DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HERC2 and nekl-1

DIOPT Version :9

Sequence 1:	NP_608388.2	Gene:	HERC2 / 33035	FlyBaseID:	FBgn0031107	Length:	4912	Species:	Drosophila melanogaster
Sequence 2:	NP_001293320.1	Gene:	nekl-1 / 189769	WormBaseID:	WBGene00021461	Length:	983	Species:	Caenorhabditis elegans

Alignment Length:	901	Identity:	187/901 - (20%)
Similarity:	325/901 - (36%)	Gaps:	253/901 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly  3775 SMALVMSLLDSRLAPRQPSVL-LRLASALAACSQLGALTTAQ----RIWSLRK---LHAVLLLEQ 3831
            |:.||...|.|.|||....:: :.:.:.:...:.....|:||    ||.::.|   ..|||.
Worm   127 SVRLVSRFLSSELAPHNRRIVEIYINNEIMITNPNPRATSAQNRYERIRTVGKGAFGSAVLY--- 188

  Fly  3832 APRPQDPSLSTLLQPLIPELLRQYEYEEPQVRGGIH-------------LMHSDYFKTLAALACD 3883
             .|.:|.||      :|.:.:..|:.:..|.|..::             :.:.|.|:....|..:
Worm   189 -RRREDSSL------VIIKEINMYDLDSSQRRLALNEVSLLSRIEHPNIIAYYDSFEEEGVLMIE 246

  Fly  3884 MQ-LDAALPATSSSSSSSAAPGAISSTGDVHKWAWFKRYCIAVR-VAQSLIRRTELPRAFCLEVR 3946
            |: .|....|...|.:.:....  ...||:     ..:.|.||. :.::.:...:|..|.....|
Worm   247 MEYADGGTLAQMLSRTQNLLDE--EQIGDM-----MIQMCSAVAYLHENSVLHRDLKTANVFLTR 304

  Fly  3947 KKFAEMLPSSSSNSNANPGCQSPGASMLNSTTSLSSSTVSNVSPP--------PGIT-GEQPD-- 4000
            ..|.::              ...|.|.:..|.:|:....:.|..|        .|:: .|:.|
Worm   305 DSFVKI--------------GDFGISKIMGTETLAQGAKTVVGTPYYISPEMCSGVSYNEKSDMW 355

  Fly  4001 -LHCHAHQLESTSTLLHED-------------HTLFQAPHDAQLLQWLNRRPDDWALSWGGASTI 4051
             |.|..:::.........|             :|..:.|:.|::...:...
Worm   356 ALGCILYEMCCLKKAFEGDNLPALVNSIMTCAYTPVKGPYSAEMKMVIREL-------------- 406

  Fly  4052 YGWGHNHRGQLGGLEGSRIKTPTPCEALSLLRPVQ-----LAGGEQSLFAVTPDGKLFATGYGSG 4111
                         |:....|.|:..:||.:|||.:     .:|..:|..:       |.|.|
Worm   407 -------------LQLDPQKRPSAPQALKMLRPSENRHRHTSGSMRSSVS-------FTTLY--- 448

  Fly  4112 GRLGVGGSDSWAIPTL-LGSL----QHVFVKKVAVNSGGKHCLALTTEGEVYAWGEGEDGKLGHG 4171
                     ...:||: |.|:    ..:.:|:||::.  .|.:.||.:.|::.:|:...|:||.|
Worm   449 ---------DLHVPTITLSSIPDLPSRISIKQVALSK--THTMVLTNDNELFGFGDNSCGQLGFG 502

  Fly  4172 NRMSYDRPKLVEHLNGMSVADIACGSAHSAAITASGHVLTWGKGRYGRLGHG-DSEDQLRPKLVE 4235
            .....:..:|||.|.|..:..:..|:..|......|.:||:|..:  .||.| |::|..:|.|:|
Worm   503 KFSKMENGRLVESLKGRDIQSVGVGNYFSVICCDRGTLLTFGTAK--NLGLGKDAKDSAKPMLLE 565

