DRSC/TRiP Functional Genomics Resources

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Protein Alignment HERC2 and Yap1

DIOPT Version :9

Sequence 1:NP_608388.2 Gene:HERC2 / 33035 FlyBaseID:FBgn0031107 Length:4912 Species:Drosophila melanogaster
Sequence 2:XP_006509915.1 Gene:Yap1 / 22601 MGIID:103262 Length:494 Species:Mus musculus


Alignment Length:535 Identity:117/535 - (21%)
Similarity:174/535 - (32%) Gaps:186/535 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly  1277 PKGGP--PPADPETHYVRRADMENLLLDGSRCIILAGYVCDLSGYNCESETLRSVLDSGLGKDLT 1339
            |.|.|  |||.|..|.|               :.:.|          :|||....|.:.:....|
Mouse    23 PAGTPAAPPAPPAGHQV---------------VHVRG----------DSETDLEALFNAVMNPKT 62

  Fly  1340 AEMSSQVH---RTAMEHILEHHKLGKYMVQASTEE-KSSAPGPSRLTHFSSECALAQLLG----- 1395
            |.:...|.   |...:...:..:...:..||||:. .:.|..|..:...||..:|.  ||     
Mouse    63 ANVPQTVPMRLRKLPDSFFKPPEPKSHSRQASTDAGTAGALTPQHVRAHSSPASLQ--LGAVSPG 125

  Fly  1396 -LVANLMCSGPALQPAELQCRQLDKSSL-------LSGGLQLLQPSNPFDEEKGEAR-SSHSCHS 1451
             |.|:.:.||||..||....||   ||.       |..|.::.:.|:      |:.. .:|:..:
Mouse   126 TLTASGVVSGPAAAPAAQHLRQ---SSFEIPDDVPLPAGWEMAKTSS------GQRYFLNHNDQT 181

  Fly  1452 TAGNTP-----TELPPPLPMQQQLAPGRGKSQLQLRADAFISGLAEARVSEPPV---------AA 1502
            |....|     ::|..|.|    .:|...::.:...:.....|..:|...:..|         .:
Mouse   182 TTWQDPRKAMLSQLNVPAP----ASPAVPQTLMNSASGPLPDGWEQAMTQDGEVYYINHKNKTTS 242

  Fly  1503 WL--ALTERYCKAHNLMWHQEFATEHPVQELERLLSAVLIRHQYLGGLVLNALETEVPPPRQLGE 1565
            ||  .|..|:.||.|    |......||::                           |||     
Mouse   243 WLDPRLDPRFGKAMN----QRITQSAPVKQ---------------------------PPP----- 271

  Fly  1566 IIRLVHQAKWSVV------RTRQQLNRSYKEVCAPILERLRF----LLYEVRPA----ISP---- 1612
               |..|:....|      ..:||:.....::   ..||||.    |..:|||.    |:|    
Mouse   272 ---LAPQSPQGGVLGGGSSNQQQQIQLQQLQM---EKERLRLKQQELFRQVRPQAIRNINPSTAN 330

  Fly  1613 ----QQRGLR-RLPILQRPPRFKMLVRR--LLQELRS----------------SRQ--------- 1645
                |:..|| :||.|::.......|..  :.||||:                ||.         
Mouse   331 APKCQELALRSQLPTLEQDGGTPNAVSSPGMSQELRTMTTNSSDPFLNSGTYHSRDESTDSGLSM 395

  Fly  1646 -----PAKPEDLLNA--------SIQQEQEKKPQSMPKQELEEQEEEETLLRRLNERQIHGEGE- 1696
                 |..|:|.||:        :|.|......||.....||........|..|....::.||| 
Mouse   396 SSYSIPRTPDDFLNSVDEMDTGDTISQSTLPSQQSRFPDYLEALPGTNVDLGTLEGDAMNIEGEE 460

  Fly  1697 ----LDPALMQDIVD 1707
                |..||..:|:|
Mouse   461 LMPSLQEALSSEILD 475

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HERC2NP_608388.2 RCC1 638..683 CDD:278826
RCC1 687..737 CDD:278826
RCC1 740..787 CDD:278826
RCC1 790..841 CDD:278826
RCC1_2 828..857 CDD:290274
Cyt-b5 1290..1363 CDD:278597 10/75 (13%)
MIB_HERC2 1928..1987 CDD:284184
UBA_HERC2 2515..2559 CDD:270585
Cul7 2624..2699 CDD:288381
APC10-HERC2 2762..2932 CDD:176485
RCC1 3037..3088 CDD:278826
RCC1 3091..3140 CDD:278826
RCC1 3144..3194 CDD:278826
RCC1 3197..3246 CDD:278826
RCC1 3250..3298 CDD:278826
RCC1 3302..3350 CDD:278826
RCC1_2 4136..4166 CDD:290274
RCC1 4154..4203 CDD:278826
RCC1 4206..4257 CDD:278826
RCC1 4260..4309 CDD:278826
RCC1 4312..4360 CDD:278826
RCC1 4364..4413 CDD:278826
HECTc 4509..4880 CDD:238033
HECTc 4553..4878 CDD:214523
Yap1XP_006509915.1 FAM181 <61..>141 CDD:373671 21/81 (26%)
WW 159..188 CDD:238122 5/34 (15%)
WW 217..246 CDD:366073 5/28 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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