREKASSSNKRQSSRASDADSTVLSIG 3452

  Fly  3412 AARQAALGHVLRAMSILQARQLIVAALTSHSKVNFKERGAVGGEEDHL------IGGP------- 3463
            .::...:....||:::|    :|:..||.      |:...:|...|.:      :.||
Mouse  3453 GSKPEDMLWFHRALTLL----IILRHLTK------KDPQGLGVTSDAIADACQALVGPTAHSRLL 3507

  Fly  3464 -IMGAPLQLAETIAQGG--------GEAPADATDAGLQEHSPEAAVDALTGGMSGGANTLPPLSA 3519
             |.|.|..|.|.:.:|.        |....|.....||:..|:...|...|..|       .:.:
Mouse  3508 VISGIPTHLDEAVVRGAIRKACNAHGGVFKDEIYIPLQDEDPKKPKDKAEGSDS-------KVES 3565

  Fly  3520 GPLSAFQSLTGSLSMSGSLSSSALPQHKHSRMSASAMSVMAATMTQQEEMLSHISHCHGLDDFGG 3584
            ..|..|.|:.   |:.||.|||..|          |||:.|:..|.|..:.|  |.|
Mouse  3566 EKLLGFPSVD---SLEGSTSSSLAP----------AMSISASASTSQASVCS--SQC-------- 3607

  Fly  3585 LLGEPEAKSLVELLKLAVCGRCGPPSTSQTIADTLISLGAGTPAVAAMLLETCITELEDLCTSRH 3649
                                      .|||.:|..:.     |..:.:
Mouse  3608 --------------------------VSQTASDLSVD-----PLPSGL----------------- 3624

  Fly  3650 CLGKLP-KPVMQESSHPYVDNVNVTGVVRIPGAEMLRLEFDSQCSTEKRNDPLVIMDGTGRVLAM 3713
               :|| .||:.|   |:|          :...|.|.:   |.|||
Mouse  3625 ---ELPVPPVLLE---PHV----------VSSQESLDI---SLCST------------------- 3651

  Fly  3714 RSGREFAHWAPEIRVLGDELRWKFSSDSSVNGWGWRFWVHAIMPAATLGESGSDRAVLSQPSMAL 3778
                                                         .:||..||    |.:|
Mouse  3652 ---------------------------------------------GSLGSLGS----LGEP---- 3663

  Fly  3779 VMSLLDSRLAPRQPSVLLRLASALAACSQLGALTTAQRIWSLRKLHAVLLLEQAPRPQDPSLSTL 3843
                ||:   |...||           |.:|::.|.                       .||.|
Mouse  3664 ----LDN---PETASV-----------SDVGSMYTV-----------------------TSLDT- 3686

  Fly  3844 LQPLIPELLRQYEYEEPQVRGGIHLMHSDYFKT-----LAAL-----ACDMQLDAALPATSSSSS 3898
             |||....::.:...|.:.|..|..:.:..|..     |::|     ..:|..:..|..:..:.|
Mouse  3687 -QPLATRPIKGFAVVEIRSRAKIEKIRASLFNNNDLIGLSSLDGEDELMEMSTEEILTVSVVNQS 3750

  Fly  3899 ---SSAAPGAISSTGDVHKWAWFKRYCIAVRVAQSLIRRTELPRAFCLEVRKKFAEMLPSSSSNS 3960
               :..:||......|                 :|:.....:|.|     |:...|:..|.:.:
Mouse  3751 LFDTQGSPGLEDYFSD-----------------KSIKGEKLVPGA-----REVLTEIFKSCAHS- 3792

  Fly  3961 NANPGCQSPGASMLNSTTSLSSSTVSNVSPPPGITGEQPDLHCHAHQLESTS--TLLHEDHTLFQ 4023
                          ..|.||:.:....||          |::....|:.|.:  .|||...|..:
Mouse  3793 --------------EQTLSLTPAKPIRVS----------DIYLSKEQINSQTPGNLLHLFFTNVR 3833

