DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment HERC2 and HECTD1

DIOPT Version :9

Sequence 1:NP_608388.2 Gene:HERC2 / 33035 FlyBaseID:FBgn0031107 Length:4912 Species:Drosophila melanogaster
Sequence 2:NP_056197.3 Gene:HECTD1 / 25831 HGNCID:20157 Length:2610 Species:Homo sapiens


Alignment Length:2899 Identity:585/2899 - (20%)
Similarity:922/2899 - (31%) Gaps:996/2899 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   689 LLTWGRGTYARLGHGNSDDRSLPTL-----VVALSDHM---------------VVDVALG-SGDA 732
            ||.|     .::|.|:..|..|..|     ::.:||::               :..:.|. |...
Human     9 LLEW-----LQMGQGDERDMQLIALEQLCMLLLMSDNVDRCFETCPPRTFLPALCKIFLDESAPD 68

  Fly   733 HSLALTSEGLVF------------AWGDGDYGKLGNGNCNGSLQPILVESLPRVQRVFAGSQFSV 785
            :.|.:|:..:.:            ...||....|    ||   :.::||...|..|..|.....|
Human    69 NVLEVTARAITYYLDVSAECTRRIVGVDGAIKAL----CN---RLVVVELNNRTSRDLAEQCVKV 126

  Fly   786 ----ALSSEGQLYTWGKATCL-------GH-----------QLVER----------SVQGCSVPR 818
                .....|.::..|...|:       ||           .:|.|          |::.| |..
Human   127 LELICTRESGAVFEAGGLNCVLTFIRDSGHLVHKDTLHSAMAVVSRLCGKMEPQDSSLEIC-VES 190

  Fly   819 LVSSLQHKRIVDVAVSVAHCLALSSSGEVFGWGRNDSQQICPASVSSEPLLRTPILVSLPTFPAS 883
            |.|.|:|:   |..||.......:|..:.|.....|...:....::.|.|.|........:.|:|
Human   191 LSSLLKHE---DHQVSDGALRCFASLADRFTRRGVDPAPLAKHGLTEELLSRMAAAGGTVSGPSS 252

  Fly   884 GIACTSAQSLVWTQS--SHQGVPRRAPFVVDL------GEP--TFRLLDQLLGMCSSQDNRQTPN 938
              ||...:|.....|  :...:..:...:|.|      |.|  |..||...|     .|:.::..
Human   253 --ACKPGRSTTGAPSTTADSKLSNQVSTIVSLLSTLCRGSPVVTHDLLRSEL-----PDSIESAL 310

  Fly   939 QESE-CIAVACLNLFRL--QLLALIANGVE--PRQVGLASGSRLLCSLKTRILGL----AGGS-- 992
            |..| |:    |:..||  .||.|:..|.:  |:....::|         ||.||    :.|.  
Human   311 QGDERCV----LDTMRLVDLLLVLLFEGRKALPKSSAGSTG---------RIPGLRRLDSSGERS 362

  Fly   993 --QVLRTIQVAAQQALQDGWSVLLPTAAERAQTLTSLLPSEPGQASSAGHRFMTDLLV--SSLMA 1053
              |::..|:.....||.|.    :.|.|.....:..:..:....||:.|.:.|.:.|.  .:.:.
Human   363 HRQLIDCIRSKDTDALIDA----IDTGAFEVNFMDDVGQTLLNWASAFGTQEMVEFLCERGADVN 423

  Fly  1054 EGGLESALQHAI---------RLESSSCSADCGD-GVHLPLLQLITRLLSNNAALSQTRLSP--- 1105
            .|...|:|.:|.         .|.....:.|..| ....||.:...|..|...|:.|   ||   
Human   424 RGQRSSSLHYAACFGRPQVAKTLLRHGANPDLRDEDGKTPLDKARERGHSEVVAILQ---SPGDW 485

  Fly  1106 ----TLGKQQEKEEEER-EQQHQEPSTSPSLSLLH----------RFQRLLLSHIHQAQPEEETT 1155
                ..|..::|::..: |::..||...|.::.::          .||:.:|..|.:|.      
Human   486 MCPVNKGDDKKKKDTNKDEEECNEPKGDPEMAPIYLKRLLPVFAQTFQQTMLPSIRKAS------ 544

