DRSC/TRiP Functional Genomics Resources

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Protein Alignment HERC2 and Magi3

DIOPT Version :9

Sequence 1:NP_608388.2 Gene:HERC2 / 33035 FlyBaseID:FBgn0031107 Length:4912 Species:Drosophila melanogaster
Sequence 2:NP_620784.3 Gene:Magi3 / 245903 RGDID:621362 Length:1470 Species:Rattus norvegicus


Alignment Length:1699 Identity:328/1699 - (19%)
Similarity:513/1699 - (30%) Gaps:581/1699 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly  2102 HYLSLLEQPAGNEAGVYRQLHCLRLLQLILAQWGAE-----EEPRMPALVHQLFATLGRIALHCP 2161
            |:||.:::.|.:.||....|             |||     |....|        .|||:.....
  Rat    10 HWLSKVQECAVSWAGPPGDL-------------GAEIRGGAERGEFP--------YLGRLRDEPG 53

  Fly  2162 GDASLLPTAEGKA----RVLLTASH---SGSVAEELVALLR------RLHTLPSWNPVINSFLAQ 2213
            |.........|||    .|||..:.   ||....:.:|::|      ||.|:.. ..|||.    
  Rat    54 GGGGTCCVVSGKAPSPGDVLLEVNGTPVSGLTNRDTLAVIRHFREPIRLKTVKP-GKVINK---- 113

  Fly  2214 KLCVAAELLAEQSHSTALDSEQVFVLGVLGAMGGHDLRPRVGLHCFHEGSHMVIASFTPKGRCLL 2278
                                               |||..:.|. |.:||               
  Rat   114 -----------------------------------DLRHYLSLQ-FQKGS--------------- 127

  Fly  2279 APGGVGSGVGFVKVQLPAVMPHLDHTVFSLSRLPMNEMLLNAWTVLLYGPAPELRELPSSADGRL 2343
                                  :||   .|.::..:.:.|.  |:.....||...|:|.     :
  Rat   128 ----------------------IDH---KLQQVIRDNLYLR--TIPCTTRAPRDGEVPG-----V 160

  Fly  2344 DLALLRAQQLQMAVLHTNGVLYRHQVALRRILKQRAPGSIYASPDEPDRSDAESQQPGEQ---DQ 2405
            |...:..:|.:  .|..:|.|         :......|:.|.:|..|.........|.:|   |.
  Rat   161 DYNFISVEQFK--ALEESGAL---------LESGTYDGNFYGTPKPPAEPSPFQPDPVDQVLFDN 214

  Fly  2406 QLSSGSGQEPQLLIQCILLRATQASPVKACYSYMDLATAALNCIQSLATQAHQELSE--GGGVPP 2468
            :..:.|.::          |.|..|.::.    ||         .||..:...|..|  .|....
  Rat   215 EFDTESQRK----------RTTSVSKMER----MD---------SSLPEEEEDEDKEAVNGSGSM 256

  Fly  2469 NGRALSSPPQPTMVHGVPVYNVA------RKEQKPSEQVEQKSK-WPAAATDAQLIGQIMEMGFT 2526
            ..|.:.|......:..||.||..      |......|.:|...| |..|.||.   |.|..:...
  Rat   257 ETREMHSESSDCWMKTVPSYNQTNRSMDFRNYMMRDENLEPLPKNWEMAYTDT---GTIYFIDHN 318

  Fly  2527 RRTVELALKQLSLQA---------------EIMPTPEQIVQWI--LEHPDVCANTIEE-DTLPLA 2573
            .:|......:|..:|               |.:..|:....::  |.......|.:|| ......
  Rat   319 TKTTTWLDPRLCKKAKAPEDCEDGELPYGWEKIEDPQYGTYYVDHLNQKTQFENPVEEAKRKKQI 383

  Fly  2574 SSASSHDPEADSD----NECPS--SNSTTSSSTSSDTVEGQPMAVSGPAPPVKFESRKDFQTADL 2632
            ..|.:|..:.|.:    ...||  ......:|....|: |....:.|...|.:|           
  Rat   384 GQAETHSAKTDVERAHFTRDPSQLKGVLVRASLKKSTM-GFGFTIIGGDRPDEF----------- 436

  Fly  2633 YALYVRGLVRPGMTVRCCRDFEEIKQGDMGTVLIVDTEGLHDLNVQVDWRNHGSTYWVC------ 2691
              |.|:.:::.|...:    ..::..||    :|||..|...|.     ..|.....:.      
  Rat   437 --LQVKNVLKDGPAAQ----DGKMAPGD----VIVDINGNCVLG-----HTHADVVQMFQLVPVN 486