  Fly  4024 APH---DAQLLQWLNRRPDDWALSWGGASTIYGWGHNHRGQLGGLEGSRIKTPTPCEALSLLRPV 4085
            .|.   :.||.|.|.:               ||
Mouse  3834 PPKKVLEDQLTQILRK---------------YG-------------------------------- 3851

  Fly  4086 QLAGGEQSLFAVTPDGKLFATGYGSGGRLGVGGSDSWAIPTLLGSLQHVFVKKVAVNSGGKHCLA 4150
                        .|..||..:.|...|:                 .||. ||.|
Mouse  3852 ------------VPKPKLDKSKYSKAGK-----------------EQHP-VKVV----------- 3875

  Fly  4151 LTTEGEVYAWGEGEDGKLGHGNRMSYDRPKLVEHLNGMSVADIACGSAHSAAITASGHVLTWGKG 4215
                                    |..||             :....|...|:.:|
Mouse  3876 ------------------------STKRP-------------VTKPPAKDKAVLSS--------- 3894

  Fly  4216 RYGRLGHGDSEDQLRPKLVEALLGYRAIDIACGSGDAQTLCITDDDNVWSWGDGDYGKLGRGGSD 4280
             ..|....:.:..::||..|                                     |......|
Mouse  3895 -LSRTALSEKKPTVKPKSPE-------------------------------------KSKPDEKD 3921

  Fly  4281 GCKLPYKIESLAGLGVVKVECGSQFSVALTKSG------AVYTWGKG-DFHRLGHGSVDHVRRPK 4338
            ..|.|.|.:.:.....:.:|...:|.:...|..      |:.:.|.. .|.|.....|.|.::..
Mouse  3922 PEKSPTKKQEVPEEKYLTLEGFHKFVIDRAKQDIRSVWRAILSCGYDLHFERCACIDVRHAQKAS 3986

  Fly  4339 K-------VAALQG----KKIISIATGSLHCVACSDSGEVYTWGDNDEGQLGDGTVTAIQRPRLV 4392
            :       ||.:|.    .:.::|....||      ..|||.    |.....|        ||:.
Mouse  3987 RKWTLEMDVALVQYINRLCRHLAITPARLH------PHEVYL----DPADAAD--------PRMA 4033

  Fly  4393 AALQGKHIVKVTCGSAHTLALSTSQLSERLRPLPNPPLEYDLVRDLAPEALHARLILLH------ 4451
            .                               |.|.|:          |:|..|..||.
Mouse  4034 C-------------------------------LSNVPI----------ESLRLRFALLQSLNTTL 4057

  Fly  4452 --HFSELVCPCLAMLPISGDLSLGAL----KDVLVYNIKEAAFRKVIQTTMVRDKQH-GPVIELN 4509
              .|..||  .|...|:... |:.||    |.::.|:.|.....:|:..|:.|...| .|.|.|:
Mouse  4058 ETFFLPLV--ELRQTPMYAH-SIAALLKEAKGLIFYDTKVTVMNRVLNATVQRTADHAAPEITLD 4119

  Fly  4510 RIQVKRSRNRCNGLAGIDGMKSVFGQMVQKLPLLTQEALAL-------PHRVWKVKFVGESVDDC 4567
            .:::.....|.:       ..|.|.|..::|..:....|.:       |...:.::|.||.|...
Mouse  4120 PLEIVGGEIRAS-------ENSYFCQAARQLASVPSSQLCVKLASGGDPTYAFNIRFTGEEVHGT 4177

  Fly  4568 GGGYSESIAEMCDELQNGSVPLLINTPNGRGEAGANRDCFLLDPTLSSVLQMNMFRFLGVLMGIA 4632
            .|.:...:.::|.|||:.|:.||:..|:  .....|:..::|.|:..:..:..:..|||.|:|||
Mouse  4178 SGSFRHFLWQVCKELQSSSLSLLLLCPS--SAVNKNKGKYILTPSPITYGEEQLLHFLGQLLGIA 4240

