Protein Alignment HERC2 and Herc1

DIOPT Version :9

• Sequence 1: NP_608388.2
• Gene: HERC2 / 33035
• FlyBaseID: FBgn0031107
• Length: 4912
• Species: Drosophila melanogaster
• Sequence 2: XP_006511166.1
• Gene: Herc1 / 235439
• MGIID: 2384589
• Length: 4885
• Species: Mus musculus
• Alignment Length: 5659
• Identity: 1322/5659 - (23%)
• Similarity: 2049/5659 - (36%)
• Gaps: 1638/5659 - (28%)

  Fly    69 PDLYLRPLPFLDAKWLRADLIASLRNAADGAVLWNHLIQDCELVSSPTAPLLNARGQL------S 127
            |.:.|:.|..|::.|:..| ..|:.......||::.||.:.|:|..|...|.....||      |
Mouse     6 PPVKLKWLEHLNSSWITED-SESIATREGVTVLYSKLISNKEVVPLPQQVLCLKGPQLPDFERES 69

  Fly   128 YLGDDGKHYCGAQQLKCSCCQPEYCGPLSACNCDGCRPLDSDTAIKKLTTQAAAQQAAHLSQATD 192
            ...|:..||..|.                         |.|..|:.|:.
Mouse    70 LSSDEQDHYLDAL-------------------------LSSQLALAKMV---------------- 93

  Fly   193 MVLSGWLWSQPPSQQARLDCQRSMISELQELALRAAGNCLSAQHLRQQLFIYERYFVAL------ 251
                               |..|..                |..||::|.:.:|.|.||
Mouse    94 -------------------CSDSPF----------------AGALRKRLLVLQRVFYALSNKYHD 123

  Fly   252 KRERERERKSTTSAQAVASVTTANTTIAATTANAAVESQPAEQQAEHGALGLARVATHAALNFSF 316
            |.:.::::.|..|:...|.|.:.:....::| :|.:|                 :.....|:..|
Mouse   124 KGKVKQQQHSPESSSGSADVHSVSERPRSST-DALIE-----------------MGVRTGLSLLF 170

  Fly   317 AFLRRAWR---SGEDTEMCSELLSEALASLQELPEATLFEAAVVSSLWLEVMERSIKFLRLVAL- 377
            |.||::|.   ||....:|::::..|:..:..||..:|...:.:..:.|:.:.:...||:.|.:
Mouse   171 ALLRQSWMMPVSGPGLSLCNDVIHTAIEVVSSLPPLSLANESKIPPMGLDCLSQVTTFLKGVTIP 235

  Fly   378 ---GDPMGNRCTAPLNDRHTALCLLLELGVQKGTLAATLECVVLLL------LLWEKDRAGNDNR 433
               .|.:|.|..:.         |||.|..|:|:|...||.:.:.|      ...||::..:...
Mouse   236 NSGADTLGRRLASE---------LLLGLAAQRGSLRYLLEWIEMALGASAVVYTMEKNKLLSSQE 291

  Fly   434 -------------DMPRKTGAPLQRILLRYQKIGATAKGGGIAGGEPAPVASATETFLRFLSLPK 485
                         .|.|..|:...|...|                ||.                :
Mouse   292 GMISFDCFMAILMQMRRSLGSSADRSQWR----------------EPT----------------R 324

  Fly   486 SSAAIVDLRRAAVVIISHLDRMVQPLMPRCL----LRGGQATAASSSSAPQQRIYALGWPSLSKD 546
            :|..:..|..||:.:...:.||.......|.    ::.|.|...|.:.    .:|.  |.|.|..
Mouse   325 TSEGLCSLYEAALCLFEEVCRMASDYSRTCASPDSIQTGDAPIVSETC----EVYV--WGSNSSH 383

  Fly   547 Q-----QGFSAEPTLSWSGESAGVPTLS----CRFQIK---QVACCETQMLILSQEGKLYTWRLA 599
            |     |....:|.|:.|...|  .|:.    |.|.|.   .|..|          ||....||.
Mouse   384 QLVEGTQEKILQPKLAPSFSDA--QTIEAGQYCTFVISTDGSVRAC----------GKGSYGRLG 436

  Fly   600 KPEA------EPLPMEEVAHDVFISIAGHCEGRHFLAIDSNHNAYSWGTGEDHRLGHGDTHARAV 658
            ..::      :.|..|.......:|.:...:| |.||..:....:|||.|:..:||||::..:..
Mouse   437 LGDSNNQSTLKKLTFEPHRSIKKVSSSKGSDG-HTLAFTTEGEVFSWGDGDYGKLGHGNSSTQKY 500

  Fly   659 PTKI-AALEQHCVQSVYCGCSYSAAITCGGNLLTWGRGTYARLGHGNSDDRSLPTLVVALSDHMV 722
            |..| ..|:...|..|..|..:|||:|..|.|.|||.|.:.|||||:|:.|::||||..:|:  |
Mouse   501 PKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELYTWGEGDFGRLGHGDSNSRNIPTLVKDISN--V 563