  Fly  4236 ALLGYRAIDIACGSGDAQTLCITDDDNVWSWGDGDYGKLGRGGSDGCKLPYKIESLAGLGVVKVE 4300
            .||.....||.||..  ..:.:.:......||...||:||....:....|.||...:...:|..:
Worm   566 QLLRENIKDIYCGHD--HVVAVLESGECLGWGSNQYGQLGLPTLEHFFAPTKIPMPSNKKIVYGK 628

  Fly  4301 CGSQFSVALTKSGAVYTWGKGDFHRLG------------HGSVDHVRRPKKVAALQG--KKIISI 4351
            .|...::.|:..|::...|....::|.            ....|:|.:|   ..|||  ::::..
Worm   629 AGKDATMLLSDDGSLIAMGSNKHNKLNLTQRVGFFTKEKKTPNDYVNKP---TILQGFPERVVDF 690

  Fly  4352 ATGSLHCVACSDSGEVYTWGDNDEGQLGDGT--VTAIQRPRLVAALQGKHIVKVTCGSAHTLALS 4414
            :.||.|.....:||:|..:|.||..:||.|.  ..|::..:.|.:|.......|.||...||..:
Worm   691 SVGSYHSGVILESGQVMIFGRNDNTELGLGNSQKMAVRCVKPVKSLLHHACTHVLCGDGFTLVST 755

  Fly  4415 TSQLSERLRPLPNPPLEYDLVRDLAPEALHARLILLHHFSELVCPCLAMLPISGDLSLGALKDVL 4479
            |.|           .|.:...:||..|                                   ||.
Worm   756 TEQ-----------ELYFWGRKDLTDE-----------------------------------DVC 774

  Fly  4480 VYNIKEAAFRKVIQ---TTMVRDKQHGPVIELN----RIQVKRSRN--RCNGLAGIDGMKSVFGQ 4535
            :.:::|....|.::   ||.:.||.   |:.|.    |:|.:|...  |.:|||       |.|:
Worm   775 IDDLEETVTEKKMKRGTTTEIFDKN---VVTLPSLILRLQDERGDKGIRLSGLA-------VSGR 829

  Fly  4536 MVQ-KLPLLTQEALALPHRVWKVKFVGESVDDCGGGYSESIAEMCDELQNGSVPLL 4590
            .|. .:.:|  |...||                     .::||.|   ::||.|.:
Worm   830 KVHVAVDML--EGKRLP---------------------SALAERC---RSGSAPAI 859

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HERC2	NP_608388.2	RCC1	638..683	CDD:278826
		RCC1	687..737	CDD:278826
		RCC1	740..787	CDD:278826
		RCC1	790..841	CDD:278826
		RCC1_2	828..857	CDD:290274
		Cyt-b5	1290..1363	CDD:278597
		MIB_HERC2	1928..1987	CDD:284184
		UBA_HERC2	2515..2559	CDD:270585
		Cul7	2624..2699	CDD:288381
		APC10-HERC2	2762..2932	CDD:176485
		RCC1	3037..3088	CDD:278826
		RCC1	3091..3140	CDD:278826
		RCC1	3144..3194	CDD:278826
		RCC1	3197..3246	CDD:278826
		RCC1	3250..3298	CDD:278826
		RCC1	3302..3350	CDD:278826
		RCC1_2	4136..4166	CDD:290274	8/29 (28%)
		RCC1	4154..4203	CDD:278826	13/48 (27%)
		RCC1	4206..4257	CDD:278826	18/51 (35%)
		RCC1	4260..4309	CDD:278826	11/48 (23%)
		RCC1	4312..4360	CDD:278826	12/61 (20%)
		RCC1	4364..4413	CDD:278826	17/50 (34%)
		HECTc	4509..4880	CDD:238033	20/89 (22%)
		HECTc	4553..4878	CDD:214523	6/38 (16%)
nekl-1	NP_001293320.1	STKc_Nek	170..423	CDD:270855	50/310 (16%)
nekl-1	NP_001293320.1	ATS1	449..764	CDD:227511	85/334 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920