  Fly  4633 VRTGSPLSINLAEPVWRQLTGEVLRP-TDLTEVD---RDYVAGLLCIRNMDDDPKL--------- 4684
            :|...||.::|....|:.|.||.|.| .||.|.|   .:||..   ..:::|:.:|
Mouse  4241 IRADVPLPLDLLPSFWKTLVGEPLDPDQDLQEADILTYNYVKK---FESINDESELEALCAEIAS 4302

  Fly  4685 -FTALELP--------FSTSSARGHEVPLSTRYTHI--SPRNRAEYVRLALGFRLHEFD--EQVK 4736
             ..|.|.|        |:..:..|.||.|.:|..||  :..|:..|.......||.|..  |.|.
Mouse  4303 QHLATESPEGPKPCCRFTYLTMTGEEVELCSRGRHIPVAWENKDIYAAAIRSLRLRELQNMECVT 4367

  Fly  4737 AVRDGMSKVIPVPLLSLFSAAELQAMVCGSPDIPLGLLKSVATYK-GFDPSSALVTWFWEVMEEF 4800
            |||.|:..:||:.||:..|..|::...||.|.|.|..||:...|: |...:...:..||..:|.|
Mouse  4368 AVRAGLGSIIPLQLLTTLSPLEMELRTCGLPYINLEFLKAHTMYQVGLMETDQHIELFWGALEMF 4432

  Fly  4801 TNQERSLFLRFVWGRTRLPRTIADFRGRDFVLQV----LEKNPPDHFL--PES-----YTCFFLL 4854
            |.:|...|::|...:.|:|.|.....|......|    ::..|||...  |:|     .||.|::
Mouse  4433 TQEELCKFIKFACNQERIPFTCPCKDGGPDTAHVPPYPMKIAPPDGTAGPPDSRYIRVETCMFMI 4497

  Fly  4855 KMPRYSCKAVLLEKLKYAIHF 4875
            |:|:||....:||||:.|||:
Mouse  4498 KLPQYSSLETMLEKLRCAIHY 4518

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HERC2	NP_608388.2	RCC1	638..683	CDD:278826	10/59 (17%)
		RCC1	687..737	CDD:278826	12/55 (22%)
		RCC1	740..787	CDD:278826	10/53 (19%)
		RCC1	790..841	CDD:278826	8/58 (14%)
		RCC1_2	828..857	CDD:290274	4/28 (14%)
		Cyt-b5	1290..1363	CDD:278597	26/109 (24%)
		MIB_HERC2	1928..1987	CDD:284184	11/98 (11%)
		UBA_HERC2	2515..2559	CDD:270585	8/83 (10%)
		Cul7	2624..2699	CDD:288381	27/175 (15%)
		APC10-HERC2	2762..2932	CDD:176485	30/170 (18%)
		RCC1	3037..3088	CDD:278826	12/56 (21%)
		RCC1	3091..3140	CDD:278826	19/74 (26%)
		RCC1	3144..3194	CDD:278826	7/49 (14%)
		RCC1	3197..3246	CDD:278826	6/48 (13%)
		RCC1	3250..3298	CDD:278826	6/47 (13%)
		RCC1	3302..3350	CDD:278826	1/47 (2%)
		RCC1_2	4136..4166	CDD:290274	3/29 (10%)
		RCC1	4154..4203	CDD:278826	4/48 (8%)
		RCC1	4206..4257	CDD:278826	5/50 (10%)
		RCC1	4260..4309	CDD:278826	7/48 (15%)
		RCC1	4312..4360	CDD:278826	12/65 (18%)
		RCC1	4364..4413	CDD:278826	7/48 (15%)
		HECTc	4509..4880	CDD:238033	117/412 (28%)
		HECTc	4553..4878	CDD:214523	110/361 (30%)
Hectd4	XP_006530414.1	CCDC154	149..>233	CDD:373856	26/136 (19%)
		SPRY_HECT_like	2507..2662	CDD:293970	14/154 (9%)
		HECTc	4127..4520	CDD:391658	117/404 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810