  Fly  2692 -FVHIELVEAAQTHHQPRPPPI-AVGARVRLRTSSLRYGMLC----PLRLGR----SQGSSAIGV 2746
             :|::.|............|.: .|.|...:...||..|..|    ..:||.    ..|.|    
  Rat   487 QYVNLTLCRGYALPDDSEDPVVDIVAATPVINGQSLAKGEACMSTQDFKLGAMVLDQNGKS---- 547

  Fly  2747 VSSVRSKQLTVDFPDQPAWQGHINEVELV---ASQPTSATLP----------SLGDS-------- 2790
                 .|.|:.|..:.|: ..:.....|.   :|||...|:|          ::.||        
  Rat   548 -----GKLLSSDHLNGPS-DSNEQRASLASSGSSQPELVTIPLVKGPKGFGFAIADSPTGQKVKM 606

  Fly  2791 ------CSQMPPSDLIED-WSRCIRSLTVSSNEAAAKHLLNGSNQPWQSCSSGPCRHWIRLELHD 2848
                  |..:...|:|:: :.:.:::||........|....|::.|......|||          
  Rat   607 ILDSQWCQGLQKGDIIKEIYHQNVQNLTHLQVVEVLKQFPVGADVPLLILRGGPC---------- 661

  Fly  2849 RILVHSLTLKVSPEDHSHMPSLLEIRVGDCVDSLKEYTWIPVPAGASRVLLMQQVPTYYPWVEVV 2913
                       ||...:.|.:..:...|. ::::.|.|..|:|...|  ::....|...| .||.
  Rat   662 -----------SPTKTAKMKTDTKETSGS-LETINEPTPQPMPFPPS--IIRSGSPKLDP-SEVY 711

  Fly  2914 VKQCQNNGIQCKIHGIKFVGRRQQPDLQHILANAQFLASEYS-------AGVGPGSTAGAGAV-- 2969
            :|.             |.:...:.|:.:.:   ..||..:.|       .|.||..:...||:  
  Rat   712 LKS-------------KTLYEDKPPNTKDL---DVFLRKQESGFGFRVLGGDGPDQSIYIGAIIP 760

  Fly  2970 -STSHEEAAAAPEQDLPCT--VMVWGLNDKEQLG---------------------GLKGSKVKVP 3010
             ..:.::.......:|.|.  :.|.|.:.|:.|.                     |.|..:.:.|
  Rat   761 LGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLDLMTTAARNGHVLLTVRRKIFYGEKQPEDESP 825

  Fly  3011 -TFSQTIS-RLRPIHI---AGGSKSLFIVSQDGKVYACGEGTNGRLGLGV--THNVPLPHQLPVL 3068
             .|||:.| ||....:   :...:|..::.|        ...|...|..:  :.:.|.|..:|  
  Rat   826 QAFSQSGSPRLNRTELPTRSAPQESYDVILQ--------RKENEGFGFVILTSKSKPPPGVIP-- 880

  Fly  3069 RQYVVKKVAVHSGGKHALALTLDGKVFSWGEGEDGKLGHGNRTTLDKPRLVEALRAKKIRDVACG 3133
                           |.:...:||.    .....|:|..|:.        :.|:..:.|.|:   
  Rat   881 ---------------HKIGRVIDGS----PADRCGRLKVGDH--------ISAVNGQSIVDL--- 915

  Fly  3134 SSHS---AAISSQGELYTWGL---GEYGRLGHGDNTTQLKPKLVTALAGRRVVQVACGSRDAQTL 3192
             ||.   ..|...|...|..:   .|:.....|.|:.:..|.|.....|:.......|.|.|.  
  Rat   916 -SHDNIVQLIKDAGVTVTLTVVAEEEHHGPPSGTNSARQSPALQHRPMGQAQATHIPGDRTAL-- 977

  Fly  3193 ALTEDGAV---------FSWGD------GDFGKLGRGGSEGSDT----PHEIER-LSGIGVVQIE 3237
                :|.|         .||.|      .|...:...||..|.:    |.|:|| ..|.|     
  Rat   978 ----EGEVGKDVCSSYRHSWSDHKHLAQPDTAVISVVGSRHSQSLGCYPVELERGPRGFG----- 1033

  Fly  3238 CGAQFSLALTRAGEVWTWG--------KGDYYRLG--HGGDQHVR-KPQPIGGLRGRRVIH-VAV 3290
                |||   |.|:.:..|        .|...:.|  |.|||.|. ..:|..|:...|.|. :..
  Rat  1034 ----FSL---RGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQA 1091

  Fly  3291 GALHCLAV--TDAGQVYAWGDNDHGQQGSGNTFVNKKPALVIGLDAVFVNRVACGSSHSIAWGLP 3353
            |....|.:  ...|.:...||.|.....|.|...:::|.             ...||||      
  Rat  1092 GGNKVLLLLRPGTGLIPDHGDWDIYSPSSSNVIYDEQPP-------------PLPSSHS------ 1137