  Fly   723 VDVALGSGDAHSLALTSEG-LVFAWGDGDYGKLGNGNCNGSLQPILVESLPR--VQRVFAGSQFS 784
            .:|:.||  :|::||:.:| .|:::|.||.||||:|:.|...:|.::|:|..  :::|.||||.|
Mouse   564 GEVSCGS--SHTIALSKDGRTVWSFGGGDNGKLGHGDTNRVYKPKVIEALQGMFIRKVCAGSQSS 626

  Fly   785 VALSSEGQLYTWGKATCLGHQLVERSVQGCSVPRLVSSLQHKRIVDVAVSVAHCLALSSSGEVFG 849
            :||:|.||:|.||...|||....|.:...   |:|:..|...||||:::..:|||:||...||:.
Mouse   627 LALTSTGQVYAWGCGACLGCGSSEATALR---PKLIEELAATRIVDISIGDSHCLSLSHDNEVYA 688

  Fly   850 WGRNDSQQICPASVSSEPLLRTPILVSLPTFPASGIACTSAQSLVWT--QSSHQGVPRRAPFVVD 912
            ||.|...| |....|:.|:.:...:..|.......|:..::.||.||  ....|.|....|:.||
Mouse   689 WGNNSMGQ-CGQGNSTGPITKPKKVSGLDGIAIQQISAGTSHSLAWTALPRDRQVVAWHRPYCVD 752

  Fly   913 LGEPTFRLLDQLLGMCSSQDNRQTP------NQESECIAVACLNLFRLQLLALIANGVEPRQVGL 971
            |.|.||..|...|.....:.|.:.|      ::|.......||.|....|...:|.||....:|.
Mouse   753 LEESTFSHLRSFLERYCDKINSEIPPLPFPSSREHHNFLKLCLKLLSNHLALALAGGVATSILGR 817

  Fly   972 ASGSRLLCSLKTRILGLAGGSQVLRTIQVAAQQALQDGWSVLLPTAAERAQTLTSLLPSEPG--Q 1034
            .:|.  |.:|..|::    .|.|...||....:.|..|.::|||...||.:.|.||||..|.  :
Mouse   818 QAGP--LRNLLFRLM----DSTVPDEIQEVVIETLSVGATMLLPPLRERMELLHSLLPQGPDRWE 876

  Fly  1035 ASSAGHRFMTDLLVSSLMAEGGLESALQHAIRLESSSCSADC-----------GDGVHLP---LL 1085
            :.|.|.|...|::::||.....:.|.|.::...:::..|..|           |..:..|   |.
Mouse   877 SLSKGQRMQLDIILTSLQDHTHVASLLGYSSPSDAADLSTVCMGYGNLSDQPYGSQICHPDTHLA 941

  Fly  1086 QLITRLLSNNAALSQTRLSPTLGKQQEK------EEEEREQQHQEPSTSPSLSLLHRFQRLLLS- 1143
            :::.:.|..|......:....|.|..:|      ..|..:..|..       .||...|:.||:
Mouse   942 EILMKTLLRNLGFYTDQAFGELEKNSDKYLLGTSSSENSQPAHLH-------ELLCSLQKQLLAF 999

  Fly  1144 -HIHQAQPEEETTGAEALLLQYMHALIPACVATLQKAHELALQCREPGENSFGQMVGHLGRVLQA 1207
             ||:..   .|.:.:.|||.:::..|:|.......::..|..:  .|...|.|:   .|..|:..
Mouse  1000 CHINNV---TENSSSVALLHKHLQLLLPHATDIYSRSANLLKE--SPWNGSVGE---KLRDVIYV 1056

  Fly  1208 DISDALLNELLVGLLLLKRD--RPQCLGGLRWARLFLPLLRVLDRLNRALGEGELRDGDDMGWPG 1270
            ..:.::|.:::..||||...  ||       .....|.||..||.|||.|....|.:..::.||
Mouse  1057 SAAGSMLCQIVNSLLLLPVSVARP-------LLSYLLDLLPPLDCLNRLLPAAALLEDQELQWP- 1113

  Fly  1271 IICRGGPK----GGPPPADPETHYVRRADMENL-----------LLDGS---------------- 1304
              ..|||:    .|.|...|...:|...|:|..           :|.||
Mouse  1114 --LHGGPEVIDPAGVPLPQPAQSWVWLVDLERTIALLIGRCLGGMLQGSPVSPEEQDTAYWMKTP 1176

  Fly  1305 --------------RC------IILAG-----------------YVCDLSGYNCESETLR----S 1328
                          :|      :.|:|                 || ||: ..|..|..|    |
Mouse  1177 LFSDGVEMDTPQLDKCMSCLLEVALSGNEEQKPFDYKLRPEVAVYV-DLA-LGCSKEPARSLWIS 1239