  Fly  1156 GAEALLLQYMHALIPACVATLQKAHELALQCREPGENSFGQMVGHLGRVLQADISDALLNE---- 1216
                  |..:..:|..|...|.|         |..::.    |||....:..:|:..:|::    
Human   545 ------LALIRKMIHFCSEALLK---------EVCDSD----VGHNLPTILVEITATVLDQEDDD 590

  Fly  1217 ---LLVGLLLLKRDRPQCLGGLRWARLFLPLLRVLDRLNRALGEGELRDGDDMGWPGIICRGGPK 1278
               ||.  |.:.||.....|.:           .||:|.|.               |:|.:....
Human   591 DGHLLA--LQIIRDLVDKGGDI-----------FLDQLARL---------------GVISKVSTL 627

  Fly  1279 GGPPPAD-------PETHYVRRADMENL------------LLDGSRCIILAGYVCDLSGYNCESE 1324
            .||...|       ||.....:.|.:.|            ::.|..|:.:......|...|..:.
Human   628 AGPSSDDENEEESKPEKEDEPQEDAKELQQGKPYHWRDWSIIRGRDCLYIWSDAAALELSNGSNG 692

  Fly  1325 TLRSVLDSGL-----------GKDLTAEMSSQVHRTAMEHILEHHKLGKYMVQASTEEKS--SAP 1376
            ..|.:||..|           |.| ::|..|:        .||..:..:..|:.||..:.  |||
Human   693 WFRFILDGKLATMYSSGSPEGGSD-SSESRSE--------FLEKLQRARGQVKPSTSSQPILSAP 748

  Fly  1377 GPSRLTHFSSECALAQLLGLVAN--LMCSGPALQPAELQCRQLD--KSSLLSGGLQLLQPSNPFD 1437
            ||::||              |.|  |.|    |:..|:.....|  ::::|...|    |...|:
Human   749 GPTKLT--------------VGNWSLTC----LKEGEIAIHNSDGQQATILKEDL----PGFVFE 791

  Fly  1438 EEKGEARSSHSCHSTAGNTPTELPPPLPMQQQLAPG----RG---KSQLQ------------LRA 1483
            ..:| .:.|.:..::.|:             :...|    ||   ||:|:            |..
Human   792 SNRG-TKHSFTAETSLGS-------------EFVTGWTGKRGRKLKSKLEKTKQKVRTMARDLYD 842

  Fly  1484 DAFISGLAEAR--------VSEPPVAAWLALTERYCKAHNLMWHQEFATEHPVQELERLLSAVLI 1540
            |.|.:..:..|        ::....::|...|.|.|......|.....|     .||.|:  ||:
Human   843 DHFKAVESMPRGVVVTLRNIATQLESSWELHTNRQCIESENTWRDLMKT-----ALENLI--VLL 900

  Fly  1541 RHQYLGGLVLNALETEVPPPRQLGEIIRLVHQAKWSVVRTRQQLNRSYKEVCAPILERLRFLLY- 1604
            :.           |..:.|......  .|| ||..:|:.....|:  .|:.|:.::||:..... 
Human   901 KD-----------ENTISPYEMCSS--GLV-QALLTVLNNSMDLD--MKQDCSQLVERINVFKTA 949

  Fly  1605 -------EVRPAISPQQRGLRRLPILQRPPRFKMLVRRLLQELRS-SRQPA----KPEDLLNASI 1657
                   |.|||::                    |:|:|:..|.| .|.|.    .|....|..|
Human   950 FSENEDDESRPAVA--------------------LIRKLIAVLESIERLPLHLYDTPGSTYNLQI 994

  Fly  1658 QQEQEKKPQSMPKQELEEQEEEETLLRRLNERQIHGEGELDPALMQDIVD-----FALQDSCDVE 1717
                                    |.|||..|.....||      ..::|     ..::....||
Human   995 ------------------------LTRRLRFRLERAPGE------TALIDRTGRMLKMEPLATVE 1029

  Fly  1718 TARRAMYCQMQRYQLRLAGLQ----------IVQQLLELHGLLDAAQYSL-LNG---FLGLHLKS 1768
            :        :::|.|::...|          .|::|.|....:...|:.. .||   ::|.:.|:
Human  1030 S--------LEQYLLKMVAKQWYDFDRSSFVFVRKLREGQNFIFRHQHDFDENGIIYWIGTNAKT 1086

