DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment HERC2 and glo-4

DIOPT Version :9

Sequence 1:NP_608388.2 Gene:HERC2 / 33035 FlyBaseID:FBgn0031107 Length:4912 Species:Drosophila melanogaster
Sequence 2:NP_505392.3 Gene:glo-4 / 179306 WormBaseID:WBGene00017195 Length:1386 Species:Caenorhabditis elegans


Alignment Length:1774 Identity:357/1774 - (20%)
Similarity:583/1774 - (32%) Gaps:603/1774 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly  2005 SGSEASPTSDSHPSKLLRHCAAKLLQILAVGT----GLHGAQLDKDALRGMTSMFRTIIYPKPSM 2065
            |.:.:|.||.|..|.||     .||.....|.    |....|..|.|.|.|..        .|.:
 Worm    13 SANSSSDTSTSSESLLL-----PLLNNTKAGARSQKGSVHRQSGKKARRKMME--------NPYV 64

  Fly  2066 ------------SNISYALGWLNLGFIRAISGDCPRLCLELSTPGWLSHYLSLLEQPAGNEAGVY 2118
                        |.|.|::          .|.|...|.|.|::.|.:..||.........:..|.
 Worm    65 CSLELDELSADDSIIDYSV----------FSDDSFLLILLLTSKGDVQAYLETSRDTKPRKNVVN 119

  Fly  2119 RQLHCLRLLQLILAQWGAEEEPRMPALVHQLFATLGRIALHCPGDASLLPTAEGKARVLLTASHS 2183
            .:..|...:..:....|::          ..||..|.      .|.:||.|   ..|:|:..:..
 Worm   120 IKTACSLNVSPVTVCIGSQ----------AAFAIFGL------ADGNLLVT---PIRLLIDVTWG 165

  Fly  2184 GS--VAEELVALLRRLHTLPSWNP----------VINSF-------------------LAQKLCV 2217
            ||  ....::.|     :||:.:|          .:::|                   |..:.||
 Worm   166 GSSWATTTVIDL-----SLPTVDPCLATPTCTKCFVSNFPPCTMAVVANKAGNILLVDLHLRKCV 225

  Fly  2218 AAELLAEQS-H--STALDSEQVFVLGVLGAMGGHDLRP--RVGLHCFHEGSHMVIASFTPKGRCL 2277
             :||.|.|| |  ...||...:.:| |.|..|...:.|  |.|     :|...|:.:..|....:
 Worm   226 -SELKAPQSLHQIDILLDENSIELL-VTGFTGAQWIIPIERSG-----KGFREVLTTCVPSDLTV 283

  Fly  2278 LAPGGV----GSGVGFVKVQLPAVMPHLDHTVFSLS-------RLPMNEMLLNAWTVLLYGPAPE 2331
            |.|..:    ....|.|.:.....:..:.:|..||:       ::|....:::|...:|:     
 Worm   284 LEPATMQFFAADSCGVVALDTTESIVEVYNTFHSLAHSSKRTFKVPPETWMVHAGDNMLF----- 343

  Fly  2332 LRELPSSADGRLDLALLRAQQLQMAVLHTNGVLYRHQVALRRILKQRAPGSIYASPDEPDRSDAE 2396
                ..|.|..:           .:.||...:..|.:..|.|......|..|.|.|..|.:. |.
 Worm   344 ----TVSNDNEI-----------RSALHFGFMSSRLEYTLVRTSTNWRPLGIVAMPSRPHKL-AG 392

  Fly  2397 SQQPGEQDQQLSSGSGQEPQLLIQCILLRATQASPVKACYSYMDLATAALNCIQSLATQAHQELS 2461
            .....|:.                  |:|..|::              ||| :..:|::....||
 Worm   393 IFVVNERG------------------LVRVEQST--------------ALN-LTKIASEFFFRLS 424

  Fly  2462 EGGGVPPNGRALSSPPQPTMVHGVPVYNVARKEQKPSEQVEQKSKWPAAATDAQLIGQIMEMGFT 2526
                             |..::           .|...||....:...|...:.||..::.   |
 Worm   425 -----------------PLQLN-----------SKSVAQVANACRIDTAEFQSALIPNLLS---T 458

  Fly  2527 RRTVELALKQLS----------------LQA-EIMPTPEQIVQWIL--------EHPDVCANTIE 2566
            |:..:|..|:||                |:| |.....||::..:|        :|.::....:|
 Worm   459 RKNRQLTNKELSQIYSIAKAINLSMSDLLKAFENESIGEQLLPEVLNTIQTNPAKHDNLMQRVVE 523