  Fly  1329 VLDSGLGKDL-TAEMSSQ-----VHRTAMEHILEHHKLGKYMVQASTEEKSSAPGPS-----RLT 1382
            :.|..:.||. :|.:|::     |.|..:..:|:|..|   :.||..|.:.. ||.|     |..
Mouse  1240 MQDYAVSKDWDSATLSNESLLDTVSRFVLAALLKHTNL---LSQACGESRYQ-PGKSLSEVYRCV 1300

  Fly  1383 H-FSSECALAQLLGLVANLMCS----------GPALQPAELQ-CRQLDKSSLLSGGLQLL----Q 1431
            : ..|.....:.|.|:.....|          ...:.|.|.. .|.:|:.:.:.   :|.    :
Mouse  1301 YKVRSRLLACKNLELIQTRSSSRDRWITDNQDSADVDPQEHSFTRTIDEEAEME---ELAERDRE 1362

  Fly  1432 PSNPFDEEKGEARSSHSCHSTAGNT-----PTELPPPLPMQQQLAPGRGKSQLQLRADAFISGLA 1491
            ..:|..|::.|.| .|.. .||||.     .||:.......:::|..|.:.::...|.   ||:
Mouse  1363 DGHPEPEDEEEER-EHEV-MTAGNLVFVLHVTEIFQCFLSAREVARSRDRDRMNSGAG---SGV- 1421

  Fly  1492 EARVSEPPVAAWLALTERYCKAHNLMWHQEFATEHPVQELERLLSAVLIRHQYLGGLVLNALETE 1556
              |..:||                           |..:.||.:|                  |:
Mouse  1422 --RADDPP---------------------------PQSQQERRVS------------------TD 1439

  Fly  1557 VPPPRQLGEIIRLVHQAKWSVVRTRQQLNRSYKEVCAPILERLRFLLYEVRPAISPQQRGLRRLP 1621
            :|..:.:                        |...|..::.|...|:..|.|.|...|: .|...
Mouse  1440 LPEGQDV------------------------YTAACNSVIHRCALLILGVSPVIDELQK-RREEG 1479

  Fly  1622 ILQRP---------------------------PRFKMLVRRLLQELRSSRQPAKPED------LL 1653
            .||:|                           |.::::..|...:|   .||...|:      ..
Mouse  1480 QLQQPSVSASEGTGLMTRSESLTAESRLVHASPSYRLIKSRSESDL---SQPESDEEGYALSGRR 1541

  Fly  1654 NASIQQEQEKKPQSMPKQELEEQEEEETLLRRLNE----RQIHGEGELD-------PALMQDIVD 1707
            |.........:.:.....:||...:..|.|:...:    .....|.:.|       ..|::::|.
Mouse  1542 NVDFDLASSHRKRGPMHSQLESLSDSWTRLKHTRDWFYNSSYSFESDFDLTKSLGVHTLIENVVS 1606

  Fly  1708 FALQD--------------SCDVETARRAMYCQMQRYQLRLAGLQIVQQLLE---------LHG- 1748
            |...|              |...:.:..||..|..|.:|||..|..:..||.         |.|
Mouse  1607 FVSGDVGNAPGFKEPEESMSTSPQASIIAMEQQQLRAELRLEALHQILTLLSGMEEKGNVLLTGS 1671

  Fly  1749 ----------LLDAAQYSLLNGFLGLHLKSTSSGGGSTGSGSSLH--------------VLGQLN 1789
                      ||.:.:...|.|..||   .|....|:.|....||              |..|:.
Mouse  1672 RSSSGFQSSTLLTSVRLQFLAGCFGL---GTVGHTGTKGESGRLHHYQDGIRAAKRNIQVEIQVA 1733

  Fly  1790 MISAYQKARLLLAQSRVLDWAVRELRRLVNQEQQ----------GHARGKD-----STNL----- 1834
            :...||:.      |..|:.|::..:..:..:|:          .|.:..|     ||.|
Mouse  1734 VHKIYQQL------SATLERALQANKHHIEAQQRLLLVTVFALSVHYQPVDVSLAISTGLLNVLS 1792

  Fly  1835 ---GTYVL----LKRLPRA-----------------RFLLSVFGLLAKELGPNELGFLINSGLLG 1875
               ||..:    |:.||:.                 :.|....|..|.:|.|..:..|::. |..
Mouse  1793 QLCGTDTMLGQPLQLLPKTGVSQLSTALKVASTRLLQILAITTGTYADKLSPKVVQSLLDL-LCS 1856

  Fly  1876 TVLGLLAQTG-------GEGATGGQVHGELSIL-------YEDSVLKQKSSKAQLSGPDLAKLMK 1926
            .:..||:|||       |||..|.:...::...       :..::.||.:::..| |..|..|.:
Mouse  1857 QLKNLLSQTGVLFMASFGEGEEGEEEEKKVDSSGEAEKRDFRAALRKQHAAELHL-GDFLVFLRR 1920

  Fly  1927 -IGTRIVRG--ADWKWGD----------QDGNP-PG--EGRII-------------SEVGEDGWV 1962
             :.::.::.  |..||.:          ..|.| .|  ..|::             |.|.:|...
Mouse  1921 VVSSKAIQSKMASPKWTEVLLNIASQKCSSGIPLVGNLRTRLLALHVLEAVLPACESGVEDDQMA 1985

