DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment HERC2 and Nedd4

DIOPT Version :9

Sequence 1:NP_608388.2 Gene:HERC2 / 33035 FlyBaseID:FBgn0031107 Length:4912 Species:Drosophila melanogaster
Sequence 2:NP_001344927.1 Gene:Nedd4 / 17999 MGIID:97297 Length:1207 Species:Mus musculus


Alignment Length:557 Identity:135/557 - (24%)
Similarity:233/557 - (41%) Gaps:128/557 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly  4363 DSGEVY---------TWGDNDEGQLGDGTVTAIQRPRLVAALQGKHIVKVTCGSAHTLALSTSQL 4418
            |.|..|         ||        ...|:....|.::.|.|:||                |.  
Mouse   737 DRGRSYYVDHNSKTTTW--------SKPTMQDDPRSKIPAHLRGK----------------TD-- 775

  Fly  4419 SERLRPLPNPPLEYDLVRDLAPEALH--ARLILLHH---FSELVCPCLAMLPISGDLSLGALKDV 4478
            |..|.||| |..|         |..|  .|:..::|   .::...|.|..:.|:|. ::...:| 
Mouse   776 SNDLGPLP-PGWE---------ERTHTDGRVFFINHNIKKTQWEDPRLQNVAITGP-AVPYSRD- 828

  Fly  4479 LVYNIKEAAFRKVI--QTTMVRDKQHGPVIELNRIQVKRSRNRCNGLAGIDGMKSVFGQMVQKLP 4541
              |..|...||:.:  ||.:.           |:.::|  ..|.|.|.  |..:.:.|  |::..
Mouse   829 --YKRKYEFFRRKLKKQTDIP-----------NKFEMK--LRRANILE--DSYRRIMG--VKRAD 874

  Fly  4542 LLTQEALALPHRVWKVKFVGESVDDCGGGYSESIAEMCDELQN-----------GSVPLLINTPN 4595
            ||..       |:| ::|.||...|.||...|....:..|:.|           .:..|.||..:
Mouse   875 LLKA-------RLW-IEFDGEKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQINPNS 931

  Fly  4596 GRGEAGANRDCFLLDPTLSSVLQMNMFRFLGVLMGIAVRTGSPLSINLAEPVWRQLTGEVLRPTD 4660
            |.    .|.|            .::.|:|:|.:.|:||..|..|......|.::.:..:::...|
Mouse   932 GL----CNED------------HLSYFKFIGRVAGMAVYHGKLLDGFFIRPFYKMMLQKLITLHD 980

  Fly  4661 LTEVDRDYVAGLLCIRNMDDDPKLFTALELPFSTSS---ARGHEVPLSTRYTHI--SPRNRAEYV 4720
            :..||.:|.:.|..|  :::||   |.|:|.|....   .:.|:..|.|..:.|  :.:|:.||:
Mouse   981 MESVDSEYYSSLRWI--LENDP---TELDLRFIIDEELFGQTHQHELKTGGSEIVVTNKNKKEYI 1040

  Fly  4721 RLALGFR-LHEFDEQVKAVRDGMSKVIPVPLLSLFSAAELQAMVCGSPDIPLGLLKSVATYK-GF 4783
            .|.:.:| ::...:|:.|.::|..::||..|:.:|...||:.::||..|:.:...:....|| |:
Mouse  1041 YLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGLGDVDVNDWREHTKYKNGY 1105

  Fly  4784 DPSSALVTWFWEVMEEFTNQERSLFLRFVWGRTRLPRT-IADFRG----RDFVLQVLEKNPPDHF 4843
            ..:..::.|||:.:....:::|...|:||.|.:|:|.. .|:..|    :.|.::  :...||. 
Mouse  1106 SMNHQVIHWFWKAVWMMDSEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQSFTVE--QWGTPDK- 1167

  Fly  4844 LPESYTCFFLLKMPRYSCKAVLLEKLKYAIHFCKSID 4880
            ||.::|||..|.:|.|.....|.:||:.||...:..|
Mouse  1168 LPRAHTCFNRLDLPPYESFDELWDKLQMAIENTQGFD 1204

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HERC2NP_608388.2 RCC1 638..683 CDD:278826
RCC1 687..737 CDD:278826
RCC1 740..787 CDD:278826
RCC1 790..841 CDD:278826
RCC1_2 828..857 CDD:290274
Cyt-b5 1290..1363 CDD:278597
MIB_HERC2 1928..1987 CDD:284184
UBA_HERC2 2515..2559 CDD:270585
Cul7 2624..2699 CDD:288381
APC10-HERC2 2762..2932 CDD:176485
RCC1 3037..3088 CDD:278826
RCC1 3091..3140 CDD:278826
RCC1 3144..3194 CDD:278826
RCC1 3197..3246 CDD:278826
RCC1 3250..3298 CDD:278826
RCC1 3302..3350 CDD:278826
RCC1_2 4136..4166 CDD:290274
RCC1 4154..4203 CDD:278826
RCC1 4206..4257 CDD:278826
RCC1 4260..4309 CDD:278826
RCC1 4312..4360 CDD:278826
RCC1 4364..4413 CDD:278826 10/57 (18%)
HECTc 4509..4880 CDD:238033 100/393 (25%)
HECTc 4553..4878 CDD:214523 90/347 (26%)
Nedd4NP_001344927.1 C2 <477..530 CDD:326325
WW 574..602 CDD:238122
WW 727..756 CDD:306827 5/26 (19%)
WW 781..813 CDD:197736 10/41 (24%)
HECTc 874..1203 CDD:214523 92/360 (26%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.900

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