DRSC/TRiP Functional Genomics Resources

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Protein Alignment HERC2 and NEDD4L

DIOPT Version :9

Sequence 1:NP_608388.2 Gene:HERC2 / 33035 FlyBaseID:FBgn0031107 Length:4912 Species:Drosophila melanogaster
Sequence 2:XP_006722489.1 Gene:NEDD4L / 23327 HGNCID:7728 Length:1019 Species:Homo sapiens


Alignment Length:619 Identity:137/619 - (22%)
Similarity:235/619 - (37%) Gaps:176/619 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly  4374 DEGQLGDGTVT-------AIQRPR--------LVAALQG------KHIVKVTCGS---------- 4407
            ::|..|..|.:       .|:|||        |.|.|:|      :..||.|..:          
Human   448 EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYN 512

  Fly  4408 ----AHTLALSTSQLSERLRPLPN-----------------PPLEYDL---------VRDLAP-- 4440
                .|.:..|.......:|..||                 |.|::.:         ..||.|  
Human   513 SPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLP 577

  Fly  4441 ----EALH--ARLILLHHFSELVC---------------------PCLAMLPISGDLSLGALKDV 4478
                |.:|  .|...:.|.|:::|                     |.|....|:|.    |:...
Human   578 PGWEERIHLDGRTFYIDHSSQVLCGENDTRESVPSYDSKITQWEDPRLQNPAITGP----AVPYS 638

  Fly  4479 LVYNIKEAAFRKVIQTTMVRDKQHGPVIELNRIQVKRSRNRCNGLAGIDGMKSVFGQMVQKLPLL 4543
            ..:..|...|||         |...|....||.::|..||            ::|.:..::: :.
Human   639 REFKQKYDYFRK---------KLKKPADIPNRFEMKLHRN------------NIFEESYRRI-MS 681

  Fly  4544 TQEALALPHRVWKVKFVGESVDDCGGGYSESIAEMCDELQN-----------GSVPLLINTPNGR 4597
            .:....|..|:| ::|..|...|.||...|....:..|:.|           .:..|.||..:|.
Human   682 VKRPDVLKARLW-IEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGL 745

  Fly  4598 GEAGANRDCFLLDPTLSSVLQMNMFRFLGVLMGIAVRTGSPLSINLAEPVWRQLTGEVLRPTDLT 4662
                .|.|            .::.|.|:|.:.|:||..|..|......|.::.:.|:.:...|:.
Human   746 ----CNED------------HLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDME 794

  Fly  4663 EVDRDYVAGLLCIRNMDDDPKLFTALELPF---STSSARGHEVPLSTRYTHI--SPRNRAEYVRL 4722
            .||.:|...|..|  :::||   |.|:|.|   ..:..:.::|.|....:.|  :..|:.||:.|
Human   795 SVDSEYYNSLKWI--LENDP---TELDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDL 854

  Fly  4723 ALGFR-LHEFDEQVKAVRDGMSKVIPVPLLSLFSAAELQAMVCGSPDIPLGLLKSVATYK-GFDP 4785
            .:.:| ::...:|:.|..:|.::::|:.|:.:|...||:.::||..|:.:...:..:.|| |:.|
Human   855 VIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCP 919

  Fly  4786 SSALVTWFWEVMEEFTNQERSLFLRFVWGRTRLPRT-IADFRGRDFVLQVLEKNPPDHF------ 4843
            :..::.|||:.:.....::|...|:||.|.:|:|.. .|:..|         .|.|..|      
Human   920 NHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYG---------SNGPQLFTIEQWG 975

  Fly  4844 ----LPESYTCFFLLKMPRYSCKAVLLEKLKYAI 4873
                ||.::|||..|.:|.|.....|.|||..|:
Human   976 SPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAV 1009

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HERC2NP_608388.2 RCC1 638..683 CDD:278826
RCC1 687..737 CDD:278826
RCC1 740..787 CDD:278826
RCC1 790..841 CDD:278826
RCC1_2 828..857 CDD:290274
Cyt-b5 1290..1363 CDD:278597
MIB_HERC2 1928..1987 CDD:284184
UBA_HERC2 2515..2559 CDD:270585
Cul7 2624..2699 CDD:288381
APC10-HERC2 2762..2932 CDD:176485
RCC1 3037..3088 CDD:278826
RCC1 3091..3140 CDD:278826
RCC1 3144..3194 CDD:278826
RCC1 3197..3246 CDD:278826
RCC1 3250..3298 CDD:278826
RCC1 3302..3350 CDD:278826
RCC1_2 4136..4166 CDD:290274
RCC1 4154..4203 CDD:278826
RCC1 4206..4257 CDD:278826
RCC1 4260..4309 CDD:278826
RCC1 4312..4360 CDD:278826
RCC1 4364..4413 CDD:278826 15/73 (21%)
HECTc 4509..4880 CDD:238033 96/394 (24%)
HECTc 4553..4878 CDD:214523 89/350 (25%)
NEDD4LXP_006722489.1 C2_NEDD4_NEDD4L 21..179 CDD:175999
WW 224..250 CDD:278809
WW 413..442 CDD:278809
WW 526..556 CDD:238122 4/29 (14%)
WW 575..625 CDD:197736 8/49 (16%)
HECTc 662..1016 CDD:238033 94/392 (24%)
HECTc 686..1015 CDD:214523 90/355 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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