  Fly  1963 RV-----------EWYT---GATNSYRMGKEGQYDLQLADSALNVASPTEPEREDVSGSEASPTS 2013
            :|           .|.|   .|.::.:: ||.:.:::|....       |.|.||    |..|..
Mouse  1986 QVVERLFSLLSDCMWETPIAQAKHAIQI-KEKEQEIKLQKQG-------ELEEED----ENLPIQ 2038

  Fly  2014 D-SHPSKLLRHCAAKLLQILAVGTGLHGAQLDKDALRGMTS-MFRTIIY-PKPSMSNISYALG-- 2073
            : |...:..:.|..:..|||..|:|..|..|   |..|:|| .::...| .|.:..|....:|
Mouse  2039 EVSFDPEKAQCCIVENGQILTHGSGGKGYGL---ASTGVTSGCYQWKFYIVKENRGNEGTCVGVS 2100

  Fly  2074 ---------------WLNLGFIRAISGDCPRLCLELSTPGWLSHYLSLLEQPAGNEAGVYRQLHC 2123
                           ||    .||.||:       |...|..:..||...|      |.:  :.|
Mouse  2101 RWPVHDFNHRTTSDMWL----YRAYSGN-------LYHNGEQTLTLSSFTQ------GDF--ITC 2146

  Fly  2124 LRLLQLILAQWGAE-EEPRMPALVHQLFATLGRIALH-C-------PGDASLLPTAE--GKARVL 2177
            :..::.....:|.. |||::      .|..:....|: |       ||:...:...:  |..|.|
Mouse  2147 VLDMEARTISFGKNGEEPKL------AFEDVDAAELYPCVMFYSSNPGEKVKICDMQMRGTPRDL 2205

  Fly  2178 LTASH-----SGSVAEELVALLRRLHTLPSWNPVINSFLAQ-----KLCVAA------------- 2219
            |....     :..:||..:.|:|.||....|...||..:.:     |:|:..
Mouse  2206 LPGDPICSPVAAVLAEATIQLIRILHRTDRWTYCINKKMMERLHKIKICIKESGQKLKKSRSVQS 2270

  Fly  2220 ----ELLAEQS-----------HSTALDSEQ------VFVLGVLGAMGGHDLRPRVGLHCFHE-- 2261
                |:..|:.           |..|..||.      :.|..||..:||.|...|||..|.|:
Mouse  2271 REENEMREEKENKEEEKGKHNRHGLADLSEPQLRTLCIEVWPVLAVIGGVDAGLRVGGRCVHKQT 2335

  Fly  2262 GSHMVIASFTPKGRCLLAPGGVGSGVGFVKVQLPAVMPHLDHTVFSLSRLPMNEMLLNAWTVLLY 2326
            |.|..:..       ::..|...:.|.:.:.::....|    |.:|.|..|:..  |.....||:
Mouse  2336 GRHATLLG-------VVKEGSTSAKVQWDEAEITISFP----TFWSPSDTPLYN--LEPCEPLLF 2387

  Fly  2327 GPAPELRELPSSADGRLDLALLRAQQLQMAVLHTN---GVLYRHQVALRRILKQRAPGSIYASPD 2388
            ..| ..|.|.:|.  .|||..|..       :|.:   ..:.||:...|...:::  |.|...|:
Mouse  2388 DVA-RFRGLTASV--LLDLTYLTG-------IHEDVGKQSIKRHEKKHRHESEEK--GDIEQKPE 2440

  Fly  2389 EPD---------RSDAESQ-------------------QPG-EQDQQLSSGSGQEPQLLIQCILL 2424
            ...         ..|.:||                   .|| |...|::.|..:..:.:.:...:
Mouse  2441 SESILDVRTGLMSDDVKSQGTTSSKSENEIASFSLEPTLPGVESQHQITEGKRKNHEHISKTHDI 2505

  Fly  2425 RATQASPVKACYSYMDLATAALNCIQSLATQAH-----QELSEGGGVPPNGRALSSPPQPTMVHG 2484
            ..::...|:..|.|:. |..:|:.:...:..|.     :.|:|.|   .|....|||    :||
Mouse  2506 AQSEIRAVQLSYLYLG-AMKSLSALLGCSKYAELLLIPKVLAENG---HNSDCASSP----VVH- 2561

  Fly  2485 VPVYNVARKEQKPSEQVEQKSKWPAAATDAQLIGQIMEMGFTRRTVELALKQLSLQAEIMPTPEQ 2549
                          |.||.:      |....|:..:::....|..::.||....|:.......:.
Mouse  2562 --------------EDVEMR------AALQFLMRHMVKRAVMRSPIKRALGLADLERAQAMIYKL 2606