  Fly  3354 NASSDEEKRGPVPFSSTRDPLGGSSLGIYEAETMQTLK---QEAK-PLNQS-------SLSESLA 3407
             |::.||...||    |.|.|    :.:...|..:.||   ||.| .||.|       |:.::::
  Rat  1138 -AATFEESHVPV----TEDSL----IRVQTCEKAEELKDTVQEKKSTLNGSQPEMKYQSVQKNVS 1193

  Fly  3408 LETPAARQAALGH-----------VLRAMSILQARQLIVAALTSHSKVNFKERGAVGGEEDHL-- 3459
            .:.|:...   ||           |.|.......::    ::..||             |:||  
  Rat  1194 KKDPSRSH---GHGDKNLPKGENGVTRRGRSASPKK----SVNRHS-------------EEHLEK 1238

  Fly  3460 IGGPIMGAPLQLAE---------------TIAQGGGEAPADATDAGLQEHSPEAAVDALTGGMSG 3509
            |..|:...|...:.               ||..|.|:.|. ..|.| :..||...       ...
  Rat  1239 IPRPLRSDPKGKSRDRSLSPRKGENKGQVTIKAGSGQDPC-RKDRG-RSSSPRKQ-------QKI 1294

  Fly  3510 GANTLPPLSAGPLSAFQSLTGSLSMSGS-----LSSSA---LPQHKH----SRMSASAMSVMAAT 3562
            |.|:|           .:..|.||.:||     |||.:   ||:.|.    ||.... :|.:...
  Rat  1295 GGNSL-----------SNTEGKLSEAGSRRAAGLSSDSPEQLPEGKEKSGVSRKDLK-LSQLGKN 1347

  Fly  3563 MTQQEEMLS 3571
            .|:..|..|
  Rat  1348 RTRSPEKRS 1356

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HERC2NP_608388.2 RCC1 638..683 CDD:278826
RCC1 687..737 CDD:278826
RCC1 740..787 CDD:278826
RCC1 790..841 CDD:278826
RCC1_2 828..857 CDD:290274
Cyt-b5 1290..1363 CDD:278597
MIB_HERC2 1928..1987 CDD:284184
UBA_HERC2 2515..2559 CDD:270585 8/60 (13%)
Cul7 2624..2699 CDD:288381 13/81 (16%)
APC10-HERC2 2762..2932 CDD:176485 35/197 (18%)
RCC1 3037..3088 CDD:278826 6/52 (12%)
RCC1 3091..3140 CDD:278826 10/51 (20%)
RCC1 3144..3194 CDD:278826 11/52 (21%)
RCC1 3197..3246 CDD:278826 18/68 (26%)
RCC1 3250..3298 CDD:278826 15/59 (25%)
RCC1 3302..3350 CDD:278826 11/47 (23%)
RCC1_2 4136..4166 CDD:290274
RCC1 4154..4203 CDD:278826
RCC1 4206..4257 CDD:278826
RCC1 4260..4309 CDD:278826
RCC1 4312..4360 CDD:278826
RCC1 4364..4413 CDD:278826
HECTc 4509..4880 CDD:238033
HECTc 4553..4878 CDD:214523
Magi3NP_620784.3 Interaction with ADRB1 and TGFA. /evidence=ECO:0000269|PubMed:16316992 18..108 26/111 (23%)
PDZ_signaling 24..103 CDD:238492 22/99 (22%)
NK 125..>199 CDD:418433 20/131 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 184..266 20/104 (19%)
HUL4 <211..>373 CDD:227354 34/187 (18%)
WW 299..329 CDD:238122 8/32 (25%)
WW 345..375 CDD:238122 4/29 (14%)
Interaction with PTEN. /evidence=ECO:0000250 413..495 19/108 (18%)
PDZ 416..496 CDD:214570 18/106 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 550..575 4/25 (16%)
PDZ 578..659 CDD:214570 12/80 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 665..700 7/37 (19%)
PDZ 729..812 CDD:214570 14/82 (17%)
Interaction with ADGRB1. /evidence=ECO:0000250 729..811 14/81 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 818..847 8/28 (29%)
PDZ_signaling 851..936 CDD:238492 20/125 (16%)
Interaction with LPAR2 and GRIN2B. /evidence=ECO:0000250 852..939 20/127 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 939..976 8/36 (22%)
PDZ_signaling 1023..1101 CDD:238492 24/89 (27%)
PTZ00112 1115..>1405 CDD:240274 67/311 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1124..1146 8/41 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1167..1470 49/231 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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