  Fly  1769 ---------------TSSGGGSTGSGSSLHVLGQ----LNMISAYQKARLLLAQSRVLD---WAV 1811
                           |||.|.:...|....:|.:    ||..|...|....     .:|   |.:
Human  1087 AYEWVNPAAYGLVVVTSSEGRNLPYGRLEDILSRDNSALNCHSNDDKNAWF-----AIDLGLWVI 1146

  Fly  1812 RELRRLVNQEQQGHARGKDSTNLGTYVLLKRLPRARFLLSVFG---------------------- 1854
            .....|      .||||...:.|..:|         |.:|..|                      
Human  1147 PSAYTL------RHARGYGRSALRNWV---------FQVSKDGQNWTSLYTHVDDCSLNEPGSTA 1196

  Fly  1855 ----------------LLAKELGPNELG---FLINSG--LLGTVLGLLAQTGGEGATGGQVHGEL 1898
                            :..|::|.|..|   :|..||  |.|||.|:.....|:.|...      
Human  1197 TWPLDPPKDEKQGWRHVRIKQMGKNASGQTHYLSLSGFELYGTVNGVCEDQLGKAAKEA------ 1255

  Fly  1899 SILYEDSVLKQKSSKAQLSGPDLAKLMKIGTRIVRGADWKWGDQDGNPPGEGRIISEVGEDGWVR 1963
                |.::.:|:    :|....:.|.|..|.|::||.||||.||||:|.|||.:..|: .:||:.
Human  1256 ----EANLRRQR----RLVRSQVLKYMVPGARVIRGLDWKWRDQDGSPQGEGTVTGEL-HNGWID 1311

  Fly  1964 VEWYTGATNSYRMGKEGQYDLQLA-----DSALNVASPTEPEREDVSGSEASPTSDSHPSKLLRH 2023
            |.|..|.:||||||.||::||:||     |:   |||| :|....|||     |:.|..|.:..:
Human  1312 VTWDAGGSNSYRMGAEGKFDLKLAPGYDPDT---VASP-KPVSSTVSG-----TTQSWSSLVKNN 1367

  Fly  2024 CAAKLLQILAVGTGLHGAQLDKDALRGMTSMFRTIIYPKPSMSNISYALGWLNLGFIRA------ 2082
            |..|.           .|.....:.:|.:|...::    .|.|:||       ||..:.      
Human  1368 CPDKT-----------SAAAGSSSRKGSSSSVCSV----ASSSDIS-------LGSTKTERRSEI 1410

  Fly  2083 ------ISG-DCPRLCLELSTP---------GWLSHYLSLLEQPAGNEAGVYRQLHCLRLLQLIL 2131
                  :|| |.....:.||:.         ...|...|.|....|:| ...|:|          
Human  1411 VMEHSIVSGADVHEPIVVLSSAENVPQTEVGSSSSASTSTLTAETGSE-NAERKL---------- 1464

  Fly  2132 AQWGAEEEPRMPALVHQLFATLGRIALHCPGDAS--------------LLPTAEGKARV--LLTA 2180
               |.:...|.|.  .....::|.:::..|..:|              |..:|..:..|  ||.|
Human  1465 ---GPDSSVRTPG--ESSAISMGIVSVSSPDVSSVSELTNKEAASQRPLSSSASNRLSVSSLLAA 1524

  Fly  2181 ----SHSGSV-------AEELVALLRRLHTLPSWNPVINSFLAQKLCVAAELLAEQSHSTALDSE 2234
                |.|.||       ...|.:.:||:..:...|...|..|              |.|::.::.
Human  1525 GAPMSSSASVPNLSSRETSSLESFVRRVANIARTNATNNMNL--------------SRSSSDNNT 1575

  Fly  2235 QVFVLGVLGAMGGHDLRPRVGLHCFHEGSHMVIASFTPKGRCLLAPGGVGSGVGFVKVQLPAVMP 2299
            ......|:...    ..|.:|...|..               |..||...:              
Human  1576 NTLGRNVMSTA----TSPLMGAQSFPN---------------LTTPGTTST-------------- 1607