  Fly  2550 IVQWILE-------HPDVCANTIEEDTLPLASSASSHDPEADSDNECPSSN--STTSSSTSSDTV 2605
            :|..:||       ..::.....|.|....|.:..:..|.|.|.....||:  .||:::|.....
Mouse  2607 VVHGLLEDQFGGKIKQEIDQQAEESDQAQQAQTPVTTSPSASSTTSFMSSSLEDTTTATTPVTDT 2671

  Fly  2606 EGQPMAVSGPAPPVKFESRKDFQTADLYALYVRGLVRPGMTVRCCRDFEEIKQGDMGTVLIVDTE 2670
            |..|.:.|....|:....:..........|..|....|.::.......:|:  |...::...|::
Mouse  2672 ETVPASESPGVMPLSLLRQMFSSYPTTTVLPTRRAQTPPISSLPASPSDEV--GRRQSLTSPDSQ 2734

  Fly  2671 GLHDLN--VQVDWRNHGSTYWVCFVHIELVEAAQTHHQPRPPPIAVGARVRLRTSSLRYGMLCPL 2733
            .....|  ...|..:..||                  .|.||.|||..                |
Mouse  2735 STRPANRTALSDPSSRLST------------------SPPPPAIAVPL----------------L 2765

  Fly  2734 RLGRS-----QGSSAIGVVSSVRSKQLTVDFPDQPAWQ----GHINEVELVASQPTS-------A 2782
            .:|.|     :...|.|......::.:||    ...|.    ||.:|.|   .||:|       |
Mouse  2766 EMGFSLRQIAKAMEATGARGEADAQSITV----LAMWMIEHPGHEDEEE---PQPSSTADSRHGA 2823

  Fly  2783 TLPSLG----DSCSQMPPSD--------LIEDWSRCIRSLTVSSNEAAAKHLLNGSNQPWQSCSS 2835
            |:...|    |.|....|.|        :.|.:|....:|..:.|.|      :||..|.:..|:
Mouse  2824 TVLGSGGKSNDPCYLQSPGDIPSADAAEMEEGFSESPDNLDHTENAA------SGSGPPTRGRST 2882

  Fly  2836 GPCRHWIRLELHDRILVHSLTLKVSPEDHSHMPSLLEIRVGDCVDSLKEYTWIPVPAGASRVLLM 2900
            ...||...|                                                 |:|.||.
Mouse  2883 VTRRHKFDL-------------------------------------------------AARTLLA 2898

  Fly  2901 QQVPTYYPWVEVVVKQCQNNGIQCKIHGIKFVGRRQQP--------------DLQHILANAQFLA 2951
            :....|        :..|.:..|.:..||..   :|.|              ||......|.|
Mouse  2899 RAAGLY--------RSVQAHRNQSRREGISL---QQDPGALYDFNLDEELEIDLDDEAMEAMF-- 2950

  Fly  2952 SEYSAGVGPGSTAGAGAVSTSHEEAAA--APE-QDLPCTVMVWGLNDKEQLGGLKGSKVKVPTFS 3013
                           |...||..:...  .|| .|.| |..|....|:|::...:..:..|.:|:
Mouse  2951 ---------------GQDLTSDNDILGMWIPEVLDWP-TWHVCESEDREEVVVCELCECNVVSFN 2999

  Fly  3014 QTISRLRPIHIAGGSKSLFIVSQDGKVYACGEGTNGRLGLGVTHNVPLPHQLPVLRQYVVKKVAV 3078
            |.:.|..|                    .||...|                    ||      ..
Mouse  3000 QHMKRNHP--------------------GCGRSAN--------------------RQ------GY 3018

  Fly  3079 HSGGKHALALTLDGKVFSWGEGEDGKLGHGNRTTLDKPRLVEALRAKKIRDVACGSSHSAAISSQ 3143
            .|.|.:     :||    |..||   .|.||...|                 .|||.....::.:
Mouse  3019 RSNGSY-----VDG----WFGGE---CGSGNPYYL-----------------LCGSCREKYLALK 3054

  Fly  3144 GELYTWGLGEYGRLGHGDNTTQLK---PKLVTALAGRRVVQVACGSRDAQTLALTEDGAVFSWGD 3205
            .:..|            .|:.:.|   |.|:    |:   |.:....|...|.:.||..:  .|:
Mouse  3055 TKTKT------------TNSERYKGQAPDLI----GK---QDSVYEEDWDMLDVDEDEKL--TGE 3098

  Fly  3206 GDF----GKLGRGGSEGSDTPHEIERLSGIG---------------VVQIECGAQFSLALTRAGE 3251
            .:|    |.||.........|.:......:|               ::||.|..  |:..:.:|.
Mouse  3099 EEFELLAGPLGLNDRRIVPEPVQFPDSDPLGASVAMVTATNSMEETLMQIGCHG--SVEKSSSGR 3161

  Fly  3252 VWTWGKGDYYRLGHGGDQHVRKPQPIGGLRGRRVIHVAVGALHCLAVTDAGQVYAWGDNDHGQQG 3316
            |..            |:|......|          |..|.||.  .||.|.||..
Mouse  3162 VTL------------GEQAAALANP----------HDRVVALR--RVTAAAQVLL---------- 3192

