Protein Alignment HERC2 and SERGEF

DIOPT Version :10

• Sequence 1: NP_608388.2
• Gene: HERC2 / 33035
• FlyBaseID: FBgn0031107
• Length: 4912
• Species: Drosophila melanogaster
• Sequence 2: NP_036271.1
• Gene: SERGEF / 26297
• HGNCID: 17499
• Length: 458
• Species: Homo sapiens
• Alignment Length: 436
• Identity: 127/436 - (29%)
• Similarity: 188/436 - (43%)
• Gaps: 67/436 - (15%)

  Fly  4048 ASTIYGWGHNHRGQLGGLEGSRIKTPTP----CEALSLLRPVQLAGGEQSLFAVTPDGKLFATGY 4108
            |:.::.||.|..||||......:..|..    |:..|:.|   :.||......||..|.||..|.
Human    14 AAALFAWGANSYGQLGLGHKEDVLLPQQLNDFCKPRSVRR---ITGGGGHSAVVTDGGDLFVCGL 75

  Fly  4109 GSGGRLGVGGSDSWAIPTLLGSLQHVFVKKVAVNSGGKHCLALTTEGEVYAWGEGEDGKLG--HG 4171
            ...|:||:|.::.....|...||....:::||  .|....:.||..|:|.:.|....|:||  ||
Human    76 NKDGQLGLGHTEDIPYFTPCKSLFGCPIQQVA--CGWDFTIMLTENGQVLSCGSNSFGQLGVPHG 138

  Fly  4172 NRMSYDRPKLVEHLNGMSVADIACGSAHSAAITASGHVLTWGKGRYG---RLGHGDSEDQL---- 4229
            .|... .|:.:| |:...|..||.|..|:.|.||||.|..||.|...   ||..|.:....
Human   139 PRRCV-VPQAIE-LHKEKVVCIAAGLRHAVAATASGIVFQWGTGLASCGRRLCPGQTLPLFFTAK 201

  Fly  4230 RPKLVEALLGYRAIDIACGSGDAQTLCITDDDNVWSWGDGDYGKLGRGGSDGCKLPYKIES--LA 4292
            .|..|..|...:|:.:..||..:.:|  ||...|:.||...:|:|....: ...:|.|||:  ..
Human   202 EPSRVTGLENSKAMCVLAGSDHSASL--TDAGEVYVWGSNKHGQLANEAA-FLPVPQKIEAHCFQ 263

  Fly  4293 GLGVVKVECGSQFSVALTKSGAVYTWGKGDFHRLGHGSVDHVRRPKKVAALQGKKI--------- 4348
            ...|..:..|....||.|::|.::|||:.|:.:||          :|:...:|.|:
Human   264 NEKVTAIWSGWTHLVAQTETGKMFTWGRADYGQLG----------RKLETYEGWKLEKQDSFLPC 318

  Fly  4349 ---ISIATGSLHC------VACSD-------SGEVYTWGDNDEGQLGDGTVTAIQRPRLVAALQG 4397
               .:....|.||      |:|..       .|..|:||.|:.|..||||...:..|:.|.||..
Human   319 SRPPNSMPSSPHCLTGATEVSCGSEHNLAIIGGVCYSWGWNEHGMCGDGTEANVWAPKPVQALLS 383

  Fly  4398 KHIVKVTCGSAHTLALSTSQLSERLRPLPNPPLEYDLVRDLAPEAL 4443
            ...:.|.||:.|:|||  .||......:.:|.:.|     |:|:|:
Human   384 SSGLLVGCGAGHSLAL--CQLPAHPALVQDPKVTY-----LSPDAI 422

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HERC2	NP_608388.2	ATS1	625..>894	CDD:444065
		Cyt-b5	1292..1364	CDD:459698
		MIB_HERC2	1928..1988	CDD:461991
		UBA_HERC2	2515..2559	CDD:270585
		Cul7	2624..2699	CDD:463286
		APC10-HERC2	2762..2932	CDD:176485
		ATS1	2987..3320	CDD:444065
		RCC1	3302..3350	CDD:395335
		ATS1	4050..4389	CDD:444065	108/378 (29%)
		HECTc	4509..4880	CDD:238033
SERGEF	NP_036271.1	RCC1 1	15..67		15/54 (28%)
		ATS1	23..375	CDD:444065	106/371 (29%)
		RCC1 2	68..119		16/52 (31%)
		RCC1 3	120..171		19/52 (37%)
		RCC1 4	172..230		16/59 (27%)
		RCC1 5	231..283		14/52 (27%)
		RCC1 6	284..351		15/76 (20%)
		RCC1 7	352..402		20/51 (39%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	420..458		1/3 (33%)