  Fly  2567 EDTLPLASSASSHDPEADSDNECPSSNSTTSSSTSSDTVEGQPMAVSGPAPPVKFESRKDFQTAD 2631
            .......|:..:.|...:.|.|.            |:.:........|.....|....|..||  
 Worm   524 MFVKRSLSAEGNMDKIREYDAEL------------SNFLARHEHLHKGSVDCAKAGMWKCTQT-- 574

  Fly  2632 LYALYVRGLVRPGMTVRCCRDFEEIKQGDMGT-VLIVDTEGLHDLNVQVDWRNHGSTYWVCFVHI 2695
                    |||        ||..|.|..|..| ||:...:.    .:|: |....||        
 Worm   575 --------LVR--------RDVHETKSIDTSTEVLLYIIKN----RLQI-WNEANST-------- 610

  Fly  2696 ELVEAAQTHHQPRPPPIAVGARVRLRTSSLRYGMLCPL---RLGRSQGSSAIGVVSSVRSKQLTV 2757
                                  .||:..||    :|.|   :|..:.|:....::|         
 Worm   611 ----------------------DRLQIMSL----VCHLDWSKLADADGARVCAILS--------- 640

  Fly  2758 DFPDQPAWQGHINEVELVASQPTSATLPSLGDSCSQMPPSDLIEDWSRCIRSLTVSSNEAAAKHL 2822
                  |||..|             :|||..:.|.::.                          :
 Worm   641 ------AWQRDI-------------SLPSYHEMCLRIA--------------------------I 660

  Fly  2823 LNGSNQPWQSCSSGPCRHWIRLELHDRIL-----VHSLT-LKVSPEDHSHMPSLLEIRVG-DCVD 2880
            .|....|      .||          :||     :|.|: .|:|  :|:::|:.|.:..| :|..
 Worm   661 TNSDRFP------RPC----------QILSLVSSIHILSEKKIS--NHANLPNFLPLAGGNNCGA 707

  Fly  2881 SLKEYTWIPVPAGASRVLLMQQVPTYYPWVEVVVKQCQNNGIQCKIHGIKFVGRRQQPDLQHILA 2945
            ::.|         ..|:::         |.                   .|...:|:.::..:  
 Worm   708 TITE---------DDRLMI---------WG-------------------NFTNAQQRMEMPQM-- 733

  Fly  2946 NAQFLASEYSAGVGPGSTAGAGAVSTSHEEAAAAPEQDLPCTVMVWGLNDKEQLGGLKGSKVKVP 3010
            ||:   |:.|..|    |.||..:    ...|..|||.||..:        |..||         
 Worm   734 NAK---SKRSDSV----TNGAPTL----PPPAPKPEQHLPRVL--------EYPGG--------- 770

  Fly  3011 TFSQTISRLRPIHIAGGSKSLFIVSQDGKVYACGEGTNGRLGLGVTHNVPLPHQL----PVLRQY 3071
                     ||..||.|::.:.::|..|::.|.|....|:.|:|.:..:...||:    |     
 Worm   771 ---------RPRAIACGAEHILVLSSSGQLSAWGGNRFGQCGVGHSFRIANLHQVDGDWP----- 821

  Fly  3072 VVKKVAVHSGGKHALALTLDGKVFSWGEGEDGKLGHGNRTTLDK--PRLVEALRAKKIRDVACGS 3134
            .::|:|  .|..|:..:..||.::::|.|..|:||||.|...::  |..|..|.. |:..:|||.
 Worm   822 AIEKIA--CGQFHSAFICSDGSLWTFGWGVWGQLGHGGRNNSNQLVPTRVNGLIC-KVTQIACGR 883

  Fly  3135 SHSAAISSQGELYTWGLGEYGRLGHGDNTTQLKPKLVTALAGRRVVQVACGSRDAQTLALTEDGA 3199
            :|:..::..|.:...|.|.||::|..|:..::.......|...||..:|  :....::.:|||..
 Worm   884 AHTVVLTDTGRVLVCGSGSYGQMGVDDDIKKVFAFTPLPLGPLRVRDIA--THYYHSICITEDNR 946

  Fly  3200 VFSWG-------------------------DGDFGKLGRGGSE---GSDTPHEIER--------- 3227
            ||.||                         |.........||.   ..:.|.||.|         
 Worm   947 VFEWGRNPQELKMRMFVMKKIRSAQLKNTEDPSSPSPSTNGSTPRVNLNLPAEIPREDLGLREVK 1011