  Fly  3317 SGNTFVNKKPALVIGLDAVFVNRVACGSSHSIAWGLPN--------------------------- 3354
             ..|.|.:..:|:          ...|||.|:|.||.:
Mouse  3193 -ARTMVMRALSLL----------SVSGSSCSLAAGLESLGLTDIRTLVRLMCLAAAGRAGLSTSP 3246

  Fly  3355 ---ASSDEEKRGPVPFSSTRDPLG-----GSSLGIYEAETMQTLKQEAKPLNQSSLSES-----L 3406
               ||:.|..||  ..|....|:.     .:::|...:.|....|...:...|:.:|.:     .
Mouse  3247 SAIASTSERSRG--GHSKASKPISCLAYLSTAVGCLASNTPSAAKLLVQLCTQNLISAATGVNLT 3309

  Fly  3407 ALETPAARQAALGHVLRAMS------------ILQARQLIVAALT--------SHSKVNFKERGA 3451
            .::.|..|: .|...||.::            :.||   :||.|.        ::.|...:::|.
Mouse  3310 TVDDPIQRK-FLPSFLRGIAEENKLVTSPNFVVTQA---LVALLADKGAKLRPNYDKTEIEKKGF 3370

  Fly  3452 VGGEEDHLIGGPIMGAPLQLAETIA----------------------------QGGGEAPADATD 3488
            :.....|....|....||:||..:|                            :....||....|
Mouse  3371 IAQLYAHPSYDPSAVGPLELANALAACCLSSRLSSQHRQWAAQQLVRTLAAHDRDNQTAPQTLAD 3435

  Fly  3489 AG----------LQEHSPEAAVDA--------LTGGMSGGAN----TLPPLSAGPLSAFQSLTGS 3531
            .|          |:.|........        .|.|..|...    |....|......|..|.|
Mouse  3436 MGGDLRKCSFIKLEAHQNRVMTCVWCNKKGLLATSGNDGTIRVWNVTKKQYSLQQTCVFNRLEG- 3499

  Fly  3532 LSMSGSLSSSALPQHKHSRMSASAMSVMAATMTQQEEMLS--HISHCHGLDD----FGGLLGEPE 3590
             ....||.|.:.|.......|.|...:..|.    |:|::  .::...||.|    :...|..||
Mouse  3500 -DAEESLGSPSDPSFSPVSWSISGKYLAGAL----EKMVNIWQVNGGKGLVDIQPHWVSALAWPE 3559

  Fly  3591 AKSLVELLKLAVCGRCGPPSTSQTIADTLISLGAGTPAVAAMLLETCITELEDLCTSRHCLGKLP 3655
            .               ||.:|....:..|:.:|....::.       :.|:.|:.|...
Mouse  3560 E---------------GPATTWSGESPELLLVGRMDGSLG-------LIEVVDVSTMHR------ 3596

  Fly  3656 KPVMQESSHPYVDNVNVT-----------GVVRIPGAEML----RLEFDSQCSTEKRNDPLVIM- 3704
                :|..|.|..:|:||           .|....|..::    .||.......:...:.||.|
Mouse  3597 ----RELEHCYRKDVSVTCIAWFSEDRPFAVGYFDGKLLMGTKEPLEKGGIVLIDAHKETLVSMK 3657

  Fly  3705 -DGTGRVLAMRSGREFAH-WAP-----------------------EIRVLGDELR---------- 3734
             |.||.:|...:..|... |.|                       .:...|.:::
Mouse  3658 WDPTGHILMTCAKEENVKLWGPVSGCWRCLHSLCHPSTVNGIAWCSLPGKGSKMQLLMATGCQNG 3722

  Fly  3735 ----WKFSSD------SSVNGW---------GWRFWVHA---------IMPAATLGESGSDRAVL 3771
                |:...|      :|..||         |:|....|         |.|..|:..| ||...|
Mouse  3723 LVCVWRIPQDTTQTSMTSSEGWWDQESNCQDGYRKSAGAKCVYQLRGHITPVRTVAFS-SDGLAL 3786

  Fly  3772 SQPSMALVMSLLDSRLAPRQPSVLLRLAS----------ALAACSQ-----LGALTTAQRIW--- 3818
            ....:..:|::...|......:|::...:          .:||||.     |....||:  |
Mouse  3787 VSGGLGGLMNIWSLRDGSVLQTVVIGSGAIQTTVWIPEVGVAACSNRSKDVLVVNCTAE--WASA 3849

  Fly  3819 --------SLRKLHAVLLLEQAPRPQDPSLSTLLQPLIPELLRQYEYEEPQVRGGIHLMHSDYFK 3875
                    :..|...||.|..|     |.:...|:.|...|..||.||:|.|..|..|:||.|.:
Mouse  3850 NHILATCRTALKQQGVLGLNMA-----PCMRAFLERLPMMLQEQYAYEKPHVVCGDQLVHSPYMQ 3909