  Fly  2300 HLDHTVFSLSRLPMNEMLLNAWTVLLYGPAPELRELPSSADGRLDLALLRAQQLQMAVLHTNGVL 2364
                ...|.|.:..:..:..|.|||..|     :.|.::....|......:...|.|        
Human  1608 ----VTMSTSSVTSSSNVATATTVLSVG-----QSLSNTLTTSLTSTSSESDTGQEA-------- 1655

  Fly  2365 YRHQVALRRILKQRAPGSIYASPD------EPDRSDAESQQPGEQDQQLSSGSGQEPQLLIQCIL 2423
               :.:|...|......::.|..|      |||..|.|::...::||:..           :.::
Human  1656 ---EYSLYDFLDSCRASTLLAELDDDEDLPEPDEEDDENEDDNQEDQEYE-----------EVMI 1706

  Fly  2424 LRATQASPVKACYSYMDLATAALNCIQSLATQAHQELSEGGGVPPNGRALSSPPQPTMVHGVPVY 2488
            ||  :.|..:...|..|:...|:       |....::..|.|..|.|                  
Human  1707 LR--RPSLQRRAGSRSDVTHHAV-------TSQLPQVPAGAGSRPIG------------------ 1744

  Fly  2489 NVARKEQKPSEQVEQKSKWPAAATDAQLIGQIMEMGFTRRTVE---LALKQLS-LQAEIMPTPEQ 2549
                  ::..|:.|.|                   |..|||.:   :..:|.| |.....|.|.:
Human  1745 ------EQEEEEYETK-------------------GGRRRTWDDDYVLKRQFSALVPAFDPRPGR 1784

  Fly  2550 IVQWILEHPDVCANTIEEDTLPLASSASSHDPEADSDNEC-PSSN-STTSSSTSSDTVEGQPMAV 2612
                        .|..:...|.:....:.|. |...:.|| ||.. :.|...|...|.....:  
Human  1785 ------------TNVQQTTDLEIPPPGTPHS-ELLEEVECTPSPRLALTLKVTGLGTTREVEL-- 1834

  Fly  2613 SGPAPPVKFESRKDFQTADLYALYVRGLVR---------PGMTV--RCCRDFEEIKQ-GDMGTVL 2665
                |...|.|...:....|..|...|.|:         |..|:  |..:|.::.|: |.||...
Human  1835 ----PLTNFRSTIFYYVQKLLQLSCNGNVKSDKLRRIWEPTYTIMYREMKDSDKEKENGKMGCWS 1895

  Fly  2666 IVDTE---GLHDLNVQVDWRNHGSTYWVCFVHIELVEAAQTHHQPRPPPIAVGARVRLRTSS--- 2724
            |...|   |..:|.     :|...||..     :..:||...|..     ..|....:|.:.   
Human  1896 IEHVEQYLGTDELP-----KNDLITYLQ-----KNADAAFLRHWK-----LTGTNKSIRKNRNCS 1945

  Fly  2725 ---LRYGMLCP--LRLGRSQGSSAIGVVSSVRSKQLTVDFPDQPAWQGH-----------INEVE 2773
               ..|...|.  .:.|.:||  ||..:.|.....||.:.|...|..|.           :..:.
Human  1946 QLIAAYKDFCEHGTKSGLNQG--AISTLQSSDILNLTKEQPQAKAGNGQNSCGVEDVLQLLRILY 2008

  Fly  2774 LVASQPTSATLPSLGDSCSQ--MPPSDLIEDWSRCIRSLTVSSNEAAAKHLLNGSNQPWQSCSSG 2836
            :|||.|.|......||...|  .||.:..   |:.|.:..:...|.... |.:|:...|....:.
Human  2009 IVASDPYSRISQEDGDEQPQFTFPPDEFT---SKKITTKILQQIEEPLA-LASGALPDWCEQLTS 2069

  Fly  2837 PCRHWIRLELH-----------DRILVHSLTLKVSPEDHSHMPSLL------EIRVGDCVDSLKE 2884
            .|...|..|..           .|.:|.....:.:..:.:...|.:      |.|||    .|| 
Human  2070 KCPFLIPFETRQLYFTCTAFGASRAIVWLQNRREATVERTRTTSSVRRDDPGEFRVG----RLK- 2129