  Fly  3228 --LSGIGVVQIECGAQFSLALTRAGEVWTWGKGDYYRLGHGGDQHVRKPQPIGGLRGRRVIHVAV 3290
              |.| .:|.:.||...|..:|..|.::|||||..|:||||......:|..:....|.:.::|::
 Worm  1012 HFLDG-NIVSVACGLSHSALITSEGTLYTWGKGLDYQLGHGNKNERMEPHQVFEPNGAKWVNVSL 1075

  Fly  3291 GALHCLAVTDAGQVYAWGDNDHGQQG-----SGNTF-VNKKPALVIGLDAVFVNRVACGSSHSIA 3349
            |..|.:|.||.|.|:|||.||.||.|     :||:. |.||          |..:...|...   
 Worm  1076 GNNHTIASTDDGSVFAWGKNDFGQCGVLTKKNGNSADVTKK----------FFFQARDGRRF--- 1127

  Fly  3350 WGLPNASSDE--EKRGPVPFSSTRDPLGGSSLGIYEAETMQTLKQ-------------------- 3392
              :||....:  :|.|.:|....|:.....:.|:.:.|.:..||.                    
 Worm  1128 --MPNVDESQFVQKPGLIPDVRVRNLNEDGNEGVDKEEIVDRLKASDVNVVQAVSKHLYSPIEGK 1190

  Fly  3393 ------EAKPLNQSSLSESL--ALETPAARQAALGHVL-----RAM---------------SILQ 3429
                  |.:|.|.....::.  ..:.|.....||.|::     ||:               |::.
 Worm  1191 CNGSIIEDEPRNGKIQKQNKYDGEDGPLCTTTALVHLIAGDVKRAIRMIEWLKTDSSTCEKSLMV 1255

  Fly  3430 ARQLIVAALTSHSKVNFKERGAVGGEEDHLIGGPIMGAPLQLAETIAQGGGEAPADATDAGLQEH 3494
            ...|:...:.:|..|..:|  |:.....|:   | |...::..:.|||   ..||...|..:|. 
 Worm  1256 LSSLVWEVMANHEDVQSRE--ALSAAFRHV---P-MSDSMRKGKQIAQ---LWPAVWNDERVQS- 1310

  Fly  3495 SPEAAVDALTGGMSGGANTLPPLSAGPLSAFQSLTGSLSMSGSLSSSALPQHKHSRMSASAMSVM 3559
              ..::|.....:.|..:...|:|...:.     :.||.:|..:...|  |..|:..:|......
 Worm  1311 --SLSIDEKIAMLDGFTSASKPVSCPTIP-----SSSLEVSSKIRVYA--QCAHAEPAAVGSPPE 1366

  Fly  3560 AATMTQQEEMLSHISHCHG 3578
            .:|..  :|....:.|..|
 Worm  1367 CSTCL--DEWTEKVRHTLG 1383

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HERC2NP_608388.2 RCC1 638..683 CDD:278826
RCC1 687..737 CDD:278826
RCC1 740..787 CDD:278826
RCC1 790..841 CDD:278826
RCC1_2 828..857 CDD:290274
Cyt-b5 1290..1363 CDD:278597
MIB_HERC2 1928..1987 CDD:284184
UBA_HERC2 2515..2559 CDD:270585 15/68 (22%)
Cul7 2624..2699 CDD:288381 18/75 (24%)
APC10-HERC2 2762..2932 CDD:176485 26/176 (15%)
RCC1 3037..3088 CDD:278826 13/54 (24%)
RCC1 3091..3140 CDD:278826 18/50 (36%)
RCC1 3144..3194 CDD:278826 11/49 (22%)
RCC1 3197..3246 CDD:278826 18/87 (21%)
RCC1 3250..3298 CDD:278826 16/47 (34%)
RCC1 3302..3350 CDD:278826 17/53 (32%)
RCC1_2 4136..4166 CDD:290274
RCC1 4154..4203 CDD:278826
RCC1 4206..4257 CDD:278826
RCC1 4260..4309 CDD:278826
RCC1 4312..4360 CDD:278826
RCC1 4364..4413 CDD:278826
HECTc 4509..4880 CDD:238033
HECTc 4553..4878 CDD:214523
glo-4NP_505392.3 RCC1_2 773..801 CDD:290274 7/27 (26%)
RCC1_2 823..852 CDD:290274 8/30 (27%)
RCC1 839..889 CDD:278826 18/50 (36%)
RCC1_2 876..905 CDD:290274 8/28 (29%)
RCC1 893..941 CDD:278826 11/49 (22%)
RCC1_2 1018..1047 CDD:290274 11/28 (39%)
RCC1 1034..1082 CDD:278826 16/47 (34%)
RCC1_2 1070..1099 CDD:290274 13/28 (46%)
VAD1-2 1303..>1371 CDD:291956 14/77 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5184
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1062377at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.820

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