  Fly  3876 TLAALACDMQLDAAL---PATSSSSSSSAAPGAISSTGDVHKWAWFKRYCIAVRVAQSLIRRTEL 3937
            .||:||..:.||..|   |......:....|    ::.:.::|||.:.:...::.|::|....:.
Mouse  3910 CLASLAVGLHLDQLLCNPPVPPHHQNCLPDP----TSWNPNEWAWLECFSTTIKAAEALTNGAQF 3970

  Fly  3938 PRAFCLEVRKKFAEMLPSSSSNSNANPGCQSPGASMLNSTTSLSSSTVSNVSPPPGITGEQPDLH 4002
            |.:|                                          ||.::.|.|
Mouse  3971 PESF------------------------------------------TVPDLEPVP---------- 3983

  Fly  4003 CHAHQLESTSTLLHEDHTLFQAPHDAQLLQWLNRRPDDWALSWGGASTIYGWGHNHRGQLGGLEG 4067
                  |....|| .|::.:....|.|::.|...||:||.|  ||...:|.||....|||.  |.
Mouse  3984 ------EDELVLL-MDNSKWINGMDEQIMSWATSRPEDWHL--GGKCDVYLWGAGRHGQLA--EA 4037

  Fly  4068 SRIKTPTPCEALSLLRPVQLAGGEQSLFAVTPDGKLFATGYGSGGRLGVGGSDSWAIPTLLGSLQ 4132
            .| ....|..|.|..:..|:..|:...|.:..:|.:.|.|.||.||||.|.||...:.|::.:||
Mouse  4038 GR-NVMVPATAPSFSQAQQVICGQNCTFVIQANGTVLACGEGSYGRLGQGNSDDLHVLTVISALQ 4101

  Fly  4133 HVFVKKVAVNSGGK-HCLALTTEGEVYAWGEGEDGKLGHGNRMSYDRPKLVEHLNGMSVADIACG 4196
            ...|.::..:.|.. |.:|||..|||::||:|:.|||||||.....||:.:|.|.|..|..::||
Mouse  4102 GFVVTQLVTSCGSDGHSMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCG 4166

  Fly  4197 SAHSAAITASGHVLTWGKGRYGRLGHGDSEDQLRPKLVEALLGYRAIDIACGSGDAQTLCITDDD 4261
            ..|||.:|:.|.:.|:|.|.|||||.|::.::..|:.|.||.||:...:|||..  .||.::.|.
Mouse  4167 FKHSAVVTSDGKLFTFGNGDYGRLGLGNTSNKKLPERVTALEGYQIGQVACGLN--HTLAVSADG 4229

  Fly  4262 N-VWSWGDGDYGKLGRGGSDGCKLPYKIESLAGLGVVKVECGSQFSVALTKSGAVYTWGKGDFHR 4325
            : ||::|||||||||.|.|.....|.|::.|.|:|:.||.||:||||||||.|.|||:|:.....
Mouse  4230 SMVWAFGDGDYGKLGLGNSTAKSSPQKVDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIG 4294

  Fly  4326 LGHGSVDHVRRPKKVAALQGKKIISIATGSLHCVACSDSGEVYTWGDNDEGQLGDGTVTAIQRPR 4390
            |..|...:..||:::..|.|..|..:|.|:.|.:|.:.:|:||.||.|.|||||.|....::.|.
Mouse  4295 LPEGRARNHNRPQQIPVLAGVVIEDVAVGAEHTLALASTGDVYAWGSNSEGQLGLGHTNHVREPT 4359

  Fly  4391 LVAALQGKHIVKVTCGSAHTLALSTSQLSERLRPLPNP---------PLEYDLVRDLAPEALHAR 4446
            ||..||||:|.:::.|..|:.|.:...:..|...:..|         |.:|..:|:::...:.||
Mouse  4360 LVTVLQGKNIRQISAGRCHSAAWTAPPVPPRAPGVSVPLQLGLPDAVPPQYGALREVSIHTVRAR 4424

  Fly  4447 LILLHHFSELVCPCLAMLPISGD--------------LSLGALKDVLVYNIKEAAFRKVIQTTMV 4497
            |.||:|||:|:.....:|.:|.:              :..|.|:.:|...:......:.|..|||
Mouse  4425 LRLLYHFSDLMYSSWRLLNLSPNNQNSTSHYNAGTWGIVQGQLRPLLAPRVYTLPMVRSIGKTMV 4489

  Fly  4498 RDKQHGPVIELNRIQVKRSRNRCNGLAGIDGMKSVFGQMVQKLPLLTQEALALPHRVWKVKFVGE 4562
            :.|.:||.|.:.||.. |.| :|         |.:|.|:.:::..|....|.||.|.||||.|||
Mouse  4490 QGKNYGPQITVKRIST-RGR-KC---------KPIFVQIARQVVKLNASDLRLPSRAWKVKLVGE 4543