  Fly  2885 YTWIPVPAGASRVLLMQQVPTYYPWVEVVVKQCQNNGIQCKIHGIKFVGRRQQPDLQHILANAQF 2949
            :..:.||.|.|   ||:       |.|.|:          :||.          |.:.:| ..:|
Human  2130 HERVKVPRGES---LME-------WAENVM----------QIHA----------DRKSVL-EVEF 2163

  Fly  2950 LASEYSAGVGPGSTAGAGAVSTSHEEAAAAPEQDLPCTVMVWGLNDKEQL-----GGLK--GSKV 3007
            |..|   |.|.|.|....|:     .||.....||...:......|.|..     ||||  |..|
Human  2164 LGEE---GTGLGPTLEFYAL-----VAAEFQRTDLGAWLCDDNFPDDESRHVDLGGGLKPPGYYV 2220

  Fly  3008 K---------VPTFSQTISRLRPI-HIAGGSKSLFIVS--QDGKVYACGEGTNGRLGLGVTHNVP 3060
            :         .|..|..:.|:..: |..|    :|:..  ||.::                  |.
Human  2221 QRSCGLFTAPFPQDSDELERITKLFHFLG----IFLAKCIQDNRL------------------VD 2263

  Fly  3061 LPHQLPVLR-------QYVVKKVAVHSGGKHALALTLDGKVFSWGEGED----GKLGHGNRT--T 3112
            ||...|..:       :..:.|:...|.|...|..|......|..||.|    |.....:::  .
Human  2264 LPISKPFFKLMCMGDIKSNMSKLIYESRGDRDLHCTESQSEASTEEGHDSLSVGSFEEDSKSEFI 2328

  Fly  3113 LDKPR-----------------LVEALRA---KKIRDVA 3131
            ||.|:                 ||...||   |:|:|:|
Human  2329 LDPPKPKPPAWFNGILTWEDFELVNPHRARFLKEIKDLA 2367

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HERC2NP_608388.2 RCC1 638..683 CDD:278826
RCC1 687..737 CDD:278826 13/68 (19%)
RCC1 740..787 CDD:278826 11/62 (18%)
RCC1 790..841 CDD:278826 17/78 (22%)
RCC1_2 828..857 CDD:290274 6/28 (21%)
Cyt-b5 1290..1363 CDD:278597 16/95 (17%)
MIB_HERC2 1928..1987 CDD:284184 32/58 (55%)
UBA_HERC2 2515..2559 CDD:270585 9/47 (19%)
Cul7 2624..2699 CDD:288381 19/89 (21%)
APC10-HERC2 2762..2932 CDD:176485 41/199 (21%)
RCC1 3037..3088 CDD:278826 9/57 (16%)
RCC1 3091..3140 CDD:278826 16/67 (24%)
RCC1 3144..3194 CDD:278826
RCC1 3197..3246 CDD:278826
RCC1 3250..3298 CDD:278826
RCC1 3302..3350 CDD:278826
RCC1_2 4136..4166 CDD:290274
RCC1 4154..4203 CDD:278826
RCC1 4206..4257 CDD:278826
RCC1 4260..4309 CDD:278826
RCC1 4312..4360 CDD:278826
RCC1 4364..4413 CDD:278826
HECTc 4509..4880 CDD:238033
HECTc 4553..4878 CDD:214523
HECTD1NP_056197.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 246..269 6/24 (25%)
Ank_2 366..457 CDD:403870 17/94 (18%)
ANK repeat 366..393 CDD:293786 6/30 (20%)
ANK 1 395..424 5/28 (18%)
ANK repeat 396..426 CDD:293786 5/29 (17%)
ANK 2 426..455 4/28 (14%)
ANK repeat 428..457 CDD:293786 5/28 (18%)
ANK 3 459..491 8/34 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 489..513 5/23 (22%)
ANK 4 579..612 8/45 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 627..657 7/29 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 707..748 10/49 (20%)
Sad1_UNC 1107..1240 CDD:400199 27/152 (18%)
MIB_HERC2 1277..1335 CDD:399589 32/58 (55%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1343..1406 22/90 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1433..1483 10/65 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1496..1515 2/18 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1592..1611 5/51 (10%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1674..1757 23/145 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1777..1797 4/31 (13%)
BTHB 1892..1965 CDD:408209 16/87 (18%)
K-box 2029..2103 13/77 (17%)
HECTc 2131..2608 CDD:238033 66/298 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2297..2318 5/20 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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