DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HERC2 and Plekha5

DIOPT Version :9

Sequence 1:	NP_608388.2	Gene:	HERC2 / 33035	FlyBaseID:	FBgn0031107	Length:	4912	Species:	Drosophila melanogaster
Sequence 2:	NP_647556.1	Gene:	Plekha5 / 246237	RGDID:	621175	Length:	1281	Species:	Rattus norvegicus

Alignment Length:	981	Identity:	183/981 - (18%)
Similarity:	292/981 - (29%)	Gaps:	408/981 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly  2110 PAGNEAG-VYRQLHCLRLLQLILAQW-------GAEEEPR-----------MPALVHQLFA---- 2151
            |...||. |.::.:.::.|:    ||       |.|||||           ||:...|:.|
  Rat   403 PLATEADRVIQRTNSMQQLE----QWIKVQKGRGLEEEPRGVISYQTLPRNMPSHRAQILARYPE 463

  Fly  2152 ---TLGRIALHCPGD-ASLLPTAEGKARVLLTASHSGSVAEELVALLR--RLHTLPSWNP----V 2206
               ||.|.:...|.. .|:.|:...|         :|..|||....:|  .:..|..|..    .
  Rat   464 GYRTLPRNSKTRPESICSVTPSGHEK---------TGPGAEEKRRSMRDDTMWQLYEWQQRQFYH 519

  Fly  2207 INSFLAQKLCVAA-----ELLAEQSHSTALDSEQVFVLGVLGAMGGHDLRPRVG----------- 2255
            ..|.|.:..|:::     ::..:..||.......|......|.......|..|.
  Rat   520 KQSTLPRHSCLSSPKAMGKVSDQTMHSIPTSPSHVPAAAYQGFSPQRTYRSEVSSPIQRGDVTID 584

  Fly  2256 -LHCFHEGSHMVIASFTPKGRCLLAPGGVGSGVGFVKVQLPAVMPH------------------- 2300
             .|..|...|:    :.|..|.:  |.|:.         |.||.|.
  Rat   585 RRHRPHHPKHV----YVPDRRSM--PAGLA---------LQAVSPQSLHGRTPEELTLLLIKLRR 634

  Fly  2301 --------LDHTVFSLSRL------PMNEML---LNAWTVLLYGPAPELRELPSSADGRLDLALL 2348
                    .:||:..|.:|      |.||:|   |...|:.|.....|...:.:.....::.:.|
  Rat   635 QQAELSSIREHTLAQLMQLKLEAHSPKNEILSHHLQRNTIYLDHQMKENEPIITMVHTMIENSAL 699

  Fly  2349 RAQQLQMAVLHTNGVLYRHQVALRRILKQRAPGSIYA-SPDEPDRSDAESQQPGEQD-------- 2404
            |.|..|..:...|      :::|..:.:....|::|. .|:|.| .||:..:..|||
  Rat   700 RPQLYQQFLRQKN------KISLYCLSQDECRGTLYKYRPEEVD-IDAKLSRLCEQDKVVRALEE 757

  Fly  2405 --QQLSS----------GSGQEPQL------LIQCILL-----------------RATQASPVKA 2434
              |||..          .:.||.::      .||.::|                 ||| |...:|
  Rat   758 KLQQLHKEKYTLEQALLSASQEIEMNADNPAAIQTVVLQRDDLQNGLLSTCRELSRAT-AELERA 821

  Fly  2435 CYSYMDL---ATAALNCIQSLATQAHQELSEGGGV------------------------------ 2466
            ...|..|   .|...|.:|....:..:..||..|:
  Rat   822 WREYDKLEYDVTVTRNQMQDQLDRLGEVQSESAGIQRAQIQKELWRIQDVMEGLSKHKQQRGSSE 886

  Fly  2467 -------------------------PPNGRALSSPPQPTMVHGVP-------VYN---VARKEQK 2496
                                     ||..|:.....||.::..:|       .|:   |...|:|
  Rat   887 TGLAGPKPFPAVKYKSEEEEVVPPRPPLPRSYDFTEQPPIIPPLPSDSSSLLCYSRGPVHLPEEK 951