  Fly  4563 SVDDCGGGYSESIAEMCDELQNGSVPLLINTPNGRGEAGANRDCFLLDPTLSSVLQMNMFRFLGV 4627
            ..||.||.:.::|.|||.||:.|.|.|||.:||...|.|.|||.||.:|:......:..|:|||:
Mouse  4544 GADDAGGVFDDTITEMCQELETGIVDLLIPSPNATAEVGYNRDRFLFNPSACLDEHLMQFKFLGI 4608

  Fly  4628 LMGIAVRTGSPLSINLAEPVWRQLTGEVLRPTDLTEVDRDYVAGLLCIRNMDD----DPKLFTAL 4688
            |||:|:||..||.::||..||:||....|...||.|||..||..|..|.:::|    :......:
Mouse  4609 LMGVAIRTKKPLDLHLAPLVWKQLCCVPLTLEDLEEVDLLYVQTLNSILHIEDSGITEESFHEMI 4673

  Fly  4689 EL-PFSTSSARGHEVPL--STRYTHISPRNRAEYVRLALGFRLHEFDEQVKAVRDGMSKVIPVPL 4750
            .| .|...||.|..||:  ......::..||.|||..|:.:||||.|.||.|||:|||.::||||
Mouse  4674 PLDSFVGQSADGKMVPIIPGGNSIPLTFSNRKEYVERAIEYRLHEMDRQVAAVREGMSWIVPVPL 4738

  Fly  4751 LSLFSAAELQAMVCGSPDIPLGLLKSVATYKGFDPSSALVTWFWEVMEEFTNQERSLFLRFVWGR 4815
            |||.:|.:|:.||||.|:|.:.:||.|..|:..|....||.|.|..:|||:|:||.||:|||.||
Mouse  4739 LSLLTAKQLEQMVCGMPEICVDVLKKVVRYREVDEQHQLVQWLWRTLEEFSNEERVLFMRFVSGR 4803

  Fly  4816 TRLPRTIADFRGRDFVLQVLEKNPPDHFLPESYTCFFLLKMPRYSCKAVLLEKLKYAIHFCKSID 4880
            :|||...||...|   .|:::.:.|...||.|.||||.|::|.||.:.|:.|:|:|||:.|:|||
Mouse  4804 SRLPANTADISQR---FQIMKVDRPYDSLPTSQTCFFQLRLPPYSSQLVMAERLRYAINNCRSID 4865

  Fly  4881 TDEY 4884
            .|.|
Mouse  4866 MDNY 4869

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HERC2	NP_608388.2	RCC1	638..683	CDD:278826	16/45 (36%)
		RCC1	687..737	CDD:278826	23/49 (47%)
		RCC1	740..787	CDD:278826	20/49 (41%)
		RCC1	790..841	CDD:278826	19/50 (38%)
		RCC1_2	828..857	CDD:290274	13/28 (46%)
		Cyt-b5	1290..1363	CDD:278597	27/146 (18%)
		MIB_HERC2	1928..1987	CDD:284184	16/100 (16%)
		UBA_HERC2	2515..2559	CDD:270585	8/50 (16%)
		Cul7	2624..2699	CDD:288381	10/76 (13%)
		APC10-HERC2	2762..2932	CDD:176485	36/192 (19%)
		RCC1	3037..3088	CDD:278826	7/50 (14%)
		RCC1	3091..3140	CDD:278826	12/48 (25%)
		RCC1	3144..3194	CDD:278826	9/52 (17%)
		RCC1	3197..3246	CDD:278826	12/67 (18%)
		RCC1	3250..3298	CDD:278826	9/47 (19%)
		RCC1	3302..3350	CDD:278826	9/47 (19%)
		RCC1_2	4136..4166	CDD:290274	12/30 (40%)
		RCC1	4154..4203	CDD:278826	24/48 (50%)
		RCC1	4206..4257	CDD:278826	21/50 (42%)
		RCC1	4260..4309	CDD:278826	27/49 (55%)
		RCC1	4312..4360	CDD:278826	15/47 (32%)
		RCC1	4364..4413	CDD:278826	22/48 (46%)
		HECTc	4509..4880	CDD:238033	164/377 (44%)
		HECTc	4553..4878	CDD:214523	151/331 (46%)
Herc1	XP_006511166.1	ATS1	374..731	CDD:227511	125/379 (33%)
		SPRY_HERC1	2039..2196	CDD:293939	39/184 (21%)
		UBA_HERC1	2760..2803	CDD:270584	11/62 (18%)
		WD40	3448..3799	CDD:392136	70/389 (18%)
		WD40 repeat	3456..3499	CDD:293791	7/42 (17%)
		WD40 repeat	3513..3548	CDD:293791	8/38 (21%)
		WD40 repeat	3610..3648	CDD:293791	5/37 (14%)
		WD40 repeat	3653..3689	CDD:293791	10/35 (29%)
		WD40 repeat	3697..3736	CDD:293791	3/38 (8%)
		WD40 repeat	3774..3810	CDD:293791	7/36 (19%)
		ATS1	4022..4370	CDD:227511	147/352 (42%)
		HECTc	4497..4865	CDD:238033	165/381 (43%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102650
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.720