DRSC/TRiP Functional Genomics Resources

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Protein Alignment HERC2 and Plekha7

DIOPT Version :9

Sequence 1:NP_608388.2 Gene:HERC2 / 33035 FlyBaseID:FBgn0031107 Length:4912 Species:Drosophila melanogaster
Sequence 2:XP_017177675.1 Gene:Plekha7 / 233765 MGIID:2445094 Length:1359 Species:Mus musculus


Alignment Length:1234 Identity:236/1234 - (19%)
Similarity:378/1234 - (30%) Gaps:410/1234 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   599 AKPEAEPLPMEEVAHDVFISIAGHCEGRHFLAIDSNHNAY-SWGTGEDHRL-GHGDT-HARAVPT 660
            :|..:..||.||.|  :|:.:.|...|:......:..|.. .:|.||.:.. |:..| ..||.|.
Mouse   358 SKARSPYLPAEEDA--LFVDLPGGPRGQQAQPQRAEKNGVPPYGLGEQNGTNGYQRTAPPRANPE 420

  Fly   661 KIAALEQHCVQSVYCGCSYSAAITCGGNLLTWGRGTYARLGHGNSDDRSLPTLVVALSDHMVVDV 725
            |.:..:....|:.:                 |   |.|:.|    |.||||           :|.
Mouse   421 KHSQRKTGLAQAEH-----------------W---TKAQKG----DGRSLP-----------LDQ 450

  Fly   726 AL-GSGDAHSLALTSEGLVFAWGDGDYGKLGNGNCNGSLQPILVESLPRVQRVFAGSQ------- 782
            .| ..|.:..|:.                           |...:|||:..|..:||.       
Mouse   451 TLPRQGPSQPLSF---------------------------PENYQSLPKSTRHLSGSSSPPPRNL 488

  Fly   783 -----------FSVALSSE----------GQLYTWGKATCLGHQLVERSVQGCSVPRLVSSLQHK 826
                       ..:.:|||          .|||.|.:.....|......: |...|......:.:
Mouse   489 PSDYKYAQDRASHLKMSSEERRAHRDGTVWQLYEWQQRQQFRHGSPTAPI-GAGSPEFTEQGRSR 552

  Fly   827 RIVDVAVSVAHCLALSSSGEVFGWGRNDSQQICPASVSS--EPLLRTPILVSLPTFPASGIACTS 889
            .:::|..|::                      .|.|.|.  .|....|.....|..||..:....
Mouse   553 SLLEVPRSIS----------------------VPPSPSDIPPPGPPRPFPPRRPHTPAERVTVKP 595

  Fly   890 AQSLVWTQSSHQGVPRRAPFVVDLGEPTFRLLDQLLGMCSSQDNRQTPNQ--ESECIAVACLNLF 952
            .:.......|..|.||:|             ........|..|.|..|:.  .:..::...|:..
Mouse   596 PEQRRSVDISLGGSPRKA-------------RGHAAKNSSHVDRRSMPSMGYMTHTVSAPSLHGK 647

  Fly   953 RLQLLALIANGVEPRQVGLASGSRLLCSLKTRILGLAGGSQVLRTIQVAAQQALQDGWSVL---- 1013
            .|:.|:|:...::..|..|||           :...|.|..:...:...|.|| .|.:..|    
Mouse   648 SLEELSLLLTRLQRHQSKLAS-----------VRNFAVGQLLHHYLTFPACQA-DDTYLQLKKDL 700

  Fly  1014 --LPTAAERAQTLTSLL---------PSEPGQASSAGHRFMTDLLVSSL-MAEGGLESALQHAIR 1066
              |....:..:.|.::|         ...||: |..|...:.|..:..: :||..::..|  :|.
Mouse   701 EYLDLKIKNNEPLINVLYKVLKKSARGCRPGR-SMTGRDLLKDRSLKPMKIAESDIDVKL--SIF 762

  Fly  1067 LESSSCSADCGDGVHLPLLQLITRLLSNNAALSQTRLSPTLGKQQEKEEEEREQ-QHQEPSTSPS 1130
            .|......|..|.:         |.|..|    :.:|...|.....:.|:.|:| ||.|..|.. 
Mouse   763 CEQDRILQDLEDKI---------RALKEN----KDQLESVLEVLHRQTEQYRDQPQHLEKITCQ- 813

  Fly  1131 LSLLHRFQRLL---LSHIHQAQPEEETTGAEALLLQY--MHALIPACVATLQKAHELALQCREPG 1190
                   ||||   |.|| :|:...|:|..|....:|  :...:.....|||:.|..|...:|..
Mouse   814 -------QRLLQEDLVHI-RAELCRESTEMENAWNEYLKLEKDVEQLKQTLQEQHRRAFFFQEKS 870

  Fly  1191 ENSFGQMVGHLGRVLQADISDALLNELLVGLLLLKRDRPQCLGGLR-WARLFLPLLRVLDRLNRA 1254
            :             :|.|:  ..:.:::.||...|.:....:|.:: ..|..:||          
Mouse   871 Q-------------IQKDL--WRIEDVMAGLSANKENYRVLVGSVKNPERKTVPL---------- 910