  Fly  2497 PSEQV----------------------------------EQKSKWPAAATDAQLI-GQIMEMGF- 2525
            .|.||                                  |:||: ||:..:|.:: |....:|.
  Rat   952 KSHQVQGYPRNGSHCGPDYRLYKSEPELTTVAEVDESNGEEKSE-PASEAEAPVVRGSHFPVGVP 1015

  Fly  2526 ---------------------TRRTVEL-------ALKQLSLQAEIMP--TPEQIVQWILEHPDV 2560
                                 |::.|||       |::||.|.....|  |.|:.::.|..|...
  Rat  1016 LRTKSPTPESSTIASYVTLRKTKKMVELRTERPRSAVEQLCLAESTRPRMTVEEQLERIRRHQQA 1080

  Fly  2561 CANTIEEDTLPLASSASSHDPEADSDNECPSSNSTTSSSTSSDTVEGQPMAVSGPAPPVKFESRK 2625
            |....::....|::|    ||   |.::.|||        ..|:....|..|           |:
  Rat  1081 CLREKKKGLNVLSAS----DP---SPSQSPSS--------VRDSPSRVPQTV-----------RR 1119

  Fly  2626 DFQTADLYALYVRGLVRPGMTVRCCRDFEEIKQGDMGTVLIVDTEGLHDLNVQVDWRNHGSTYWV 2690
            |..|.:|.|::.....:|        |::
  Rat  1120 DDNTKELDAVHRENDGKP--------DYD------------------------------------ 1140

  Fly  2691 CFVHIELVEAAQTHH--QPRPPPIAVGARVRLRTSSLRYGMLC---PLR-------LGRSQGSSA 2743
                   ..||:|.|  :..|....||.::: ||.|:.|.||.   ||.       :.:.:....
  Rat  1141 -------TSAAETAHPEEAEPQSADVGRKLK-RTESIFYEMLYTPEPLNGLTSEEVMAKERQEEQ 1197

  Fly  2744 I--GVVSSVRSKQLTVDF----PDQPAWQGHINEVELVASQPTSAT-----------LPSLGDSC 2791
            :  |.|.|::.:....:.    |.:.|...|..|..|.:.:|...|           .||...|.
  Rat  1198 VPEGAVCSLQEEAAMANHQAEGPPEEAESLHEEEEALASCEPAPETPRENQTTVKSLSPSPDSST 1262

  Fly  2792 SQMPPS 2797
            :..||:
  Rat  1263 AADPPT 1268

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HERC2	NP_608388.2	RCC1	638..683	CDD:278826
		RCC1	687..737	CDD:278826
		RCC1	740..787	CDD:278826
		RCC1	790..841	CDD:278826
		RCC1_2	828..857	CDD:290274
		Cyt-b5	1290..1363	CDD:278597
		MIB_HERC2	1928..1987	CDD:284184
		UBA_HERC2	2515..2559	CDD:270585	15/75 (20%)
		Cul7	2624..2699	CDD:288381	7/74 (9%)
		APC10-HERC2	2762..2932	CDD:176485	11/47 (23%)
		RCC1	3037..3088	CDD:278826
		RCC1	3091..3140	CDD:278826
		RCC1	3144..3194	CDD:278826
		RCC1	3197..3246	CDD:278826
		RCC1	3250..3298	CDD:278826
		RCC1	3302..3350	CDD:278826
		RCC1_2	4136..4166	CDD:290274
		RCC1	4154..4203	CDD:278826
		RCC1	4206..4257	CDD:278826
		RCC1	4260..4309	CDD:278826
		RCC1	4312..4360	CDD:278826
		RCC1	4364..4413	CDD:278826
		HECTc	4509..4880	CDD:238033
		HECTc	4553..4878	CDD:214523
Plekha5	NP_647556.1	WW	13..42	CDD:278809
		WW	59..88	CDD:278809
		PH_PEPP1_2_3	165..268	CDD:270068
		PH	171..267	CDD:278594
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900