DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment HERC2 and Hace1

DIOPT Version :9

Sequence 1:NP_608388.2 Gene:HERC2 / 33035 FlyBaseID:FBgn0031107 Length:4912 Species:Drosophila melanogaster
Sequence 2:XP_006512697.1 Gene:Hace1 / 209462 MGIID:2446110 Length:921 Species:Mus musculus


Alignment Length:644 Identity:143/644 - (22%)
Similarity:231/644 - (35%) Gaps:184/644 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly  4267 GDGDYGKLGRGGSDGCKLPYKIESLAGLGVVKVECGSQFSVALTKSGAVYTWGKGDFHRLGHGSV 4331
            |.|.|..|..|..|.     |.|.|||......:|....||...:..||                
Mouse   424 GPGSYESLPPGPGDS-----KPEVLAGEQEASADCQDVISVTANRLSAV---------------- 467

  Fly  4332 DHVRRPKKVAALQGKKIISIATGSLHCVACSDSGEVYTWGDNDEGQLGDGTVTAIQRPRLVAALQ 4396
                    :.|.            ..|.:|               |:..|..:    ||      
Mouse   468 --------IQAF------------YMCCSC---------------QMPPGMTS----PR------ 487

  Fly  4397 GKHIVKVTCGSAHTLALSTSQLSERLRPLPNPPLEYDLVRDLAPEALHARLILLHHFSELV-CPC 4460
               .::..|.....|....::         ||.:.:|                  ||..|: || 
Mouse   488 ---FIEFVCKHDEVLKCFVNR---------NPKIIFD------------------HFHFLLECP- 521

  Fly  4461 LAMLPISGDLSLGALKDVLVYNIKEAAFRKVIQTTMVR--------DKQHGPVIELNRIQVKRS- 4516
                         .|....::.||...|:...:.....        |..|.||.|.:.:.|.|. 
Mouse   522 -------------ELMSRFMHIIKAQPFKDRCEWFYEHLHSGQPDSDMVHRPVSENDILLVHRDS 573

  Fly  4517 --RNRCNGLAGIDGMKSVFGQMVQKLPLLTQEALALPHRVWKVKFVGESVDDCGGGYSESIAE-- 4577
              |:.|..::..:..|             .::.:|       |:|.||.      |..:.:..  
Mouse   574 IFRSSCEIVSKANCAK-------------LKQGIA-------VRFHGEE------GMGQGVVREW 612

  Fly  4578 ---MCDELQNGSVPLLINTPNGRGEAGANRDCFLLDPTLSSVL---QMNMFRFLGVLMGIAVRTG 4636
               :.:|:.|....|...:.:|.          ...|..:|.:   .:|.|||.|.::|:|:...
Mouse   613 FDILSNEIVNPDYALFTQSADGT----------TFQPNSNSYVNPDHLNYFRFAGQILGLALNHR 667

  Fly  4637 SPLSINLAEPVWRQLTGEVLRPTDLTEVDRDYVAGLLCIRNMDDDPKLFTALELPFSTSS---AR 4698
            ..::|......::.:.|..:...|:..:|.:|...|..|  :|:|.. ...|||.||..:   ..
Mouse   668 QLVNIYFTRSFYKHILGIPVNYQDVASIDPEYAKNLQWI--LDNDIS-DLGLELTFSVETDVFGA 729

  Fly  4699 GHEVPLSTRYTHI--SPRNRAEYVRLALGFRL-HEFDEQVKAVRDGMSKVIPVPLLSLFSAAELQ 4760
            ..||||......|  :..|:||||:|....|: .....|:.|...|....||..|:.||...||:
Mouse   730 MEEVPLKPGGGSILVTQNNKAEYVQLVTELRMTRAIQPQINAFLQGFHMFIPPSLIQLFDEYELE 794

  Fly  4761 AMVCGSPDIPLG-LLKSVATYKGFDPSSALVTWFWEVMEEFTNQERSLFLRFVWGRTRLPR-TIA 4823
            .::.|.|:|.:. .:|:.....|::....::.|||||:|:.|.:||.|.|:||.|.:|:|. ..|
Mouse   795 LLLSGMPEIDVNDWIKNTEYTSGYEREDPVIQWFWEVVEDITQEERVLLLQFVTGSSRVPHGGFA 859

  Fly  4824 DFRG----RDFVLQVLEKNPPDHFLPESYTCFFLLKMPRYSCKAVLLEKLKYAIHFCKS 4878
            :..|    ::|.:..:...|  :.||.|.||..:||:|.|..|.:|.::|..|:| |.|
Mouse   860 NIMGGSGLQNFTIAAVPYTP--NLLPTSSTCINMLKLPEYPSKEILKDRLLVALH-CGS 915

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HERC2NP_608388.2 RCC1 638..683 CDD:278826
RCC1 687..737 CDD:278826
RCC1 740..787 CDD:278826
RCC1 790..841 CDD:278826
RCC1_2 828..857 CDD:290274
Cyt-b5 1290..1363 CDD:278597
MIB_HERC2 1928..1987 CDD:284184
UBA_HERC2 2515..2559 CDD:270585
Cul7 2624..2699 CDD:288381
APC10-HERC2 2762..2932 CDD:176485
RCC1 3037..3088 CDD:278826
RCC1 3091..3140 CDD:278826
RCC1 3144..3194 CDD:278826
RCC1 3197..3246 CDD:278826
RCC1 3250..3298 CDD:278826
RCC1 3302..3350 CDD:278826
RCC1_2 4136..4166 CDD:290274
RCC1 4154..4203 CDD:278826
RCC1 4206..4257 CDD:278826
RCC1 4260..4309 CDD:278826 14/41 (34%)
RCC1 4312..4360 CDD:278826 4/47 (9%)
RCC1 4364..4413 CDD:278826 6/48 (13%)
HECTc 4509..4880 CDD:238033 101/393 (26%)
HECTc 4553..4878 CDD:214523 94/344 (27%)
Hace1XP_006512697.1 ANK repeat 66..95 CDD:293786
Ank_2 69..194 CDD:372319
ANK repeat 97..128 CDD:293786
ANK repeat 130..161 CDD:293786
ANK repeat 163..194 CDD:293786
Ank_2 168..263 CDD:372319
ANK repeat 196..233 CDD:293786
HECTc 566..915 CDD:238033 100/390 (26%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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