  Fly  1255 LGEGELRDGDDMGWPGIICRGGPKGGP-----PPADPETHYVRRADMENLLLDGSRCIILAGYVC 1314
                       ...|.:......:..|     ||..|                            
Mouse   911 -----------FPHPSVPSLSPTESKPALQPSPPTSP---------------------------- 936

  Fly  1315 DLSGYNCESETLRSVLDSGLGKDLTAEMSSQVHRTAMEHILEHHKLGKYMVQASTEEKSSA---- 1375
                       :|:.|:..|...|...:..:.|...:..::.       .:|:.|:.|..|    
Mouse   937 -----------VRTPLEVRLFPQLQTYVPYRPHPPQLRKVMS-------PLQSPTKAKPQAEDEA 983

  Fly  1376 -PGPSRLTHFSSECALAQLLGLVANLMCSGPALQPAELQCRQLDKSSLLSGGLQLLQPSNPFDEE 1439
             |.|.....:|.|              ...||:.|...:...:..:|:  .||:........|.|
Mouse   984 PPRPPLPELYSPE--------------DQPPAVPPLPREATIIRHTSV--RGLKRQSDERKRDRE 1032

  Fly  1440 KG---------EARSSHS---CHSTAGNTPTELPPPLPM-----QQQLAPGRGKSQLQLRADAFI 1487
            :|         |.||..|   ..|.:|:.|   .|.|.:     :.|..||||           :
Mouse  1033 QGQCVNGDLKVELRSYVSEPELASLSGDVP---QPSLSLVGSESRYQTLPGRG-----------L 1083

  Fly  1488 SGLAEARVSEPPVAAWLALTERYCKAHNLMWHQEFAT-EHPVQELERLLSAVLIRHQYLGGLVLN 1551
            ||..........:|.::.| .|...|.|     ..|| ..|...||||.|.   .||        
Mouse  1084 SGSTSRLQQSSTIAPYVTL-RRGLNAEN-----SSATFSRPKSALERLYSG---DHQ-------- 1131

  Fly  1552 ALETEVPPPRQLGEIIRLVHQAKWSVVRTRQQLNRSYKEVCAPILERLRFLLYEVRPAISPQQRG 1616
                                :.|.|   ..:||.|..:...|.:.||.|.|       ...::.|
Mouse  1132 --------------------RGKMS---AEEQLERMKRHQKALVRERKRTL-------SQGEKTG 1166

  Fly  1617 LRRLPILQRPPRFKMLVRRLLQELRS-SRQPAKPEDLLNASIQQEQEKKP------QSMPKQE-- 1672
            |.....|.:|         |..:|.| .|:......||..:.|.:::.|.      |:.|..|  
Mouse  1167 LLSARYLSQP---------LPGDLGSWKREQEFDLQLLERAAQGDRKDKEEGWLKVQATPVMELD 1222

  Fly  1673 LEEQEEEETLLRRLN--------ERQIHGEGELDPALMQDIVDFALQDSCDVETARRAMYCQMQ 1728
            ||.|:.:..:.|.|:        ||.:..:.|..|:|.:....:...:......||.:| |.:|
Mouse  1223 LEPQDYDLDISRELSKPEKVSIPERYVELDPEEPPSLEELQARYQKAEKIRNILARSSM-CNLQ 1285

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HERC2NP_608388.2 RCC1 638..683 CDD:278826 10/47 (21%)
RCC1 687..737 CDD:278826 13/50 (26%)
RCC1 740..787 CDD:278826 7/64 (11%)
RCC1 790..841 CDD:278826 10/60 (17%)
RCC1_2 828..857 CDD:290274 2/28 (7%)
Cyt-b5 1290..1363 CDD:278597 5/72 (7%)
MIB_HERC2 1928..1987 CDD:284184
UBA_HERC2 2515..2559 CDD:270585
Cul7 2624..2699 CDD:288381
APC10-HERC2 2762..2932 CDD:176485
RCC1 3037..3088 CDD:278826
RCC1 3091..3140 CDD:278826
RCC1 3144..3194 CDD:278826
RCC1 3197..3246 CDD:278826
RCC1 3250..3298 CDD:278826
RCC1 3302..3350 CDD:278826
RCC1_2 4136..4166 CDD:290274
RCC1 4154..4203 CDD:278826
RCC1 4206..4257 CDD:278826
RCC1 4260..4309 CDD:278826
RCC1 4312..4360 CDD:278826
RCC1 4364..4413 CDD:278826
HECTc 4509..4880 CDD:238033
HECTc 4553..4878 CDD:214523
Plekha7XP_017177675.1 WW 10..39 CDD:366073
WW 55..84 CDD:366073
PH_PEPP1_2_3 158..280 CDD:270068
Smc <692..>894 CDD:224117 51/241 (21%)
PHA03247 <903..1009 CDD:223021 24/186 (13%)
PRK10263 <912..>1118 CDD:236669 50/287 (17%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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